Development and Application of Organic Sonosensitizers in Cancer Therapy DOI Creative Commons
Yuhan Ding,

Yuchen Yang,

Ömer Aras

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

ABSTRACT Sonodynamic therapy (SDT) is an innovative cancer modality that harnesses the energy of ultrasound to activate sonosensitizers for producing reactive oxygen species (ROS), culminating in eradication tumor cells. Compared with photodynamic therapy, SDT has capacity penetrate deeply into biological tissues, thereby holding significant promise addressing situated or surgically inaccessible tumors. The effectiveness greatly dependent on characteristics sonosensitizers, and unlike inorganic organic offer a more controlled synthesis process have excellent biocompatibility. This review presents meticulous undertaking categorize elucidate their mechanisms action therapeutic effects context SDT. Design strategies are also summarized, we emphasize critical role nanotechnology localization, imaging, multimodal synergistic offering approach achieving precise targeting. In addition, impact delineated when integrated other oncological modalities, such as photothermal enhance efficacy. Finally, discusses challenges future perspectives advancement clinical within realm oncology.

Language: Английский

Tumor-microenvironment-activatable organic phototheranostic agents for cancer therapy DOI

Shuang Zeng,

Zhihan Guo,

Yifu Hao

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 509, P. 215786 - 215786

Published: March 20, 2024

Language: Английский

Citations

27
Biomimetic Gold Nanorods‐Manganese Porphyrins with Surface‐Enhanced Raman Scattering Effect for Photoacoustic Imaging‐Guided Photothermal/Photodynamic Therapy DOI
Huihui Liu, Cunji Gao,

Peijing Xu

et al.

Small, Journal Year: 2024, Volume and Issue: 20(42)

Published: June 20, 2024

Abstract Surface‐enhanced Raman scattering (SERS) imaging integrating photothermal and photodynamic therapy (PTT/PDT) is a promising approach for achieving accurate diagnosis effective treatment of cancers. However, most available reporters show multiple signals in the fingerprint region, which overlap with background from cellular biomolecules. Herein, 4T1 cell membrane‐enveloped gold nanorods‐manganese porphyrins system (GMCMs) designed successfully fabricated as biomimetic theranostic nanoplatform. Manganese are adsorbed on surface Au nanorods via terminal alkynyl group. Cell membrane encapsulation protects manganese falling off nanorods. The GMCMs confirm specific homologous targeting to cells good dispersibility, excellent photoacoustic (PA) properties, preferable 1 O 2 generation performance. exhibit distinct SERS silent region without endogenous biomolecule interference both vitro vivo. ions could not only quench fluorescence enhance effect but also deplete GSH increase yield. Both vivo studies demonstrate that effectively eradicate tumors through SERS/PA imaging‐guided PTT/PDT. This study provides feasible strategy augmenting effects group GSH‐depletion PTT/PDT efficacy.

Language: Английский

Citations

18
Multi-pathway oxidative stress amplification via controllably targeted nanomaterials for photoimmunotherapy of tumors DOI Creative Commons
Hang Li,

Yunheng Liu,

Xiaokang Zhang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 22, 2025

Photoimmunotherapy, which combines phototherapy with immunotherapy, exhibits significantly improved therapeutic effects compared mono-treatment regimens. However, its use is associated drawbacks, such as insufficient reactive oxygen species (ROS) production and uneven photosensitizer distribution. To address these issues, we developed a controllable, targeted nanosystem that enhances oxidative stress through multiple pathways, achieving synergistic photothermal, photodynamic, immunotherapy for tumor treatment. These nanoparticles (D/I@HST NPs) accurately target overexpressed transferrin receptors (TfRs) on the surface of cells surface-modified (Tf). After endocytosis, D/I@HST NPs generate ROS under 808-nm laser irradiation, breaking ROS-responsive crosslinking agent increasing drug release utilization. Tf also carries Fe3+, reduced to Fe2+ by iron reductase in acidic microenvironment (TME). Consequently, endoperoxide bridge structure dihydroartemisinin cleaved, causing additional generation. Furthermore, released IR-780 exerts both photodynamic photothermal effects, enhancing cell death. This multi-pathway amplification effect can trigger immunogenic death tumors, promoting relevant antigens damage-associated molecular patterns, thereby dendritic maturation sensitivity immunotherapy. Mature transmit signals T cells, infiltration activation, facilitating growth inhibition suppression lung metastasis. myeloid-derived suppressor decreases after In summary, this stress-amplified effectively inhibits reverses immunosuppressive microenvironment, provides new insights into combined phototherapy.

Language: Английский

Citations

3
Multifunctional Porphyrin‐Based Sonosensitizers for Sonodynamic Therapy DOI
Jiajun Chen, Qi Zhou, Wenwu Cao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(40)

Published: July 3, 2024

Abstract Sonodynamic therapy (SDT), as a promising non‐invasive therapeutic modality combining ultrasound (US) and sonosensitizers to produce cytotoxic reactive oxygen species (ROS) for treating deep‐seated tumors, has received increasing attention in recent years. Porphyrins are multifunctional organic materials, which can be excited both by light US ROS possess various fascinating features, including controllable synthetic processes, excellent biodegradability, low cytotoxicity without or US. Nevertheless, their poor water solubility, skin‐photosensitive toxicity, insufficient target specificity hinder clinical applications sonosensitizer. Although the issue may improved using nanoparticle carriers, SDT efficacy enhanced with other modalities, such combination makes it more confusing about true mechanism of SDT. This review will focus on following points: 1) Why porphyrin‐based considered most sonosensitizer SDT? 2) Recent progress development sonosensitizers. 3) What new insight been gained years? 4) The trend designing efficient existing challenges. Finally, future perspective practical based discussed.

Language: Английский

Citations

16
Recent advances and clinical challenges of phototherapeutic nanoparticles in cancer monotherapy or combination therapy DOI
Yuanying Zhang,

Yanling Zhang,

Gege Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216069 - 216069

Published: July 15, 2024

Language: Английский

Citations

16
Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy DOI

Fuhong Yang,

Jingqi Lv,

Wen Ma

et al.

Small, Journal Year: 2024, Volume and Issue: 20(44)

Published: July 6, 2024

Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.

Language: Английский

Citations

14
Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy DOI

Qiuhong Ouyang,

Ying Zhao, Kunyao Xu

et al.

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications disease treatment. HA possesses good biocompatibility, biodegradability, and ability to interact various cell surface receptors. Its wide range of molecular weights modifiable chemical groups make it an effective drug carrier for delivery. Additionally, overexpression specific receptors on surfaces many states enhances accumulation drugs at pathological sites through receptor binding. In this review, modification drugs, major proteins, latest advances receptor‐targeted nano delivery systems (DDS) treatment tumors inflammatory diseases are summarized. Furthermore, functions varying vivo selection methods different discussed.

Language: Английский

Citations

14
Octa-Cationic Porphyrin-Functionalized Biocompatible Nanocomposite: A Promising Candidate for Enhanced Combinatorial Photodynamic and Photothermal Tumor Therapy DOI

Chang-Hao Jiang,

Yonghui Li,

Yue Yuan

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

The integration of photodynamic therapy (PDT) and photothermal (PTT) offers a promising strategy for enhancing phototherapy efficiency. Herein, we present dual-functional, biocompatible nanocomposite system combination PDT/PTT therapy. utilizes highly nanoparticle assembled by an amphiphilic short peptide with the assistance Zn2+ as carrier. convertor is loaded within nanoparticle, while cationic porphyrin photosensitizer on surface. water-soluble (M8PzEOPP), designed eight positive charges, provides strong electrostatic interaction stable assembly This location-independent effectively maintains optical characteristics both convertor, endowing effective properties. exhibits excellent tumor-targeting accumulation behavior, low dark toxicity, robust extracellular biostability, high cell internalization Its enhanced performance in combinatorial demonstrated through vitro vivo experiments.

Language: Английский

Citations

1
“Mix‐and‐Match”: Self‐Sorting Assembly Governed Supramolecular Polymeric Nanomedicine for Boosting Combined Chemo/Phototherapy DOI

Yanggui Wu,

Ting Li,

Zeke Li

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Precise cancer nanomedicine requires rational molecular instructions of therapeutic agents. Harnessing the structure‐property‐function relationships represents a practical strategy toward smart and effective nanomedicine. A structurally novel hydrogen‐bonded (H‐bonded) supramolecular nanoformulation generated by orthogonal self‐sorting assembly chemo‐prodrug (FPtF) phototherapeutics (BPeB) is here reported, to reach an autonomous with improved anti‐tumor efficacy combining chemo/phototherapy (CT/PT). The high‐fidelity H‐bonding modularity from privileged heterocomplementary diaminopyridine/5‐fluorouracil (DAP/FU) Hamilton wedge/barbiturate (HW/Ba) pairs, respectively enable precise spatial control binding interactions FPtF BPeB, in turn allowing process specific “mix‐and‐match” capability. To directly stimulate phototherapy BPeB via near‐infrared (NIR) light, spectral matched upconversion nanoparticles (UCNPs, β‐NaYF 4 :Yb,Er) are encapsulated simultaneously. As result, polymeric nanomicelles, i.e., F/B/U@PHDO, readily fabricated. Moreover, distinct association constant (Ka) DAP/FU (≈10 2 M −1 ) HW/Ba 4‐5 pairs reflect different strengths stabilities H‐bonds, thus endowing programmable dissociation, accompanied release through pH/thermal‐stimuli. Therapeutic regime appreciated outcomes ultimately accomplished combined CT/PT. opportunities offered design anticipated point new paradigm for therapy.

Language: Английский

Citations

1
Current roles of metals in arming sonodynamic cancer therapy DOI

Zhuoli Chen,

Xianbo Wu, Jinzhe Liang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 521, P. 216169 - 216169

Published: Aug. 24, 2024

Language: Английский

Citations

8