3D printing of magneto-active smart materials for advanced actuators and soft robotics applications

European Polymer Journal, Год журнала: 2024, Номер 205, С. 112718 - 112718

Опубликована: Янв. 2, 2024

In the contemporary era, novel manufacturing technologies like additive (AM) have revolutionized different engineering sectors including biomedical, aerospace, electronics, etc. Four-dimensional (4D) printing aka AM of smart materials is gaining popularity among scientific community, which has excellent ability to make soft structures such as robots, actuators, and grippers. These are developed by applying various stimuli pH, temperature, magnetic field, many combinations onto materials. Stimuli in 3D permit shape-morphing behaviors bending, twisting, folding, swelling, rolling, shrinking, origami, or locomotion. A wide variety can be fabricated through incorporation hard particles into resulting magneto-active (MASMs). With this integration, magneto-thermal coupling actuation allows diverse magneto-deformations, facilitating development personalized devices that capable enhanced deformation. review, guidelines provided on for MASMs polymers (MAPs), composites, hydrogels (MAHs) booming flexible wearable biomimetic devices. Moreover, 3D-printed robotics an outstanding capacity adapt complicated situations advanced actuating applications. Finally, some current challenges emerging areas exciting technology been proposed. Lastly, it anticipated technological advancements developing intelligent will a significant impact design real-world

Язык: Английский

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Empowering Precision Medicine: The Impact of 3D Printing on Personalized Therapeutic

AAPS PharmSciTech, Год журнала: 2023, Номер 24(8)

Опубликована: Ноя. 14, 2023

Abstract This review explores recent advancements and applications of 3D printing in healthcare, with a focus on personalized medicine, tissue engineering, medical device production. It also assesses economic, environmental, ethical considerations. In our the literature, we employed comprehensive search strategy, utilizing well-known databases like PubMed Google Scholar. Our chosen keywords encompassed essential topics, including printing, nanotechnology, related areas. We first screened article titles abstracts then conducted detailed examination selected articles without imposing any date limitations. The for inclusion, comprising research studies, clinical investigations, expert opinions, underwent meticulous quality assessment. methodology ensured incorporation high-quality sources, contributing to robust exploration role realm healthcare. highlights printing's potential customized drug delivery systems, patient-specific implants, prosthetics, biofabrication organs. These innovations have significantly improved patient outcomes. Integration nanotechnology has enhanced precision biocompatibility. demonstrates cost-effectiveness sustainability through optimized material usage recycling. healthcare sector witnessed remarkable progress promoting patient-centric approach. From implants radiation shielding offers tailored solutions. Its transformative applications, coupled economic viability sustainability, revolutionize Addressing biocompatibility, standardization, concerns is responsible adoption. Graphical

Язык: Английский

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Roadmap for Clinical Translation of Mobile Microrobotics

Advanced Materials, Год журнала: 2024, Номер 36(23)

Опубликована: Фев. 21, 2024

Medical microrobotics is an emerging field to revolutionize clinical applications in diagnostics and therapeutics of various diseases. On the other hand, mobile has important obstacles pass before translation. This article focuses on these challenges provides a roadmap medical microrobots enable their use. From concept "magic bullet" physicochemical interactions complex biological environments applications, there are several translational steps consider. Clinical translation only possible with close collaboration between experts researchers address technical microfabrication, safety, imaging. The application potential can be materialized by designing that solve current main challenges, such as actuation limitations, material stability, imaging constraints. strengths weaknesses progress discussed for near future outlined.

Язык: Английский

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Cross‐Scale Drug Delivery of Diatom Microrobots Based on A Magnetic Continuum Robot for Combined Chemical and Photodynamic Therapy of Glioblastoma

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Апрель 2, 2024

Abstract Micro/nanorobots with active movement capabilities provide a new option for the treatment of glioblastoma (GBM). However, long working distance intravenous injection and protection blood‐brain barrier can prevent micro/nanorobots from reaching target location. Photodynamic therapy (PDT) has gradually appeared in GBM research. The limitation penetrating strength light source will nevertheless hinder application range PDT. Herein, magnetic continuum robot (MCR) to deliver optical fibers microrobots combined chemotherapy PDT is used. prepared diatom effectively move biological fluids upstream. Vacuum loading improve drug efficiency. photosensitizer frustule cavity be explosively released short time through ultrasound. chemotherapeutic drugs have long‐term pH‐sensitivity release characteristics. In vitro cell experiments showed that administration TMZ‐loaded photosensitizer‐loaded synergistic effect. model demonstrated an MCR fiber drug‐loaded microrobots. This enables cross‐scale delivery deep method may expand selectivity possibility intracranial

Язык: Английский

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A Human‐Scale Clinically Ready Electromagnetic Navigation System for Magnetically Responsive Biomaterials and Medical Devices

Advanced Materials, Год журнала: 2024, Номер 36(31)

Опубликована: Май 11, 2024

Abstract Magnetic navigation systems are used to precisely manipulate magnetically responsive materials enabling the realization of new minimally invasive procedures using magnetic medical devices. Their widespread applicability has been constrained by high infrastructure demands and costs. The study reports on a portable electromagnetic system, Navion, which is capable generating large field over workspace. system easy install in hospital operating rooms transportable through health care facilities, aiding adoption First, design implementation approach for introduced its performance characterized. Next, vitro different microrobot structures demonstrated gradients rotating fields. Spherical permanent magnets, electroplated cylindrical microrobots, microparticle swarms, composite bacteria‐inspired helical investigated. catheters also two challenging endovascular tasks: 1) an angiography procedure 2) deep within circle Willis. Catheter porcine model vivo perform under guidance.

Язык: Английский

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Metareview: a survey of active matter reviews

The European Physical Journal E, Год журнала: 2025, Номер 48(2)

Опубликована: Фев. 1, 2025

In the past years, amount of research on active matter has grown extremely rapidly, a fact that is reflected in particular by existence more than 1000 reviews this topic. Moreover, field become very diverse, ranging from theoretical studies statistical mechanics particles to applied work medical applications microrobots and biological systems artificial swimmers. This makes it difficult get an overview over as whole. Here, we provide such form metareview article surveys existing review articles books matter. Thereby, provides useful starting point for finding literature about specific

Язык: Английский

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MXBOTs: Biodegradable Ti₃C₂ MXene-Based Microrobots for Targeted Delivery and Synergistic Chemo-Photothermal Therapy

ACS Materials Letters, Год журнала: 2024, Номер 6(5), С. 1801 - 1810

Опубликована: Апрель 3, 2024

Functions such as biocompatibility, degradability, therapeutics, and imaging are critical for use of microrobots in clinical scenarios; however, incorporation these functions into a single microrobotic entity is still challenging. Herein, we report multifunctional Ti3C2 MXene-based magnetically actuated (MXBOTs), which prepared by sequentially electrostatic coating nanosheets Fe3O4 nanoparticles on the surface biodegradable gelatin methacryloyl (GelMA)-based helical microstructures. These MXBOTs can move along predefined paths under rotating magnetic field. The provides with an advantageous photothermal effect photoacoustic (PA) capability. Additionally, be loaded fluorescent molecules, enabling fluorescence imaging. After loading chemotherapeutic drug DOX, MXBOTs@DOX were able to accelerate release DOX stimulation temperature acidic pH. This work presents viable approach developing functional targeted delivery synergistic chemo-photothermal therapy.

Язык: Английский

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Recent advances in bioinspired walking microbots: Design, manufacturing, and challenges

Sensors and Actuators A Physical, Год журнала: 2024, Номер 372, С. 115321 - 115321

Опубликована: Март 30, 2024

Язык: Английский

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Higher‐Order Behaviours in Bio‐Inspired Materials

ChemSystemsChem, Год журнала: 2024, Номер 6(4)

Опубликована: Апрель 16, 2024

Abstract Bio‐inspired approaches in materials science and systems chemistry are yielding a variety of stimuli‐responsive dynamic that gradually changing our everyday life. However, the ability to chemically program these exhibit macroscopic higher‐order behaviours such as self‐assembly, contractility, swarming, taxis, chemical communication, or predator‐prey dynamics remains an ongoing challenge. While still its infancy, successful fabrication bio‐inspired displaying not only will help bridging gap between living non‐living matter, but it also contribute development advanced for potential applications ranging from tissue engineering biotechnology, soft robotics regenerative medicine. Our Mini‐Review systematically discuss developed thus far systems, namely (i) polymer networks (ii) microbots, (iii) protocells, (iv) prototissues. For each system provide key examples highlight how emergent behaviour could be programmed.

Язык: Английский

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Multifunctional Hydrogel with 3D Printability, Fluorescence, Biodegradability, and Biocompatibility for Biomedical Microrobots

Molecules, Год журнала: 2024, Номер 29(14), С. 3351 - 3351

Опубликована: Июль 17, 2024

As micron-sized objects, mobile microrobots have shown significant potential for future biomedical applications, such as targeted drug delivery and minimally invasive surgery. However, to make these viable clinical several crucial aspects should be implemented, including customizability, motion-controllability, imageability, biodegradability, biocompatibility. Developing materials meet requirements is of utmost importance. Here, a gelatin methacryloyl (GelMA) (2-(4-vinylphenyl)ethene-1,1,2-triyl)tribenzene (TPEMA)-based multifunctional hydrogel with 3D printability, fluorescence biocompatibility demonstrated. By using direct laser writing method, the exhibits its versatility in customization fabrication microstructures. Spherical were fabricated decorated magnetic nanoparticles on their surface render them magnetically responsive, demonstrated excellent movement performance motion controllability. The microstructures also represented loading/release capacity degradability by collagenase, along stable properties. Moreover, cytotoxicity assays showed that was non-toxic, well able support cell attachment growth, indicating hydrogel. developed great are integrated controllability, capacity, degradability, biocompatibility, thus being realize real vivo applications microrobots.

Язык: Английский

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