International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137818 - 137818
Published: Nov. 1, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: Feb. 20, 2025
The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.
Language: Английский
Citations
3
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
To simplify the composition and improve efficacy of metal-phenolic network (MPN)-based nanomedicine, herein, we designed an MPN platform to deliver programmed death ligand-1 (PD-L1) antibody (anti-PD-L1) for combined tumor chemo/chemodynamic/immune therapy. Here, generation 5 poly(amidoamine) dendrimers conjugated with gossypol (Gos) through boronic ester bonds were used as a synthetic polyphenol coordinate Mn2+, then complexed anti-PD-L1 obtain nanocomplexes (for short, DPGMA). The prepared DPGMA exhibited good water dispersibility hydrodynamic size 166.3 nm tumor-microenvironment-responsive drug release behavior. integration Gos Mn2+ within resulted in significant inhibition immunogenic cell activation Gos-mediated chemotherapy Mn2+-catalyzed chemodynamic therapy, respectively, thereby leading dendritic maturation due role played mediate stimulator interferon genes (STING) pathway. Moreover, promoted recognition uptake by PD-L1-overexpressed tumors targeting, achieving combinational therapy mouse melanoma model, where immunotherapy modes three parts via chemotherapy/CDT-mediated ICD, Mn2+-mediated STING activation, antibody-mediated immune checkpoint blockade. With Mn2+-endowed r1 relaxivity (1.38 mM–1 s–1), can also be MR imaging. dendrimer-mediated may developed advanced nanomedicine tackle other cancer types.
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(7), P. 942 - 942
Published: July 15, 2024
Glioblastoma multiforme (GBM), a potential public health issue, is huge challenge for the advanced scientific realm to solve. Chemodynamic therapy (CDT) based on Fenton reaction emerged as state-of-the-art therapeutic modality treat GBM. However, crossing blood–brain barrier (BBB) reach GBM another endless marathon. In this review, physiology of BBB has been elaborated understand mechanism these barriers Moreover, designing Fenton-based nanomaterials discussed production reactive oxygen species in tumor area eradicate cancer cells. For effective targeting, biological that can cross via neurovascular transport channels have also explored. To overcome neurotoxicity caused by inorganic nanomaterials, use smart nanoagents having both enhanced biocompatibility and targeting ability enhance efficiency CDT are systematically summarized. Finally, advancements intelligent nanosystems multimodal approach addition demonstrated. Hopefully, systematic review will provide better understanding insight into treatment.
Language: Английский
Citations
2
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 189, P. 491 - 504
Published: Sept. 24, 2024
Language: Английский
Citations
2
Small, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 15, 2024
Abstract The treatment of brain diseases has always been the focus attention. Due to presence blood‐brain barrier (BBB), most small molecule drugs are difficult reach brain, leading undesirable therapeutic outcomes. Recently, nanomedicines that can cross BBB and precisely target lesion sites have emerged as thrilling tools enhance early diagnosis treat various intractable disorders. Extensive research shown reactive oxygen species (ROS) play a crucial role in occurrence progression diseases, including tumors neurodegenerative (NDDs) such Alzheimer's disease, Parkinson's stroke, or traumatic injury, making ROS potential target. In this review, on structure function well mechanisms first elaborated through which nanomedicine traverses it. Then, recent studies production summarized photodynamic therapy (PDT), chemodynamic (CDT), sonodynamic (SDT) for treating tumors, depletion NDDs. This provides valuable guidance future design ROS‐targeted disease treatment. ongoing challenges perspectives developing nanomedicine‐based management also discussed outlined.
Language: Английский
Citations
2
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13615 - 13651
Published: Dec. 1, 2024
Macrophage is an important component in the tumor immune microenvironment, which exerts significant influence on development and metastasis. Due to their dual nature of promoting suppressing inflammation, macrophages can serve as both targets for immunotherapy tools treating malignancies. However, abundant infiltration tumor-associated dominated by immunosuppressive phenotype maintains a pro-tumor engineering using nanotechnology manipulate microenvironment represent feasible approach cancer immunotherapy. Additionally, considering phagocytic specifically tumor-targeting capabilities M1 macrophages, manipulated through cellular nanotechnology, well macrophage-derived exosomes macrophage membranes, also become effective treatment. In conclusion, nanotherapeutics targeting remains immense potential macrophage-mediated treatment methods will further enhance our understanding, diagnosis, various malignants.
Language: Английский
Citations
2
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137818 - 137818
Published: Nov. 1, 2024
Language: Английский
Citations
0