Macromolecular Materials and Engineering,
Год журнала:
2024,
Номер
310(3)
Опубликована: Ноя. 23, 2024
Properties
of
pH-responsive
electrospun
nanofibers
incorporated
with
biocompatible/degradable
Carbopol®,
commonly
used
in
pharmaceuticals
and
personal
care
products,
are
reported.
Sonication
Carbopol®
dispersions
prior
to
electrospinning
leads
uniform
incorporation
into
fibers
the
host
polymer
polyvinylpyrrolidone.
The
hydration
behavior
is
strongly
influenced
by
pH
conditions,
forming
a
viscous
network
at
higher
pH.
Since
more
responsive
pH,
>
6
increasing
concentration
increased
uptake
volume
buffer
solution,
faster
rate
complete
gel
formation.
physical
spreadability
(resulting
from
combination
viscoelastic
properties
structural
network)
hydrated
was
evaluated
for
multiple
concentrations
conditions.
At
low
starting
4,
amount
results
slightly
viscosity
while
maintain
solution
On
other
hand,
high
8
result
significant
reduction
which
turn
decreases
increases
its
spreadability.
These
findings
provide
guidelines
rational
designs
various
applications,
including
drug
delivery,
wound
dressing,
contraceptive
devices,
prevention
sexually
transmitted
diseases.
Advanced Materials,
Год журнала:
2024,
Номер
36(33)
Опубликована: Июнь 14, 2024
Infectious
diseases
caused
by
bacterial,
viral,
and
fungal
pathogens
present
significant
global
health
challenges.
The
rapid
emergence
of
antimicrobial
resistance
exacerbates
this
issue,
leading
to
a
scenario
where
effective
antibiotics
are
increasingly
scarce.
Traditional
antibiotic
development
strategies
proving
inadequate
against
the
swift
evolution
microbial
resistance.
Therefore,
there
is
an
urgent
need
develop
novel
with
mechanisms
distinct
from
those
existing
antibiotics.
Nanozybiotics,
which
nanozyme-based
antimicrobials,
mimic
catalytic
action
lysosomal
enzymes
in
innate
immune
cells
kill
infectious
pathogens.
This
review
reinforces
concept
nanozymes
provides
comprehensive
summary
recent
research
advancements
on
potential
candidates.
Initially,
nanozybiotics
categorized
based
their
activities,
mimicking
either
oxidoreductase-like
or
hydrolase-like
functions,
thereby
highlighting
superior
combating
then
discusses
progress
treating
infections,
confirming
as
translational
nanozybiotic-based
products,
including
hydrogels,
nanorobots,
sprays,
bandages,
masks,
protective
clothing,
also
considered.
Finally,
current
challenges
future
prospects
nanozybiotic-related
products
explored,
emphasizing
design
capabilities
for
applications.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(16)
Опубликована: Март 20, 2024
Diabetic
wounds
are
susceptible
to
bacterial
infections,
largely
linked
high
blood
glucose
levels
(hyperglycemia).
To
treat
such
wounds,
enzymes
like
oxidase
(GOx)
can
be
combined
with
nanozymes
(nanomaterials
mimic
enzymes)
use
effectively
for
purposes.
However,
there
is
still
room
improvement
in
these
systems,
particularly
terms
of
process
simplification,
enzyme
activity
regulation,
and
treatment
effects.
Herein,
the
approach
utilizes
GOx
directly
facilitate
biomineralized
growth
osmium
(Os)
nanozyme
(GOx-OsNCs),
leading
dual-active
centers
remarkable
triple
activities.
Initially,
GOx-OsNCs
vicinal
centers,
enabling
a
self-cascaded
mechanism
that
significantly
enhances
sensing
performance
compared
step-by-step
reactions,
surpassing
capabilities
other
metal
sources
as
gold
platinum.
In
addition,
integrated
into
glucose-sensing
gel,
instantaneous
visual
feedback.
infected
diabetic
exhibit
multifaceted
benefits
by
lowering
exhibiting
antibacterial
properties
through
generation
hydroxyl
free
radicals,
thereby
expediting
healing
fostering
favorable
microenvironment.
Furthermore,
catalase-like
aids
reducing
oxidative
stress,
inflammation,
hypoxia,
culminating
improved
outcomes.
Overall,
this
synergistic
enzyme-nanozyme
blend
user-friendly
holds
considerable
promise
diverse
applications.
Abstract
The
repair
and
reconstruction
of
large‐scale
bone
defects
face
enormous
challenges
because
the
failure
to
reconstruct
osteo‐vascularization
network.
Herein,
a
near‐infrared
(NIR)
light‐responsive
hydrogel
system
is
reported
achieve
programmed
tissue
regeneration
through
synergetic
effects
on‐demand
drug
delivery
mild
heat
stimulation.
spatiotemporal
(HG/MPa)
composed
polydopamine‐coated
Ti
3
C
2
T
x
MXene
(MP)
nanosheets
decorated
with
acidic
fibroblast
growth
factor
(aFGF,
potent
angiogenic
drug)
hydroxypropyl
chitosan/gelatin
(HG)
developed
orchestrate
network
boost
regeneration.
Upon
exposure
NIR
light
irradiation,
engineered
HG/MPa
can
initial
complete
release
aFGF
induce
rapid
angiogenesis
provide
sufficient
blood
supply,
maximizing
its
biofunction
in
defect
area.
This
integrated
demonstrated
good
therapeutic
efficacy
promoting
cell
adhesion,
proliferation,
migration,
angiogenesis,
osteogenic
differentiation
periodic
irradiation.
In
vivo,
animal
experiments
further
revealed
that
spatiotemporalized
platform
synergized
photothermal
treatment
significantly
accelerated
critical‐sized
healing
by
increasing
density,
recruiting
endogenous
stem
cells,
facilitating
production
osteogenesis/angiogenesis‐related
factors.
Overall,
smart‐responsive
could
enhance
Precision medicine and engineering.,
Год журнала:
2024,
Номер
1(1), С. 100001 - 100001
Опубликована: Июль 28, 2024
Stimulus-responsive
hydrogels
can
undergo
controllable
shape
deformation
and
exhibit
sol-gel
transition
behavior
under
stimulus
signals
such
as
pH,
reactive
oxygen
species
(ROS),
heat,
light.
Polysaccharides
have
become
ideal
candidates
for
constructing
stimulus-responsive
due
to
their
biocompatibility
biodegradability.
The
diversity
of
molecular
weights
functional
groups
polysaccharides
allows
them
self-assemble
or
cooperate
with
other
materials
obtain
through
physical
chemical
crosslinking.
Bioactive
ingredients
nanomaterials
be
conveniently
encapsulated
in
the
hydrogel
matrix
meet
various
requirements.
polysaccharide-based
are
widely
used
biomedical
field,
especially
fields
drug
delivery,
tissue
engineering,
biosensors,
imaging.
In
this
review,
design
strategies
recent
research
advances
stimuli-responsive
summarized.
Future
challenges
also
presented,
review
will
guide
study
polysaccharide
hydrogels.
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101075 - 101075
Опубликована: Апрель 28, 2024
Regenerating
skin
nerves
in
deep
burn
wounds
poses
a
significant
clinical
challenge.
In
this
study,
we
designed
an
electrospun
wound
dressing
called
CuCS/Cur,
which
incorporates
copper-doped
calcium
silicate
(CuCS)
and
curcumin
(Cur).
The
unique
releases
bioactive
Cu2+-Cur
chelate
that
plays
crucial
role
addressing
By
rebuilding
the
"factory"
(hair
follicle)
responsible
for
producing
nerve
cells,
CuCS/Cur
induces
high
expression
of
nerve-related
factors
within
hair
follicle
cells
promotes
abundant
source
wounds.
Moreover,
activates
differentiation
into
mature
cell
network,
thereby
efficiently
promoting
reconstruction
neural
network
Additionally,
significantly
stimulates
angiogenesis
area,
ensuring
ample
nutrients
repair,
regeneration,
regeneration.
This
study
confirms
chelation
synergy
between
ions
flavonoids
regeneration
neuralized
through
dressings,
providing
valuable
insights
development
new
biomaterials
aimed
at
enhancing
repair.
