Biomedical Metal–Organic framework materials on antimicrobial therapy: Perspectives and challenges

Materials Today Chemistry, Год журнала: 2024, Номер 41, С. 102300 - 102300

Опубликована: Сен. 7, 2024

Язык: Английский

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An ATP-activated spatiotemporally controlled hydrogel prodrug system for treating multidrug-resistant bacteria-infected pressure ulcers

Bioactive Materials, Год журнала: 2024, Номер 45, С. 301 - 321

Опубликована: Ноя. 27, 2024

Язык: Английский

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Cerium dioxide nanozyme doped hybrid hydrogel with antioxidant and antibacterial abilities for promoting diabetic wound healing

Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 154517 - 154517

Опубликована: Авг. 3, 2024

Язык: Английский

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Hyperthermia-enhanced immunoregulation hydrogel for oxygenation and ROS neutralization in diabetic foot ulcers

Опубликована: Март 1, 2025

Язык: Английский

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A multifunctional hydrogel with mild photothermal antibacterial and antioxidant properties based on quercetin and dopamine-coated zinc oxide nanoparticles for healing bacteria-infected wound

Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 154518 - 154518

Опубликована: Авг. 5, 2024

Язык: Английский

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Enhanced diabetic foot ulcer treatment with a chitosan-based thermosensitive hydrogel loaded self-assembled multi-functional nanoparticles for antibacterial and angiogenic effects

Carbohydrate Polymers, Год журнала: 2024, Номер 347, С. 122740 - 122740

Опубликована: Сен. 12, 2024

Язык: Английский

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ROS sensitive adaptive injectable hydrogels Based on GAPBA nanofibers and PVA/EGCG for accelerating diabetic wound healing through regulating the inflammation microenvironment

European Polymer Journal, Год журнала: 2025, Номер unknown, С. 113723 - 113723

Опубликована: Янв. 1, 2025

Язык: Английский

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Hydrogen bonding-mediated phase-transition gelatin-based bioadhesives to regulate immune microenvironment for diabetic wound healing

Bioactive Materials, Год журнала: 2025, Номер 46, С. 434 - 447

Опубликована: Янв. 5, 2025

Язык: Английский

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Enhanced hemostatic efficacy of cryogel with copper ion-loaded mesoporous bioactive glasses for acute and persistent bleeding

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 12, 2025

Uncontrolled acute and persistent bleeding, as well with infection, is a great challenge because of the high mortality during treating patients injuries, complex surgery or bone marrow failure. Here, we develop an external form natural components which based on phosphorylated methacrylated gelatin (GelMA, G) cryogel (GP) loaded tannic acid (TA)-mixed copper ion (Cu2+) mesoporous bioactive glasses (MBG), named after GP@MBG-Cu-TA cryogel, to address goals reduce bleeding enhance antibacterial activity. Structurally, GP, MBG TA Cu2+ adheres GP via hydrogen bonding. In vitro, displays good biocompatibility, hemostatic antimicrobial capability. vivo studies, can effect in liver injury SD rats for aplastic anemia hemophilia A mice tail amputation bleeding. addition, accelerates skin wound repair bacterial contamination at site. sum, not only endowed dual function capability, but also stop objects either normal abnormal coagulation function. Thus, provides promising candidate dressing managing complications clinic.

Язык: Английский

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Microenvironment-sensitive hydrogels as promising drug delivery systems for co-encapsulating microbial homeostasis probiotics and anti-inflammatory drugs to treat periodontitis

Materials Today Bio, Год журнала: 2025, Номер 32, С. 101711 - 101711

Опубликована: Март 27, 2025

Developing and utilizing effective local antimicrobial agents can help treat periodontitis while minimizing the risks associated with systemic antibiotic use. Recent studies have shown that mucosal adhesion properties of hydrogels play a potential role in treatment periodontitis. The hydrogel improve contact retention time drugs periodontal pocket. Through mucosa, it interacts mucin coating surface epithelium teeth to form specific interface force. exhibits strong (adhesion strength: 5-6 N/cm2) prolonged pockets (≥6 h), enabling sustained drug release through dynamic sol-gel transitions triggered by pH reactive oxygen species (ROS). This design overcomes limitations poor mechanical stability conventional formulations. balance oral microbiota plays an important maintaining health. Probiotics, colonizing cavity, transform infected site from environment rich inflammatory cytokines more benign environment, inhibit harmful pathogenic microorganisms, contribute overall Microenvironment sensitive perform sol gel transformation situ, accurately control when exposed various stimuli (such as temperature change, light, species, etc.). Oral probiotics anti-inflammatory are encapsulated proliferation pathogens planting mouth producing metabolites, effectively preventing treating diseases.

Язык: Английский

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