Invasion and metastasis in cancer: molecular insights and therapeutic targets
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Фев. 20, 2025
The
progression
of
malignant
tumors
leads
to
the
development
secondary
in
various
organs,
including
bones,
brain,
liver,
and
lungs.
This
metastatic
process
severely
impacts
prognosis
patients,
significantly
affecting
their
quality
life
survival
rates.
Research
efforts
have
consistently
focused
on
intricate
mechanisms
underlying
this
corresponding
clinical
management
strategies.
Consequently,
a
comprehensive
understanding
biological
foundations
tumor
metastasis,
identification
pivotal
signaling
pathways,
systematic
evaluation
existing
emerging
therapeutic
strategies
are
paramount
enhancing
overall
diagnostic
treatment
capabilities
for
tumors.
However,
current
research
is
primarily
metastasis
within
specific
cancer
types,
leaving
significant
gaps
our
complex
cascade,
organ-specific
tropism
mechanisms,
targeted
treatments.
In
study,
we
examine
sequential
processes
elucidate
driving
organ-tropic
systematically
analyze
tumors,
those
tailored
organ
involvement.
Subsequently,
synthesize
most
recent
advances
technologies
challenges
opportunities
encountered
pertaining
bone
metastasis.
Our
objective
offer
insights
that
can
inform
future
practice
crucial
field.
Язык: Английский
Dendrimer-Mediated Generation of a Metal-Phenolic Network for Antibody Delivery to Elicit Improved Tumor Chemo/Chemodynamic/Immune Therapy
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
To
simplify
the
composition
and
improve
efficacy
of
metal-phenolic
network
(MPN)-based
nanomedicine,
herein,
we
designed
an
MPN
platform
to
deliver
programmed
death
ligand-1
(PD-L1)
antibody
(anti-PD-L1)
for
combined
tumor
chemo/chemodynamic/immune
therapy.
Here,
generation
5
poly(amidoamine)
dendrimers
conjugated
with
gossypol
(Gos)
through
boronic
ester
bonds
were
used
as
a
synthetic
polyphenol
coordinate
Mn2+,
then
complexed
anti-PD-L1
obtain
nanocomplexes
(for
short,
DPGMA).
The
prepared
DPGMA
exhibited
good
water
dispersibility
hydrodynamic
size
166.3
nm
tumor-microenvironment-responsive
drug
release
behavior.
integration
Gos
Mn2+
within
resulted
in
significant
inhibition
immunogenic
cell
activation
Gos-mediated
chemotherapy
Mn2+-catalyzed
chemodynamic
therapy,
respectively,
thereby
leading
dendritic
maturation
due
role
played
mediate
stimulator
interferon
genes
(STING)
pathway.
Moreover,
promoted
recognition
uptake
by
PD-L1-overexpressed
tumors
targeting,
achieving
combinational
therapy
mouse
melanoma
model,
where
immunotherapy
modes
three
parts
via
chemotherapy/CDT-mediated
ICD,
Mn2+-mediated
STING
activation,
antibody-mediated
immune
checkpoint
blockade.
With
Mn2+-endowed
r1
relaxivity
(1.38
mM–1
s–1),
can
also
be
MR
imaging.
dendrimer-mediated
may
developed
advanced
nanomedicine
tackle
other
cancer
types.
Язык: Английский
Chemodynamic Therapy of Glioblastoma Multiforme and Perspectives
Pharmaceutics,
Год журнала:
2024,
Номер
16(7), С. 942 - 942
Опубликована: Июль 15, 2024
Glioblastoma
multiforme
(GBM),
a
potential
public
health
issue,
is
huge
challenge
for
the
advanced
scientific
realm
to
solve.
Chemodynamic
therapy
(CDT)
based
on
Fenton
reaction
emerged
as
state-of-the-art
therapeutic
modality
treat
GBM.
However,
crossing
blood–brain
barrier
(BBB)
reach
GBM
another
endless
marathon.
In
this
review,
physiology
of
BBB
has
been
elaborated
understand
mechanism
these
barriers
Moreover,
designing
Fenton-based
nanomaterials
discussed
production
reactive
oxygen
species
in
tumor
area
eradicate
cancer
cells.
For
effective
targeting,
biological
that
can
cross
via
neurovascular
transport
channels
have
also
explored.
To
overcome
neurotoxicity
caused
by
inorganic
nanomaterials,
use
smart
nanoagents
having
both
enhanced
biocompatibility
and
targeting
ability
enhance
efficiency
CDT
are
systematically
summarized.
Finally,
advancements
intelligent
nanosystems
multimodal
approach
addition
demonstrated.
Hopefully,
systematic
review
will
provide
better
understanding
insight
into
treatment.
Язык: Английский
Nanotherapeutics for Macrophage Network Modulation in Tumor Microenvironments: Targets and Tools
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 13615 - 13651
Опубликована: Дек. 1, 2024
Macrophage
is
an
important
component
in
the
tumor
immune
microenvironment,
which
exerts
significant
influence
on
development
and
metastasis.
Due
to
their
dual
nature
of
promoting
suppressing
inflammation,
macrophages
can
serve
as
both
targets
for
immunotherapy
tools
treating
malignancies.
However,
abundant
infiltration
tumor-associated
dominated
by
immunosuppressive
phenotype
maintains
a
pro-tumor
engineering
using
nanotechnology
manipulate
microenvironment
represent
feasible
approach
cancer
immunotherapy.
Additionally,
considering
phagocytic
specifically
tumor-targeting
capabilities
M1
macrophages,
manipulated
through
cellular
nanotechnology,
well
macrophage-derived
exosomes
macrophage
membranes,
also
become
effective
treatment.
In
conclusion,
nanotherapeutics
targeting
remains
immense
potential
macrophage-mediated
treatment
methods
will
further
enhance
our
understanding,
diagnosis,
various
malignants.
Язык: Английский
Biomimetic Copper-Containing Nanogels for Imaging-Guided Tumor Chemo-Chemodynamic-Immunotherapy
Acta Biomaterialia,
Год журнала:
2024,
Номер
189, С. 491 - 504
Опубликована: Сен. 24, 2024
Язык: Английский
P-selectin-targeted Polyguluronate sulfate-copper peroxide Nanomicelles for Chemodynamic therapy of breast Cancer
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
unknown, С. 137818 - 137818
Опубликована: Ноя. 1, 2024
Язык: Английский
ROS Regulation in CNS Disorder Therapy: Unveiling the Dual Roles of Nanomedicine
Small,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 15, 2024
Abstract
The
treatment
of
brain
diseases
has
always
been
the
focus
attention.
Due
to
presence
blood‐brain
barrier
(BBB),
most
small
molecule
drugs
are
difficult
reach
brain,
leading
undesirable
therapeutic
outcomes.
Recently,
nanomedicines
that
can
cross
BBB
and
precisely
target
lesion
sites
have
emerged
as
thrilling
tools
enhance
early
diagnosis
treat
various
intractable
disorders.
Extensive
research
shown
reactive
oxygen
species
(ROS)
play
a
crucial
role
in
occurrence
progression
diseases,
including
tumors
neurodegenerative
(NDDs)
such
Alzheimer's
disease,
Parkinson's
stroke,
or
traumatic
injury,
making
ROS
potential
target.
In
this
review,
on
structure
function
well
mechanisms
first
elaborated
through
which
nanomedicine
traverses
it.
Then,
recent
studies
production
summarized
photodynamic
therapy
(PDT),
chemodynamic
(CDT),
sonodynamic
(SDT)
for
treating
tumors,
depletion
NDDs.
This
provides
valuable
guidance
future
design
ROS‐targeted
disease
treatment.
ongoing
challenges
perspectives
developing
nanomedicine‐based
management
also
discussed
outlined.
Язык: Английский