Gold nanostars-diagnosis, bioimaging and biomedical applications DOI
Seyyed Mojtaba Mousavi, Maryam Zarei, Seyyed Alireza Hashemi

и другие.

Drug Metabolism Reviews, Год журнала: 2020, Номер 52(2), С. 299 - 318

Опубликована: Март 9, 2020

Gold Nanostars (GNS) have attracted tremendous attention toward themselves owing to their multi-branched structure and unique properties. These state of the art metallic nanoparticles possess intrinsic features like remarkable optical properties exceptional physiochemical activities. star-shaped gold can predominantly be utilized in biosensing, photothermal therapy, imaging, surface-enhanced Raman spectroscopy target drug delivery applications due low toxicity extraordinary features. In current review, recent approaches matter GNS case diagnosis, bioimaging biomedical were summarized reported. this regard, first an overview about general reported thence detailed information regarding diagnostic, bioimaging, such novel nanomaterials presented detail. Summarized clearly highlighting superior capability as potential multi-functional materials for applications.

Язык: Английский

Ultrasmall CuCo2S4 Nanocrystals: All‐in‐One Theragnosis Nanoplatform with Magnetic Resonance/Near‐Infrared Imaging for Efficiently Photothermal Therapy of Tumors DOI
Bo Li, Fukang Yuan, Guanjie He

и другие.

Advanced Functional Materials, Год журнала: 2017, Номер 27(10)

Опубликована: Янв. 23, 2017

Copper‐based ternary bimetal chalcogenides have very promising potential as multifunctional theragnosis nanoplatform for photothermal treatment of tumors. However, the design and synthesis such an effective platform remains challenging. In this study, hydrophilic CuCo 2 S 4 nanocrystals (NCs) with a desirable size ≈10 nm are synthesized by simple one‐pot hydrothermal route. The as‐prepared ultrasmall NCs show: 1) intense near‐infrared absorption, which is attributed to 3d electronic transitions from valence band intermediate band, identified density functional theory calculations; 2) high performance conversion efficiency up 73.4%; 3) capability magnetic resonance (MR) imaging, result unpaired electrons cobalt. Finally, it demonstrated that “all‐in‐one” cancer therapy under irradiation 915 laser at safe power 0.5 W cm −2 , guided MR infrared thermal imaging. This work further promotes applications therapy.

Язык: Английский

Процитировано

116

Constructing metal–organic framework nanodots as bio-inspired artificial superoxide dismutase for alleviating endotoxemia DOI
Lu Zhang, Yan Zhang, Zhenzhen Wang

и другие.

Materials Horizons, Год журнала: 2019, Номер 6(8), С. 1682 - 1687

Опубликована: Янв. 1, 2019

Here, Cu-TCPP MOF nanodots (denoted as CTMDs) were fabricated; they could functionally and structurally mimic the antioxidant superoxide diamutase (SOD) for alleviating endotoxemia with ability of renal enrichment clearance. CTMDs featured a biomimetic size, similar Cu active site coordination environment to that natural SOD ordered channels substrate exhibited highest SOD-like activity among other nanozymes. Together GPx-like activity, bio-inspired protect cell components in vitro well reduce systemic inflammation mortality an model vivo.

Язык: Английский

Процитировано

109

Biodegradable Inorganic Nanoparticles for Cancer Theranostics: Insights into the Degradation Behavior DOI
Hui Zhou, Jianxian Ge, Qingqing Miao

и другие.

Bioconjugate Chemistry, Год журнала: 2019, Номер 31(2), С. 315 - 331

Опубликована: Ноя. 25, 2019

Inorganic nanoparticles as a versatile nanoplatform have been broadly applied in the diagnosis and treatment of cancers due to their inherent superior physicochemical properties (including magnetic, thermal, optical, catalytic performance) excellent functions (e.g., imaging, targeted delivery, controlled release drugs) through surface functional modification or ingredient dopant. However, practical biological applications, inorganic nanomaterials are relatively difficult degrade excrete, which induces long residence time living organisms thus may cause adverse effects, such inflammation tissue cysts. Therefore, development biodegradable is great significance for biomedical application. This Review will focus on recent advances degradable cancer theranostics with highlight degradation mechanism, aiming offer an in-depth understanding behavior related applications. Finally, key challenges guidelines be discussed explore minimized toxicity issues, facilitating potential clinical translation treatment.

Язык: Английский

Процитировано

109

Enhancing Osteosarcoma Killing and CT Imaging Using Ultrahigh Drug Loading and NIR‐Responsive Bismuth Sulfide@Mesoporous Silica Nanoparticles DOI
Yao Lu, Lihua Li, Zefeng Lin

и другие.

Advanced Healthcare Materials, Год журнала: 2018, Номер 7(19)

Опубликована: Авг. 13, 2018

Abstract Despite its 5‐year event‐free survival rate increasing to 60–65% due surgery and chemotherapy, osteosarcoma (OS) remains one of the most threatening malignant human tumors, especially in young patients. Therefore, a new approach that combines early diagnosis with efficient tumor eradication bioimaging is urgently needed. Here, type mesoporous silica–coated bismuth sulfide nanoparticles (Bi 2 S 3 @MSN NPs) developed. The well distributed pores large surface areas hold great promise for drug protection encapsulation (doxorubicin (DOX), 99.85%). Moreover, high photothermal efficiency Bi @MSNs (36.62%) offers possibility cancer synergistic treatment highly near‐infrared‐triggered release (even at an ultralow power density 0.3 W cm −2 ). After covalently conjugated arginine‐glycine‐aspartic acid (RGD) peptide [c(RGDyC)], NPs exhibit specificity finally accumulate cells (tenfold more than peritumoral tissues) computed tomography (CT) imaging ablation. Importantly, therapy–chemotherapy RGD–Bi @MSN/DOX significantly ablates OS. It further proved superior combined killing effect achieved by activating mitochondrial apoptosis pathway. Hence, smart theranostic platform promising candidate future applications CT monitoring tumors.

Язык: Английский

Процитировано

107

Gold nanostars-diagnosis, bioimaging and biomedical applications DOI
Seyyed Mojtaba Mousavi, Maryam Zarei, Seyyed Alireza Hashemi

и другие.

Drug Metabolism Reviews, Год журнала: 2020, Номер 52(2), С. 299 - 318

Опубликована: Март 9, 2020

Gold Nanostars (GNS) have attracted tremendous attention toward themselves owing to their multi-branched structure and unique properties. These state of the art metallic nanoparticles possess intrinsic features like remarkable optical properties exceptional physiochemical activities. star-shaped gold can predominantly be utilized in biosensing, photothermal therapy, imaging, surface-enhanced Raman spectroscopy target drug delivery applications due low toxicity extraordinary features. In current review, recent approaches matter GNS case diagnosis, bioimaging biomedical were summarized reported. this regard, first an overview about general reported thence detailed information regarding diagnostic, bioimaging, such novel nanomaterials presented detail. Summarized clearly highlighting superior capability as potential multi-functional materials for applications.

Язык: Английский

Процитировано

102