Biocatalysis: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(1), P. 88 - 119

Published: June 18, 2020

Abstract Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes organic synthesis, especially make chiral compounds for pharmaceuticals well the flavors and fragrance industry, are most prominent examples. In addition, biocatalysts used on a large scale specialty even bulk chemicals. This review intends give illustrative examples this field with special focus scalable production using enzymes. It also discusses opportunities limitations enzymatic syntheses distinct provides outlook emerging enzyme classes.

Language: Английский

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Lignocellulosic biomass from agricultural waste to the circular economy: a review with focus on biofuels, biocomposites and bioplastics

Journal of Cleaner Production, Journal Year: 2023, Volume and Issue: 402, P. 136815 - 136815

Published: March 16, 2023

Industries are working to minimize their reliance on petrochemicals and petroleum-based industrial components replace them with biobased, sustainable, environmentally friendly alternatives due the global warming emergency caused by uncontrolled production of greenhouse gases. The agricultural waste provides large volumes lignocellulosic biomass, a sustainable resource material develop wide portfolio bioproducts. Recent developments in integrated biorefineries have enhanced utilization lignocellulose generate biofuels, platform chemicals, resins, bioplastics, additives, other biobased materials for variety applications. Here this review, we summarized recent advancements processing biomass from waste. Additionally, review thoroughly discussed technological various constituents biocomposites, bioplastics. Finally, an assessment currently existing literature gaps prospective future perspectives development has been conducted.

Language: Английский

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Biocatalysis

Nature Reviews Methods Primers, Journal Year: 2021, Volume and Issue: 1(1)

Published: June 24, 2021

Language: Английский

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Power of Biocatalysis for Organic Synthesis

ACS Central Science, Journal Year: 2021, Volume and Issue: 7(1), P. 55 - 71

Published: Jan. 14, 2021

Biocatalysis, using defined enzymes for organic transformations, has become a common tool in synthesis, which is also frequently applied industry. The generally high activity and outstanding stereo-, regio-, chemoselectivity observed many biotransformations are the result of precise control reaction active site biocatalyst. This achieved by exact positioning reagents relative to each other fine-tuned 3D environment, specific activating interactions between protein, subtle movements catalyst. Enzyme engineering enables one adapt catalyst desired process. A well-filled biocatalytic toolbox ready be used various reactions. Providing nonnatural conditions evolving biocatalysts play with myriad options creating novel transformations thereby opening new, short pathways target molecules. Combining several pot perform reactions concurrently increases efficiency biocatalysis even further.

Language: Английский

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Recent trends in biocatalysis

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(14), P. 8003 - 8049

Published: Jan. 1, 2021

Technological developments enable the discovery of novel enzymes, advancement enzyme cascade designs and pathway engineering, moving biocatalysis into an era technology integration, intelligent manufacturing enzymatic total synthesis.

Language: Английский

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Unifying views on catalyst deactivation

Nature Catalysis, Journal Year: 2022, Volume and Issue: 5(10), P. 854 - 866

Published: Sept. 29, 2022

Language: Английский

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New frontiers in enzyme immobilisation: robust biocatalysts for a circular bio-based economy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(10), P. 5850 - 5862

Published: Jan. 1, 2021

This tutorial review focuses on recent advances in technologies for enzyme immobilisation, enabling their cost-effective use the bio-based economy and continuous processing general.

Language: Английский

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Enzyme entrapment, biocatalyst immobilization without covalent attachment

Green Chemistry, Journal Year: 2021, Volume and Issue: 23(14), P. 4980 - 5005

Published: Jan. 1, 2021

The entrapment of enzymes in organic, inorganic or biomaterials can yield active immobilized biocatalysts for chemical transformations without the need to form covalent bonds with protein.

Language: Английский

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Molecular Cavity for Catalysis and Formation of Metal Nanoparticles for Use in Catalysis

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(14), P. 12244 - 12307

Published: April 19, 2022

The employment of weak intermolecular interactions in supramolecular chemistry offers an alternative approach to project artificial chemical environments like the active sites enzymes. Discrete molecular architectures with defined shapes and geometries have become a revolutionary field research recent years because their intrinsic porosity ease synthesis using dynamic non-covalent/covalent interactions. Several porous cages been constructed from simple building blocks by self-assembly, which undergoes many self-correction processes form final architecture. These systems developed demonstrate numerous applications, such as guest stabilization, drug delivery, catalysis, smart materials, other related fields. In this respect, catalysis confined nanospaces has seen significant growth over years. discrete contain suitable apertures for easy intake substrates smooth release products exhibit exceptional catalytic efficacy. This review highlights advancements activity influenced nanocavities hydrogen-bonded cages, metal–ligand coordination or reversible covalently bonded organic different solvent media. Synthetic strategies these three types are discussed briefly follow similar simplistic approaches manifested starting materials benign conditions. examples progress various functionalized specific transformations aqueous nonaqueous Finally, we discuss enduring challenges cage compounds that need be overcome further developments work.

Language: Английский

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Roadmap to Biodegradable Plastics—Current State and Research Needs

ACS Sustainable Chemistry & Engineering, Journal Year: 2021, Volume and Issue: 9(18), P. 6170 - 6187

Published: April 30, 2021

Plastics, with their ubiquitous presence in our daily lives and environment, pose an uncomfortable conundrum. Producers consumers are aware of the value these organic ingredients material flow, yet persistence disruption to ecological milieu desperately stipulate a shift status quo. Biodegradable plastics—as name suggests—has its appeal ensuring safe return carbon ecosystems by complete assimilation degraded product as food source for soil or aquatic microorganisms. However, despite more than decade commercial presence, plastics still far from replacing demand fossil-fuel-based commodity plastics. We discuss this apparent disconnect herein through chain perspective. review current state biodegradable contrast it against desired zero-waste-focused circular economy. To close gap, we suggest critical research needs concerning structure properties plastics, testing standards, application development, waste management. The ultimate success displacing conventional alternatives will be predicated on collaboration between all stakeholders across chain.

Language: Английский

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