ACS Materials Letters,
Год журнала:
2024,
Номер
7(1), С. 1 - 23
Опубликована: Ноя. 21, 2024
With
the
continuous
increase
in
average
life
expectancy,
population
aging
has
become
a
significant
health
issue
21st
century.
The
rising
prevalence
of
age-related
diseases
brought
tremendous
pressure
on
social
medical
systems
and
economy.
Against
this
backdrop,
research
anticellular
hot
spot
field
biomedicine,
biomaterials
are
showing
new
trends
potential
area.
Compared
to
drugs
other
traditional
anti-aging
strategies,
can
be
personalized
target
characteristics
different
tissues,
serving
as
drug
delivery
carriers
enhance
targeting,
directly
influence
cellular
process
by
modulating
microenvironment.
Furthermore,
offer
innovative
approaches
diagnosing
building
sophisticated
models,
which
our
understanding
biology
behind
speed
up
advancement
novel
treatments.
This
review
synthesizes
latest
advancements
biomaterial
for
combating
aging,
exploring
future
prospects
challenges.
ACS Materials Letters,
Год журнала:
2024,
Номер
6(7), С. 2533 - 2547
Опубликована: Май 24, 2024
Contemporary
options
for
multidrug-resistant
bacteria
infected
diabetic
foot
ulcers
(IDFUs)
are
predominantly
nonspecific.
These
IDFU
injuries
often
display
prolonged
inflammation
and
delayed
tissue
repair,
mainly
attributed
to
an
overabundance
of
M1
macrophages
in
the
hostile
microenvironment.
Although
immunomodulatory
hydrogels
show
promise
IDFU-focused
care,
a
targeted,
safe
transition
from
M2
using
simplified
techniques
remains
significant
obstacle.
Here,
we
introduce
hybrid
hydrogel
(GGG)
with
inherent
capabilities
IDFUs.
GGG
is
composed
interpenetrating
polymer
networks
featuring
gallium-induced
self-assembling
glycyrrhizic
acid
photo-cross-linked
gelatin
methacryloyl
matrix.
Importantly,
effectively
decreases
ratio
conditions
drug-resistant
by
disrupting
iron
metabolism
scavenging
reactive
oxygen
species,
which
contributes
enhanced
treatment
results
wounds.
To
sum
up,
strategy
present
provides
straightforward,
safe,
highly
effective
therapeutic
avenue
managing
Advances in Colloid and Interface Science,
Год журнала:
2023,
Номер
321, С. 103030 - 103030
Опубликована: Окт. 20, 2023
The
impairment
of
articular
cartilage
due
to
traumatic
incidents
or
osteoarthritis
has
posed
significant
challenges
for
healthcare
practitioners,
researchers,
and
individuals
suffering
from
these
conditions.
Due
the
absence
an
approved
treatment
strategy
complete
restoration
defects
their
native
state,
tissue
condition
often
deteriorates
over
time,
leading
osteoarthritic
(OA).
However,
recent
advancements
in
field
regenerative
medicine
have
unveiled
promising
prospects
through
utilization
injectable
hydrogels.
This
versatile
class
biomaterials,
characterized
by
ability
emulate
characteristics
cartilage,
offers
distinct
advantage
minimally
invasive
administration
directly
site
damage.
These
hydrogels
can
also
serve
as
ideal
delivery
vehicles
a
diverse
range
bioactive
agents,
including
growth
factors,
anti-inflammatory
drugs,
steroids,
cells.
controlled
release
such
biologically
active
molecules
hydrogel
scaffolds
accelerate
healing,
stimulate
chondrogenesis,
modulate
inflammatory
microenvironment
halt
progression.
present
review
aims
describe
methods
used
design
hydrogels,
expound
upon
applications
molecules,
provide
update
on
advances
leveraging
systems
foster
regeneration.
Journal of Orthopaedic Translation,
Год журнала:
2023,
Номер
41, С. 54 - 62
Опубликована: Июль 1, 2023
Osteoarthritis
(OA)
poses
a
significant
burden
for
countless
individuals,
inflicting
relentless
pain
and
impairing
their
quality
of
life.
Although
traditional
treatments
OA
focus
on
management
surgical
interventions,
they
often
fall
short
addressing
the
underlying
cause
disease.
Fortunately,
emerging
biomaterial-based
scaffolds
offer
hope
therapy,
providing
immense
promise
cartilage
regeneration
in
OA.
These
innovative
are
ingeniously
designed
to
provide
support
mimic
intricate
structure
natural
extracellular
matrix,
thus
stimulating
damaged
cartilage.
In
this
comprehensive
review,
we
summarize
discuss
current
landscape
Furthermore,
delve
into
diverse
range
biomaterials
employed
construction
explore
cutting-edge
techniques
utilized
fabrication.
By
examining
both
preclinical
clinical
studies,
aim
illuminate
remarkable
versatility
untapped
potential
context
thoroughly
state
research
review
provides
valuable
insights
that
bridge
gap
between
scientific
knowledge
practical
application.
This
is
crucial
clinicians
researchers
who
strive
develop
go
beyond
symptom
directly
target
Through
analysis
multidisciplinary
approach,
paves
way
translation
applications,
ultimately
improving
lives
individuals
suffering
from
shaping
future
orthopedic
medicine.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(9)
Опубликована: Янв. 23, 2024
Abstract
Partial‐thickness
cartilage
defect
(PTCD)
is
a
common
and
formidable
clinical
challenge
without
effective
therapeutic
approaches.
The
inherent
anti‐adhesive
characteristics
of
the
extracellular
matrix
within
pose
significant
impediment
to
integration
cells
or
biomaterials
with
native
during
repair.
Here,
an
injectable
photocrosslinked
bioadhesive
hydrogel,
consisting
gelatin
methacryloyl
(GM),
acryloyl‐6‐aminocaproic
acid‐
g
‐N‐hydroxysuccinimide
(AN),
poly(lactic‐
co
‐glycolic
acid)
microspheres
loaded
kartogenin
(KGN)
(abbreviated
as
GM/AN/KGN
hydrogel),
designed
enhance
interfacial
repair
PTCD.
After
injected
in
situ
at
irregular
defect,
stable
robust
hydrogel
network
rapidly
formed
by
ultraviolet
irradiation,
it
can
be
quickly
tightly
adhered
through
amide
bonds.
exhibits
good
adhesion
strength
up
27.25
±
1.22
kPa
lap
shear
experiments.
demonstrates
adhesion,
low
swelling,
resistance
fatigue,
biocompatibility,
chondrogenesis
properties
vitro.
A
rat
model
PTCD
restoration
smoother
surface,
seamless
integration,
abundant
aggrecan
type
II
collagen
production.
adhesive
long‐term
chondrogenic
differentiation
capacity
shows
great
potential
facilitate
Biomacromolecules,
Год журнала:
2024,
Номер
25(4), С. 2243 - 2260
Опубликована: Март 25, 2024
Cartilage
repair
has
been
a
significant
challenge
in
orthopedics
that
not
yet
fully
resolved.
Due
to
the
absence
of
blood
vessels
and
almost
cell-free
nature
mature
cartilage
tissue,
limited
ability
resulted
socioeconomic
pressures.
Polysaccharide
materials
have
recently
widely
used
for
tissue
due
their
excellent
cell
loading,
biocompatibility,
chemical
modifiability.
They
also
provide
suitable
microenvironment
regeneration.
In
this
Review,
we
summarize
techniques
clinically
repair,
focusing
on
polysaccharides,
polysaccharides
differences
between
these
other
materials.
addition,
engineering
strategies
an
outlook
developing
next-generation
regeneration
from
polysaccharides.
This
Review
will
theoretical
guidance
polysaccharide-based
with
clinical
applications
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(4)
Опубликована: Окт. 20, 2023
Abstract
Due
to
thiolation
of
poly‐
and
oligosaccharides
numerous
favorable
properties
for
tissue
engineering
wound
healing
can
be
introduced.
Poly‐
thiolated
via
hydroxyl‐to‐thiol
conversions
or
the
covalent
attachment
sulfhydryl
ligands
hydroxyl,
carbonic
acid
amino
groups
on
them.
Since
cross‐link
disulfide
bonds,
they
form
stable
3D
networks
with
defined
microarchitecture,
stiffness,
elasticity,
degradability.
Furthermore,
thiol
enhance
cell
adhesion
since
cells
exhibit
cysteine‐rich
subdomains
their
surface
that
bonds
Sulfhydryl
also
participate
in
signaling
pathways
favoring
various
cellular
processes
like
proliferation,
migration,
spreading,
differentiation
are
beneficial
healing.
In
addition,
a
controlled
release
active
ingredients
such
as
growth
factors
being
bound
achieved
thiol/disulfide
exchange
reactions.
Over
last
two
decades,
number
hyaluronic
chitosan
used
has
increased
tremendously.
Within
this
review,
an
overview
is
provided
about
chemistry
oligosaccharides,
key
properties,
applications
performance
clinical
trials
marketed
products.
Abstract
Polyhedral
oligomeric
silsesquioxane
(POSS)
is
a
3D,
cage‐like
nanoparticle
with
an
inorganic
Si–O–Si
core
and
eight
tunable
corner
functional
groups.
Its
well‐defined
structure
grants
it
distinctive
physical,
chemical,
biological
properties
has
been
widely
used
for
preparing
high‐performance
materials.
Recently,
click
chemistry
enabled
the
synthesis
of
various
POSS‐based
materials
diverse
biomedical
applications.
This
article
reviews
recent
applications
in
field,
including
cancer
treatment,
tissue
engineering,
antibacterial
use,
imaging.
Representative
examples
are
discussed
detail.
Among
applications,
treatment
engineering
most
important.
Finally,
this
review
presents
current
limitations
provides
guidance
future
research.
