Biocatalysis: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, Год журнала: 2020, Номер 60(1), С. 88 - 119

Опубликована: Июнь 18, 2020

Abstract Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes organic synthesis, especially make chiral compounds for pharmaceuticals well the flavors and fragrance industry, are most prominent examples. In addition, biocatalysts used on a large scale specialty even bulk chemicals. This review intends give illustrative examples this field with special focus scalable production using enzymes. It also discusses opportunities limitations enzymatic syntheses distinct provides outlook emerging enzyme classes.

Язык: Английский

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Lignocellulosic biomass from agricultural waste to the circular economy: a review with focus on biofuels, biocomposites and bioplastics

Journal of Cleaner Production, Год журнала: 2023, Номер 402, С. 136815 - 136815

Опубликована: Март 16, 2023

Industries are working to minimize their reliance on petrochemicals and petroleum-based industrial components replace them with biobased, sustainable, environmentally friendly alternatives due the global warming emergency caused by uncontrolled production of greenhouse gases. The agricultural waste provides large volumes lignocellulosic biomass, a sustainable resource material develop wide portfolio bioproducts. Recent developments in integrated biorefineries have enhanced utilization lignocellulose generate biofuels, platform chemicals, resins, bioplastics, additives, other biobased materials for variety applications. Here this review, we summarized recent advancements processing biomass from waste. Additionally, review thoroughly discussed technological various constituents biocomposites, bioplastics. Finally, an assessment currently existing literature gaps prospective future perspectives development has been conducted.

Язык: Английский

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Biocatalysis

Nature Reviews Methods Primers, Год журнала: 2021, Номер 1(1)

Опубликована: Июнь 24, 2021

Язык: Английский

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Power of Biocatalysis for Organic Synthesis

ACS Central Science, Год журнала: 2021, Номер 7(1), С. 55 - 71

Опубликована: Янв. 14, 2021

Biocatalysis, using defined enzymes for organic transformations, has become a common tool in synthesis, which is also frequently applied industry. The generally high activity and outstanding stereo-, regio-, chemoselectivity observed many biotransformations are the result of precise control reaction active site biocatalyst. This achieved by exact positioning reagents relative to each other fine-tuned 3D environment, specific activating interactions between protein, subtle movements catalyst. Enzyme engineering enables one adapt catalyst desired process. A well-filled biocatalytic toolbox ready be used various reactions. Providing nonnatural conditions evolving biocatalysts play with myriad options creating novel transformations thereby opening new, short pathways target molecules. Combining several pot perform reactions concurrently increases efficiency biocatalysis even further.

Язык: Английский

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Recent trends in biocatalysis

Chemical Society Reviews, Год журнала: 2021, Номер 50(14), С. 8003 - 8049

Опубликована: Янв. 1, 2021

Technological developments enable the discovery of novel enzymes, advancement enzyme cascade designs and pathway engineering, moving biocatalysis into an era technology integration, intelligent manufacturing enzymatic total synthesis.

Язык: Английский

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Unifying views on catalyst deactivation

Nature Catalysis, Год журнала: 2022, Номер 5(10), С. 854 - 866

Опубликована: Сен. 29, 2022

Язык: Английский

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New frontiers in enzyme immobilisation: robust biocatalysts for a circular bio-based economy

Chemical Society Reviews, Год журнала: 2021, Номер 50(10), С. 5850 - 5862

Опубликована: Янв. 1, 2021

This tutorial review focuses on recent advances in technologies for enzyme immobilisation, enabling their cost-effective use the bio-based economy and continuous processing general.

Язык: Английский

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Enzyme entrapment, biocatalyst immobilization without covalent attachment

Green Chemistry, Год журнала: 2021, Номер 23(14), С. 4980 - 5005

Опубликована: Янв. 1, 2021

The entrapment of enzymes in organic, inorganic or biomaterials can yield active immobilized biocatalysts for chemical transformations without the need to form covalent bonds with protein.

Язык: Английский

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Molecular Cavity for Catalysis and Formation of Metal Nanoparticles for Use in Catalysis

Chemical Reviews, Год журнала: 2022, Номер 122(14), С. 12244 - 12307

Опубликована: Апрель 19, 2022

The employment of weak intermolecular interactions in supramolecular chemistry offers an alternative approach to project artificial chemical environments like the active sites enzymes. Discrete molecular architectures with defined shapes and geometries have become a revolutionary field research recent years because their intrinsic porosity ease synthesis using dynamic non-covalent/covalent interactions. Several porous cages been constructed from simple building blocks by self-assembly, which undergoes many self-correction processes form final architecture. These systems developed demonstrate numerous applications, such as guest stabilization, drug delivery, catalysis, smart materials, other related fields. In this respect, catalysis confined nanospaces has seen significant growth over years. discrete contain suitable apertures for easy intake substrates smooth release products exhibit exceptional catalytic efficacy. This review highlights advancements activity influenced nanocavities hydrogen-bonded cages, metal–ligand coordination or reversible covalently bonded organic different solvent media. Synthetic strategies these three types are discussed briefly follow similar simplistic approaches manifested starting materials benign conditions. examples progress various functionalized specific transformations aqueous nonaqueous Finally, we discuss enduring challenges cage compounds that need be overcome further developments work.

Язык: Английский

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Roadmap to Biodegradable Plastics—Current State and Research Needs

ACS Sustainable Chemistry & Engineering, Год журнала: 2021, Номер 9(18), С. 6170 - 6187

Опубликована: Апрель 30, 2021

Plastics, with their ubiquitous presence in our daily lives and environment, pose an uncomfortable conundrum. Producers consumers are aware of the value these organic ingredients material flow, yet persistence disruption to ecological milieu desperately stipulate a shift status quo. Biodegradable plastics—as name suggests—has its appeal ensuring safe return carbon ecosystems by complete assimilation degraded product as food source for soil or aquatic microorganisms. However, despite more than decade commercial presence, plastics still far from replacing demand fossil-fuel-based commodity plastics. We discuss this apparent disconnect herein through chain perspective. review current state biodegradable contrast it against desired zero-waste-focused circular economy. To close gap, we suggest critical research needs concerning structure properties plastics, testing standards, application development, waste management. The ultimate success displacing conventional alternatives will be predicated on collaboration between all stakeholders across chain.

Язык: Английский

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