Single-Atom-Based Nanoenzyme in Tissue Repair DOI

Ziliang Fu,

Kexin Fan,

Xingjian He

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(20), P. 12639 - 12671

Published: May 8, 2024

Since the discovery of ferromagnetic nanoparticles Fe3O4 that exhibit enzyme-like activity in 2007, research on nanoenzymes has made significant progress. With in-depth study various and rapid development related nanotechnology, have emerged as a promising alternative to natural enzymes. Within nanozymes, there is category metal-based single-atom nanozymes been rapidly developed due low cast, convenient preparation, long storage, less immunogenicity, especially higher efficiency. More importantly, possess capacity scavenge reactive oxygen species through mechanisms, which beneficial tissue repair process. Herein, this paper systemically highlights types metal their catalytic recent applications repair. The existing challenges are identified prospects future composed metallic nanomaterials proposed. We hope review will illuminate potential repair, encouraging sequential clinical translation.

Language: Английский

Biosystem‐Inspired Engineering of Nanozymes for Biomedical Applications DOI
Lu Zhang, Huan Wang, Xiaogang Qu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Jan. 9, 2023

Abstract Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to become surrogates of natural enzymes in many fields by virtue their advantages high catalytic stability, ease functionalization, and low cost. However, due the lack predictable descriptors, most nanozymes reported past been obtained mainly through trial‐and‐error strategies, efficacy, substrate specificity, as well practical application effect under physiological conditions, are far inferior that enzymes. To optimize efficacies functions biomedical settings, recent studies introduced biosystem‐inspired strategies into nanozyme design. In this review, advances engineering leveraging refined structure enzymes, simulating behavior changes process, mimicking specific biological processes or living organisms, introduced. Furthermore, currently involved applications summarized. More importantly, current opportunities challenges design discussed. It is hoped based on bioinspired will be beneficial for constructing new generation broadening applications.

Language: Английский

Citations

165
Reactive-oxygen-species-scavenging nanomaterials for resolving inflammation DOI Creative Commons
Xue Huang, Dongyang He,

Zheng Pan

et al.

Materials Today Bio, Journal Year: 2021, Volume and Issue: 11, P. 100124 - 100124

Published: June 1, 2021

Reactive oxygen species (ROS) mediate multiple physiological functions; however, the over-accumulation of ROS causes premature aging and/or death and is associated with various inflammatory conditions. Nevertheless, there are limited clinical treatment options that currently available. The good news owing to considerable advances in nanoscience, types nanomaterials unique ROS-scavenging abilities influence temporospatial dynamic behaviors biological systems have been developed. This has led emergence next-generation nanomaterial-controlled strategies aimed at ameliorating ROS-related Accordingly, herein we reviewed recent progress research on nanotherapy based scavenging. underlying mechanisms employed emphasized. Furthermore, important issues developing cross-disciplinary nanomedicine-based for ROS-based conditions discussed. Our review this increasing interdisciplinary field will benefit ongoing studies applications nanomedicine

Language: Английский

Citations

123
Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects DOI
Xianlong Zhang, Guoliang Li, Guang Chen

et al.

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(50)

Published: Sept. 8, 2021

Abstract Multiple enzyme‐driven biological catalytic cascades occur in living organisms, guiding highly efficient and selective transformations of substrates. Inspired by the merits these cascade systems, enormous efforts have been devoted to developing novel systems mimic reactions over past few years. Nanozymes, a class enzyme mimics, are nanomaterials with enzyme‐like activity. The emergence development nanozymes has significantly advanced biomimetic nanoreactors. Currently, nanoreactors driven widely used exhibit many advantages such as superior efficiency high stability, resulting significant advancements biosensing biomedical applications. latest advances understanding mechanism nanozyme‐engineered their progressive applications for comprehensively covered here. First, nanozyme enzyme/nanozyme‐engineered categorized according properties. Then, applications, including cancer therapy, antibacterial activity, antioxidation, hyperuricemia therapy covered. conclusion describes most important challenges opportunities remaining this exciting area research.

Language: Английский

Citations

121
White Blood Cell Membrane‐Coated Nanoparticles: Recent Development and Medical Applications DOI
Dan Wang, Shuyan Wang, Zhidong Zhou

et al.

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 11(7)

Published: Aug. 31, 2021

White blood cells (WBCs) are immune that play essential roles in critical diseases including cancers, infections, and inflammatory disorders. Their dynamic diverse functions have inspired the development of WBC membrane-coated nanoparticles (denoted "WBC-NPs"), which formed by fusing plasma membranes WBCs, such as macrophages, neutrophils, T cells, natural killer onto synthetic nanoparticle cores. Inheriting entire source cell antigens, WBC-NPs act decoys simulate their broad biointerfacing properties with intriguing therapeutic potentials. Herein, recent medical applications focusing on four areas, carriers for drug delivery, countermeasures biological neutralization, nanovaccines modulation, tools isolation circulating tumor fundamental research is reviewed. Overall, studies established platform versatile nanotherapeutics application

Language: Английский

Citations

118
Nanozymes for Regenerative Medicine DOI
Xiaozhou Mou, Qingyuan Wu,

Zheao Zhang

et al.

Small Methods, Journal Year: 2022, Volume and Issue: 6(11)

Published: Oct. 6, 2022

Abstract Nanozymes refer to nanomaterials that catalyze enzyme substrates into products under relevant physiological conditions following kinetics. Compared natural enzymes, nanozymes possess the characteristics of higher stability, easier preparation, and lower cost. Importantly, magnetic, fluorescent, electrical properties nanomaterials, making them promising replacements for enzymes in industrial, biological, medical fields. On account rapid development recently, their application potentials regeneration medicine are gradually being explored. To highlight achievements field, this review summarizes catalytic mechanism four types representative nanozymes. Then, strategies improve biocompatibility discussed. covers recent advances tissue including wound healing, nerve defect repair, bone regeneration, cardiovascular disease treatment. In addition, challenges prospects nanozyme researches summarized.

Language: Английский

Citations

86
Biomimetic cell membrane‐coated poly(lactic‐ co ‐glycolic acid) nanoparticles for biomedical applications DOI Creative Commons
Nasrullah Jan, Asadullah Madni, Safiullah Khan

et al.

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(2)

Published: Nov. 2, 2022

Abstract Poly(lactic‐ co ‐glycolic acid) (PLGA) nanoparticles (NPs) are commonly used for drug delivery because of their favored biocompatibility and suitability sustained controlled release. To prolong NP circulation time, enable target‐specific overcome physiological barriers, NPs camouflaged in cell membranes have been developed evaluated to improve delivery. Here, we discuss recent advances membrane‐coated PLGA NPs, preparation methods, application cancer therapy, management inflammation, treatment cardiovascular disease control infection. We address the current challenges highlight future research directions needed effective use membrane‐camouflaged NPs.

Language: Английский

Citations

84
Machine‐Learning‐Assisted Nanozyme Design: Lessons from Materials and Engineered Enzymes DOI
Jie Zhuang, Adam C. Midgley,

Yonghua Wei

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Jan. 26, 2023

Abstract Nanozymes are nanomaterials that exhibit enzyme‐like biomimicry. In combination with intrinsic characteristics of nanomaterials, nanozymes have broad applicability in materials science, chemical engineering, bioengineering, biochemistry, and disease theranostics. Recently, the heterogeneity published results has highlighted complexity diversity terms consistency catalytic capacity. Machine learning (ML) shows promising potential for discovering new materials, yet it remains challenging design based on ML approaches. Alternatively, is employed to promote optimization intelligent application engineered enzymes. Incorporation successful algorithms used enzymes can concomitantly facilitate guided development next‐generation desirable properties. Here, recent progress ML, its utilization enzymes, how emergent applications serve as strategies circumvent challenges associated time‐expensive laborious testing nanozyme research summarized. The examples ML‐aided also highlighted, special focus unified aims enhancing recapitulation substrate selectivity activity.

Language: Английский

Citations

75
Advanced strategies to evade the mononuclear phagocyte system clearance of nanomaterials DOI Creative Commons
Junjie Lu,

Xiao Gao,

Siyao Wang

et al.

Exploration, Journal Year: 2023, Volume and Issue: 3(1)

Published: Jan. 5, 2023

Nanomaterials are promising carriers to improve the bioavailability and therapeutic efficiency of drugs by providing preferential drug accumulation at their sites action, but delivery efficacy is severely limited a series biological barriers, especially mononuclear phagocytic system (MPS)-the first major barrier encountered systemically administered nanomaterials. Herein, current strategies for evading MPS clearance nanomaterials summarized. First, engineering methods including surface modification, cell hitchhiking, physiological environment modulation reduce explored. Second, disabling blockade, suppression macrophage phagocytosis, macrophages depletion examined. Last, challenges opportunities in this field further discussed.

Language: Английский

Citations

67
Designing nanozymes for in vivo applications DOI
Ruofei Zhang, Bing Jiang, Kelong Fan

et al.

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(10), P. 849 - 868

Published: July 18, 2024

Language: Английский

Citations

63
Antioxidant and Prooxidant Nanozymes: From Cellular Redox Regulation to Next‐Generation Therapeutics DOI
Namrata Singh,

G. R. Sherin,

Govindasamy Mugesh

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(33)

Published: April 21, 2023

Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted tremendous interest in recent years owing to their ability replace natural enzymes various biomedical applications, such as biosensing, therapeutics, drug delivery, and bioimaging. In particular, the nanozymes capable of regulating cellular redox status by mimicking antioxidant mammalian cells are great therapeutic significance oxidative-stress-mediated disorders. As distinction physiological oxidative stress (oxidative eustress) pathological distress) occurs at a fine borderline, it is challenge design that can differentially sense two extremes cells, tissues organs mediate appropriate chemical reactions. this Review, we summarize advances development redox-active applications. We primarily highlight prooxidant disease model systems, cancer, neurodegeneration, cardiovascular diseases. The future perspectives emerging area research challenges associated applications described.

Language: Английский

Citations

61