Biomimetic reactive oxygen/nitrogen nanoscavengers inhibit “ferroptosis storm” and modulate immune targeting for acute kidney injury

Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 59 - 76

Опубликована: Янв. 8, 2025

Язык: Английский

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Herbal Theranostics: Controlled, Targeted Delivery and Imaging of Herbal Molecules

Nanotheranostics, Год журнала: 2024, Номер 8(3), С. 344 - 379

Опубликована: Янв. 1, 2024

Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they used.Since the herbal remedy is given through dated ineffective method drug administration, its effectiveness diminished.The novel form delivery has potential to increase substances while decreasing their side effects.This main idea behind utilising different ways treatments.Several benefits arise from formulations compounds as compared conventional counterparts.These include enhanced penetrating ability into tissues, constant effective doses, resistance physical chemical degradation.Controlled targeted that components allow for more traditional dosing simultaneously increasing efficacy.Enhancing biodistribution target site accumulation systemically administered medicines goal nanomedicine formulations.The field nanotheranostics made significant advancements development by combining diagnostic therapeutic functions single nanoscale platform.It critically important create theranostic nanoplatform derived plants intrinsically "all-in-one" molecules.In addition examining mechanistic approach nanoparticle synthesis, this review highlights effects phytochemical systems.Furthermore, we have evaluated scope future field, discussed several nanoparticles been developed recently imaging, provided experimental evidence supports usage.

Язык: Английский

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Lignin-Based Antioxidant Hydrogel Patch for the Management of Atopic Dermatitis by Mitigating Oxidative Stress in the Skin

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(26), С. 33135 - 33148

Опубликована: Июнь 20, 2024

Atopic dermatitis (AD), a chronic skin condition characterized by itching, redness, and inflammation, is closely associated with heightened levels of endogenous reactive oxygen species (ROS) in the skin. ROS can contribute to onset progression AD through oxidative stress, which leads release proinflammatory cytokines, T-cell differentiation, exacerbation symptoms. In this study, we aim develop therapeutic antioxidant hydrogel patch for potential treatment using lignin, biomass waste material. Lignin contains polyphenol groups that enable it scavenge exhibit properties. The lignin patches, possessing optimized mechanical properties control cross-linker ratio, demonstrated high ROS-scavenging capabilities. Furthermore, excellent biocompatibility skin, exhibiting beneficial protecting human keratinocytes under conditions. When applied an mouse model, effectively reduced epidermal thickness inflamed regions, decreased mast cell infiltration, regulated inflammatory cytokine levels. These findings collectively suggest serves as managing modulating stress its ability.

Язык: Английский

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Sulfated Pelvetia siliquosa Polysaccharides Inhibit CaOx Stone Formation by Inhibiting Calcium Oxalate Crystallization, Cellular Inflammation, and Crystal Adhesion

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер 73(2), С. 1542 - 1562

Опубликована: Янв. 1, 2025

Hyperoxaluria can easily induce calcium oxalate (CaOx) crystals and cause cell damage, thereby increasing the risk of kidney stone formation. In this study, three sulfated Pelvetia siliquosa polysaccharides (PSPs) were obtained by sulfur trioxide-pyridine method. The antioxidant activity PSPs inhibitory effects on CaOx crystallization, cellular oxidative inflammation explored in vitro, used to treat hyperoxaluria-induced crystallization model mice order validate stone-preventive effect vivo. inhibit crystal formation, as well reduce reactive oxygen species (ROS) levels through their own properties up-regulation enzyme (SOD CAT) expression, which turn reduces release lactate dehydrogenase (LDH) malondialdehyde (MDA), improves lysosomal integrity, morphology, cytoskeleton, inhibits decrease mitochondrial membrane potential, adhesion protein (CD44 OPN) alleviates inflammatory factor (IL-6, TNF-α, IL-1β) levels, apoptosis. PSP3, has highest degree sulfation, had best protection capacity. PSP3 also showed good antistone ability mice, it may be a potential drug for prevention.

Язык: Английский

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Electron-donable heterojunctions with synergetic Ru-Cu pair sites for biocatalytic microenvironment modulations in inflammatory mandible defects

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Ноя. 6, 2024

Abstract The clinical treatments of maxillofacial bone defects pose significant challenges due to complex microenvironments, including severe inflammation, high levels reactive oxygen species (ROS), and potential bacterial infection. Herein, we propose the de novo design an efficient, versatile, precise electron-donable heterojunction with synergetic Ru-Cu pair sites (Ru-Cu/EDHJ) for superior biocatalytic regeneration inflammatory mandible pH-controlled antibacterial therapies. Our studies demonstrate that unique structure Ru-Cu/EDHJ enhances electron density Ru atoms optimizes binding strength species, thus improving enzyme-like catalytic performance. Strikingly, this biocompatible can efficiently switch between ROS scavenging in neutral media generation acidic media, simultaneously exhibiting repair functions bioadaptive properties treating male mice. We believe synthesizing such heterojunctions exceptional capabilities will offer a promising pathway engineering materials treat trauma, tumors, or infection-caused defects.

Язык: Английский

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Safety Landscape of Therapeutic Nanozymes and Future Research Directions

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Окт. 24, 2024

Abstract Oxidative stress and inflammation are at the root of a multitude diseases. Treatment these conditions is often necessary but current standard therapies to fight excessive reactive oxygen species (ROS) ineffective or complicated by substantial safety concerns. Nanozymes emerging nanomaterials with intrinsic enzyme‐like properties that hold great promise for effective cancer treatment, bacterial elimination, anti‐inflammatory/anti‐oxidant therapy. While there rapid progress in tailoring their catalytic activities as evidenced recent integration single‐atom catalysts (SACs) create next‐generation nanozymes superior activity, selectivity, stability, better understanding tuning profile imperative successful clinical translation. This review outlines applied assessment approaches provides comprehensive summary knowledge therapeutic nanozymes. Overall, so far show good vitro vivo biocompatibility despite considerable differences composition enzymatic activities. However, investigations mostly cover limited set basic toxicological endpoints, which do not allow thorough deep assessment. Ultimately, remaining research gaps should be carefully addressed future studies highlighted, optimize early pre‐clinical development.

Язык: Английский

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Carbon Dots in the Pathological Microenvironment: ROS Producers or Scavengers?

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(29)

Опубликована: Июль 22, 2024

Reactive oxygen species (ROS), as metabolic byproducts, play pivotal role in physiological and pathological processes. Recently, studies on the regulation of ROS levels for disease treatments have attracted extensive attention, mainly involving ROS-induced toxicity therapy mediated by producers antioxidant scavengers. Nanotechnology advancements led to development numerous nanomaterials with ROS-modulating capabilities, among which carbon dots (CDs) standing out noteworthy nanomedicines own their distinctive physicochemical properties, high stability, excellent biocompatibility. Despite progress treating ROS-related diseases based CDs, critical issues such rational design principles remain underexplored. The primary cause these may stem from intricate amalgamation core structure, defects, surface states, inherent poses challenges establishing a consistent generalization. This review succinctly summarizes recently ROS-modulated approaches using CDs treatment. Specifically, it investigates established therapeutic strategies CDs-regulated ROS, emphasizing interplay between intrinsic structure generation or scavenging ability. conclusion raises several unresolved key scientific prominent technological bottlenecks, explores future perspectives comprehensive CDs-based therapy.

Язык: Английский

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Multifunctional integrated polyphenol-copper nanozymes for sepsis-induced acute liver injury via ameliorating endoplasmic reticulum stress and reprogramming inflammatory microenvironment

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160293 - 160293

Опубликована: Фев. 1, 2025

Язык: Английский

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Tannic acid‑cerium nanoenzymes serve as broad-spectrum antioxidants to alleviate acute kidney injury by modulating macrophage polarization, mitophagy and endoplasmic reticulum stress

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 892 - 909

Опубликована: Фев. 20, 2025

Язык: Английский

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MiR675-5p Acts on HIF-1α to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma

Theranostics, Год журнала: 2016, Номер 6(8), С. 1105 - 1118

Опубликована: Янв. 1, 2016

Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they used.Since the herbal remedy is given through dated ineffective method drug administration, its effectiveness diminished.The novel form delivery has potential to increase substances while decreasing their side effects.This main idea behind utilising different ways treatments.Several benefits arise from formulations compounds as compared conventional counterparts.These include enhanced penetrating ability into tissues, constant effective doses, resistance physical chemical degradation.Controlled targeted that components allow for more traditional dosing simultaneously increasing efficacy.Enhancing biodistribution target site accumulation systemically administered medicines goal nanomedicine formulations.The field nanotheranostics made significant advancements development by combining diagnostic therapeutic functions single nanoscale platform.It critically important create theranostic nanoplatform derived plants intrinsically "all-in-one" molecules.In addition examining mechanistic approach nanoparticle synthesis, this review highlights effects phytochemical systems.Furthermore, we have evaluated scope future field, discussed several nanoparticles been developed recently imaging, provided experimental evidence supports usage.

Язык: Английский

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