Unleashing the power within: Enhancing hydrogel bio-mimetic polymer actuators (HBPA) through sodium alginate crosslinking with cordyceps polysaccharide (CO-PS)

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142916 - 142916

Опубликована: Апрель 1, 2025

Язык: Английский

---

Polysaccharide-based hydrogels for cartilage regeneration

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Окт. 11, 2024

Cartilage defect is one of the common tissue clinical diseases and may finally lead to osteoarthritis (OA) which threat patients’ physical psychological health. Polysaccharide main component extracellular matrix (ECM) in cartilage tissue. In past decades, polysaccharide-based hydrogels have shown great potential for regeneration considering unique qualities such as biocompatibility, enhanced cell proliferation, drug delivery, low toxicity, many others. Structures chain length branching make polysaccharides different chemical properties. this review, current treatment options defection repair were illustrated. We focus on how components structures recently developed materials affect performance. The challenges perspectives also discussed depth.

Язык: Английский

---

Progress in the Application of Multifunctional Composite Hydrogels in Promoting Tissue Repair

ACS Omega, Год журнала: 2024, Номер 9(49), С. 47964 - 47975

Опубликована: Ноя. 21, 2024

Tissue repair is an extremely complex process, and effectively promoting tissue regeneration remains a significant clinical challenge. Hydrogel materials, which exhibit physical properties closely resembling those of living tissues, including high water content, oxygen permeability, softness, have the potential to revolutionize field repair. However, presence various conditions, such as infection, ischemia, hypoxia in defects, means that hydrogels with simple structures functions are often insufficient meet diverse needs Researchers focused on integrating multiple drugs, nanomaterials, bioactive substances, stem cells into hydrogel matrices develop novel multifunctional composite for addressing these challenges, superior antibacterial properties, hemostatic abilities, self-healing capacities, excellent mechanical properties. These designed enhance become important direction current research. This review provides comprehensive recent advances application repair, drug-loaded hydrogels, nanomaterial substance cell hydrogels.

Язык: Английский

---

Transforming Osteoarthritis Treatment: Embracing Hydrogel Microspheres

ACS Materials Letters, Год журнала: 2024, Номер unknown, С. 3862 - 3882

Опубликована: Июль 24, 2024

Osteoarthritis (OA) is a chronic condition characterized by degeneration of the articular cartilage and subsequent bone hyperplasia. With increasing prevalence driven factors such as aging obesity, OA poses growing health economic burden. Current treatments, including NSAIDs corticosteroid injections, offer limited efficacy often result in adverse effects, highlighting urgent need for novel therapeutic approaches. Emerging research has identified hydrogel microspheres promising solution management. These microspheres, with their tunable physicochemical properties biocompatibility, provide conducive environment regeneration sustained drug delivery. Unlike bulk hydrogels, enhanced injectability, uniform distribution, reduced tissue damage. This review discusses recent advancements microsphere technology, focusing on fabrication, unique mechanisms, applications OA. Additionally, we address challenges future directions clinical translation, aim to optimize treatment.

Язык: Английский

---

Polysaccharide nanosystems for osteoarthritis therapy: Mechanisms, combinations, and future directions

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 279, С. 135146 - 135146

Опубликована: Авг. 30, 2024

Язык: Английский

---

Advanced Biomaterials Derived from Functional Polyphosphoesters: Synthesis, Properties, and Biomedical Applications

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Polyphosphoesters (PPEs) represent an innovative class of biodegradable polymers, with the phosphate ester serving as core repeating unit their polymeric backbone. Recently, biomaterials derived from functionalized PPEs have garnered significant interest in biomedical applications because commendable biocompatibility, biodegradability, and capacity for functional modification. This review commences a brief overview synthesis methodologies distinctive properties PPEs, including thermoresponsiveness, degradability, stealth effect, biocompatibility. Subsequently, delves into latest PPEs-based nanocarriers drug or gene delivery prodrugs scaffolds field, presenting several illustrative examples each application. By encapsulating advancements recent years, this aims to offer enhanced understanding serve reference PPEs.

Язык: Английский

---

The Biological Macromolecules constructed Matrigel for cultured organoids in biomedical and tissue engineering

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 247, С. 114435 - 114435

Опубликована: Дек. 7, 2024

Язык: Английский

---

Enhanced Adsorption Stability and Biofunction Durability with Phosphonate-Grafted, PEGylated Copolymer on Hydroxyapatite Surface

Langmuir, Год журнала: 2024, Номер 40(6), С. 3190 - 3201

Опубликована: Янв. 31, 2024

Nonfouling surfaces are crucial in applications such as biosensors, medical implants, marine coatings, and drug delivery vehicles. However, their long-term coating stability robust surface binding strength physiological media remain challenging. Herein, a phosphonate-grafted, PEGylated copolymer on the hydroxyapatite (HA) is proposed to significantly improve adsorption thus enhance biofunction durability accordingly. The phosphoryl (−PO3) grafted branch employed functional polymer facilitate attaching HA substrate. In addition, integrates nonfouling brushes of poly(ethylene glycol) (PEG) with cell-adhesive moiety cyclic Arg-Gly-Asp-d-Phe-Cys peptides (cRGD). A systematic study as-synthesized graft indicates synergistic mechanism NH2 PO3 groups HA, achieving high coverage desirable stability. cRGD/PEGylated copolymers optimized grafting architecture proven effectively adsorb self-assembled monolayer, showing minimal desorption even complex, medium preventing nonspecific protein examined X-ray photoelectron spectroscopy (XPS) quartz crystal microbalance dissipation (QCM-D). Direct adhesion assays further confirm that enhanced cRGD-PEGylated can considerably promote osteoblast attachment surfaces, meanwhile microbial adhesion. This research has resulted solution self-assembly structure optimization exhibits stable characteristics.

Язык: Английский

---

3D cell culture of nanofiber hydrogel promotes the growth and osteogenesis of bone marrow mesenchymal stem cells (BMSC)

Materials Express, Год журнала: 2024, Номер 14(5), С. 727 - 733

Опубликована: Фев. 29, 2024

Hydrogels, as a type of polymer network material with high water content, find wide application in various tissue repair procedures. In addition, three-dimension (3D) cell culture platform similar to natural extracellular matrix can be constructed vitro by modifying chains. Therefore, this study based on hydrogel, the introduction inorganic nanoparticles POSS prepare GelMA-POSS nanohydrogel. The physical and chemical properties hydrogel were evaluated through SEM, swelling test degradation analysis. Subsequently, nano-hydrogel was used rBMSCs . CCK-8 flow cytometry detect proliferation ability apoptosis rate rBMSCs. expression osteogenic markers detected qPCR, Western Blotting ELISA assay, differentiation ALP staining alizarin red staining. results indicate that compared pure gelatin (Gel) nanohydrogel has slower better retention capacity. Furthermore, experiments showed had good biocompatibility, could promote increase level cells, induce significantly improves Gel biocompatibility rBMSCs, Thus, it holds great promise potential for repairing bone defects.

Язык: Английский

---

Nanostructured Biopolymer‐Based Constructs for Cartilage Regeneration: Fabrication Techniques and Perspectives

Macromolecular Bioscience, Год журнала: 2024, Номер 24(8)

Опубликована: Май 15, 2024

The essential functions of cartilage, such as shock absorption and resilience, are hindered by its limited regenerative capacity. Although current therapies alleviate symptoms, novel strategies for cartilage regeneration desperately needed. Recent developments in three-dimensional (3D) constructs aim to address this challenge mimicking the intrinsic characteristics native using biocompatible materials, with a significant emphasis on both functionality stability. Through fabrication methods 3D printing electrospinning, researchers making progress regeneration; nevertheless, it is still very difficult translate these advances into clinical practice. review emphasizes importance integrating various techniques create stable constructs. Meticulous design material selection required achieve seamless integration durability. outlines need challenges focuses latest production hybrid based biodegradable polymers. Furthermore, acknowledges limitations research provides perspectives potential avenues effectively regenerating defects future.

Язык: Английский

---