Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 110 - 110
Опубликована: Янв. 15, 2025
Nanotechnology is a promising and rapidly developing area in the 21st century, which affects various fields of science: physics, chemistry, biology, engineering, microelectronics, medicine [...]
Язык: Английский
Exploration, Год журнала: 2023, Номер 3(1)
Опубликована: Янв. 5, 2023
Nanomaterials are promising carriers to improve the bioavailability and therapeutic efficiency of drugs by providing preferential drug accumulation at their sites action, but delivery efficacy is severely limited a series biological barriers, especially mononuclear phagocytic system (MPS)-the first major barrier encountered systemically administered nanomaterials. Herein, current strategies for evading MPS clearance nanomaterials summarized. First, engineering methods including surface modification, cell hitchhiking, physiological environment modulation reduce explored. Second, disabling blockade, suppression macrophage phagocytosis, macrophages depletion examined. Last, challenges opportunities in this field further discussed.
Язык: Английский
Процитировано
67
International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 4751 - 4778
Опубликована: Авг. 1, 2023
Abstract: Exosomes, as natural nanocarriers, characterized with low immunogenicity, non-cytotoxicity and targeted delivery capability, which have advantages over synthetic nanocarriers. Recently, exosomes shown great potential diagnostic markers for diseases are also considered a promising cell-free therapy. Engineered significantly enhanced the efficacy precision of delivering therapeutic agents, currently being extensively employed in investigations various ailments, including oncology, inflammatory disorders, degenerative conditions. Particularly, engineered enable agent loading, modification, evasion MPS phagocytosis, intelligent control, bioimaging, been developed multifunctional nano-delivery platforms recent years. The utilization bioactive scaffolds that loaded exosome has to substantially augment retention, extend release, enhance efficacy. This approach advanced from conventional hydrogels nanocomposite hydrogels, nanofiber 3D printing, resulting superior physical biological properties effectively address limitations scaffolds. Additionally, plant-derived exosomes, can participate gut flora remodeling via oral administration, an ideal platform treatment intestinal diseases. Consequently, there is interest nanocarriers applications. comprehensive review provides overview biogenesis, composition, isolation methods exosomes. it examines pathological mechanisms diseases, tumors, Furthermore, this highlights significance microbial-derived Strategies specific applications scaffold-loaded further summarized, especially some new techniques such large-scale loading technique, macromolecular development nano-scaffold-loaded delivery. benefits using gut-related discussed. challenges, opportunities, prospects exosome-based disease diagnosis summarized both preclinical clinical viewpoints. Keywords: diagnosis,
Язык: Английский
Процитировано
42
Quantitative Imaging in Medicine and Surgery, Год журнала: 2024, Номер 14(8), С. 5460 - 5472
Опубликована: Фев. 23, 2024
Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor-sensitizing (EGFR-sensitizing) mutations exhibit a positive response to tyrosine kinase inhibitors (TKIs). Given the limitations of current clinical predictive methods, it is critical explore radiomics-based approaches. In this study, we leveraged deep-learning technology multimodal radiomics data more accurately predict EGFR-sensitizing mutations.
Язык: Английский
Процитировано
26
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Май 22, 2024
Abstract Rapid uptake of nanoparticles by mononuclear phagocyte system (MPS) significantly hampers their therapeutic efficacy. Temporal MPS blockade is one the few ways to overcome this barrier – approach rediscovered many times under different names but never extensively used in clinic. Using meta-analysis published data we prove efficacy technique for enhancing particle circulation blood and delivery tumours, describe a century its evolution potential combined mechanism behind it. Finally, discuss future directions research focusing on features essential successful clinical translation method.
Язык: Английский
Процитировано
21
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 203, С. 115116 - 115116
Опубликована: Окт. 21, 2023
Язык: Английский
Процитировано
28
Exploration, Год журнала: 2023, Номер 4(3)
Опубликована: Дек. 7, 2023
Abstract Atherosclerosis, a chronic disease associated with metabolism, poses significant risk to human well‐being. Currently, existing treatments for atherosclerosis lack sufficient efficiency, while the utilization of surface‐modified nanoparticles holds potential deliver highly effective therapeutic outcomes. These can target and bind specific receptors that are abnormally over‐expressed in atherosclerotic conditions. This paper reviews recent research (2018–present) advances various ligand‐modified nanoparticle systems targeting by specifically signature molecules hope precise treatment at molecular level concludes discussion challenges prospects this field. The intention review is inspire novel concepts design advancement targeted nanomedicines tailored atherosclerosis.
Язык: Английский
Процитировано
24
Journal of Controlled Release, Год журнала: 2024, Номер 372, С. 85 - 94
Опубликована: Июнь 14, 2024
Язык: Английский
Процитировано
13
Advanced Science, Год журнала: 2024, Номер 11(19)
Опубликована: Март 13, 2024
Abstract Efferocytosis, an intrinsic regulatory mechanism to eliminate apoptotic cells, will be suppressed due the delayed apoptosis process in aging‐related diseases, such as osteoarthritis (OA). In this study, cartilage lesion‐localized hydrogel microspheres are developed remodel situ efferocytosis reverse senescence and recruit endogenous stem cells accelerate repair. Specifically, aldehyde‐ methacrylic anhydride (MA)‐modified hyaluronic acid (AHM), loaded with pro‐apoptotic liposomes (liposomes encapsulating ABT263, A‐Lipo) PDGF‐BB, namely A‐Lipo/PAHM, prepared by microfluidic photo‐cross‐linking techniques. By a degraded porcine explant OA model, lesion location experiment illustrated that aldehyde‐functionalized promote affinity for cartilage. vitro data showed A‐Lipo induced of senescent chondrocytes (Sn‐chondrocytes), which can then phagocytosed macrophages, remodeling facilitated protection normal maintained chondrogenic differentiation capacity MSCs. vivo experiments confirmed localized reversed promoted repair OA. It is believed strategy great significance tissue regeneration diseases.
Язык: Английский
Процитировано
12
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)
Опубликована: Апрель 2, 2024
Atherosclerotic plaque formation is considered the primary pathological mechanism underlying atherosclerotic cardiovascular diseases, leading to severe events such as stroke, acute coronary syndromes, and even sudden cardiac death. Early detection timely intervention of plaques are challenging due lack typical symptoms in initial stages. Therefore, precise early play a crucial role risk stratification achieving favorable post-interventional outcomes. The continuously advancing nanoplatforms have demonstrated numerous advantages including high signal-to-noise ratio, enhanced bioavailability, specific targeting capabilities for imaging agents therapeutic drugs, enabling effective visualization management plaques. Motivated by these superior properties, various noninvasive modalities recognition preliminary stage atherosclerosis comprehensively summarized. Additionally, several strategies proposed enhance efficacy treating Finally, existing challenges promising prospects accelerating clinical translation nanoplatform-based molecular therapy discussed. In conclusion, this review provides an insightful perspective on diagnosis
Язык: Английский
Процитировано
12
Nano TransMed, Год журнала: 2024, Номер 3, С. 100042 - 100042
Опубликована: Июль 11, 2024
Novel drug delivery systems comprise sophisticated technology merged into systems. These are created with the aim of addressing limitations conventional For instance, inefficient in tackling challenging human diseases such as cancer. thus formed materials to enhance permeation target cells. They improve patients' compliance and efficacy. include self-powered microelectromechanical Nanotechnology is a rapidly growing promising field, especially system development disease therapy. often utilise nanocarriers due their numerous advantages. One benefits ability manipulate size surface functionalisation achieve site-specific targeting. Many researchers have reported controlled targeted release profiles. Nanocarriers propelled tissues, where entrapped drugs released, prolonging therapeutic efficacy decreasing undesired side effects. Hence, these offer delivery, low toxicity, high bioavailability improved efficiency. It essential understand mechanisms toxicity order develop efficient safe This review describes utilisation novel also dwells on loading, targeting from nanocarriers. The primary concerns clinical applications potential presented. expected that this will be helpful formulation seeking solutions cancer cardiovascular diseases.
Язык: Английский
Процитировано
11