Drug Metabolism Reviews,
Год журнала:
2020,
Номер
52(2), С. 299 - 318
Опубликована: Март 9, 2020
Gold
Nanostars
(GNS)
have
attracted
tremendous
attention
toward
themselves
owing
to
their
multi-branched
structure
and
unique
properties.
These
state
of
the
art
metallic
nanoparticles
possess
intrinsic
features
like
remarkable
optical
properties
exceptional
physiochemical
activities.
star-shaped
gold
can
predominantly
be
utilized
in
biosensing,
photothermal
therapy,
imaging,
surface-enhanced
Raman
spectroscopy
target
drug
delivery
applications
due
low
toxicity
extraordinary
features.
In
current
review,
recent
approaches
matter
GNS
case
diagnosis,
bioimaging
biomedical
were
summarized
reported.
this
regard,
first
an
overview
about
general
reported
thence
detailed
information
regarding
diagnostic,
bioimaging,
such
novel
nanomaterials
presented
detail.
Summarized
clearly
highlighting
superior
capability
as
potential
multi-functional
materials
for
applications.
Advanced Functional Materials,
Год журнала:
2017,
Номер
27(10)
Опубликована: Янв. 23, 2017
Copper‐based
ternary
bimetal
chalcogenides
have
very
promising
potential
as
multifunctional
theragnosis
nanoplatform
for
photothermal
treatment
of
tumors.
However,
the
design
and
synthesis
such
an
effective
platform
remains
challenging.
In
this
study,
hydrophilic
CuCo
2
S
4
nanocrystals
(NCs)
with
a
desirable
size
≈10
nm
are
synthesized
by
simple
one‐pot
hydrothermal
route.
The
as‐prepared
ultrasmall
NCs
show:
1)
intense
near‐infrared
absorption,
which
is
attributed
to
3d
electronic
transitions
from
valence
band
intermediate
band,
identified
density
functional
theory
calculations;
2)
high
performance
conversion
efficiency
up
73.4%;
3)
capability
magnetic
resonance
(MR)
imaging,
result
unpaired
electrons
cobalt.
Finally,
it
demonstrated
that
“all‐in‐one”
cancer
therapy
under
irradiation
915
laser
at
safe
power
0.5
W
cm
−2
,
guided
MR
infrared
thermal
imaging.
This
work
further
promotes
applications
therapy.
Materials Horizons,
Год журнала:
2019,
Номер
6(8), С. 1682 - 1687
Опубликована: Янв. 1, 2019
Here,
Cu-TCPP
MOF
nanodots
(denoted
as
CTMDs)
were
fabricated;
they
could
functionally
and
structurally
mimic
the
antioxidant
superoxide
diamutase
(SOD)
for
alleviating
endotoxemia
with
ability
of
renal
enrichment
clearance.
CTMDs
featured
a
biomimetic
size,
similar
Cu
active
site
coordination
environment
to
that
natural
SOD
ordered
channels
substrate
exhibited
highest
SOD-like
activity
among
other
nanozymes.
Together
GPx-like
activity,
bio-inspired
protect
cell
components
in
vitro
well
reduce
systemic
inflammation
mortality
an
model
vivo.
Bioconjugate Chemistry,
Год журнала:
2019,
Номер
31(2), С. 315 - 331
Опубликована: Ноя. 25, 2019
Inorganic
nanoparticles
as
a
versatile
nanoplatform
have
been
broadly
applied
in
the
diagnosis
and
treatment
of
cancers
due
to
their
inherent
superior
physicochemical
properties
(including
magnetic,
thermal,
optical,
catalytic
performance)
excellent
functions
(e.g.,
imaging,
targeted
delivery,
controlled
release
drugs)
through
surface
functional
modification
or
ingredient
dopant.
However,
practical
biological
applications,
inorganic
nanomaterials
are
relatively
difficult
degrade
excrete,
which
induces
long
residence
time
living
organisms
thus
may
cause
adverse
effects,
such
inflammation
tissue
cysts.
Therefore,
development
biodegradable
is
great
significance
for
biomedical
application.
This
Review
will
focus
on
recent
advances
degradable
cancer
theranostics
with
highlight
degradation
mechanism,
aiming
offer
an
in-depth
understanding
behavior
related
applications.
Finally,
key
challenges
guidelines
be
discussed
explore
minimized
toxicity
issues,
facilitating
potential
clinical
translation
treatment.
Advanced Healthcare Materials,
Год журнала:
2018,
Номер
7(19)
Опубликована: Авг. 13, 2018
Abstract
Despite
its
5‐year
event‐free
survival
rate
increasing
to
60–65%
due
surgery
and
chemotherapy,
osteosarcoma
(OS)
remains
one
of
the
most
threatening
malignant
human
tumors,
especially
in
young
patients.
Therefore,
a
new
approach
that
combines
early
diagnosis
with
efficient
tumor
eradication
bioimaging
is
urgently
needed.
Here,
type
mesoporous
silica–coated
bismuth
sulfide
nanoparticles
(Bi
2
S
3
@MSN
NPs)
developed.
The
well
distributed
pores
large
surface
areas
hold
great
promise
for
drug
protection
encapsulation
(doxorubicin
(DOX),
99.85%).
Moreover,
high
photothermal
efficiency
Bi
@MSNs
(36.62%)
offers
possibility
cancer
synergistic
treatment
highly
near‐infrared‐triggered
release
(even
at
an
ultralow
power
density
0.3
W
cm
−2
).
After
covalently
conjugated
arginine‐glycine‐aspartic
acid
(RGD)
peptide
[c(RGDyC)],
NPs
exhibit
specificity
finally
accumulate
cells
(tenfold
more
than
peritumoral
tissues)
computed
tomography
(CT)
imaging
ablation.
Importantly,
therapy–chemotherapy
RGD–Bi
@MSN/DOX
significantly
ablates
OS.
It
further
proved
superior
combined
killing
effect
achieved
by
activating
mitochondrial
apoptosis
pathway.
Hence,
smart
theranostic
platform
promising
candidate
future
applications
CT
monitoring
tumors.
Drug Metabolism Reviews,
Год журнала:
2020,
Номер
52(2), С. 299 - 318
Опубликована: Март 9, 2020
Gold
Nanostars
(GNS)
have
attracted
tremendous
attention
toward
themselves
owing
to
their
multi-branched
structure
and
unique
properties.
These
state
of
the
art
metallic
nanoparticles
possess
intrinsic
features
like
remarkable
optical
properties
exceptional
physiochemical
activities.
star-shaped
gold
can
predominantly
be
utilized
in
biosensing,
photothermal
therapy,
imaging,
surface-enhanced
Raman
spectroscopy
target
drug
delivery
applications
due
low
toxicity
extraordinary
features.
In
current
review,
recent
approaches
matter
GNS
case
diagnosis,
bioimaging
biomedical
were
summarized
reported.
this
regard,
first
an
overview
about
general
reported
thence
detailed
information
regarding
diagnostic,
bioimaging,
such
novel
nanomaterials
presented
detail.
Summarized
clearly
highlighting
superior
capability
as
potential
multi-functional
materials
for
applications.
