Cited by Making the case for prophylactic use of betaine to promote brain health in young (15–24 year old) athletes at risk for concussion

Making the case for prophylactic use of betaine to promote brain health in young (15–24 year old) athletes at risk for concussion DOI

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Сен. 22, 2023

Betaine supplementation in the context of human nutrition, athletic performance, and clinical therapy demonstrate that osmolyte methyl donor, betaine, is cytoprotective beneficial to health. These studies also betaine healthy humans straight-forward with no reported adverse effects. Here, we explore uptake central nervous system (CNS) contribute evidence may be uniquely protective brain. We specifically describe therapeutic potential implications on inhibition mediated by GABA glycine neurotransmission. The influence neurophysiology complement betaine’s role as an metabolite consistent betaine-mediated improvements cognitive function (reported elderly populations) its anti-convulsant properties. Betaine’s neurological disorders including epilepsy neurodegenerative diseases combined benefits performance support unique application a prophylaxis concussion. As example, identify young athletes (15–24 years old), especially females, for prophylactic promote brain health resilience cohort at high risk concussion developing Alzheimer’s disease.

Язык: Английский

Neuroprotective Assessment of Betaine against Copper Oxide Nanoparticle-Induced Neurotoxicity in the Brains of Albino Rats: A Histopathological, Neurochemical, and Molecular Investigation DOI

Asmaa R. Hashim,

Dina W. Bashir, Eman Rashad

и другие.

ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(8), С. 1684 - 1701

Опубликована: Апрель 2, 2024

Copper oxide nanoparticles (CuO-NPs) are commonly used metal oxides. Betaine possesses antioxidant and neuroprotective activities. The current study aimed to investigate the neurotoxic effect of CuO-NPs on rats capability betaine mitigate neurotoxicity. Forty rats; 4 groups: group I a control, II intraperitoneally (0.5 mg/kg/day), III orally (250 mg/kg/day) CuO-NPs, IV for 28 days. Rats were subjected neurobehavioral assessments. Brain samples processed biochemical, molecular, histopathological, immunohistochemical analyses. Behavioral performance demonstrated increasing locomotion cognitive abilities. Group exhibited significantly elevated malondialdehyde (MDA), overexpression interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α). Significant decrease in glutathione (GSH), downregulation acetylcholine esterase (AChE), nuclear factor erythroid 2-like protein 2 (Nrf-2), superoxide dismutase (SOD). Histopathological alterations; neuronal degeneration, pericellular spaces, neuropillar vacuolation. Immunohistochemically, an intense immunoreactivity is observed against IL-1β glial fibrillary acidic (GFAP). partially neuroprotected associated alterations. A significant at MDA, IL-1β, TNF-α, increase GSH, upregulation AChE, Nrf-2, SOD. alterations ameliorated. Immunohistochemical intensity GFAP reduced. It concluded that most CuO-NP effects through cell redox system stimulating efficacy.

Язык: Английский

Процитировано

Betaine alleviates deficits in motor behavior, neurotoxic effects, and neuroinflammatory responses in a rat model of demyelination DOI

Amina E. Essawy,

G. Bekheet,

Shérine Abdel Salam

и другие.

Toxicology Reports, Год журнала: 2025, Номер 14, С. 101974 - 101974

Опубликована: Фев. 28, 2025

Multiple sclerosis (MS) is characterized as a chronic inflammatory demyelinating neurodegenerative disorder that leads to the deterioration of myelin sheath and loss axons. Betaine, trimethylglycine compound, recognized for its ability penetrate blood-brain barrier (BBB) exhibits properties are antioxidant, anti-inflammatory, neuroprotective. The cuprizone (CPZ) model serves an effective tool investigating processes demyelination remyelination associated with MS. In our research, we examined protective therapeutic effects betaine in rat MS induced by CPZ. experimental protocol involved administering 600 mg/kg CPZ orally 7 days, followed 2 weeks 200 group received combination (1 g/kg/day, orally) (200 mg/kg/day), while was treated (600 mg/kg) alongside three weeks. Behavioral assessments were conducted using inverted screen rotarod tests measure balance, motor coordination, grasping ability. Following these evaluations, rats euthanized analysis oxidative stress biomarkers, toluidine blue staining, transmission electron microscopy (TEM) imaging, basic protein (MBP) immunostaining corpus callosum (CC). results indicated significantly enhanced ability, decreasing stress, inhibiting interleukin (IL)-4 IL-17 levels, reversing caused Notably, also mitigated increase homocysteine (Hcy) levels facilitated remyelination, evidenced presence normal compacted increased expression MBP CC. This study substantiates remyelinating context CPZ-induced demyelination. It suggests it may contribute repair through modulation behavioral deficits, neuroinflammation, ultrastructural changes, indicating potential complementary agent management

Язык: Английский

Процитировано

Loperamide, a peripheral Mu-Opioid receptor agonist, attenuates chemotherapy-induced neuropathic pain in rats DOI