Inorganic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 26, 2024
Here,
we
show
particle
size-dependent
therapeutic
efficacy
with
a
Zn-based
metal-organic
framework
(MOF).
The
size
of
MOFs
was
tuned
in
specific
ranges
(∼100,
200,
and
300
nm)
built
upon
the
manipulation
synthetic
conditions.
X-ray
photoelectron
spectroscopy,
infrared,
PXRD,
dynamic
light
scattering
scanning
electron
microscopy
analyses
were
used
to
identify
synthesized
structures.
various
revealed
minimal
changes
molecular
properties
these
structures
regardless
their
size,
confirming
our
hypothesis
regarding
preservation
identity
MOF
nanoparticles
despite
variation.
carriers
undergo
structure
relative
destruction
response
weak
acidic
tumor
microenvironment,
this
degradation
allows
release
Nimesulide
drug
into
environment.
Interestingly,
anticancer
studies
resulting
SKBR3
(Human
breast
cancer
cell)
cells
indicate
that
different
sizes
resulted
inhibition
capacities
against
cells.
This
work
shows
importance
optimizing
geometry
carrier,
such
as
shape,
achieve
highest
cellular
uptake
performance.
Besides,
theoretical
carried
out
using
B3LYP/6-31G
(d,p)
density
functional
theory
methods
more
consider
adsorption
mechanism.
ACS Materials Letters,
Journal Year:
2024,
Volume and Issue:
6(2), P. 498 - 507
Published: Jan. 3, 2024
Controllable
and
sufficient
concentrations
of
therapeutic
agents
in
gene
therapy
are
critical
to
achieve
satisfactory
outcomes.
Herein,
a
Zn2+/Cu2+
bimetallic
nano
metal–organic
framework
loaded
with
rolling
circle
amplification
(RCA)
substrates
(termed
PZCT)
was
established
for
precise
efficient
DNAzyme-based
chemo-dynamic
combined
therapy.
The
activation
PZCT
is
bioorthogonally
controlled
by
tumor-specific
miR-21,
which
generates
numerous
DNAzyme
silencing
EGR-1
mRNA
the
assistance
Zn2+
from
PZCT.
Simultaneously,
doped
copper
ions
on
exert
(CDT)
reducing
glutathione
(GSH)
converting
endogenous
hydrogen
peroxide
(H2O2)
into
hydroxyl
radical
(·OH).
These
combination
therapies
exhibited
remarkable
tumor
elimination
effects
vivo
promised
excellent
specificity
via
bioorthogonal
strategy.
proposed
nanoplatform
offers
new
prospects
cancer
therapeutics
overcoming
low
transfection
efficiency
off-target
toxicity
approaches.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: June 13, 2024
Metal-organic
frameworks
(MOFs)
have
emerged
as
promising
nanocarriers
for
cancer
treatment
due
to
their
unique
properties.
Featuring
high
porosity,
extensive
surface
area,
chemical
stability,
and
good
biocompatibility,
MOFs
are
ideal
efficient
drug
delivery,
targeted
therapy,
controlled
release.
They
can
be
designed
target
specific
cellular
organelles
disrupt
metabolic
processes
in
cells.
Additionally,
functionalization
with
enzymes
mimics
catalytic
activity,
enhancing
photodynamic
therapy
overcoming
apoptosis
resistance
The
controllable
regular
structure
of
MOFs,
along
tumor
microenvironment
responsiveness,
make
them
anticancer
drugs.
These
carriers
effectively
deliver
a
wide
range
drugs
improved
bioavailability,
release
rate,
delivery
efficiency
compared
alternatives.
In
this
article,
we
review
both
experimental
computational
studies
focusing
on
the
interaction
between
drug,
explicating
mechanisms
stability
physiological
conditions.
Notably,
explore
relationship
MOF
its
ability
damage
cells,
elucidating
why
excellent
candidates
bio-applicability.
By
understanding
problem
exploring
potential
solutions,
provides
insights
into
future
directions
harnessing
full
ultimately
leading
therapeutic
outcomes
treatment.
Small Structures,
Journal Year:
2024,
Volume and Issue:
5(7)
Published: April 26, 2024
Nanozymes,
nanomaterials
exhibiting
enzyme‐mimicking
activities,
have
gained
considerable
interest
in
biomedicine
due
to
their
stability,
adjustability,
and
cost‐efficiency.
Among
these,
metal–organic
framework
(MOF)‐based
nanozymes
distinguish
themselves
by
distinct
structure
customizable
characteristics.
Researchers
explored
MOF‐based
as
a
platform
for
developing
stimuli‐responsive
behaviors.
This
work
first
presents
the
categorization
of
nanozymes,
which
are
designed
mimic
catalytic
functions
oxidases,
peroxidases,
catalase,
superoxide
dismutase,
hydrolases,
multifunctional
enzymes.
Crafting
includes
customizing
reactions
particular
stimuli,
including
pH,
temperature,
light,
or
biomolecular
triggers,
ensuring
enhanced
specificity
potency
performance
amid
environmental
changes.
Moreover,
these
exhibit
immense
potential
biomedical
applications,
playing
crucial
roles
therapeutic
interventions
like
cancer
therapy
tissue
regeneration.
Finally,
article
delves
into
future
opportunities
challenges
within
emerging
research
frontiers.
These
offer
novel
avenues
advanced
strategies,
providing
prospects
innovative
applications.
Smart Molecules,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 14, 2024
Abstract
As
a
novel
drug
development
paradigm,
selective
activation
of
prodrugs
provides
the
potential
for
precise
tumor
chemotherapy,
thereby
presenting
an
opportunity
advancing
cancer
treatment.
The
combination
photodynamic
therapy
(PDT)
and
prodrug
can
enhance
therapeutic
efficacy
while
simultaneously
enabling
real‐time
monitoring
distribution
release.
However,
hypoxia
microenvironment
frequent
high‐dose
administration
significantly
impede
escalate
treatment‐related
risks.
Herein,
microenvironment‐specific
release
is
constructed,
termed
NBS‐2S‐5FU.
Under
influence
glutathione
(GSH),
NBS‐2S‐5FU
undergoes
activation,
leading
to
photosensitizer
NBS
chemotherapeutic
agent
5‐FU
derivatives.
irradiation,
produces
sufficient
superoxide
radical
()
derivatives
inhibit
DNA
biosynthesis,
effectively
suppressing
growth
at
low
doses.
Subsequent
in
vivo
studies
utilizing
liposomes
exhibit
outstanding
anti‐cancer
effectiveness.
This
study
highlights
promising
direction
combined
that
integrate
PDT
chemotherapy.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(9), P. 10532 - 10542
Published: April 18, 2024
Nanoscaled
metal–organic
frameworks
(MOFs)
have
great
prospects
in
drug
delivery.
As
a
unique
architecture,
MOF-on-MOF
has
emerged
as
promising
strategy
to
enhance
loading
and
release
efficacy.
Herein,
ZIF-8-on-ZIF-8
nanoplatform
been
fabricated
via
the
for
doxorubicin
(DOX)
loading,
resulting
core–shell
hierarchical
nanostructure
(DOX@ZIF-8-on-ZIF-8,
DZZ).
This
exhibited
pH
GSH
dual-responsive
DOX-releasing
behavior,
which
are
features
of
tumor
microenvironment
(TME).
Compared
monolayer
DOX-encapsulated
ZIF-8
(DOX@ZIF-8,
DZ),
DZZ
can
significantly
increase
efficiency
(DLE)
by
56-fold,
encapsulation
(DEE)
25-fold,
penetration
depth
DOX,
improve
selective
inhibition
on
breast
cancer
4T1
cells
both
vitro
vivo.
Such
ZIF-on-ZIF
provides
an
efficient
tumor-targeted
delivery
treatments.
