Aggregation‐induced emission luminogens for in vivo molecular imaging and theranostics in cancer

Aggregate, Год журнала: 2023, Номер 4(5)

Опубликована: Май 6, 2023

Abstract Cancer is one of the most fatal diseases for decades. Aggregation‐induced emission luminogens (AIEgens) have been recently used as molecular imaging or therapeutic agents in cancers, due to advantages large Stokes shift, high quantum yield, great biocompatibility, and strong photostability. AIEgens can specifically target different types cancer via diverse targeting strategies. AIEgen‐based fluorescence imaging, especially near‐infrared demonstrated deep penetration suitable signal‐to‐noise ratio, which allows reliable vivo imaging. Combined with other modalities, multimodal could provide multidimensional hallmarks from perspectives. In addition, phototherapy be photodynamic therapy photothermal therapy, facilitate ablation cells good biosafety effects vivo. nanoparticles fabricated some specific chemicals, drugs, siRNA, display synergistic cancers. This paper comprehensively describes current status future perspectives AIEgens, showed a potential preclinical clinical translation on theranostics cancer.

Язык: Английский

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Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 197, С. 114821 - 114821

Опубликована: Апрель 9, 2023

Язык: Английский

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Tumor–Antigen Activated Dendritic Cell Membrane-Coated Biomimetic Nanoparticles with Orchestrating Immune Responses Promote Therapeutic Efficacy against Glioma

ACS Nano, Год журнала: 2023, Номер 17(3), С. 2341 - 2355

Опубликована: Янв. 23, 2023

Immunotherapy has had a profound positive effect on certain types of cancer but not improved the outcomes glioma because blood–brain barrier (BBB) and immunosuppressive tumor microenvironment. In this study, we developed an activated mature dendritic cell membrane (aDCM)-coated nanoplatform, rapamycin (RAPA)-loaded poly(lactic-co-glycolic acid) (PLGA), named aDCM@PLGA/RAPA, which is simple, efficient, individualized strategy to cross BBB improve immune microenvironment precisely. vitro cells uptake transwell model revealed that aDCM@PLGA/RAPA can enhance homotypic-targeting BBB-crossing efficiently. According in vivo response efficacy immature (DCs) could be stimulated into matured status, leads further activation cells, such as tumor-infiltrating T natural killer induce subsequent responses through direct indirect way. The treatment only inhibit growth significantly also favorable potential ability glial differentiation orthotopic glioma. Moreover, aDCM@PLGA robust CD8+ effector therefore suppress prophylactic setup, indicates immunity. Overall, our work provides effective antiglioma drug delivery system great for combination immunotherapy.

Язык: Английский

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Lighting up Micro-/Nanorobots with Fluorescence

Chemical Reviews, Год журнала: 2022, Номер 123(7), С. 3944 - 3975

Опубликована: Сен. 15, 2022

Micro-/nanorobots (MNRs) can be autonomously propelled on demand in complex biological environments and thus may bring revolutionary changes to biomedicines. Fluorescence has been widely used real-time imaging, chemo-/biosensing, photo-(chemo-) therapy. The integration of MNRs with fluorescence generates fluorescent unique advantages optical trackability, on-the-fly environmental sensitivity, targeting chemo-/photon-induced cytotoxicity. This review provides an up-to-date overview MNRs. After the highlighted elucidation about various propulsion mechanisms introductory information emphasis materials, we systematically illustrate design preparation strategies integrate substances their biomedical applications imaging-guided drug delivery, intelligent sensing In end, summarize main challenges provide outlook future directions work is expected attract inspire researchers from different communities advance creation practical application a broad horizon.

Язык: Английский

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Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Июль 26, 2022

Abstract Cancer remains a serious threat to human health owing the lack of effective treatments. Photodynamic therapy (PDT) has emerged as promising non-invasive cancer treatment that consists three main elements: photosensitizers (PSs), light and oxygen. However, some traditional PSs are prone aggregation-caused quenching (ACQ), leading reduced reactive oxygen species (ROS) generation capacity. Aggregation-induced emission (AIE)-PSs, due their distorted structure, suppress strong molecular interactions, making them more photosensitive in aggregated state instead. Activated by light, they can efficiently produce ROS induce cell death. PS is one core factors efficient PDT, so proceeding from design preparation AIE-PSs, including how manipulate electron donor (D) receptor (A) configuration, introduce heavy atoms or metal complexes, Type I polymerization-enhanced photosensitization nano-engineering approaches. Then, preclinical experiments AIE-PSs treating different types tumors, such ovarian cancer, cervical lung breast its great potential clinical applications discussed. In addition, perspectives on further development presented. This review hopes stimulate interest researchers fields chemistry, materials science, biology, medicine, promote translation AIE-PSs. Graphical

Язык: Английский

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Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

ACS Nano, Год журнала: 2024, Номер 18(3), С. 1820 - 1845

Опубликована: Янв. 9, 2024

The blood–brain barrier (BBB) is a specialized semipermeable structure that highly regulates exchanges between the central nervous system parenchyma and blood vessels. Thus, BBB also prevents passage of various forms therapeutic agents, nanocarriers, their cargos. Recently, many multidisciplinary studies focus on developing cargo-loaded nanoparticles (NPs) to overcome these challenges, which are emerging as safe effective vehicles in neurotheranostics. In this Review, first we introduce anatomical physiological functions BBB. Second, present endogenous exogenous transport mechanisms by NPs cross We report nanomaterials, carriers, cargos, with detailed uptake permeability characteristics. Third, describe effect regulating size, shape, charge, surface ligands affect permeability, can be exploited enhance promote classify typical functionalized nanomaterials developed for crossing. Fourth, provide comprehensive review recent progress functional polymeric applications multimodal bioimaging, therapeutics, drug delivery. Finally, conclude discussing existing directions, future perspectives employing

Язык: Английский

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Brightness of fluorescent organic nanomaterials

Chemical Society Reviews, Год журнала: 2023, Номер 52(14), С. 4525 - 4548

Опубликована: Янв. 1, 2023

Brightness is a fundamental property of fluorescent nanomaterials reflecting their capacity to absorb and emit light. In sensing materials, brightness crucial for high-sensitivity (bio)molecular detection, while in optical bioimaging it ensures high spatial temporal resolution. Fluorescent organic nanoparticles (NPs) are particularly attractive because superior compared dyes. With the ever-growing diversity nanomaterials, important establish universal principles measuring estimating brightness. This tutorial review provides definitions describes major approaches its analysis based on ensemble single-particle techniques. We present current chemical fight Aggregation-Caused Quenching (ACQ) fluorophores, which challenge design bright nanomaterials. The main classes NPs described, including conjugated polymer NPs, aggregation-induced emission neutral ionic Their other properties systematically compared. Some brightest examples bulk solid-state emissive materials also mentioned. Finally, we analyse importance particle biological applications, such as biosensing. will provide guidelines chemists with improved performance help them estimate compare new literature reports. Moreover, biologists select appropriate imaging applications.

Язык: Английский

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Neutrophil-like Biomimic AIE Nanoparticles with High-Efficiency Inflammatory Cytokine Targeting Enable Precise Photothermal Therapy and Alleviation of Inflammation

ACS Nano, Год журнала: 2023, Номер 17(8), С. 7394 - 7405

Опубликована: Апрель 3, 2023

Although photothermal therapy (PTT) has thrived as a promising treatment for drug-resistant bacterial infections by avoiding the abuse of antibiotics, remaining challenges that limit efficiency are poor targeting properties infected lesions and low penetration to cell membrane Gram-negative bacteria. Herein, we developed biomimetic neutrophil-like aggregation-induced emission (AIE) nanorobot (CM@AIE NPs) precise inflammatory site homing efficient PTT effects. Due their surface-loaded neutrophil membranes, CM@AIE NPs can mimic source thus interact with immunomodulatory molecules would otherwise target endogenous neutrophils. Coupled secondary near-infrared region absorption excellent AIE luminogens (AIEgens), localization, in sites be achieved, thereby minimizing damage surrounding normal tissues. Moreover, NP-mediated was stimulated vivo 980 nm laser irradiation, which contributed extent therapeutic depth limited skin The good biocompatibility vitro antibacterial effects prove provide strategy broad-spectrum applications.

Язык: Английский

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NK cell-based tumor immunotherapy

Bioactive Materials, Год журнала: 2023, Номер 31, С. 63 - 86

Опубликована: Авг. 9, 2023

Natural killer (NK) cells display a unique inherent ability to identify and eliminate virus-infected tumor cells. They are particularly powerful for elimination of hematological cancers, have attracted considerable interests therapy solid tumors. However, the treatment tumors with NK less effective, which can be attributed very complicated immunosuppressive microenvironment that may lead inactivation, insufficient expansion, short life, poor infiltration Fortunately, development advanced nanotechnology has provided potential solutions these issues, could improve immunotherapy efficacy In this review, we summarize activation inhibition mechanisms in tumors, recent advances cell-based boosted by diverse nanomaterials. We also propose challenges opportunities clinical application immunotherapy.

Язык: Английский

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Innovative utilization of cell membrane‐coated nanoparticles in precision cancer therapy

Exploration, Год журнала: 2024, Номер 4(6)

Опубликована: Март 21, 2024

Abstract Cell membrane‐coated nanoparticles (CMNPs) have recently emerged as a promising platform for cancer therapy. By encapsulating therapeutic agents within cell membrane‐derived coating, these combine the advantages of synthetic and natural membranes. This review provides comprehensive overview recent advancements in utilizing CMNPs effective drug delivery vehicles The synthesis fabrication methods are comprehensively discussed. Various techniques, such extrusion, sonication, self‐assembly, employed to coat with membranes derived from different types. membrane coating enables biocompatibility, reducing risk an immune response enhancing stability bloodstream. Moreover, functionalization strategies CMNPs, primarily chemical modification, genetic engineering, external stimuli, highlighted. presence specific surface markers on coated allows targeted cells maximizes efficacy. Preclinical studies therapy demonstrated successful various agents, chemotherapeutic drugs, nucleic acids, immunotherapeutic using CMNPs. Furthermore, article explores future directions challenges this technology while offering insights into its clinical potential.

Язык: Английский

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