Constructing metal–organic framework nanodots as bio-inspired artificial superoxide dismutase for alleviating endotoxemia

Materials Horizons, Journal Year: 2019, Volume and Issue: 6(8), P. 1682 - 1687

Published: Jan. 1, 2019

Here, Cu-TCPP MOF nanodots (denoted as CTMDs) were fabricated; they could functionally and structurally mimic the antioxidant superoxide diamutase (SOD) for alleviating endotoxemia with ability of renal enrichment clearance. CTMDs featured a biomimetic size, similar Cu active site coordination environment to that natural SOD ordered channels substrate exhibited highest SOD-like activity among other nanozymes. Together GPx-like activity, bio-inspired protect cell components in vitro well reduce systemic inflammation mortality an model vivo.

Language: Английский

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Biodegradable Inorganic Nanoparticles for Cancer Theranostics: Insights into the Degradation Behavior

Bioconjugate Chemistry, Journal Year: 2019, Volume and Issue: 31(2), P. 315 - 331

Published: Nov. 25, 2019

Inorganic nanoparticles as a versatile nanoplatform have been broadly applied in the diagnosis and treatment of cancers due to their inherent superior physicochemical properties (including magnetic, thermal, optical, catalytic performance) excellent functions (e.g., imaging, targeted delivery, controlled release drugs) through surface functional modification or ingredient dopant. However, practical biological applications, inorganic nanomaterials are relatively difficult degrade excrete, which induces long residence time living organisms thus may cause adverse effects, such inflammation tissue cysts. Therefore, development biodegradable is great significance for biomedical application. This Review will focus on recent advances degradable cancer theranostics with highlight degradation mechanism, aiming offer an in-depth understanding behavior related applications. Finally, key challenges guidelines be discussed explore minimized toxicity issues, facilitating potential clinical translation treatment.

Language: Английский

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Enhancing Osteosarcoma Killing and CT Imaging Using Ultrahigh Drug Loading and NIR‐Responsive Bismuth Sulfide@Mesoporous Silica Nanoparticles

Advanced Healthcare Materials, Journal Year: 2018, Volume and Issue: 7(19)

Published: Aug. 13, 2018

Abstract Despite its 5‐year event‐free survival rate increasing to 60–65% due surgery and chemotherapy, osteosarcoma (OS) remains one of the most threatening malignant human tumors, especially in young patients. Therefore, a new approach that combines early diagnosis with efficient tumor eradication bioimaging is urgently needed. Here, type mesoporous silica–coated bismuth sulfide nanoparticles (Bi 2 S 3 @MSN NPs) developed. The well distributed pores large surface areas hold great promise for drug protection encapsulation (doxorubicin (DOX), 99.85%). Moreover, high photothermal efficiency Bi @MSNs (36.62%) offers possibility cancer synergistic treatment highly near‐infrared‐triggered release (even at an ultralow power density 0.3 W cm −2 ). After covalently conjugated arginine‐glycine‐aspartic acid (RGD) peptide [c(RGDyC)], NPs exhibit specificity finally accumulate cells (tenfold more than peritumoral tissues) computed tomography (CT) imaging ablation. Importantly, therapy–chemotherapy RGD–Bi @MSN/DOX significantly ablates OS. It further proved superior combined killing effect achieved by activating mitochondrial apoptosis pathway. Hence, smart theranostic platform promising candidate future applications CT monitoring tumors.

Language: Английский

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Gold nanostars-diagnosis, bioimaging and biomedical applications

Drug Metabolism Reviews, Journal Year: 2020, Volume and Issue: 52(2), P. 299 - 318

Published: March 9, 2020

Gold Nanostars (GNS) have attracted tremendous attention toward themselves owing to their multi-branched structure and unique properties. These state of the art metallic nanoparticles possess intrinsic features like remarkable optical properties exceptional physiochemical activities. star-shaped gold can predominantly be utilized in biosensing, photothermal therapy, imaging, surface-enhanced Raman spectroscopy target drug delivery applications due low toxicity extraordinary features. In current review, recent approaches matter GNS case diagnosis, bioimaging biomedical were summarized reported. this regard, first an overview about general reported thence detailed information regarding diagnostic, bioimaging, such novel nanomaterials presented detail. Summarized clearly highlighting superior capability as potential multi-functional materials for applications.

Language: Английский

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Recent advances in nanoparticles mediated photothermal therapy induced tumor regression

International Journal of Pharmaceutics, Journal Year: 2021, Volume and Issue: 606, P. 120848 - 120848

Published: June 30, 2021

Language: Английский

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