Targeted Anticancer Agent with Original Mode of Action Prepared by Supramolecular Assembly of Antibody Oligonucleotide Conjugates and Cationic Nanoparticles DOI Creative Commons
Victor Lehot, Patrick Neuberg, Manon Ripoll

и другие.

Pharmaceutics, Год журнала: 2023, Номер 15(6), С. 1643 - 1643

Опубликована: Июнь 2, 2023

Despite their clinical success, Antibody-Drug Conjugates (ADCs) are still limited to the delivery of a handful cytotoxic small-molecule payloads. Adaptation this successful format alternative types payloads is high interest in search for novel anticancer treatments. Herein, we considered that inherent toxicity cationic nanoparticles (cNP), which limits use as oligonucleotide systems, could be turned into an opportunity access new family toxic We complexed anti-HER2 antibody-oligonucleotide conjugates (AOC) with polydiacetylenic micelles obtain Antibody-Toxic-Nanoparticles (ATNPs) and studied physicochemical properties, well bioactivity both vitro vivo HER2 models. After optimising AOC/cNP ratio, small (73 nm) HER2-targeting ATNPs were found selectively kill antigen-positive SKBR-2 cells over antigen-negative MDA-MB-231 serum-containing medium. Further anti-cancer activity was demonstrated SKBR-3 tumour xenograft model BALB/c mice stable 60% regression observed just after two injections 45 pmol ATNP. These results open interesting prospects such ADC-like strategies.

Язык: Английский

Polymeric Nanoparticles for Drug Delivery DOI
Maximilian A. Beach,

Umeka Nayanathara,

Yanting Gao

и другие.

Chemical Reviews, Год журнала: 2024, Номер 124(9), С. 5505 - 5616

Опубликована: Апрель 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Язык: Английский

Процитировано

254
Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease DOI
Gabriele De Rubis, Keshav Raj Paudel, Leander Corrie

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2023, Номер 397(5), С. 2793 - 2833

Опубликована: Ноя. 22, 2023

Язык: Английский

Процитировано

33
Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics DOI Creative Commons
Yuting Liu, Ziqi Lin, Yuting Wang

и другие.

Theranostics, Год журнала: 2024, Номер 14(6), С. 2490 - 2525

Опубликована: Янв. 1, 2024

Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases.Accurate detection timely therapeutic intervention on inflammatory are crucial for effective therapy inflammation-associated diseases.However, clinical outcomes inflammation-involved disorders still unsatisfactory.Therefore, there an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations traditional therapeutics.Biomedical nanotechnology one promising fields that can potentially transform diagnosis treatment inflammation.In this review, we outline recent advances in biomedical inflammation, special attention paid nanosensors nanoprobes precise inflammation-related diseases, nanotherapeutics, as well nanotheranostics combined applications.Moreover, prospects challenges translation nanomedicines highlighted.

Язык: Английский

Процитировано

18
Recent developments of polymeric delivery systems in gene therapeutics DOI
Yijia Li,

Ruizhen Tian,

Jiayun Xu

и другие.

Polymer Chemistry, Год журнала: 2024, Номер 15(19), С. 1908 - 1931

Опубликована: Янв. 1, 2024

A brief overview of main strategies to improve the gene transfection efficiency PCVs recently and their applications in certain diseases.

Язык: Английский

Процитировано

10
Recent progress of iron-based nanomaterials in gene delivery and tumor gene therapy DOI Creative Commons

Ya Gong,

Xiao Hu, Ming Chen

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июнь 2, 2024

Abstract Gene therapy aims to modify or manipulate gene expression and change the biological characteristics of living cells achieve purpose treating diseases. The safe, efficient, stable exogenous genes in is crucial for success therapy, which closely related vectors used therapy. Currently, are mainly divided into two categories: viral non-viral vectors. Viral widely due advantages persistent expression, high transfection efficiency, but they also have certain issues such as infectivity, immunological rejection, randomness insertion mutation, carcinogenicity, limited vector capacity. Non-viral non-infectivity, controllable chemical structure, unlimited capacity, efficiency low. With rapid development nanotechnology, unique physicochemical properties nanomaterials attracted increasing attention field drug delivery. Among many nanomaterials, iron-based much their superior properties, Fenton reaction, magnetic resonance imaging, magnetothermal photothermal delivery, magnetically-assisted cell tissue targeting, so on. In this paper, research progress delivery tumor reviewed, future application direction further prospected.

Язык: Английский

Процитировано

10
Polymer-siRNA nanovectors for treating lung inflammation DOI
Ritabrita Goswami, Harini Nagaraj, Yağız Anıl Çiçek

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер 378, С. 1092 - 1102

Опубликована: Янв. 5, 2025

Язык: Английский

Процитировано

1
Synthetic Polymers for Drug, Gene, and Vaccine Delivery DOI Creative Commons
Yajun Xu, Jie Chen, Jianxun Ding

и другие.

Polymer science & technology., Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Язык: Английский

Процитировано

1
Functionalization of polymers for intracellular protein delivery DOI
Yuhe Zhang, Jiahao Shi, Bin Ma

и другие.

Progress in Polymer Science, Год журнала: 2023, Номер 146, С. 101751 - 101751

Опубликована: Окт. 1, 2023

Язык: Английский

Процитировано

13
Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis DOI Creative Commons
Friederike Adams,

Christoph M. Zimmermann,

Domizia Baldassi

и другие.

Small, Год журнала: 2023, Номер 20(22)

Опубликована: Дек. 21, 2023

Abstract RNA interference (RNAi) is an efficient strategy to post‐transcriptionally silence gene expression. While all siRNA drugs on the market target liver, lung offers a variety of currently undruggable targets, which can potentially be treated with therapeutics. To achieve this goal, synthesis poly(spermine acrylamides) (P(SpAA) reported herein. Polymers are prepared via polymerization N‐acryloxysuccinimide (NAS) and afterward active ester converted into spermine‐based pendant groups. Copolymerizations decylacrylamide employed increase hydrophobicity polymers. After deprotection, polymers show excellent encapsulation obtain perfectly sized polyplexes at very low polymer/RNA ratios. In vitro 2D 3D cell culture, ex vivo in experiments reveal superior properties amphiphilic spermine‐copolymers respect delivery cells comparison commonly used lipid‐based transfection agents. line results, human explants confirm more silencing protease‐activated receptor 2 (PAR2), G protein‐coupled involved fibrosis. This study reveals importance balance between polyplex formation, cellular uptake, knockdown, toxicity for vitro, vivo, fibrotic tissue vivo.

Язык: Английский

Процитировано

13
Zwitterionic Polymer Lipid Nanoparticles Enabling Selective Organ Targeting Delivery of Small Interfering RNA for the Treatment of Hepatic and Pulmonary Inflammation DOI
Jiaxin Li, Nan Wang, Wei Zhang

и другие.

Small, Год журнала: 2024, Номер unknown

Опубликована: Дек. 4, 2024

Abstract Lipid nanoparticles (LNPs) are clinically advanced small interfering RNA (siRNA) carriers, which can prevent the breakdown of siRNA during delivery and deliver into cytoplasm to down‐regulate target gene. However, clinical LNPs limited liver, enhancing extrahepatic targeting is vital expand application in vivo. Here, zwitterionic polymer (ZP‐LNPs) assembled with polycarboxybetaine (PCB) modified 1,2‐dimyristoylglycerol (DMG) lipid DMG‐PCB n selectively liver lung, respectively. Three libraries 90 ZP‐LNPs established by adjusting degree polymerization , molar ratio lipids, mass between lipids siRNA. Physicochemical vivo biodistribution results show that B4‐3@siRNA B5‐1@siRNA high encapsulation efficiency (>85%) achieve targeted The mechanism findings indicate pKa protein corona essential determine fate tendency for specific organs. Importantly, these two siTNF‐α effectively reduce levels tumor necrosis factor α (TNF‐α) mice hepatic inflammation pulmonary inflammation, respectively, indicating their promising treatment diseases associated lung.

Язык: Английский

Процитировано

5