Materials Today Bio,
Год журнала:
2025,
Номер
32, С. 101711 - 101711
Опубликована: Март 27, 2025
Developing
and
utilizing
effective
local
antimicrobial
agents
can
help
treat
periodontitis
while
minimizing
the
risks
associated
with
systemic
antibiotic
use.
Recent
studies
have
shown
that
mucosal
adhesion
properties
of
hydrogels
play
a
potential
role
in
treatment
periodontitis.
The
hydrogel
improve
contact
retention
time
drugs
periodontal
pocket.
Through
mucosa,
it
interacts
mucin
coating
surface
epithelium
teeth
to
form
specific
interface
force.
exhibits
strong
(adhesion
strength:
5-6
N/cm2)
prolonged
pockets
(≥6
h),
enabling
sustained
drug
release
through
dynamic
sol-gel
transitions
triggered
by
pH
reactive
oxygen
species
(ROS).
This
design
overcomes
limitations
poor
mechanical
stability
conventional
formulations.
balance
oral
microbiota
plays
an
important
maintaining
health.
Probiotics,
colonizing
cavity,
transform
infected
site
from
environment
rich
inflammatory
cytokines
more
benign
environment,
inhibit
harmful
pathogenic
microorganisms,
contribute
overall
Microenvironment
sensitive
perform
sol
gel
transformation
situ,
accurately
control
when
exposed
various
stimuli
(such
as
temperature
change,
light,
species,
etc.).
Oral
probiotics
anti-inflammatory
are
encapsulated
proliferation
pathogens
planting
mouth
producing
metabolites,
effectively
preventing
treating
diseases.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 12, 2025
Uncontrolled
acute
and
persistent
bleeding,
as
well
with
infection,
is
a
great
challenge
because
of
the
high
mortality
during
treating
patients
injuries,
complex
surgery
or
bone
marrow
failure.
Here,
we
develop
an
external
form
natural
components
which
based
on
phosphorylated
methacrylated
gelatin
(GelMA,
G)
cryogel
(GP)
loaded
tannic
acid
(TA)-mixed
copper
ion
(Cu2+)
mesoporous
bioactive
glasses
(MBG),
named
after
GP@MBG-Cu-TA
cryogel,
to
address
goals
reduce
bleeding
enhance
antibacterial
activity.
Structurally,
GP,
MBG
TA
Cu2+
adheres
GP
via
hydrogen
bonding.
In
vitro,
displays
good
biocompatibility,
hemostatic
antimicrobial
capability.
vivo
studies,
can
effect
in
liver
injury
SD
rats
for
aplastic
anemia
hemophilia
A
mice
tail
amputation
bleeding.
addition,
accelerates
skin
wound
repair
bacterial
contamination
at
site.
sum,
not
only
endowed
dual
function
capability,
but
also
stop
objects
either
normal
abnormal
coagulation
function.
Thus,
provides
promising
candidate
dressing
managing
complications
clinic.
