Bioactive Materials,
Год журнала:
2023,
Номер
33, С. 483 - 496
Опубликована: Дек. 3, 2023
Limited
by
low
tumor
immunogenicity
and
the
immunosuppressive
microenvironment
(TME),
triple-negative
breast
cancer
(TNBC)
has
been
poorly
responsive
to
immunotherapy
so
far.
Herein,
a
Ca
&
Mn
dual-ion
hybrid
nanostimulator
(CMS)
is
constructed
enhance
anti-tumor
immunity
through
ferroptosis
inducing
innate
awakening,
which
can
serve
as
inducer
immunoadjuvant
for
TNBC
concurrently.
On
one
hand,
glutathione
(GSH)
depletion
reactive
oxygen
species
(ROS)
generation
be
achieved
due
mixed
valence
state
of
in
CMS.
other
an
exotic
Ca2+
supplier,
CMS
causes
mitochondrial
overload,
further
amplifies
oxidative
stress.
Significantly,
cells
undergo
because
inactivation
peroxidase
4
(GPX4)
accumulation
lipid
peroxidation
(LPO).
More
impressively,
act
awaken
alleviating
intra-tumor
hypoxia
Mn2+-induced
activation
STING
signaling
pathway,
promotes
polarization
tumor-associated
macrophages
(TAMs)
dendritic
(DCs)
antigen
presentation
subsequent
infiltration
tumor-specific
cytotoxic
T
lymphocytes
(CTLs)
into
tissues.
Taken
together,
this
work
demonstrates
novel
strategy
simultaneously
awakening
immunity,
offering
new
perspective
effective
TNBC.
Advanced Materials,
Год журнала:
2023,
Номер
36(11)
Опубликована: Дек. 14, 2023
Abstract
Benign
prostatic
hyperplasia
(BPH)
as
the
leading
cause
of
urination
disorder
is
still
a
refractory
disease,
and
there
have
no
satisfied
drugs
or
treatment
protocols
yet.
With
identifying
excessive
Zn
2+
,
inflammation,
oxidative
stress
etiology
aberrant
hyperplasia,
an
injectable
sodium
alginate
(SA)
glycyrrhizic
acid
(GA)‐interconnected
hydrogels
(SAGA)
featuring
‐triggered
in
situ
gelation
are
developed
to
load
lonidamine
for
reprogramming
prostate
microenvironment
treating
BPH.
Herein,
SAGA
can
crosslink
with
BPH
via
coordination
chelation
switch
free
bound
ones,
consequently
alleviating
‐arisen
inflammation
glycolysis.
Beyond
capturing
GA
intrinsic
immunoregulatory
property
also
alleviate
local
scavenge
reactive
oxygen
species
(ROS).
Intriguingly,
chelation‐bridged
interconnection
enhances
its
mechanical
regulates
degradation
rate
enable
continuous
release,
favoring
hyperplastic
acini
apoptosis
further
inhibiting
These
multiple
actions
cooperatively
reprogram
characteristic
symptoms
shrink
prostate.
RNA
sequencing
reveals
that
chemotaxis,
glycolysis,
tumor
necrosis
factor
(TNF)
inflammation‐related
pathways
associated
M1‐like
phenotype
polarization
discerned
action
rationales
such
endogenous
hydrogels,
providing
candidate
avenue
treat
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(29)
Опубликована: Авг. 7, 2023
Immunotherapy
is
considered
to
be
an
effective
treatment
for
cancer
and
has
drawn
extensive
interest.
Nevertheless,
the
insufficient
antigenicity
immunosuppressive
tumor
microenvironment
often
cause
unsatisfactory
therapeutic
efficacy.
Herein,
a
photo-activated
reactive
oxygen
species
(ROS)
amplifying
system
(defined
as
"M-Cu-T")
developed
induce
antitumor
immune
response
by
triggering
tumor-specific
immunogenic
pyroptosis.
In
M-Cu-T,
M1
macrophage
membrane-based
vesicles
are
used
drug
loading
targeting,
photosensitizers
(meso-tetra(4-aminophenyl)
porphyrin,
TAPP)
pyroptosis
inducer,
copper
ions
(Cu2+
)
can
enhance
ROS-induced
consuming
antioxidant
systems
in
cells.
As
expected,
prepared
M-Cu-T
targets
enrichment
into
cells
cascades
generation
of
ROS,
which
further
induces
through
caspase
3-mediated
gasdermin
E
(GSDME)
cleavage
under
laser
activation.
The
pyroptotic
accompanying
secrete
related
pattern
molecules,
cell
death,
activate
immunity
immunotherapy.
An
ablation
observed
LLC
CT26
mouse
models.
This
study
provides
inspiration
boosting
immunogenicity
achieving
satisfactory
effects
therapy.
PDL1
blockade
therapy
holds
great
promise
in
cancer
immunotherapy.
Ultrasound
imaging
of
expression
the
tumor
is
importance
predicting
therapeutic
efficacy.
As
a
proof-of-concept
study,
novel
ultrasound
contrast
agent
has
been
innovated
here
to
image
and
block
tissue.
Briefly,
extracellular
vesicles
(EVs)
are
engineered
display
truncated
PD1
(tPD1)
on
surface
bind
with
high
affinity
by
fusion
EV-abundant
transmembrane
protein
PTGFRN.
The
EVs
then
encapsulated
Ca(HCO
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(20)
Опубликована: Апрель 19, 2024
Abstract
Macrophages
play
an
essential
role
in
immunotherapy
and
tissue
regeneration
owing
to
their
remarkable
plasticity
diverse
functions.
Recent
bioengineering
developments
have
focused
on
using
external
physical
stimuli
such
as
electric
magnetic
fields,
temperature,
compressive
stress,
among
others,
micro/nanostructures
induce
macrophage
polarization,
thereby
increasing
therapeutic
potential.
However,
it
is
difficult
find
a
concise
review
of
the
interaction
between
stimuli,
advanced
micro/nanostructures,
polarization.
This
examines
present
research
stimuli‐induced
polarization
micro/nanoplatforms,
emphasizing
synergistic
fabricated
structure
stimulation
for
regeneration.
A
overview
advancements
investigating
impact
including
forces,
fluid
shear
photothermal
multiple
stimulations
macrophages
within
complex
engineered
structures,
provided.
The
prospective
implications
these
strategies
regenerative
medicine
immunotherapeutic
approaches
are
highlighted.
will
aid
creating
stimuli‐responsive
platforms
immunomodulation
Achieving
antitumor
immunotherapy
based
on
hybridization
of
multiple
types
inactivated
cells
has
attracted
a
lot
attention.
However,
the
hybridized
disordered
structure
could
result
in
shedding
antigens
and
their
transfer
to
immune
cells,
which
suppresses
tumor
immunity
through
trogocytosis.
Here,
we
report
strategy
for
situ
solidification
whole
cell
by
biomineralization
sustained
stimulation
immunity.
The
near-infrared
light
was
used
accelerate
breaking
Au=P
bonds
auranofin,
exposed
Au
atoms
biomineralize
at
secondary
(β-corner)
protein
form
nanocrystals
with
coronas
cells.
are
anchored
coronas,
fixes
morphology
rendering
them
physiologically
inactive.
Interestingly,
this
solidified
prevents
from
undergoing
trogocytosis,
inhibits
proximal
distal
growth.
Thus,
study
presents
its
potential
application
immunotherapy.
Current Oncology,
Год журнала:
2025,
Номер
32(2), С. 79 - 79
Опубликована: Янв. 30, 2025
Chimeric
antigen
receptor
(CAR)-T
cell
therapy
yields
good
results
in
the
treatment
of
various
hematologic
malignancies.
However,
efficacy
CAR-T
against
solid
tumors
has
proven
to
be
limited,
primarily
because
tumor-associated
extracellular
matrix
(ECM)
creates
an
intractable
barrier
for
cytotoxic
cells
that
are
supposed
kill
cancer
cells.
This
review
unravels
multifaceted
role
ECM
impeding
infiltration,
survival,
and
functions
within
tumors.
We
analyze
situations
when
intratumoral
limits
by
being
a
purely
physical
complicates
lymphocyte
penetration/migration
also
acts
as
immunosuppressive
factor
impairs
antitumor
activities
In
addition,
we
highlight
promising
approaches
such
engineering
with
improved
capabilities
penetrate
migrate
into/through
ECM,
combination
therapies
aimed
at
attenuating
high
density
potential
others
enable
overcoming
ECM-related
obstacles.
A
detailed
overview
data
relevant
studies
not
only
helps
better
understand
interactions
between
but
outlines
ways
more
effectively
use
Abstract
Radiofrequency
(RF)
heating
is
a
new,
less
invasive
alternative
to
methods
that
use
nanoparticles
for
tumour
therapy.
But
pinpoint
local
still
hard.
Molecular
interactions
form
hybrid
structure
with
unique
electrical
characteristics
enable
RF
in
this
work,
which
explores
biological
cell
(yeast)‐2D
FeS
2
system.
Substantial
processes
have
been
uncovered
via
experimental
investigations
and
density
functional
theory
(DFT)
computations.
At
3
W
50
MHz,
reaches
54°C
40
s,
enough
kill
yeast
cells,
while
current‐voltage
measurements
reveal
ionic
diode‐like
properties.
Interactions
between
lipid
molecules
2D
k
,
as
shown
by
density‐functional
calculations,
cause
an
imbalance
the
distribution
of
charges
creation
polar,
conductive
channels.
Insights
into
applications
based
on
radio
frequency
technology
are
offered
lays
forth
framework
investigating
material‐biomolecule
interactions.
