Advanced Functional Materials,
Год журнала:
2024,
Номер
34(27)
Опубликована: Март 5, 2024
Abstract
Conventional
magnetophoresis
techniques
for
manipulating
biocarriers
and
cells
predominantly
rely
on
large‐scale
electromagnetic
systems,
which
is
a
major
obstacle
to
the
development
of
portable
miniaturized
cell‐on‐chip
platforms.
Herein,
novel
magnetic
engineering
approach
by
tailoring
nanoscale
notch
disk
micromagnet
using
two‐step
optical
thermal
lithography
developed.
Versatile
manipulations
are
demonstrated,
such
as
separation
trapping,
carriers
mediating
changes
in
domain
structure
discontinuous
movement
energy
wells
around
circumferential
edge
caused
locally
fabricated
nano‐notch
low
field
system.
The
motion
well
regulated
configuration
strength
frequency
field,
accompanying
jump
carriers.
proposed
concepts
demonstrate
that
multiple
can
be
manipulated
sorted
optimized
multi‐notch
gates
magnetophoretic
This
highlights
potential
developing
cost‐effective
point‐of‐care
testing
lab‐on‐chip
systems
various
single‐cell‐level
diagnoses
analyses.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Апрель 25, 2024
The
significance
of
point-of-care
testing
(POCT)
in
early
clinical
diagnosis
and
personalized
patient
care
is
increasingly
recognized
as
a
crucial
tool
reducing
disease
outbreaks
improving
survival
rates.
Within
the
realm
POCT,
biosensors
utilizing
magnetic
nanoparticles
(MNPs)
have
emerged
subject
substantial
interest.
This
review
aims
to
provide
comprehensive
evaluation
current
landscape
emphasizing
its
growing
within
practice.
Subsequently,
status
combination
MNPs
Biological
detection
has
been
presented.
Furthermore,
it
delves
into
specific
domain
MNP-based
biosensors,
assessing
their
potential
impact
on
POCT.
By
combining
existing
research
spotlighting
pivotal
discoveries,
this
enhances
our
comprehension
advancements
promising
prospects
offered
by
context
It
seeks
facilitate
informed
decision-making
among
healthcare
professionals
researchers
while
also
promoting
further
exploration
field
study.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Янв. 25, 2024
The
development
of
micro/nanorobots
and
their
application
in
medical
treatment
holds
the
promise
revolutionizing
disease
diagnosis
treatment.
In
comparison
to
conventional
diagnostic
methods,
exhibit
immense
potential
due
small
size
ability
penetrate
deep
tissues.
However,
transition
this
technology
from
laboratory
clinical
applications
presents
significant
challenges.
This
paper
provides
a
comprehensive
review
research
progress
micro/nanorobotics,
encompassing
biosensors,
diagnostics,
targeted
drug
delivery,
minimally
invasive
surgery.
It
also
addresses
key
issues
challenges
facing
technology.
fusion
with
treatments
is
poised
have
profound
impact
on
future
medicine.
Cancer
poses
a
substantial
threat
and
serious
challenge
to
public
human
health,
driving
the
promotion
of
sophisticated
technologies
for
cancer
therapy.
While
conventional
chemotherapy
has
bottlenecks
such
as
low
delivery
efficiency,
strong
toxic
side
effects,
tumor
enrichment
barriers,
magnetic
micro/nanorobots
(MNRs)
emerge
promising
therapeutic
candidates
that
provide
alternative
strategies
MNR
is
kind
human-made
machine
micro-
or
nanosized,
reasonably
designed,
performs
command
tasks
through
self-actuated
externally
controlled
propulsion
mechanisms,
which
can
be
potentially
applied
in
theranostics.
Here,
this
review
first
introduces
components
constitute
typical
MNR,
including
body
part,
control
function
sensing
part.
Subsequently,
elucidates
representative
fabrication
methods
construct
MNRs
from
top-down
approaches
bottom-up
approaches,
covering
injection
molding,
self-rolling,
melt
electrospinning
writing,
deposition,
biotemplate
method,
lithography,
assembling,
3D
printing,
chemical
synthesis.
Furthermore,
focuses
on
multiple
applications
facing
diagnosis
treatment,
encompassing
imaging,
quantification,
drug
release,
synergy
with
therapies,
cell
manipulation,
surgical
assistance.
Then,
systematically
elaborates
biocompatibility
biosafety
MNRs.
Finally,
challenges
faced
by
are
discussed
alongside
future
research
directions.
This
intended
scientific
guidance
may
improve
comprehension
cognition
theranostics
platform
MNRs,
promoting
prospering
practical
application
development
Abstract
The
importance
of
mechanical
signals
in
regulating
the
fate
macrophages
is
gaining
increased
attention
recently.
However,
recently
used
normally
rely
on
physical
characteristics
matrix
with
non‐specificity
and
instability
or
loading
devices
uncontrollability
complexity.
Herein,
we
demonstrate
successful
fabrication
self‐assembled
microrobots
(SMRs)
based
magnetic
nanoparticles
as
local
signal
generators
for
precise
macrophage
polarization.
Under
a
rotating
field
(RMF),
propulsion
SMRs
occurs
due
to
elastic
deformation
via
force
hydrodynamics.
perform
wireless
navigation
toward
targeted
controllable
manner
subsequently
rotate
around
cell
generation.
Macrophages
are
eventually
polarized
from
M0
anti‐inflammatory
related
M2
phenotypes
by
blocking
Piezo1‐activating
protein‐1
(AP‐1）‐CCL2
signaling
pathway.
as‐developed
microrobot
system
provides
new
platform
polarization,
which
holds
great
potential
regulation
fate.‐
Nano Letters,
Год журнала:
2023,
Номер
23(19), С. 9056 - 9064
Опубликована: Сен. 22, 2023
Sepsis
is
an
acute
systemic
infectious
syndrome
with
high
fatality.
Fast
and
accurate
diagnosis,
monitoring,
medication
of
sepsis
are
essential.
We
exploited
the
fluorescent
metal-AIEgen
frameworks
(MAFs)
demonstrated
dual
functions
protein
detection
bacteria
identification:
(i)
ultrasensitive
point-of-care
(POC)
biomarkers
(100
times
enhanced
sensitivity);
(ii)
rapid
POC
identification
Gram-negative/positive
(selective
aggregation
within
20
min).
Fluorescent
lateral
flow
immunoassays
(LFAs)
convenient
inexpensive
for
tests.
MAFs
possess
a
large
surface
area,
excellent
photostability,
quantum
yield
(∼80%),
multiple
active
sites
serving
as
binding
domains
(IL-6/PCT)
on
LFAs.
The
limit
(LOD)
IL-6/PCT
0.252/0.333
pg/mL.
Rapid
appraisal
vital
to
guide
use
medicines.
dual-functional
have
great
potential
in
tests
clinical
diagnosis
bacterial
infections.
Advanced Materials Technologies,
Год журнала:
2023,
Номер
8(11)
Опубликована: Март 25, 2023
Abstract
Micro/nanorobots
are
the
general
terms
for
microrobot
and
nanorobot,
whose
sizes
often
between
1
nm
mm.
They
can
convert
a
variety
of
external
energy
sources
into
mechanical
energy.
In
recent
decades,
micro/nanorobots
have
made
remarkable
progress
in
research.
Based
on
different
motion
mechanisms,
achieve
efficient
movement
operation
microscale
spaces
owing
to
their
small
size
flexibility.
attracted
extensive
interest
because
significant
potential
development
biomedical
fields,
including
minimally
invasive
surgery,
targeted
therapy,
detection,
sensing.
First,
based
propulsion
methods,
research
achievements
biomedicine
reviewed
from
four
perspectives:
physical,
chemical,
biological,
hybrid
propulsions.
Subsequently,
overcoming
challenges
encountered
by
clinical
applications
is
reviewed.
Finally,
summarized
discussed.
Over
the
last
20
years,
optical
fiber-based
devices
have
been
exploited
extensively
in
field
of
biochemical
sensing,
with
applications
many
specific
areas
such
as
food
processing
industry,
environmental
monitoring,
health
diagnosis,
bioengineering,
disease
and
drug
industry
due
to
their
compact,
label-free,
highly
sensitive
detection.
The
selective
accurate
detection
biochemicals
is
an
essential
part
biosensing
devices,
which
be
done
through
effective
functionalization
recognition
agents,
enzymes,
DNA,
receptors,
etc.,
over
transducing
surface.
Among
sensing
technologies,
fiber
interferometry-based
biosensors
are
one
broadly
used
methods
advantages
biocompatibility,
compact
size,
high
sensitivity,
high-resolution
lower
limits,
operating
wavelength
tunability,
etc.
This
Review
provides
a
comprehensive
review
fundamentals
well
current
advances
developing
sensors.
In
beginning,
generic
biosensor
its
several
components
introduced,
followed
by
state-of-art
technology
behind
variety
optic
These
include
Mach–Zehnder
interferometer,
Michelson
Fabry–Perot
Sagnac
biolayer
interferometry
(BLI).
Further,
technical
reports
comprehensively
reviewed
compared
tabulated
form
for
better
comparison
along
disadvantages.
limitations
possible
solutions
these
sensors
discussed
transform
in-lab
into
commercial
applications.
At
end,
conclusion,
comments
on
prospects
development
toward
commercialization
sensor
also
provided.
targets
broad
range
audiences
including
beginners
motivates
experts
helping
solve
real
issues
industry-oriented
device.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
271, С. 115979 - 115979
Опубликована: Янв. 19, 2024
Micro/nanoplastics
(M/NPs)
in
water
have
raised
global
concern
due
to
their
potential
environmental
risks.
To
reestablish
a
M/NPs
free
world,
enormous
attempts
been
made
toward
employing
chemical
technologies
for
removal
water.
This
review
comprehensively
summarizes
the
advances
degradation
approaches
elimination.
It
details
and
discusses
promising
techniques,
including
photo-based
technologies,
Fenton-based
reaction,
electrochemical
oxidation,
novel
micro/nanomotors
approaches.
Subsequently,
critical
influence
factors,
such
as
properties
of
operating
are
analyzed
this
specifically.
Finally,
it
concludes
by
addressing
current
challenges
future
perspectives
degradation.
will
provide
guidance
scientists
further
explore
strategies
develop
feasible
methods
improved
control
remediation
future.
Procalcitonin
(PCT)
serves
as
a
crucial
biomarker
utilized
in
diverse
clinical
contexts,
including
sepsis
diagnosis
and
emergency
departments.
Its
applications
extend
to
identifying
pathogens,
assessing
infection
severity,
guiding
drug
administration,
implementing
theranostic
strategies.
However,
current
deployed
methods
cannot
meet
the
needs
for
accurate
or
real-time
quantitative
monitoring
of
PCT.
This
review
aims
introduce
these
emerging
PCT
immunoassay
technologies,
focusing
on
analyzing
their
advantages
improving
detection
performances,
such
easy
operation
high
precision.
The
fundamental
principles
characteristics
state-of-the-art
are
first
introduced,
chemiluminescence,
immunofluorescence,
latex-enhanced
turbidity,
enzyme-linked
immunosorbent,
colloidal
gold
immunochromatography,
radioimmunoassay.
Then,
improved
using
new
materials
technologies
briefly
described,
instance,
combination
with
responsive
nanomaterials,
Raman
spectroscopy,
digital
microfluidics.
Finally,
performance
parameters
importance
also
discussed.
