Biosystem‐Inspired Engineering of Nanozymes for Biomedical Applications

Advanced Materials, Год журнала: 2023, Номер 36(10)

Опубликована: Янв. 9, 2023

Abstract Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to become surrogates of natural enzymes in many fields by virtue their advantages high catalytic stability, ease functionalization, and low cost. However, due the lack predictable descriptors, most nanozymes reported past been obtained mainly through trial‐and‐error strategies, efficacy, substrate specificity, as well practical application effect under physiological conditions, are far inferior that enzymes. To optimize efficacies functions biomedical settings, recent studies introduced biosystem‐inspired strategies into nanozyme design. In this review, advances engineering leveraging refined structure enzymes, simulating behavior changes process, mimicking specific biological processes or living organisms, introduced. Furthermore, currently involved applications summarized. More importantly, current opportunities challenges design discussed. It is hoped based on bioinspired will be beneficial for constructing new generation broadening applications.

Язык: Английский

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Reactive-oxygen-species-scavenging nanomaterials for resolving inflammation

Materials Today Bio, Год журнала: 2021, Номер 11, С. 100124 - 100124

Опубликована: Июнь 1, 2021

Reactive oxygen species (ROS) mediate multiple physiological functions; however, the over-accumulation of ROS causes premature aging and/or death and is associated with various inflammatory conditions. Nevertheless, there are limited clinical treatment options that currently available. The good news owing to considerable advances in nanoscience, types nanomaterials unique ROS-scavenging abilities influence temporospatial dynamic behaviors biological systems have been developed. This has led emergence next-generation nanomaterial-controlled strategies aimed at ameliorating ROS-related Accordingly, herein we reviewed recent progress research on nanotherapy based scavenging. underlying mechanisms employed emphasized. Furthermore, important issues developing cross-disciplinary nanomedicine-based for ROS-based conditions discussed. Our review this increasing interdisciplinary field will benefit ongoing studies applications nanomedicine

Язык: Английский

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Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Advanced Functional Materials, Год журнала: 2021, Номер 31(50)

Опубликована: Сен. 8, 2021

Abstract Multiple enzyme‐driven biological catalytic cascades occur in living organisms, guiding highly efficient and selective transformations of substrates. Inspired by the merits these cascade systems, enormous efforts have been devoted to developing novel systems mimic reactions over past few years. Nanozymes, a class enzyme mimics, are nanomaterials with enzyme‐like activity. The emergence development nanozymes has significantly advanced biomimetic nanoreactors. Currently, nanoreactors driven widely used exhibit many advantages such as superior efficiency high stability, resulting significant advancements biosensing biomedical applications. latest advances understanding mechanism nanozyme‐engineered their progressive applications for comprehensively covered here. First, nanozyme enzyme/nanozyme‐engineered categorized according properties. Then, applications, including cancer therapy, antibacterial activity, antioxidation, hyperuricemia therapy covered. conclusion describes most important challenges opportunities remaining this exciting area research.

Язык: Английский

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White Blood Cell Membrane‐Coated Nanoparticles: Recent Development and Medical Applications

Advanced Healthcare Materials, Год журнала: 2021, Номер 11(7)

Опубликована: Авг. 31, 2021

White blood cells (WBCs) are immune that play essential roles in critical diseases including cancers, infections, and inflammatory disorders. Their dynamic diverse functions have inspired the development of WBC membrane-coated nanoparticles (denoted "WBC-NPs"), which formed by fusing plasma membranes WBCs, such as macrophages, neutrophils, T cells, natural killer onto synthetic nanoparticle cores. Inheriting entire source cell antigens, WBC-NPs act decoys simulate their broad biointerfacing properties with intriguing therapeutic potentials. Herein, recent medical applications focusing on four areas, carriers for drug delivery, countermeasures biological neutralization, nanovaccines modulation, tools isolation circulating tumor fundamental research is reviewed. Overall, studies established platform versatile nanotherapeutics application

Язык: Английский

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Nanozymes for Regenerative Medicine

Small Methods, Год журнала: 2022, Номер 6(11)

Опубликована: Окт. 6, 2022

Abstract Nanozymes refer to nanomaterials that catalyze enzyme substrates into products under relevant physiological conditions following kinetics. Compared natural enzymes, nanozymes possess the characteristics of higher stability, easier preparation, and lower cost. Importantly, magnetic, fluorescent, electrical properties nanomaterials, making them promising replacements for enzymes in industrial, biological, medical fields. On account rapid development recently, their application potentials regeneration medicine are gradually being explored. To highlight achievements field, this review summarizes catalytic mechanism four types representative nanozymes. Then, strategies improve biocompatibility discussed. covers recent advances tissue including wound healing, nerve defect repair, bone regeneration, cardiovascular disease treatment. In addition, challenges prospects nanozyme researches summarized.

Язык: Английский

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Biomimetic cell membrane‐coated poly(lactic‐ co ‐glycolic acid) nanoparticles for biomedical applications

Bioengineering & Translational Medicine, Год журнала: 2022, Номер 8(2)

Опубликована: Ноя. 2, 2022

Abstract Poly(lactic‐ co ‐glycolic acid) (PLGA) nanoparticles (NPs) are commonly used for drug delivery because of their favored biocompatibility and suitability sustained controlled release. To prolong NP circulation time, enable target‐specific overcome physiological barriers, NPs camouflaged in cell membranes have been developed evaluated to improve delivery. Here, we discuss recent advances membrane‐coated PLGA NPs, preparation methods, application cancer therapy, management inflammation, treatment cardiovascular disease control infection. We address the current challenges highlight future research directions needed effective use membrane‐camouflaged NPs.

Язык: Английский

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Machine‐Learning‐Assisted Nanozyme Design: Lessons from Materials and Engineered Enzymes

Advanced Materials, Год журнала: 2023, Номер 36(10)

Опубликована: Янв. 26, 2023

Abstract Nanozymes are nanomaterials that exhibit enzyme‐like biomimicry. In combination with intrinsic characteristics of nanomaterials, nanozymes have broad applicability in materials science, chemical engineering, bioengineering, biochemistry, and disease theranostics. Recently, the heterogeneity published results has highlighted complexity diversity terms consistency catalytic capacity. Machine learning (ML) shows promising potential for discovering new materials, yet it remains challenging design based on ML approaches. Alternatively, is employed to promote optimization intelligent application engineered enzymes. Incorporation successful algorithms used enzymes can concomitantly facilitate guided development next‐generation desirable properties. Here, recent progress ML, its utilization enzymes, how emergent applications serve as strategies circumvent challenges associated time‐expensive laborious testing nanozyme research summarized. The examples ML‐aided also highlighted, special focus unified aims enhancing recapitulation substrate selectivity activity.

Язык: Английский

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Designing nanozymes for in vivo applications

Nature Reviews Bioengineering, Год журнала: 2024, Номер 2(10), С. 849 - 868

Опубликована: Июль 18, 2024

Язык: Английский

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Advanced strategies to evade the mononuclear phagocyte system clearance of nanomaterials

Exploration, Год журнала: 2023, Номер 3(1)

Опубликована: Янв. 5, 2023

Nanomaterials are promising carriers to improve the bioavailability and therapeutic efficiency of drugs by providing preferential drug accumulation at their sites action, but delivery efficacy is severely limited a series biological barriers, especially mononuclear phagocytic system (MPS)-the first major barrier encountered systemically administered nanomaterials. Herein, current strategies for evading MPS clearance nanomaterials summarized. First, engineering methods including surface modification, cell hitchhiking, physiological environment modulation reduce explored. Second, disabling blockade, suppression macrophage phagocytosis, macrophages depletion examined. Last, challenges opportunities in this field further discussed.

Язык: Английский

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Engineering Antioxidative Cascade Metal-Phenolic Nanozymes for Alleviating Oxidative Stress during Extracorporeal Blood Purification

ACS Nano, Год журнала: 2022, Номер 16(11), С. 18329 - 18343

Опубликована: Ноя. 10, 2022

Oxidative stress is a compelling risk factor in chronic kidney diseases and further aggravated for individuals during extracorporeal blood purification, ultimately leading to multiple complications. Herein, antioxidative cascade metal-phenolic nanozymes (metal-tannic acid nanozymes, M-TA NMs) are synthesized via metal ions-mediated oxidative coupling of polyphenols; then NMs engineered hemoperfusion microspheres (Cu-TAn@PMS) constructed alleviating stress. show adjustable broad-spectrum activities toward reactive nitrogen oxygen species (RNOS) due the catalytic active centers. Importantly, could mimic processes superoxide dismutase catalase maintain intracellular redox balance. Detailed structural spectral analyses reveal that existence transition decrease electronic energy band gaps offer better electron transfers RNOS scavenging. Notably, dynamic experiments demonstrate Cu-TAn@PMS serve as an antioxidant defense system scavenge (ROS) effectively even complex environment protect endogenous enzymes molecules. In general, this work developed with excellent therapeutic efficacy treatment stress-related diseases, which exhibited potential clinical purification extended biomedical applications nanozymes.

Язык: Английский

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