Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 156685 - 156685
Опубликована: Окт. 1, 2024
Язык: Английский
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Авг. 14, 2024
Macrophages play a pivotal role in the healing of diabetic ulcers. The sustained elevation glucose levels damages insulin signaling pathway macrophages, leading to dysfunctional macrophages that struggle transition from pro-inflammatory (M1) reparative (M2) states. Therefore, modulating macrophage inflammatory responses via holds promise for ulcer treatment. Additionally, presence biofilm impedes drug penetration, and resulting immunosuppressive microenvironment exacerbates persistent infiltration M1 macrophages. we designed an array dissolvable microneedle (denoted as NPF@MN) loaded with self-assembled nanoparticles could deliver NPF nanoparticles, acid-sensitive NPF-releasing Protocatechualdehyde (PA) hypoglycemic insulin-like effects, regulating polarization anti-inflammatory M2 phenotype. this study extensively examined mechanism by which NPF@MN accelerates ulcers through activation pathway. Through RNA-seq GSEA analysis, identified reduction expression pathway-related factors such IR, IRS-1, IRS-2, SHC. Our work presents innovative therapeutic approach targeting underscores its translational potential clinical management.
Язык: Английский
Процитировано
13
Nano Letters, Год журнала: 2024, Номер 24(31), С. 9494 - 9504
Опубликована: Июль 26, 2024
Chronic diabetic wound patients usually show high glucose levels and systemic immune disorder, resulting in reactive oxygen species (ROS) cell dysfunction, prolonged inflammation, delayed healing. Herein, we prepared an antioxidant immunomodulatory polymer vesicle for treatment. This is self-assembled from poly(ε-caprolactone)36-block-poly[lysine4-stat-(lysine-mannose)22-stat-tyrosine)16] ([PCL36-b-P[Lys4-stat-(Lys-Man)22-stat-Tyr16]). Polytyrosine polypeptide that can scavenge ROS. d-Mannose was introduced to afford functions by promoting macrophage transformation Treg activation through inhibitory cytokines. The mice treated with vesicles showed 23.7% higher a 91.3% M2/M1 ratio than those PBS. Animal tests confirmed this accelerated healing achieved complete of S. aureus-infected wounds within 8 days. Overall, the first scavenging ROS regulating homeostasis, opening new avenues effective
Язык: Английский
Процитировано
9
Materials Today Bio, Год журнала: 2024, Номер 28, С. 101186 - 101186
Опубликована: Авг. 6, 2024
Diabetic wounds pose a clinical challenge due to persistent inflammation, severe bacterial infections, inadequate vascularization, and pronounced oxidative stress. Current therapeutic modalities fail provide satisfactory outcomes in managing these conditions, resulting considerable patient distress. Two-dimensional nanomaterials (2DNMs), characterized by their unique nanosheet structures, expansive surface areas, remarkable physicochemical properties, have garnered attention for potential applications. Emerging 2DNMs can be loaded with various pharmacological agents, including small molecules, metal ions, liposomes. Moreover, they integrated biomaterials such as hydrogels, microneedles, microspheres, thus demonstrating unprecedented advantages expediting the healing process of diabetic wounds. exhibit exceptional performance characteristics, high biocompatibility, effective antimicrobial optimal phototherapeutic effects, enhanced electrostimulation capabilities. These properties enable them modulate wound microenvironment, leading widespread application tissue repair outcomes. This review delineates several emerging 2DNMs, graphene its derivatives, black phosphorus, MXenes, transition dichalcogenides, context repair. Furthermore, it elucidates translational challenges future perspectives treatments. Overall, present highly promising strategy ameliorating wounds, providing novel avenues diagnostic strategies management.
Язык: Английский
Процитировано
9
Journal of Experimental & Clinical Cancer Research, Год журнала: 2025, Номер 44(1)
Опубликована: Март 3, 2025
Abstract The chemotherapy resistance is an awkward challenge in management of bladder cancer (BC). Cancer organoid model effective preclinical tumor that could faithfully represent clinical manifestations and simulate the biological processes chemoresistance. Recent studies have revealed stem cells (CSCs) play a significant role development chemoresistance cancer. Exosomes act as essential intercellular messengers participate controlling conversion distinct cell characteristics, including However, exosome-transmitted lncRNAs has rarely been reported. In this study, models were developed from urothelial carcinomas to explore pathophysiology mechanism BC chemoresistance, RNA-seq was performed screen for involved BC. We found enriches stem-like BC, upregulation Lung Associated Transcript 1 (LUCAT1) occurs chemotherapy-resistant organoids correlated with response. Further experimental results demonstrated LUCAT1 promotes by enhancing stemness phenotype vivo vitro. Moreover, exosomes derived can enhance delivering LUCAT1. Mechanistically, significantly mRNA stability HMGA1 via binding IGF2BP2 m6A-dependent manner. study demonstrates important potential function both diagnostic biomarker therapeutic target
Язык: Английский
Процитировано
1
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Март 5, 2025
MXene-based materials have attracted significant interest due to their distinct physical and chemical properties, which are relevant fields such as energy storage, environmental science, biomedicine. MXene has shown potential in the area of tissue regenerative medicine. However, research on its applications regeneration is still early stages, with a notable absence comprehensive reviews. This review begins detailed description intrinsic properties MXene, followed by discussion various nanostructures that can form, spanning from 0 3 dimensions. The focus then shifts biomaterials engineering, particularly immunomodulation, wound healing, bone regeneration, nerve regeneration. MXene's physicochemical including conductivity, photothermal characteristics, antibacterial facilitate interactions different cell types, influencing biological processes. These highlight modulating cellular functions essential for Although developing, versatile structural attributes suggest role advancing
Язык: Английский
Процитировано
1
ACS Nano, Год журнала: 2024, Номер unknown
Опубликована: Сен. 27, 2024
Radiation therapy, a fundamental treatment for tumors, is often accompanied by radiation-induced skin injury (RISI). Excessive production of reactive oxygen species (ROS) and subsequent inflammation are two key factors in RISI development that will cause affect radiotherapy. Herein, the co-assembled binary polyphenol natural products inspired dual-functional cascade microneedle system prevention RISI. Specifically, epigallocatechin gallate (EGCG) curcumin (CUR) were into nanoparticles (CEPG) intermolecular interactions then incorporated with catalase (CAT) to achieve microneedles (this was conducive penetrate epidermal keratinocytes where had greatest impact). When using microneedles, tip dissolved rapidly delivered CEPG CAT dermis, NPs able respond ROS decompose EGCG CUR. More importantly, formed converts superoxide anions water step-by-step, which can reduce cell damage caused free radicals early stages radiation prevention; meanwhile, CUR inhibited inflammatory pathways, achieving post-radiotherapy period. These explorations broaden strategy application
Язык: Английский
Процитировано
7
Military Medical Research, Год журнала: 2024, Номер 11(1)
Опубликована: Окт. 21, 2024
Abstract Severe tissue defects present formidable challenges to human health, persisting as major contributors mortality rates. The complex pathological microenvironment, particularly the disrupted immune landscape within these defects, poses substantial hurdles existing regeneration strategies. However, emergence of nanobiotechnology has opened a new direction in immunomodulatory nanomedicine, providing encouraging prospects for and restoration. This review aims gather recent advances nanomedicine foster regeneration. We begin by elucidating distinctive features local microenvironment defective tissues its crucial role Subsequently, we explore design functional properties nanosystems. Finally, address clinical translation development, aiming propose potent approach enhance through synergistic modulation integration.
Язык: Английский
Процитировано
7
Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110028 - 110028
Опубликована: Май 1, 2024
Язык: Английский
Процитировано
6
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Окт. 8, 2024
In diabetic wounds, hyperglycemia-induced cytotoxicity and impaired immune microenvironment plasticity directly hinder the wound healing process. Regulation of hyperglycemic remodeling are crucial.
Язык: Английский
Процитировано
6
Trends in Food Science & Technology, Год журнала: 2025, Номер 156, С. 104865 - 104865
Опубликована: Янв. 2, 2025
Язык: Английский
Процитировано
0