Cobalt-modulated dual emission carbon dots for ratiometric fluorescent vancomycin detection

RSC Advances, Год журнала: 2024, Номер 14(8), С. 5609 - 5616

Опубликована: Янв. 1, 2024

Selective fluorometric protocol for the quantification of vancomycin.

Язык: Английский

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Nanozyme as a rising star for metabolic disease management

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Май 6, 2024

Abstract Nanozyme, characterized by outstanding and inherent enzyme-mimicking properties, have emerged as highly promising alternatives to natural enzymes owning their exceptional attributes such regulation of oxidative stress, convenient storage, adjustable catalytic activities, remarkable stability, effortless scalability for large-scale production. Given the potent regulatory function nanozymes on stress coupled with fact that reactive oxygen species (ROS) play a vital role in occurrence exacerbation metabolic diseases, nanozyme offer unique perspective therapy through multifunctional achieving essential results treatment diseases directly scavenging excess ROS or regulating pathologically related molecules. The rational design strategies, nanozyme-enabled therapeutic mechanisms at cellular level, therapies several typical underlying are discussed, mainly including obesity, diabetes, cardiovascular disease, diabetic wound healing, others. Finally, pharmacokinetics, safety analysis, challenges, outlooks application also presented. This review will provide some instructive perspectives promote development strategies disease therapy. Graphical

Язык: Английский

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Metal‐Doping Strategy for Carbon‐Based Sonosensitizer in Sonodynamic Therapy of Glioblastoma

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Июль 10, 2024

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor and known for its challenging prognosis. Sonodynamic therapy (SDT) an innovative therapeutic approach that shows promise in elimination by activating sonosensitizers with low-intensity ultrasound. In this study, a novel sonosensitizer synthesized using Cu-doped carbon dots (Cu-CDs) sonodynamic treatment of GBM. Doping copper transforms into p-n type semiconductor having bandgap 1.58 eV, prolonged lifespan 10.7 µs, improved electron- hole-separation efficiency. The effect efficiency enhanced. Western blot analysis reveals Cu-CDs induces biological response leading to cell death, termed as cuproptosis. Specifically, upregulate dihydrosulfanyl transacetylase expression, thereby establishing synergistic against death when combined SDT. Furthermore, exhibit excellent permeability through blood-brain barrier potent anti-tumor activity. Importantly, effectively impede growth glioblastoma tumors prolong survival mice bearing these tumors. This study provides support application carbon-based nanomaterials therapy.

Язык: Английский

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Portable Hydrogel Kits Made with Bimetallic Nanozymes for Point-of-Care Testing of Perfluorooctanesulfonate

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(13), С. 15959 - 15969

Опубликована: Март 21, 2024

Perfluorooctanesulfonate (PFOS), an emerging organic contaminant, necessitates robust on-site detection strategies to safeguard human health and ecological balance. This study introduces a novel point-of-care testing (POCT) platform, combining hydrogel kit with nanozymes smartphone technology, for the highly sensitive of PFOS. The strategy utilizes copper-substituted cobalt-based Prussian blue analogue nanoboxes (CuCo-PBA NBs), which exhibit intricate hollow structures remarkable peroxidase-like catalytic activity, efficiently catalyzing oxidation chromogenic substrates hydrogen peroxide (H2O2). Density functional theory calculations elucidate adsorption dynamics H2O2 on CuCo-PBA NBs, identifying factors that improve efficiency. colorimetric POCT integrating interface, demonstrates practical utility achieves limit 1.43 × 10-8 mol L-1 research not only presents new nanozyme design PFOS in diverse matrices, such as lake water, whole blood, urine, milk, but also paves way developing portable efficient platform variety contaminants.

Язык: Английский

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Tuning the carboxyl content of carbon quantum dots by an electrochemical exfoliation method to enhance Fenton-like reactions for contaminants removal in a wide pH range

Journal of environmental chemical engineering, Год журнала: 2024, Номер 12(2), С. 112008 - 112008

Опубликована: Янв. 25, 2024

Язык: Английский

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Protective effect of carbon dots as antioxidants on intestinal inflammation by regulating oxidative stress and gut microbiota in nematodes and mouse models

International Immunopharmacology, Год журнала: 2024, Номер 131, С. 111871 - 111871

Опубликована: Март 16, 2024

Язык: Английский

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Preparation and Application of Carbon Dots Nanozymes

Antioxidants, Год журнала: 2024, Номер 13(5), С. 535 - 535

Опубликована: Апрель 27, 2024

Carbon dot (CD) nanozymes have enzyme-like activity. Compared with natural enzymes, CD offer several advantages, including simple preparation, easy preservation, good stability and recycling, which has made them a popular research topic in various fields. In recent years, researchers prepared variety of for biosensing detection, medicine tumor therapy, many are based on oxidative stress regulation reactive oxygen species clearance. Particularly to expand their potential applications, elemental doping been utilized enhance the catalytic capabilities other properties nanozymes. This review discusses prevalent techniques synthesis presents diverse applications characteristics. Finally, challenges encountered current utilization presented. The latest progress synthesis, application outlined can help encourage future related researches

Язык: Английский

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Single‐Atom Iridium‐doped Carbon Dots Nanozyme with High Peroxidase‐Like Activity as Colorimetric Sensors for Multimodal Detection of Mercury Ions

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Nanozyme-based colorimetric sensors are promising approaches for environmental monitoring, food safety, and medical diagnostics. However, developing novel nanozymes that exhibit high catalytic activity, good dispersion in aqueous solution, sensitivity, selectivity, stability is challenging. In this study, the first time, single-atom iridium-doped carbon dot (SA Ir-CDs) synthesized via a simple situ pyrolysis process. Doping dots with iridium form of single atoms to achieve maximum atomic utilization not only enhances peroxidase (POD)-like activity 178.81 U mg-1 but also improves dispersibility solutions over 30 days. Hence, SA Ir-CD platform developed mercury ions (Hg2+) detection exhibited linear relationship from 0.01 10 µm limit 4.4 nm. Notably, changes color can be observed through naked eye smartphone, enabling convenient field onsite monitoring without need sophisticated analytical equipment. an approach fabricating metal-based POD-like developed, new effective easy-to-use sensor Hg2+ constructed.

Язык: Английский

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Fabrication of a novel reusable nanozyme by immobilizing Co-doped carbon dots on nanocellulose aerogels for efficient dyes degradation

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 297, С. 139824 - 139824

Опубликована: Янв. 12, 2025

Язык: Английский

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Biomass spinach-drived metal-free carbon dots-based nanozyme for multimodal nitrite sensing and functionalized by glucose oxidase as ROS amplifiers to enhance tumor therapy

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140875 - 140875

Опубликована: Фев. 10, 2025

Язык: Английский

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