The Key Effect of Carboxyl Group and CuN₂O₂ Coordinate Structure for Cu, N Co‐Doped Carbon Dots with Peroxidase‐Like Property

Small, Journal Year: 2023, Volume and Issue: 19(31)

Published: April 8, 2023

Abstract Carbon dots (CDs) with good water solubility and biocompatibility have become a research hotspot in the nano‐enzyme biomedical field. However, problems of low catalytic activity ambiguous site CDs as nanozymes still need to be addressed. In this work, loaded Cu single atoms are obtained through pyrolysis, coordination structure surface functional groups regulated by adjusting pyrolysis temperature. at 300 °C (named Cu‐CDs‐300) most carboxyl content is coordinated form CuN 2 O , which can better decompose H produce free radical beneficial catalyze oxidation 3,3′,5,5′‐tetramethylbenzidine (TMB). The v max 6.56*10 −7 m s −1 6.56 times higher than that horseradish peroxidase (HRP). Moreover, Cu‐CDs‐300 effectively lead CT26 apoptosis generating much radicals. This work demonstrates synergistic effect oxygen‐containing metal structures on peroxide‐like provides new ideas for design clear active high efficiency atom catalyst.

Language: Английский

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Nanozymes‐Mediated Cascade Reaction System for Tumor‐Specific Diagnosis and Targeted Therapy

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: March 13, 2024

Abstract Cascade reactions are described as efficient and versatile tools, organized catalytic cascades can significantly improve the efficiency of chemical interworking between nanozymes. They have attracted great interest in many fields such chromogenic detection, biosensing, tumor diagnosis, therapy. However, how to selectively kill cells by enzymatic without harming normal cells, well exploring two or more enzyme‐engineered nanoreactors for cascading reactions, remain challenges field targeted specific cancer diagnostics The latest research advances nanozyme‐catalyzed cascade processes diagnosis therapy this article. Here, various sensing strategies summarized, tumor‐specific diagnostics. Targeting mechanisms treatment using nanozymes classified analyzed, “elements” “dimensions” nanozymes, types, designs structure, assembly modes highly active a variety new targeting based on reaction Finally, integrated application systems tumor‐targeted diagnostic is which will lay foundation design rational, efficient, therapeutic modalities future.

Language: Английский

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Metal‐Doping Strategy for Carbon‐Based Sonosensitizer in Sonodynamic Therapy of Glioblastoma

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 10, 2024

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor and known for its challenging prognosis. Sonodynamic therapy (SDT) an innovative therapeutic approach that shows promise in elimination by activating sonosensitizers with low-intensity ultrasound. In this study, a novel sonosensitizer synthesized using Cu-doped carbon dots (Cu-CDs) sonodynamic treatment of GBM. Doping copper transforms into p-n type semiconductor having bandgap 1.58 eV, prolonged lifespan 10.7 µs, improved electron- hole-separation efficiency. The effect efficiency enhanced. Western blot analysis reveals Cu-CDs induces biological response leading to cell death, termed as cuproptosis. Specifically, upregulate dihydrosulfanyl transacetylase expression, thereby establishing synergistic against death when combined SDT. Furthermore, exhibit excellent permeability through blood-brain barrier potent anti-tumor activity. Importantly, effectively impede growth glioblastoma tumors prolong survival mice bearing these tumors. This study provides support application carbon-based nanomaterials therapy.

Language: Английский

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Tuning the carboxyl content of carbon quantum dots by an electrochemical exfoliation method to enhance Fenton-like reactions for contaminants removal in a wide pH range

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(2), P. 112008 - 112008

Published: Jan. 25, 2024

Language: Английский

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Protective effect of carbon dots as antioxidants on intestinal inflammation by regulating oxidative stress and gut microbiota in nematodes and mouse models

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 131, P. 111871 - 111871

Published: March 16, 2024

Language: Английский

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Portable Hydrogel Kits Made with Bimetallic Nanozymes for Point-of-Care Testing of Perfluorooctanesulfonate

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(13), P. 15959 - 15969

Published: March 21, 2024

Perfluorooctanesulfonate (PFOS), an emerging organic contaminant, necessitates robust on-site detection strategies to safeguard human health and ecological balance. This study introduces a novel point-of-care testing (POCT) platform, combining hydrogel kit with nanozymes smartphone technology, for the highly sensitive of PFOS. The strategy utilizes copper-substituted cobalt-based Prussian blue analogue nanoboxes (CuCo-PBA NBs), which exhibit intricate hollow structures remarkable peroxidase-like catalytic activity, efficiently catalyzing oxidation chromogenic substrates hydrogen peroxide (H2O2). Density functional theory calculations elucidate adsorption dynamics H2O2 on CuCo-PBA NBs, identifying factors that improve efficiency. colorimetric POCT integrating interface, demonstrates practical utility achieves limit 1.43 × 10-8 mol L-1 research not only presents new nanozyme design PFOS in diverse matrices, such as lake water, whole blood, urine, milk, but also paves way developing portable efficient platform variety contaminants.

Language: Английский

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Core–Shell Structured Nanozyme with PDA-Mediated Enhanced Antioxidant Efficiency to Treat Early Intervertebral Disc Degeneration

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(4), P. 5103 - 5119

Published: Jan. 17, 2024

Early intervention during intervertebral disc degeneration (IDD) plays a vital role in inhibiting its deterioration and activating the regenerative process. Aiming at high oxidative stress (OS) IDD microenvironment, core–shell structured nanozyme composed of Co-doped NiO nanoparticle (CNO) as core encapsulated with polydopamine (PDA) shell, named PDA@CNO, was constructed, hoping to regulate pathological environment. The results indicated that coexistence abundant Ni3+/Ni2+and Co3+/Co2+redox couples CNO provided rich catalytic sites; meanwhile, quinone catechol groups PDA shell could enable proton-coupled electron transfer, thus endowing PDA@CNO multiple antioxidative enzyme-like activities scavenge •O2–, H2O2, •OH efficiently. Under OS conditions vitro, effectively reduce intracellular ROS nucleus pulposus (NP) into friendly H2O O2, protect NP cells from stagnant proliferation, abnormal metabolism (senescence, mitochondria dysfunction, impaired redox homeostasis), inflammation, thereby reconstructing extracellular matrix (ECM) homeostasis. vivo local injection experiments further proved desirable therapeutic effects rat model, suggesting great potential prohibiting deterioration.

Language: Английский

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Eco-friendly cobalt-doped carbon quantum dots for spectrofluorometric determination of pregabalin in pharmaceutical capsules

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 248, P. 116270 - 116270

Published: May 31, 2024

Language: Английский

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Antimicrobial carbon materials-based quantum dots: From synthesis strategies to antibacterial properties for diagnostic and therapeutic applications in wound healing

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216211 - 216211

Published: Sept. 18, 2024

Language: Английский

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N, P, S Codoped Carbon Nanozymes with Enhanced Peroxidase-like Activity and Binding Affinity for Total Antioxidant Capacity Assay

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(24), P. 23303 - 23312

Published: Dec. 5, 2023

Developing peroxidase-like sensors with excellent catalytic activity to construct colorimetric has been an important challenge for a long time. The electronegativity of the doped nonmetallic atoms can change chemical environment carbon material and promote redistribution electrons, thus improving electron transfer channel between nanozyme reaction substrate further enhancing activity. Herein, nitrogen (N), phosphorus (P), sulfur (S) codoped (NPS-C) was successfully designed via one-step high-temperature pyrolysis. Compared N-doped nanozymes (N–C), N P (NP-C) have lower Michaelis–Menten constant, S (NS-C) higher rate. Therefore, based on synergy different atoms, NPS-C exhibited stronger binding affinity, which effectively activated H2O2 produce reactive oxygen intermediates oxidation capacity superoxide anion radical (•O2–) promoted TMB lose be oxidized oxTMB. Moreover, ascorbic acid (AA), as antioxidant model, rapidly consume species reduce linear relationship concentration AA inhibition degree activity, sensor constructed analyze total (TAC) in beverages.

Language: Английский

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