Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101089 - 101089
Опубликована: Май 11, 2024
Catheter-associated
urinary
tract
infection
(CAUTI)
is
a
common
clinical
problem,
especially
during
long-term
catheterization,
causing
additional
pain
to
patients.
The
development
of
novel
antimicrobial
coatings
needed
prolong
the
service
life
catheters
and
reduce
incidence
CAUTIs.
Herein,
we
designed
an
catheter
coated
with
piezoelectric
zinc
oxide
nanoparticles
(ZnO
NPs)-incorporated
polyvinylidene
difluoride-hexafluoropropylene
(ZnO-PVDF-HFP)
membrane.
ZnO-PVDF-HFP
could
be
stably
onto
silicone
simply
by
one-step
solution
film-forming
method,
very
convenient
for
industrial
production.
In
vitro,
it
was
demonstrated
that
coating
significantly
inhibit
bacterial
growth
formation
biofilm
under
ultrasound-mediated
mechanical
stimulation
even
after
4
weeks.
Importantly,
on
off
activity
as
well
strenth
antibacterial
property
controlled
in
adaptive
manner
via
ultrasound.
rabbit
model,
ZnO-PVDF-HFP-coated
reduced
CAUTIs
compared
clinically-commonly
used
assistance
ultrasonication,
no
side
effect
detected.
Collectively,
study
provided
prevent
occurance
CAUTIs,
whose
on-demand
manner,
situation
promising
application.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(37), С. 49197 - 49217
Опубликована: Сен. 5, 2024
Metal
particles
incorporated
into
polymer
matrices
in
various
forms
and
geometries
are
attractive
material
platforms
for
promoting
wound
healing
preventing
infections.
However,
the
fate
of
these
metal
their
degraded
products
tissue
environment
still
unknown,
as
both
can
produce
cytotoxic
effects
promote
unwanted
reactions.
In
this
study,
we
develop
biodegradable
fibrous
biomaterials
embedded
with
that
have
an
immune
activation
functions.
Initially,
zinc
(Zn)
nanoparticles
were
modified
zein
(G),
a
protein
derived
from
corn.
The
zein-coated
(Z-G)
then
polycaprolactone
(P)
fibers
at
different
weight
ratios
to
create
via
electrospinning,
which
subsequently
analyzed
potential
applications.
We
performed
multimodal
evaluations
scaffolds,
examining
physicochemical
properties
such
fiber
morphology,
mechanical
strength,
hydrophilicity,
degradation,
release
ions
(Zn
Biomedical Materials,
Год журнала:
2025,
Номер
20(2), С. 025023 - 025023
Опубликована: Янв. 31, 2025
Titania
(TiO2)
has
superior
biocompatibility,
while
zinc
oxide
(ZnO)
is
antibacterial.
This
investigation
aimed
to
study
the
influence
of
TiO2-ZnO
composite
films
on
enhancing
biocompatibility
stainless
steel
(SS).
Radio-frequency
magnetron
sputtering
(RF-MS)
technique
used
synthesize
thin
304-SS
substrates
from
three
targets
with
typical
chemical
compositions
100%
TiO2,
90%TiO2-10%ZnO,
and
75%TiO2-25%ZnO,
mixed
by
their
respective
weight
percentages.
The
surface
chemistry,
morphology,
wettability
film
its
osseointegration
antifouling
characteristics
was
studied.
assessed
protein
adsorption
kit,
cytotoxicity
assay,
cell
adhesion
MG63
osteoblast
cells,
followed
byS.
aureusbacterial
studies.
All
RF-MS
displayed
hydrophobicity,
minimal
bacterial-cell
adhesion,
higher
cytocompatibility
than
SS.
deposited
75%TiO2-25%ZnO
target
exhibited
highest
capability
due
least
antibacterial
ZnO
concentration.
However,
increased
concentration
decreased
viability.
90%TiO2-10%ZnO
showed
mammalian
viability
≈88%
attachment.
High
plasma
caused
bacterial
TiO2film
Biocompatible
SS
offer
an
alternative
conventional
antibiotic
coatings
combat
antimicrobial
resistance
(AMR)
biofilm-related
infections.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(49), С. 67028 - 67044
Опубликована: Март 18, 2024
Bacterial
infection
and
insufficient
osteogenic
activity
are
the
main
causes
of
orthopedic
implant
failure.
Conventional
surface
modification
methods
difficult
to
meet
requirements
for
long-term
placement.
In
order
better
regulate
function
surfaces,
especially
improve
both
antibacterial
activity,
external
stimuli-responsive
(ESR)
strategies
have
been
employed
implants.
External
stimuli
act
as
"smart
switches"
interactions
with
bacteria
cells.
The
balance
between
capabilities
surfaces
can
be
achieved
through
these
specific
ESR
manifestations,
including
temperature
changes,
reactive
oxygen
species
production,
controlled
release
bioactive
molecules,
functional
ions,
etc.
This
Review
summarizes
recent
progress
on
different
(based
light,
ultrasound,
electric,
magnetic
fields)
that
effectively
performance
capability
Furthermore,
current
limitations
challenges
implants
well
future
development
direction
also
discussed.
Nanoscale Horizons,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
commonly
used
semiconductor
photocatalytic
antibacterial
materials,
methods
for
improving
their
photocatalysis
performance
and
application
bone
infection
treatment.
