Hydrogel Lego based on rehydrated laminate assembly for standardized production and customized integration of multifunctional hydrogel sensors DOI Creative Commons
Shuyi Wu, Xiaowei Xu, Lei Hu

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Abstract Hydrogel sensors have immense potential for application in fields such as flexible wearable devices. However, hydrogel still face challenges related to process standardization, convenience of long-term storage, customization diverse scenarios, and ease multifunctional integration. In this study, a strategy the rapid rehydration prefabricated gel dry films modular assembly form multilayer devices is reported. First, developed biomass polysaccharide encapsulation composite, konjac glucomannan/sodium alginate/dopamine (KSD), was utilized encapsulate various functional materials separately then dried parts films. device, through water-triggered interlayer metal–ligand chelation bonding, personalized laminated can be assembled quickly conveniently according requirements. The binding between layers occurs formation bonds calcium ions solution carboxylic acid groups sodium alginate, which results an bond 0.57 MPa after only 1.5 min. Moreover, KSD-encapsulated anisotropic thermoplastic urethane/MXene (TPU/MXene) conductive film constructed, multilayered were by lamination film. composite accurately recognize complex deformations curved surface motion multiple signals, difficult realize ordinary sensors. bacteriostatic layer integrated on top sensing based strategy. pH-responsive membrane ZIF-8/flavanone/KSD prepared using microfluidic mosaic methods displays satisfactory biocompatibility properties. several gels customized proposed paper will enable standardized batch processing integration accordance with variety scenarios

Язык: Английский

Bioorthogonal Activation of RCA-Based Amplifiable DNAzymes in Bimetallic NMOF for Precise Gene/Chemo-Dynamic Combination Therapy DOI
Ting Huang, Weilun Pan,

Mingshun Li

и другие.

ACS Materials Letters, Год журнала: 2024, Номер 6(2), С. 498 - 507

Опубликована: Янв. 3, 2024

Controllable and sufficient concentrations of therapeutic agents in gene therapy are critical to achieve satisfactory outcomes. Herein, a Zn2+/Cu2+ bimetallic nano metal–organic framework loaded with rolling circle amplification (RCA) substrates (termed PZCT) was established for precise efficient DNAzyme-based chemo-dynamic combined therapy. The activation PZCT is bioorthogonally controlled by tumor-specific miR-21, which generates numerous DNAzyme silencing EGR-1 mRNA the assistance Zn2+ from PZCT. Simultaneously, doped copper ions on exert (CDT) reducing glutathione (GSH) converting endogenous hydrogen peroxide (H2O2) into hydroxyl radical (·OH). These combination therapies exhibited remarkable tumor elimination effects vivo promised excellent specificity via bioorthogonal strategy. proposed nanoplatform offers new prospects cancer therapeutics overcoming low transfection efficiency off-target toxicity approaches.

Язык: Английский

Процитировано

8
Stimuli‐Responsive New Horizons for Biomedical Applications: Metal–Organic Framework‐Based Nanozymes DOI
Jingyu Yan, Yifan Zhao,

Meijun Du

и другие.

Small Structures, Год журнала: 2024, Номер 5(7)

Опубликована: Апрель 26, 2024

Nanozymes, nanomaterials exhibiting enzyme‐mimicking activities, have gained considerable interest in biomedicine due to their stability, adjustability, and cost‐efficiency. Among these, metal–organic framework (MOF)‐based nanozymes distinguish themselves by distinct structure customizable characteristics. Researchers explored MOF‐based as a platform for developing stimuli‐responsive behaviors. This work first presents the categorization of nanozymes, which are designed mimic catalytic functions oxidases, peroxidases, catalase, superoxide dismutase, hydrolases, multifunctional enzymes. Crafting includes customizing reactions particular stimuli, including pH, temperature, light, or biomolecular triggers, ensuring enhanced specificity potency performance amid environmental changes. Moreover, these exhibit immense potential biomedical applications, playing crucial roles therapeutic interventions like cancer therapy tissue regeneration. Finally, article delves into future opportunities challenges within emerging research frontiers. These offer novel avenues advanced strategies, providing prospects innovative applications.

Язык: Английский

Процитировано

8
MOFs for next-generation cancer therapeutics through a biophysical approach—a review DOI Creative Commons

Leon Bernet Shano,

S. Karthikeyan, L. John Kennedy

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Июнь 13, 2024

Metal-organic frameworks (MOFs) have emerged as promising nanocarriers for cancer treatment due to their unique properties. Featuring high porosity, extensive surface area, chemical stability, and good biocompatibility, MOFs are ideal efficient drug delivery, targeted therapy, controlled release. They can be designed target specific cellular organelles disrupt metabolic processes in cells. Additionally, functionalization with enzymes mimics catalytic activity, enhancing photodynamic therapy overcoming apoptosis resistance The controllable regular structure of MOFs, along tumor microenvironment responsiveness, make them anticancer drugs. These carriers effectively deliver a wide range drugs improved bioavailability, release rate, delivery efficiency compared alternatives. In this article, we review both experimental computational studies focusing on the interaction between drug, explicating mechanisms stability physiological conditions. Notably, explore relationship MOF its ability damage cells, elucidating why excellent candidates bio-applicability. By understanding problem exploring potential solutions, provides insights into future directions harnessing full ultimately leading therapeutic outcomes treatment.

Язык: Английский

Процитировано

8
A self‐reinforced activatable photosensitizer prodrug enabling synergistic photodynamic and chemotherapy DOI Creative Commons

Daipeng Huang,

Jikai Yin, Yang Zou

и другие.

Smart Molecules, Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Abstract As a novel drug development paradigm, selective activation of prodrugs provides the potential for precise tumor chemotherapy, thereby presenting an opportunity advancing cancer treatment. The combination photodynamic therapy (PDT) and prodrug can enhance therapeutic efficacy while simultaneously enabling real‐time monitoring distribution release. However, hypoxia microenvironment frequent high‐dose administration significantly impede escalate treatment‐related risks. Herein, microenvironment‐specific release is constructed, termed NBS‐2S‐5FU. Under influence glutathione (GSH), NBS‐2S‐5FU undergoes activation, leading to photosensitizer NBS chemotherapeutic agent 5‐FU derivatives. irradiation, produces sufficient superoxide radical () derivatives inhibit DNA biosynthesis, effectively suppressing growth at low doses. Subsequent in vivo studies utilizing liposomes exhibit outstanding anti‐cancer effectiveness. This study highlights promising direction combined that integrate PDT chemotherapy.

Язык: Английский

Процитировано

7
Design and fabrication of pH-responsive skin scaffolds based on carrageenan and konjac glucomannan for accelerated wound healing DOI
Xiaowei Xu,

John Ming Shyan Yong,

Lin Wang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140198 - 140198

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Facile synthesis of ZIF-8-lignosulfonate microspheres with ultra-high adsorption capacity for Congo red and tetracycline removal from water DOI
Juan Dai, Tianying Chen, Qixu Chen

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 242, С. 124672 - 124672

Опубликована: Май 9, 2023

Язык: Английский

Процитировано

17
Sulfonated vitamin K3 mediated bimetallic metal-organic framework for multistage augmented cancer therapy DOI

Qiaomei Ke,

Peng Jing,

Yehong Wan

и другие.

Journal of Colloid and Interface Science, Год журнала: 2023, Номер 654, С. 224 - 234

Опубликована: Окт. 11, 2023

Язык: Английский

Процитировано

15
Metal–Organic Frameworks-Based Nanoplatform for Treatment of Breast Cancer DOI
Yi Li,

Huilin Sun,

Chenxue Yang

и другие.

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(9), С. 10532 - 10542

Опубликована: Апрель 18, 2024

Nanoscaled metal–organic frameworks (MOFs) have great prospects in drug delivery. As a unique architecture, MOF-on-MOF has emerged as promising strategy to enhance loading and release efficacy. Herein, ZIF-8-on-ZIF-8 nanoplatform been fabricated via the for doxorubicin (DOX) loading, resulting core–shell hierarchical nanostructure (DOX@ZIF-8-on-ZIF-8, DZZ). This exhibited pH GSH dual-responsive DOX-releasing behavior, which are features of tumor microenvironment (TME). Compared monolayer DOX-encapsulated ZIF-8 (DOX@ZIF-8, DZ), DZZ can significantly increase efficiency (DLE) by 56-fold, encapsulation (DEE) 25-fold, penetration depth DOX, improve selective inhibition on breast cancer 4T1 cells both vitro vivo. Such ZIF-on-ZIF provides an efficient tumor-targeted delivery treatments.

Язык: Английский

Процитировано

5
Folate-Targeted Nanocarriers Co-Deliver Ganciclovir and miR-34a-5p for Combined Anti-KSHV Therapy DOI Open Access
Fangling Li, Dongdong Cao, Wenyi Gu

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2932 - 2932

Опубликована: Март 2, 2024

Kaposi’s sarcoma-associated herpesvirus (KSHV) can cause a variety of malignancies. Ganciclovir (GCV) is one the most efficient drugs against KSHV, but its non-specificity other side effects in patients. Nucleic acid miR-34a-5p inhibit transcription KSHV RNA and has great potential anti-KSHV therapy, there are still problems such as easy degradation low delivery efficiency. Here, we constructed co-loaded dual-drug nanocomplex (GCV@ZIF-8/PEI-FA+miR-34a-5p) that contains GCV internally adsorbs externally. The folic (FA)-coupled polyethyleneimine (PEI) coating layer (PEI-FA) was shown to increase cellular uptake nanocomplex, which conducive enrichment at infection site. released site through hydrolysis characteristics ZIF-8 “proton sponge effect” PEI. not only inhibits proliferation migration KSHV-positive cells also decreases mRNA expression level lytic latent genes. In conclusion, this may provide an attractive strategy for antiviral drug therapy.

Язык: Английский

Процитировано

4
Tannic acid and quaternized chitosan mediated puerarin-loaded octacalcium phosphate /sodium alginate scaffold for bone tissue engineering DOI

Yan Chen,

Tengbin Shi, Lan Li

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 271, С. 132632 - 132632

Опубликована: Май 24, 2024

Язык: Английский

Процитировано

4