Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июль 10, 2024
Abstract
The
development
of
intelligent,
environmentally
responsive
and
biocompatible
photothermal
system
holds
significant
importance
for
the
combined
therapy
tumors.
In
this
study,
inspired
by
Lactobacillus
(LAC),
we
prepared
a
biomimetic
nanoplatform
PDA&DOX@LAC
tumor
photothermal-chemotherapy
integrating
chemotherapeutic
drug
doxorubicin
(DOX)
with
dopamine
through
oxidative
polymerization
to
form
polydopamine
(PDA)
on
surface
LAC.
not
only
achieves
precise
controlled
release
DOX
based
slightly
acidic
microenvironment
tissues,
but
also
exhibits
enzyme-like
properties
alleviate
hypoxia.
Under
near-infrared
light
irradiation,
it
effectively
induces
ablation
cells,
enhances
cellular
uptake
increasing
temperature,
thus
efficiently
inhibits
cell
growth.
Moreover,
is
further
confirmed
in
vivo
experiments
that
cells
apoptosis,
releases
tumor-associated
antigens,
which
engulfed
dendritic
activate
cytotoxic
T
lymphocytes,
thereby
suppressing
growth
prolonging
survival
period
4T1
tumor-bearing
mice.
Therefore,
immense
potential
targeting
as
well
provides
valuable
insights
theoretical
foundations
novel
treatment
strategies
endogenous
substances
within
body.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 571 - 608
Опубликована: Янв. 1, 2024
Abstract:
With
the
development
of
nanotechnology,
nanoparticles
(NPs)
have
shown
broad
prospects
as
drug
delivery
vehicles.
However,
they
exhibit
certain
limitations,
including
low
biocompatibility,
poor
physiological
stability,
rapid
clearance
from
body,
and
nonspecific
targeting,
which
hampered
their
clinical
application.
Therefore,
novel
systems
with
improved
biocompatibility
high
target
specificity
remains
a
major
challenge.
In
recent
years,
biofilm
mediated
biomimetic
nano-drug
system
(BNDDS)
has
become
research
hotspot
focus
in
field
life
sciences.
This
new
platform
uses
bio-nanotechnology
to
encapsulate
synthetic
NPswithin
membrane,
organically
integrating
immunogenicity,
toxicity,
tumor
good
adjustability
versatility
nanocarrier,
shows
promising
applications
precision
therapy.
this
review,
we
systematically
summarize
progress
BNDDS
used
for
optimizing
delivery,
providing
theoretical
reference
designing
safe
efficient
treatment
strategies
improve
outcomes.
Keywords:
nanoparticles,
cell
targeted
therapy
Advanced Materials,
Год журнала:
2024,
Номер
36(41)
Опубликована: Июнь 9, 2024
Abstract
The
tumor
microenvironment
(TME)
of
typical
types
such
as
triple‐negative
breast
cancer
is
featured
by
hypoxia
and
immunosuppression
with
abundant
tumor‐associated
macrophages
(TAMs),
which
also
emerge
potential
therapeutic
targets
for
antitumor
therapy.
M1‐like
macrophage‐derived
exosomes
(M1‐Exos)
have
emerged
a
promising
candidate
their
tumor‐targeting
macrophage‐polarization
capabilities.
However,
the
limited
drug‐loading
efficiency
stability
M1‐Exos
hindered
effectiveness
in
applications.
Here,
hybrid
nanovesicle
developed
integrating
AS1411
aptamer‐conjugated
liposomes
(AApt‐Lips),
termed
M1E/AALs.
obtained
M1E/AALs
are
loaded
perfluorotributylamine
(PFTBA)
IR780,
P‐I,
to
construct
P‐I@M1E/AALs
reprogramming
TME
alleviating
engineering
TAMs.
P‐I@M1E/AAL‐mediated
therapy
enhances
situ
generation
reactive
oxygen
species,
repolarizes
TAMs
toward
an
phenotype,
promotes
infiltration
T
lymphocytes.
synergistic
based
on
significantly
suppresses
growth
prolongs
survival
4T1‐tumor‐bearing
mice.
By
multiple
treatment
modalities,
P‐I@M1E/AAL
nanoplatform
demonstrates
approach
overcoming
hypoxic
immunosuppressive
targeted
TAM
enhanced
photodynamic
immunotherapy.
This
study
highlights
innovative
TAM‐engineering
platform
tumors
characterized
TME.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
179, С. 117296 - 117296
Опубликована: Авг. 20, 2024
Over
the
past
decades,
cancer
immunotherapy
has
encountered
challenges
such
as
immunogenicity,
inefficiency,
and
cytotoxicity.
Consequently,
exosome-based
gained
rapid
traction
a
promising
alternative.
Exosomes,
type
of
extracellular
vesicles
(EVs)
ranging
from
50
to
150
nm,
are
self-originating
exhibit
fewer
side
effects
compared
traditional
therapies.
Exosome-based
encompasses
three
significant
areas:
vaccination,
co-inhibitory
checkpoints,
adoptive
T-cell
therapy.
Each
these
fields
leverages
inherent
advantages
exosomes,
demonstrating
substantial
potential
for
individualized
tumor
therapy
precision
medicine.
This
review
aims
elucidate
reasons
behind
promise
nanoparticles
therapies
by
examining
their
characteristics
summarizing
latest
research
advancements
in
immunotherapy.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 31, 2024
The
malignant
form
of
melanoma
is
one
the
deadliest
human
cancers
that
accounts
for
almost
all
skin
tumor-related
fatalities
in
its
later
stages.
Achieving
an
exhaustive
understanding
reliable
cancer-specific
markers
and
molecular
pathways
can
provide
numerous
practical
techniques
direct
way
toward
development
rational
curative
medicines
to
increase
lifespan
patients.
Immunotherapy
has
significantly
enhanced
treatment
metastatic
late-stage
melanoma,
resulting
incredible
positive
responses
therapy.
Despite
increasing
occurrence
median
survival
rate
patients
with
advanced,
inoperable
terminal
disease
increased
from
around
six
months
years.
current
knowledge
tumor
microenvironment
(TME)
interaction
immune
system
resulted
swift
growth
innovative
immunotherapy
treatments.
Exosomes
are
small
extracellular
vesicles
(EVs),
ranging
30
150
nm
size,
majority
cells
released
them.
possess
natural
advantages
such
as
high
compatibility
living
organisms
low
potential
causing
reactions,
making
them
delivering
therapeutic
agents
like
chemotherapy
drugs,
nucleic
acids,
proteins.
This
review
highlights
recent
advancements
using
exosomes
approach
providing
medications
melanoma.
