Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Journal of Hematology & Oncology, Год журнала: 2022, Номер 15(1)

Опубликована: Сен. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Язык: Английский

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Bioactive inorganic nanomaterials for cancer theranostics

Chemical Society Reviews, Год журнала: 2023, Номер 52(6), С. 2031 - 2081

Опубликована: Янв. 1, 2023

Bioactive materials are a special class of biomaterials that can react in vivo to induce biological response or regulate functions, thus achieving better curative effect than traditional inert biomaterials. For cancer theranostics, compared with organic polymer nanomaterials, inorganic nanomaterials possess unique physical and chemical properties, have stronger mechanical stability on the basis maintaining certain bioactivity, easy be compounded various carriers (polymer carriers, etc.), so as achieve specific antitumor efficacy. After entering nanoscale, due nano-size effect, high surface area nanostructures, exhibit effects, which significantly influence interaction organisms. Therefore, research applications bioactive theranostics attracted wide attention. In this review, we mainly summarize recent progress also introduce definition, synthesis modification strategies nanomaterials. Thereafter, tumor imaging therapy, including microenvironment (TME) regulation, catalytic gas regulatory cell death immunotherapy, discussed. Finally, biosafety challenges mentioned, their future development opportunities prospected. This review highlights bioapplication

Язык: Английский

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Recent advances in multi-configurable nanomaterials for improved chemodynamic therapy

Coordination Chemistry Reviews, Год журнала: 2022, Номер 474, С. 214861 - 214861

Опубликована: Окт. 1, 2022

Язык: Английский

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Activity Regulating Strategies of Nanozymes for Biomedical Applications

Small, Год журнала: 2023, Номер 19(11)

Опубликована: Янв. 17, 2023

Abstract On accounts of the advantages inherent high stability, ease preparation and superior catalytic activities, nanozymes have attracted tremendous potential in diverse biomedical applications as alternatives to natural enzymes. Optimizing activity is significant for widening boosting into practical level. As research regulation strategies boosting, it essential timely review, summarize, analyze advances structure–activity relationships further inspiring ingenious this prosperous area. Herein, methods recent 5 years are systematically summarized, including size morphology, doping, vacancy, surface modification, hybridization, followed by a discussion latest consisting biosensing, antibacterial, tumor therapy. Finally, challenges opportunities rapidly developing field presented more infant yet promising

Язык: Английский

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Nanozyme Inhibited Sensor Array for Biothiol Detection and Disease Discrimination Based on Metal Ion-Doped Carbon Dots

Analytical Chemistry, Год журнала: 2023, Номер 95(23), С. 8906 - 8913

Опубликована: Июнь 2, 2023

Developing highly active and sensitive nanozymes for biothiol analysis is of vital significance due to their essential roles in disease diagnosis. Herein, two metal ion-doped carbon dots (M-CDs) with high peroxidase-like activity were designed prepared detection identification through the colorimetric sensor array technique. The M-CDs can strongly catalyze decomposition H2O2, accompanied by color changes 3,3′,5,5′-tetramethylbenzidine (TMB) from colorless blue, indicating peroxidase-mimicking activities M-CDs. Compared pure (CDs), exhibited enhanced owing synergistic effect between ions CDs. However, strong binding affinity biothiols ions, catalytic could be inhibited different diverse degrees. Therefore, using TMB as a chromogenic substrate presence developed form differential fingerprints three most important (i.e., cysteine (Cys), homocysteine (Hcy), glutathione (GSH)), which accurately discriminated pattern recognition methods hierarchical clustering (HCA) principal component (PCA)) limit 5 nM. Moreover, single various concentrations mixtures was also realized. Furthermore, actual samples such cells sera well distinguished as-fabricated array, demonstrating its potential

Язык: Английский

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Ferroptosis Nanomedicine: Clinical Challenges and Opportunities for Modulating Tumor Metabolic and Immunological Landscape

ACS Nano, Год журнала: 2023, Номер 17(16), С. 15328 - 15353

Опубликована: Авг. 13, 2023

Ferroptosis, a type of regulated cell death driven by iron-dependent phospholipid peroxidation, has captured much attention in the field nanomedicine since it was coined 2012. Compared with other modes such as apoptosis and pyroptosis, ferroptosis many distinct features molecular mechanisms cellular morphology, representing promising strategy for treating cancers that are resistant to conventional therapeutic modalities. Moreover, recent insights collectively reveal is tightly connected maintenance tumor immune microenvironment (TIME), suggesting potential application therapies evoking robust antitumor immunity. From biochemical perspective, intricately multiple metabolic pathways, including iron metabolism, lipid redox etc., highlighting importance elucidate relationship between metabolism developing therapies. In this review, we provide comprehensive discussion on current understanding ferroptosis-inducing thoroughly discuss various traits tumors, which offer opportunities direct inhibition through nanointegrated approach. Extending from complex impact TIME, also discussed those important considerations development ferroptosis-based immunotherapy, challenges strategies enhance ferroptosis-enabled immunostimulatory effects while avoiding side effects. We envision study may facilitate translation nanomedicines treatment.

Язык: Английский

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A strategy of “adding fuel to the flames” enables a self-accelerating cycle of ferroptosis-cuproptosis for potent antitumor therapy

Biomaterials, Год журнала: 2024, Номер 311, С. 122701 - 122701

Опубликована: Июль 6, 2024

Язык: Английский

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Spatially Asymmetric Nanoparticles for Boosting Ferroptosis in Tumor Therapy

Nano Letters, Год журнала: 2024, Номер 24(4), С. 1284 - 1293

Опубликована: Янв. 17, 2024

Despite its effectiveness in eliminating cancer cells, ferroptosis is hindered by the high natural antioxidant glutathione (GSH) levels tumor microenvironment. Herein, we developed a spatially asymmetric nanoparticle, Fe3O4@DMS&PDA@MnO2-SRF, for enhanced ferroptosis. It consists of two subunits: Fe3O4 nanoparticles coated with dendritic mesoporous silica (DMS) and PDA@MnO2 (PDA: polydopamine) loaded sorafenib (SRF). The spatial isolation Fe3O4@DMS PDA@MnO2-SRF subunits enhances synergistic effect between GSH-scavengers ferroptosis-related components. First, increased exposure subunit Fenton reaction, leading to production reactive oxygen species. Furthermore, effectively depletes GSH, thereby inducing inactivation glutathione-dependent peroxidases 4. Moreover, SRF blocks Xc– transport augmenting GSH depletion capabilities. dual Fe3O4@DMS&PDA@MnO2-SRF significantly weakens antioxidative system, boosting chemodynamic performance cells.

Язык: Английский

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NADPH Oxidase‐Like Nanozyme for High‐Efficiency Tumor Therapy Through Increasing Glutathione Consumption and Blocking Glutathione Regeneration

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(11)

Опубликована: Янв. 12, 2024

Abstract To counteract the high level of reactive oxygen species (ROS) caused by rapid growth, tumor cells resist oxidative stress accelerating production and regeneration intracellular glutathione (GSH). Numerous studies focus on consumption GSH, but GSH will enhance reduction to stress. Therefore, inhibiting GSH; while, consuming is great significance for breaking redox balance cells. Herein, a simple termed MnO x ‐coated Au (AMO) nanoflower, as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) nanoenzyme, reported efficient therapy. nanoparticles exhibit capability catalyze oxidation NADPH, hindering regeneration; concurrently functioning photothermal agent. During process eliminating releases Mn 2+ that subsequently engages in Fenton‐like reactions, ultimately facilitating implementation chemodynamic therapy (CDT). Overall, this NOX enzyme‐based nanoplatform enhances ROS generation disrupts state equilibrium, inducing apoptosis ferroptosis blocking increasing consumption, thereby achieving collaborative treatments involving (PTT), CDT, catalytic This research contributes NADPH targeted showcases potential nanozymes.

Язык: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Язык: Английский

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