Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 122974 - 122974
Published: Nov. 26, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 303, P. 140674 - 140674
Published: Feb. 3, 2025
Language: Английский
Citations
9
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114571 - 114571
Published: Feb. 1, 2025
Language: Английский
Citations
2
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Sept. 30, 2024
Language: Английский
Citations
14
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 24, 2025
Exosomes-loaded hydrogels have potential value in wound treatment. Current studies focus on improving hydrogels' biocompatibility and optimizing different stem cell-derived exosomes for better therapeutic effect. Herein, we present a novel biocompatible recombinant human collagen (RHC) hydrogel loading with MSCs-derived promoting healing. We modify the RHC methacrylate anhydride (MA) at optimal concentration, generating (RHCMA) ideal physiochemical properties exosome delivery (MSC-exos@RHCMA). Exosomes derived from adipose-derived MSCs (ADSC-exos), bone marrow-derived (BMSC-exos) umbilical cord (ucMSC-exos) are harvested culture supernatants loaded into RHCMA, respectively. These three systems exhibit desired sustained release features, can significantly improve cell proliferation migration. In addition, these MSC-exos@RHCMAs show excellent performance treating wounds of rats. Notably, demonstrated that healing effect occurs best under treatment ucMSC-exos@RHCMA, following inflammatory resolution, angiogenesis, formation. results would supply important clinical application MSC-exos future.
Language: Английский
Citations
2
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 16, 2025
Chronic diabetic wounds are characterized by prolonged inflammation and excessive accumulation of M1 macrophages, which impede the healing process. Therefore, resolving promptly transitioning to proliferative phase critical steps for effective wound healing. Exosomes have emerged as a promising therapeutic strategy. In this study, smart hydrogel capable responding pathological cues in inflammatory microenvironment promote transition from proliferation delivering M2 macrophage-derived exosomes (M2-Exos) is developed. The synthesized through cross-linking oxidized dextran, matrix metalloproteinase (MMP)-9-sensitive peptide, carboxymethyl chitosan containing M2-Exos. response elevated MMP-9 concentrations microenvironment, demonstrates diagnostic logic, adjusting release kinetics M2-Exos accordingly. on-demand facilitated macrophage polarization phenotype, thereby promoting accelerating transcriptomic analysis further reveals that MMP-9-responsive with delivery exerts anti-inflammatory regenerative effects downregulating inflammation-related pathways. This study introduces an innovative, microenvironment-responsive exosome system enables precise control agent release, offering personalized approach treatment chronic wounds.
Language: Английский
Citations
1
ACS Nano, Journal Year: 2024, Volume and Issue: 18(50), P. 33907 - 33921
Published: Dec. 3, 2024
Acute liver failure (ALF) is a serious global disease characterized by rapid onset and high mortality. Currently, the clinical treatment of ALF faces considerable hurdles due to limited medication options scarcity transplants. Despite biomacromolecules such as hepatocyte growth factor (HGF) glutathione (GSH) having been applied for symptom relief in clinic, they still face substantial challenges including poor stability, difficulty acting on intracellular targets, inadequate therapeutic outcome. In this work, taking advantage innate targeting regenerative capabilities mesenchymal stem cells (MSCs), we harnessed MSC-derived exosomes natural bioactive carriers simultaneous delivery HGF GSH, forming fully nanodrug termed HG@Exo. Impressively, HG@Exo demonstrated potent effects against both carbon tetrachloride (CCl
Language: Английский
Citations
4
Life Sciences, Journal Year: 2025, Volume and Issue: 362, P. 123365 - 123365
Published: Jan. 4, 2025
Language: Английский
Citations
0
Carbohydrate Research, Journal Year: 2025, Volume and Issue: 550, P. 109384 - 109384
Published: Jan. 13, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Cyclophosphamide has a certain therapeutic effect on treating systemic sclerosis (SSc), while difficulties exist in controlling severe systematic side effects and enhancing targeting capacity. Here, inspired from the natural extracellular matrix composition, we propose cyclophosphamide-encapsulated nanogel based dendritic polymers polyamidoamine (PAMAM) for SSc treatment. We combine bovine serum albumin generation 5 (G5) PAMAM dendrimers with polyphenol modification to obtain nanogels featured antioxidant anti-inflammatory effects. The can possess excellent biocompatibility prevent fibroblasts oxidative stress damage TGF-β-mediated activation. Furthermore, bleomycin-induced mouse model, dendrimer encapsulating cyclophosphamide also exhibit ability attenuate fibrosis by modulating immunity, suppressing inflammation, reducing collagen synthesis. These findings underscore value of this polymer treatment chronic SSc, indicating its broader potential clinical applications.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 599 - 614
Published: Feb. 15, 2025
Language: Английский
Citations
0