Materials Today Chemistry, Год журнала: 2025, Номер 44, С. 102540 - 102540
Опубликована: Янв. 22, 2025
Язык: Английский
Advanced Materials, Год журнала: 2024, Номер 36(31)
Опубликована: Апрель 14, 2024
Although nanozymes have drawn great attention over the past decade, activities of peroxidase-like, oxidase-like, and catalase-like are often pH dependent with elusive mechanism, which largely restricts their application. Therefore, a systematical discussion on pH-related catalytic mechanisms together methods to overcome this limitation is in need. In review, various exhibiting pH-dependent collected root causes for dependence comprehensively analyzed. Subsequently, regulatory concepts including environment reconstruction direct activity improvement break restriction summarized. Moreover, applications pH-independent sensing, disease therapy, pollutant degradation overviewed. Finally, current challenges future opportunities development suggested. It anticipated that review will promote further design broaden application range higher efficiency.
Язык: Английский
Процитировано
66
Nano-Micro Letters, Год журнала: 2024, Номер 16(1)
Опубликована: Фев. 6, 2024
Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.
Язык: Английский
Процитировано
41
Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150545 - 150545
Опубликована: Март 19, 2024
Язык: Английский
Процитировано
29
Bioactive Materials, Год журнала: 2024, Номер 44, С. 131 - 151
Опубликована: Окт. 15, 2024
Язык: Английский
Процитировано
27
Nanoscale, Год журнала: 2024, Номер 16(7), С. 3324 - 3346
Опубликована: Янв. 1, 2024
POD nanozymes for bactericidal treatment.
Язык: Английский
Процитировано
23
Chemical Engineering Journal, Год журнала: 2024, Номер 489, С. 151485 - 151485
Опубликована: Апрель 20, 2024
Язык: Английский
Процитировано
22
Biomaterials, Год журнала: 2025, Номер unknown, С. 123134 - 123134
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
7
Carbohydrate Polymers, Год журнала: 2025, Номер 354, С. 123298 - 123298
Опубликована: Янв. 23, 2025
Язык: Английский
Процитировано
2
Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(29), С. 6746 - 6761
Опубликована: Янв. 1, 2023
The slow healing of diabetic wounds has seriously affected human health. Meanwhile, the open are susceptible to bacterial infection. Clinical therapeutic methods such as antibiotic therapy, insulin treatment, and surgical debridement have made great achievements in treatment wounds. However, drug-resistant bacteria will develop after long-term use antibiotics, resulting decreased efficacy. To improve effect, increasing drug concentration is a common strategy clinical practice, but it also brings serious side effects. In addition, hyperglycemia control or can easily bring negative effects patients, hypoglycemia damage normal tissue. Therefore, essential novel strategies effectively promote wound healing. recent years, nanozyme-based systems received extensive attention because they possess advantages nanomaterials natural enzymes. For example, nanozymes small size high surface area volume ratio, which enhance tissue penetration increase reactive active sites. Moreover, compared with enzymes, more stable catalytic activity, lower production cost, stronger operability. this review, we first reviewed basic characteristics then elaborated on mechanism action principle different types from three aspects: controlling infection, hyperglycemia, relieving inflammation. Finally, challenges, prospects future implementation for outlined.
Язык: Английский
Процитировано
43
ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 16(1), С. 95 - 110
Опубликована: Дек. 29, 2023
Nanozymes, emerging nanomaterials for wound healing, exhibit enzyme-like activity to modulate the levels of reactive oxygen species (ROS) at sites. Yet, solo regulation endogenous ROS by nanozymes often falls short, particularly in chronic refractory wounds with complex and variable pathological microenvironments. In this study, we report development a multifunctional dressing integrating conventional alginate (Alg) hydrogel newly developed biodegradable copper hydrogen phosphate (CuP) nanozyme, which possesses good near-infrared (NIR) photothermal conversion capabilities, sustained Cu ion release ability, pH-responsive peroxidase/catalase-mimetic catalytic activity. When examining acute infected characterized low pH environment, engineered Alg/CuP composite hydrogels demonstrated high bacterial eradication efficacy against both planktonic bacteria biofilms, attributed combined action catalytically generated hydroxyl radicals ions. contrast, when applied diabetic wounds, typically have these significant angiogenic performance. This is driven provision dissolved beneficial supplement ions released from degradable CuP nanozyme. Further, mild thermal effect induced NIR irradiation amplifies activities bioactivity ions, thereby enhancing healing process wounds. Our study validates that synergistic integration effects, activity, can concurrently yield antibacterial efficiency tissue regenerative rendering it highly promising various clinical applications healing.
Язык: Английский
Процитировано
24