The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative properties

Chemical Society Reviews, Год журнала: 2020, Номер 49(4), С. 1253 - 1321

Опубликована: Янв. 1, 2020

Bismuth-containing nanomaterials offer a new opportunity to move beyond current achievements in the fields of drug delivery, diagnosis, cancer therapy, biosensing, and tissue engineering. This review describes emerging applications perspective these nanoparticles.

Язык: Английский

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X-ray-activated nanosystems for theranostic applications

Chemical Society Reviews, Год журнала: 2019, Номер 48(11), С. 3073 - 3101

Опубликована: Янв. 1, 2019

X-rays are widely applied in clinical medical facilities for radiotherapy (RT) and biomedical imaging. However, the sole use of cancer treatment leads to insufficient radiation energy deposition due low X-ray attenuation coefficients living tissues organs, producing unavoidable excessive doses with serious side effects healthy body parts. Over past decade, developments materials science nanotechnology have led rapid progress field X-ray-activated tumor-targeting nanosystems, which able tackle even systemic tumors relieve burden exposure large doses. Additionally, novel imaging contrast agents techniques also been developed. In comparison conventional external light sources (e.g., near infrared), technique is ideal activation nanosystems applications its nearly unlimited penetration depth organisms. this review, we systematically describe interaction mechanisms between provide an overview X-ray-sensitive recent on cancer-associated theranostic applications.

Язык: Английский

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Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

Advanced Science, Год журнала: 2020, Номер 8(3)

Опубликована: Дек. 20, 2020

Abstract Reactive oxygen species (ROS) play an essential role in physiological and pathological processes. Studies on the regulation of ROS for disease treatments have caused wide concern, mainly involving topics ROS‐regulating therapy such as antioxidant triggered by scavengers ROS‐induced toxic mediated ROS‐elevation agents. Benefiting from remarkable advances nanotechnology, a large number nanomaterials with ability are developed to seek new effective ROS‐related nanotherapeutic modalities or nanomedicines. Although considerable achievements been made ROS‐based nanomedicines treatments, some fundamental but key questions rational design principle held low regard. Here, can serve initial framework scientists technicians optimize nanomedicines, thereby minimizing gap biomedical application during stage. Herein, overview current progress ROS‐associated is summarized. And then, particularly addressing these known strategies therapy, several principles presented. Finally, future perspectives also discussed depth development

Язык: Английский

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Advances in oxidase-mimicking nanozymes: Classification, activity regulation and biomedical applications

Nano Today, Год журнала: 2021, Номер 37, С. 101076 - 101076

Опубликована: Янв. 14, 2021

Язык: Английский

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Recent advances in enhanced chemodynamic therapy strategies

Nano Today, Год журнала: 2021, Номер 39, С. 101162 - 101162

Опубликована: Май 18, 2021

Язык: Английский

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Progress, challenges, and future of nanomedicine

Nano Today, Год журнала: 2020, Номер 35, С. 101008 - 101008

Опубликована: Окт. 21, 2020

Язык: Английский

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Janus Nanoparticles: From Fabrication to (Bio)Applications

ACS Nano, Год журнала: 2021, Номер 15(4), С. 6147 - 6191

Опубликована: Март 19, 2021

Janus nanoparticles (JNPs) refer to the integration of two or more chemically discrepant composites into one structure system. Studies JNPs have been significant interest due their interesting characteristics stemming from asymmetric structures, which can integrate different functional properties and perform synergetic functions simultaneously. Herein, we present recent progress particles, comprehensively detailing fabrication strategies applications. First, classification is divided three blocks, consisting polymeric composites, inorganic hybrid polymeric/inorganic composites. Then, are alternately summarized, examining self-assembly strategy, phase separation seed-mediated polymerization, microfluidic preparation nucleation growth methods, masking methods. Finally, various intriguing applications presented, including solid surfactants agents, micro/nanomotors, biomedical such as biosensing, controlled drug delivery, bioimaging, cancer therapy, combined theranostics. Furthermore, challenges future works in this field provided.

Язык: Английский

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Plasmonic AuPt@CuS Heterostructure with Enhanced Synergistic Efficacy for Radiophotothermal Therapy

Journal of the American Chemical Society, Год журнала: 2021, Номер 143(39), С. 16113 - 16127

Опубликована: Сен. 28, 2021

Integrating multifunctional nanostructures capable of radiotherapy and photothermal ablation is an emerging alternative in killing cancer cells. In this work, we report a novel plasmonic heterostructure formed by decorating AuPt nanoparticles (NPs) onto the surfaces CuS nanosheets (AuPt@CuS NSs) as highly effective nanotheranostic toward dual-modal photoacoustic/computed tomography imaging enhanced synergistic radiophotothermal therapy. These heterostructures can confer higher conversion efficiency via local electromagnetic enhancement well greater radiation dose deposition form glutathione depletion reactive oxygen species generation. As result, depth tissue penetration improved, hypoxia tumor microenvironment alleviated. With efficacy radiotherapy, be eliminated without later recurrence. It believed that these will play vital role future oncotherapy with effects under guided potential dual-modality system.

Язык: Английский

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Heterojunction Nanomedicine

Advanced Science, Год журнала: 2022, Номер 9(11)

Опубликована: Фев. 17, 2022

Exogenous stimulation catalytic therapy has received enormous attention as it holds great promise to address global medical issues. However, the therapeutic effect of is seriously restricted by fast charge recombination and limited utilization exogenous catalysts. In past few decades, many strategies have been developed overcome above serious drawbacks, among which heterojunctions are most widely used promising strategy. This review attempts summarize recent progress in rational design fabrication heterojunction nanomedicine, such semiconductor-semiconductor (including type I, II, III, PN, Z-scheme junctions) semiconductor-metal Schottky, Ohmic, localized surface plasmon resonance-mediated junctions). The mechanisms properties junction systems also discussed relation biomedical applications, especially cancer treatment sterilization. concludes with a summary challenges some perspectives on future directions this exciting still evolving field research.

Язык: Английский

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External physical field‐driven nanocatalytic cancer therapy

BMEMat, Год журнала: 2023, Номер 1(1)

Опубликована: Фев. 14, 2023

Abstract Recently, variable nanocatalysts have provided novel, highly selective, minimally invasive strategies driven by external physical fields for cancer therapy. In the catalytic reaction, less toxic or nontoxic substances can be in situ converted into agents suppression. this review, we systematically summarize therapy based on different types of fields, including light, ultrasound, electricity, temperature, X‐ray, magnetic field, and microwave. The properties, mechanisms, advantages corresponding are also introduced. Importantly, considering rapid development nanomedicine, research progress is discussed. Finally, remaining challenges outlooks that faced outlined. We believe emerging fields‐driven nanocatalytic will provide a new avenue treatment.

Язык: Английский

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