Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Feb. 1, 2024
Increasing
bacterial
infections
and
growing
resistance
to
available
drugs
pose
a
serious
threat
human
health
the
environment.
Although
antibiotics
are
crucial
in
fighting
infections,
their
excessive
use
not
only
weakens
our
immune
system
but
also
contributes
resistance.
These
negative
effects
have
caused
doctors
be
troubled
by
clinical
application
of
antibiotics.
Facing
this
challenge,
it
is
urgent
explore
new
antibacterial
strategy.
MXene
has
been
extensively
reported
tumor
therapy
biosensors
due
its
wonderful
performance.
Due
large
specific
surface
area,
remarkable
chemical
stability,
hydrophilicity,
wide
interlayer
spacing,
excellent
adsorption
reduction
ability,
shown
potential
for
biopharmaceutical
applications.
However,
there
few
antimicrobial
evaluations
on
MXene.
The
current
mechanisms
mainly
include
physical
damage,
induced
oxidative
stress,
photothermal
photodynamic
therapy.
In
paper,
we
reviewed
MXene-based
composites
discussed
guide
further
research
field.
Small,
Journal Year:
2022,
Volume and Issue:
18(27)
Published: June 9, 2022
Abstract
The
treatment
of
diabetic
wounds
remains
challenging
due
to
the
excess
levels
oxidative
stress,
vulnerability
bacterial
infection,
and
persistent
inflammation
response
during
healing.
development
hydrogel
wound
dressings
with
ideal
anti‐inflammation,
antioxidant,
anti‐infective
properties
is
an
urgent
clinical
requirement.
In
present
study,
injectable
thermosensitive
niobium
carbide
(Nb
2
C)‐based
C@Gel)
antioxidative
antimicrobial
activity
developed
promote
Nb
C@Gel
system
composed
C
a
PLGA‐PEG‐PLGA
triblock
copolymer.
fabricated
nanosheets
(NSs)
show
good
biocompatibility
in
vitro
cytotoxicity
hemocompatibility
assays
vivo
toxicity
assays.
experiments
that
NSs
can
efficiently
eliminate
reactive
oxygen
species
(ROS),
thus
protecting
cells
from
stress
damage.
Meanwhile,
also
exhibit
near‐infrared
(NIR)
photothermal
against
both
Staphylococcus
aureus
Escherichia
coli
.
results
demonstrate
promotes
healing
by
attenuating
ROS
levels,
reducing
damage,
eradicating
infection
under
NIR
irradiation,
accelerating
angiogenesis.
To
summarize,
system,
its
ROS‐scavenging,
hemostatic
activities,
be
promising
effective
strategy
for
wounds.
Nano-Micro Letters,
Journal Year:
2022,
Volume and Issue:
14(1)
Published: Aug. 24, 2022
The
pernicious
bacterial
proliferation
and
emergence
of
super-resistant
bacteria
have
already
posed
a
great
threat
to
public
health,
which
drives
researchers
develop
antibiotic-free
strategies
eradicate
these
fierce
microbes.
Although
enormous
achievements
been
achieved,
it
remains
an
arduous
challenge
realize
efficient
sterilization
cut
off
the
drug
resistance
generation.
Recently,
photothermal
therapy
(PTT)
has
emerged
as
promising
solution
efficiently
damage
integrity
pathogenic
based
on
hyperthermia
beyond
their
tolerance.
Until
now,
numerous
agents
studied
for
antimicrobial
PTT.
Among
them,
MXenes
(a
type
two-dimensional
transition
metal
carbides
or
nitrides)
are
extensively
investigated
one
most
candidates
due
high
aspect
ratio,
atomic-thin
thickness,
excellent
performance,
low
cytotoxicity,
ultrahigh
dispersibility
in
aqueous
systems.
Besides,
application
scenarios
using
antibacterial
properties
can
be
tailored
via
elaborated
designs
MXenes-based
materials.
In
this
review,
synthetic
approaches
textural
systematically
presented
first,
then
mechanisms
materials
documented.
Subsequently,
recent
progress
diverse
fields
making
use
performances
well
summarized
reveal
potential
applications
various
purposes,
including
vitro
vivo
sterilization,
solar
water
evaporation
purification,
flexible
fabrics.
Last
but
not
least,
current
challenges
future
perspectives
discussed
provide
theoretical
guidance
fabrication
systems
MXenes.
Small,
Journal Year:
2023,
Volume and Issue:
19(14)
Published: Jan. 5, 2023
The
mutations
of
bacteria
due
to
the
excessive
use
antibiotics,
and
generation
antibiotic-resistant
have
made
development
new
antibacterial
compounds
a
necessity.
MXenes
emerged
as
biocompatible
transition
metal
carbide
structures
with
extensive
biomedical
applications.
This
is
related
MXenes'
unique
combination
properties,
including
multifarious
elemental
compositions,
2D-layered
structure,
large
surface
area,
abundant
terminations,
excellent
photothermal
photoelectronic
properties.
focus
this
review
application
MXenes,
which
has
attracted
attention
researchers
since
2016.
A
quick
overview
synthesis
strategies
provided
then
summarizes
effect
various
factors
(including
structural
optical
charges,
flake
size,
dispersibility)
on
biocidal
activity
MXenes.
main
mechanisms
for
deactivating
by
are
discussed
in
detail
rupturing
bacterial
membrane
sharp
edges
nanoflakes,
generating
reactive
oxygen
species
(ROS),
bacteria.
Hybridization
other
organic
inorganic
materials
can
result
improved
activities
different
applications
such
wound
dressings
water
purification.
Finally,
challenges
perspectives
MXene
nanomaterials
agents
presented.
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
32(34)
Published: June 24, 2022
Abstract
MXenes
(viz.,
transition
metal
carbides,
carbonitrides,
and
nitrides)
have
emerged
as
a
new
subclass
of
2D
materials.
Due
to
their
outstanding
physicochemical
biological
properties,
gained
much
attention
in
the
biomedical
field
recent
years,
including
drug
delivery
systems,
regenerative
medicine,
biosensing.
Additionally,
incorporation
into
hydrogels
has
garnered
significant
interest
engineering
an
electroactive
mechanical
nanoreinforcer
capable
converting
nonconductive
scaffolds
excellent
conductors
electricity
with
impressive
effect
on
properties
for
organs
tissues
such
cardiac,
skeletal
muscle,
nerve.
However,
many
questions
problems
remain
unresolved
that
need
be
answered
usher
these
materials
toward
true
destiny.
Thus,
this
review
paper
aims
provide
overview
design
applications
MXene‐integrated
composites
applications,
cardiac
tissue
engineering,
wound
healing,
infection
therapy,
cancer
biosensors.
Moreover,
current
challenges
limitations
utilizing
vivo
are
highlighted
discussed,
followed
by
its
prospects
guideline
possible
various
futuristic
applications.
This
article
will
inspire
researchers,
who
search
opportunities,
using
nanomaterial
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(14)
Published: March 10, 2022
Abstract
Pathogenic
bacteria
infection
is
a
serious
threat
to
human
public
health
due
the
high
morbidity
and
mortality
rates.
Nano
delivery
system
for
delivering
antibiotics
provides
an
alternative
option
improve
efficiency
compared
conventional
therapeutic
agents.
In
addition
drug
loading
capacity
of
nanocarriers,
which
typically
around
10%,
further
lowers
dose
that
pathological
are
exposed
to.
Moreover,
nanocarriers
not
eliminated
from
body
may
cause
side
effects.
These
limitations
have
motivated
development
self‐delivery
systems
formed
by
self‐assembly
different
this
study,
vehicle‐free
antimicrobial
polymer
polyhexamethylene
biguanide
(PHMB,
with
bactericidal
anti‐biofilm
functions)
hybrid
gold
nanoparticle
(Au
NPs,
photothermal
therapy
(PTT))
platform
(PHMB@Au
NPs)
developed.
This
exhibits
excellent
synergistic
effect
enhance
Staphylococcus
aureus
under
near‐infrared
irradiation.
Furthermore,
results
showed
PHMB@Au
NPs
inhibit
formation
biofilms,
quickly
remove
promote
wound
healing
through
PTT
in
model
vivo,
even
mediate
transition
macrophages
M1
M2
type,
accelerate
tissue
angiogenesis.
will
promising
value
as
highly
effective
agents
patient
management.
Journal of Materials Chemistry A,
Journal Year:
2021,
Volume and Issue:
9(33), P. 17569 - 17591
Published: Jan. 1, 2021
The
photothermal
applications
of
2D
nanomaterials
in
therapy,
water
evaporation,
thermochemical
reactions,
light-driven
actuators,
electrodes,
energy
storage,
wearable
heaters
and
bacterial
inhibition.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
32(7)
Published: Nov. 5, 2021
Abstract
Pathogenic
infection
inevitably
provokes
chronic
inflammation
and
stalls
the
normal
orchestrated
course
of
wound‐healing
cascades.
However,
current
antibacterial
therapies
focus
on
inherent
bactericidal
functions
biomaterials.
To
take
full
advantage
microenvironment
(IME)
peculiarities,
an
IME‐activated
nanocatalytic
membrane
consisting
electrospun
poly
(lactic‐co‐glycolic
acid)
(PLGA)
scaffolds,
MXene/Ag
2
S
bio‐heterojunctions
(MX/AS
bio‐HJs),
lactate
oxidase
(LOx)
for
cutaneous
regeneration
is
devised
developed.
In
this
“intelligent”
system,
PLGA
membranes
gradually
degrade
to
lactate,
LOx
consumes
yield
abundant
hydrogen
peroxide
(H
O
)
in
a
microenvironment‐responsive
manner.
addition,
MX/AS
bio‐HJs
not
only
exert
benign
photothermal
effects
generate
reactive
oxygen
species
upon
NIR
light,
but
also
catalyze
produced
H
overwhelming
hydroxyl
radicals
(·OH)
through
Fenton‐like
reactions,
which
all
result
rapid
synergistic
sterilization.
Furthermore,
vivo
assays
demonstrate
that
reshape
stalled
wound
into
regenerative
by
massacring
bacteria,
stopping
bleeding,
boosting
epithelialization/collagen
deposition
beds,
promoting
angiogenesis.
As
envisaged,
proposed
tactic
opens
up
promising
opportunity
arming
with
IME‐responsive
activity
remedy
bacteria‐invaded
full‐thickness
wounds.
