Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Апрель 17, 2025
In
situ
vaccination
(ISV)
has
emerged
as
a
promising
strategy
in
cancer
immunotherapy,
offering
targeted
approach
that
uses
the
tumor
microenvironment
(TME)
to
stimulate
an
immune
response
directly
at
site.
This
method
minimizes
systemic
exposure
while
maintaining
therapeutic
efficacy
and
enhancing
safety.
Recent
advances
nanotechnology
have
enabled
new
approaches
ISV
by
utilizing
nanomaterials
with
unique
properties,
including
enhanced
permeability,
retention,
controlled
drug
release.
employing
can
induce
immunogenic
cell
death
reverse
immunosuppressive
hypoxic
TME,
thereby
converting
"cold"
into
"hot"
facilitating
more
robust
response.
review
examines
mechanisms
through
which
nanomaterials-based
enhances
anti-tumor
immunity,
summarizes
clinical
applications
of
these
strategies,
evaluates
its
capacity
serve
neoadjuvant
therapy
for
eliminating
micrometastases
early-stage
patients.
Challenges
associated
translation
ISV,
nanomaterial
metabolism,
optimization
treatment
protocols,
integration
other
therapies
such
radiotherapy,
chemotherapy,
photothermal
therapy,
are
also
discussed.
Advances
immunotherapy
continue
expand
possible
potentially
leading
improved
outcomes
across
broad
range
types.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 22, 2025
Photoimmunotherapy,
which
combines
phototherapy
with
immunotherapy,
exhibits
significantly
improved
therapeutic
effects
compared
mono-treatment
regimens.
However,
its
use
is
associated
drawbacks,
such
as
insufficient
reactive
oxygen
species
(ROS)
production
and
uneven
photosensitizer
distribution.
To
address
these
issues,
we
developed
a
controllable,
targeted
nanosystem
that
enhances
oxidative
stress
through
multiple
pathways,
achieving
synergistic
photothermal,
photodynamic,
immunotherapy
for
tumor
treatment.
These
nanoparticles
(D/I@HST
NPs)
accurately
target
overexpressed
transferrin
receptors
(TfRs)
on
the
surface
of
cells
surface-modified
(Tf).
After
endocytosis,
D/I@HST
NPs
generate
ROS
under
808-nm
laser
irradiation,
breaking
ROS-responsive
crosslinking
agent
increasing
drug
release
utilization.
Tf
also
carries
Fe3+,
reduced
to
Fe2+
by
iron
reductase
in
acidic
microenvironment
(TME).
Consequently,
endoperoxide
bridge
structure
dihydroartemisinin
cleaved,
causing
additional
generation.
Furthermore,
released
IR-780
exerts
both
photodynamic
photothermal
effects,
enhancing
cell
death.
This
multi-pathway
amplification
effect
can
trigger
immunogenic
death
tumors,
promoting
relevant
antigens
damage-associated
molecular
patterns,
thereby
dendritic
maturation
sensitivity
immunotherapy.
Mature
transmit
signals
T
cells,
infiltration
activation,
facilitating
growth
inhibition
suppression
lung
metastasis.
myeloid-derived
suppressor
decreases
after
In
summary,
this
stress-amplified
effectively
inhibits
reverses
immunosuppressive
microenvironment,
provides
new
insights
into
combined
phototherapy.
Abstract
Surface‐enhanced
Raman
scattering
(SERS)
imaging
integrating
photothermal
and
photodynamic
therapy
(PTT/PDT)
is
a
promising
approach
for
achieving
accurate
diagnosis
effective
treatment
of
cancers.
However,
most
available
reporters
show
multiple
signals
in
the
fingerprint
region,
which
overlap
with
background
from
cellular
biomolecules.
Herein,
4T1
cell
membrane‐enveloped
gold
nanorods‐manganese
porphyrins
system
(GMCMs)
designed
successfully
fabricated
as
biomimetic
theranostic
nanoplatform.
Manganese
are
adsorbed
on
surface
Au
nanorods
via
terminal
alkynyl
group.
Cell
membrane
encapsulation
protects
manganese
falling
off
nanorods.
The
GMCMs
confirm
specific
homologous
targeting
to
cells
good
dispersibility,
excellent
photoacoustic
(PA)
properties,
preferable
1
O
2
generation
performance.
exhibit
distinct
SERS
silent
region
without
endogenous
biomolecule
interference
both
vitro
vivo.
ions
could
not
only
quench
fluorescence
enhance
effect
but
also
deplete
GSH
increase
yield.
Both
vivo
studies
demonstrate
that
effectively
eradicate
tumors
through
SERS/PA
imaging‐guided
PTT/PDT.
This
study
provides
feasible
strategy
augmenting
effects
group
GSH‐depletion
PTT/PDT
efficacy.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(40)
Опубликована: Июль 3, 2024
Abstract
Sonodynamic
therapy
(SDT),
as
a
promising
non‐invasive
therapeutic
modality
combining
ultrasound
(US)
and
sonosensitizers
to
produce
cytotoxic
reactive
oxygen
species
(ROS)
for
treating
deep‐seated
tumors,
has
received
increasing
attention
in
recent
years.
Porphyrins
are
multifunctional
organic
materials,
which
can
be
excited
both
by
light
US
ROS
possess
various
fascinating
features,
including
controllable
synthetic
processes,
excellent
biodegradability,
low
cytotoxicity
without
or
US.
Nevertheless,
their
poor
water
solubility,
skin‐photosensitive
toxicity,
insufficient
target
specificity
hinder
clinical
applications
sonosensitizer.
Although
the
issue
may
improved
using
nanoparticle
carriers,
SDT
efficacy
enhanced
with
other
modalities,
such
combination
makes
it
more
confusing
about
true
mechanism
of
SDT.
This
review
will
focus
on
following
points:
1)
Why
porphyrin‐based
considered
most
sonosensitizer
SDT?
2)
Recent
progress
development
sonosensitizers.
3)
What
new
insight
been
gained
years?
4)
The
trend
designing
efficient
existing
challenges.
Finally,
future
perspective
practical
based
discussed.
Abstract
Hyaluronic
acid
(HA)
is
a
naturally
occurring
polysaccharide
found
in
the
extracellular
matrix
with
broad
applications
disease
treatment.
HA
possesses
good
biocompatibility,
biodegradability,
and
ability
to
interact
various
cell
surface
receptors.
Its
wide
range
of
molecular
weights
modifiable
chemical
groups
make
it
an
effective
drug
carrier
for
delivery.
Additionally,
overexpression
specific
receptors
on
surfaces
many
states
enhances
accumulation
drugs
at
pathological
sites
through
receptor
binding.
In
this
review,
modification
drugs,
major
proteins,
latest
advances
receptor‐targeted
nano
delivery
systems
(DDS)
treatment
tumors
inflammatory
diseases
are
summarized.
Furthermore,
functions
varying
vivo
selection
methods
different
discussed.
Abstract
Sonodynamic
therapy
(SDT),
featuring
noninvasive,
deeper
penetration,
low
cost,
and
repeatability,
is
a
promising
approach
for
deep‐seated
tumors.
However,
the
general
or
only
utilization
of
SDT
shows
efficiency
unsatisfactory
treatment
outcomes
due
to
complicated
tumor
microenvironment
(TME)
process.
To
circumvent
issues,
three
feasible
approaches
enhancing
SDT‐based
therapeutic
effects,
including
sonosensitizer
optimization,
strategies
conquering
hypoxia
TME,
combinational
are
summarized,
with
particular
focus
on
combination
other
modalities,
chemodynamic
therapy,
photodynamic
photothermal
chemotherapy,
starvation
gas
immunotherapy.
In
end,
current
challenges
in
tumors
discussed
enhanced
effects
provided.
It
envisioned
that
this
review
will
provide
new
insight
into
strategic
design
high‐efficiency
sonosensitizer‐derived
nanotheranostics,
thereby
augmenting
accelerating
potential
clinical
transformation.
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 26, 2025
The
integration
of
photodynamic
therapy
(PDT)
and
photothermal
(PTT)
offers
a
promising
strategy
for
enhancing
phototherapy
efficiency.
Herein,
we
present
dual-functional,
biocompatible
nanocomposite
system
combination
PDT/PTT
therapy.
utilizes
highly
nanoparticle
assembled
by
an
amphiphilic
short
peptide
with
the
assistance
Zn2+
as
carrier.
convertor
is
loaded
within
nanoparticle,
while
cationic
porphyrin
photosensitizer
on
surface.
water-soluble
(M8PzEOPP),
designed
eight
positive
charges,
provides
strong
electrostatic
interaction
stable
assembly
This
location-independent
effectively
maintains
optical
characteristics
both
convertor,
endowing
effective
properties.
exhibits
excellent
tumor-targeting
accumulation
behavior,
low
dark
toxicity,
robust
extracellular
biostability,
high
cell
internalization
Its
enhanced
performance
in
combinatorial
demonstrated
through
vitro
vivo
experiments.
Pharmaceutics,
Год журнала:
2024,
Номер
16(5), С. 603 - 603
Опубликована: Апрель 29, 2024
Sonodynamic
therapy
(SDT)
has
attracted
significant
attention
in
recent
years
as
it
is
an
innovative
approach
to
tumor
treatment.
It
involves
the
utilization
of
sound
waves
or
ultrasound
(US)
activate
acoustic
sensitizers,
enabling
targeted
drug
release
for
precise
This
review
aims
provide
a
comprehensive
overview
SDT,
encompassing
its
underlying
principles
and
therapeutic
mechanisms,
applications
nanomaterials,
potential
synergies
with
combination
therapies.
The
begins
by
introducing
fundamental
principle
SDT
delving
into
intricate
mechanisms
through
which
facilitates
A
detailed
analysis
presented,
outlining
how
effectively
destroys
cells
modulating
mechanisms.
Subsequently,
this
explores
diverse
range
nanomaterials
utilized
highlights
their
specific
contributions
enhancing
treatment
outcomes.
Furthermore,
combine
other
modalities
such
photothermal
(PTT)
chemotherapy
discussed.
These
combined
approaches
aim
synergistically
improve
efficacy
while
mitigating
side
effects.
In
conclusion,
emerges
promising
frontier
that
offers
personalized
effective
options
revolutionize
patient
care.
As
research
progresses,
poised
play
pivotal
role
shaping
future
landscape
oncology
providing
patients
broader
spectrum
efficacious
tailored
options.
