Enhanced Chemodynamic Therapy by Cu–Fe Peroxide Nanoparticles: Tumor Microenvironment-Mediated Synergistic Fenton Reaction

ACS Nano, Год журнала: 2022, Номер 16(2), С. 2535 - 2545

Опубликована: Янв. 26, 2022

An urgent need in chemodynamic therapy (CDT) is to achieve high Fenton catalytic efficiency at small doses of CDT agents. However, simple general promotion the reaction increases risk damaging normal cells along with cancer cells. Therefore, a tailored strategy selectively enhance reactivity tumors, for example, by taking advantage characteristics tumor microenvironment (TME), demand. Herein, heterogeneous system based on copper–iron peroxide nanoparticles (CFp NPs) designed TME-mediated synergistic therapy. CFp NPs degrade under mildly acidic conditions TME, self-supply H2O2, and released Cu Fe ions, their larger portions lower oxidation states, cooperatively facilitate hydroxyl radical production through highly efficient loop an excellent therapeutic efficacy. This distinct from previous systems that synergism closely coupled Cu+-assisted conversion Fe3+ Fe2+ rather than independent actions. As result, almost complete ablation tumors minimal treatment dose demonstrated without aid any other modality. Furthermore, generate O2 during catalysis exhibit TME-responsive T1 magnetic resonance imaging contrast enhancement, which are useful alleviating hypoxia vivo monitoring respectively.

Язык: Английский

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Nanozyme-involved biomimetic cascade catalysis for biomedical applications

Materials Today, Год журнала: 2021, Номер 44, С. 211 - 228

Опубликована: Янв. 14, 2021

Язык: Английский

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Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells

Advanced Science, Год журнала: 2021, Номер 8(22)

Опубликована: Окт. 10, 2021

Abstract Ferroptosis is a new form of regulated cell death, which characterized by the iron‐dependent accumulation lethal lipid peroxides and involved in many critical diseases. Recent reports revealed that cellular energy metabolism activities such as glycolysis, pentose phosphate pathway (PPP), tricarboxylic acid cycle are regulation key ferroptosis markers reduced nicotinamide adenine dinucleotide (NADPH), glutathione (GSH), reactive oxygen species (ROS), therefore imposing potential regulatory roles ferroptosis. Remarkably, tumor cells can activate adaptive metabolic responses to inhibit for self‐preservation upregulation glycolysis PPP. Due rapid proliferation intensified rate, has become target disrupting redox homeostasis induce Based on these emerging insights, impact those‐tumor specific aberrations systematically characterized, rewired glucose compensation through glutamine utilization analyzed underlying molecular mechanisms. Additionally, those ferroptosis‐based therapeutic strategies also discussed exploiting vulnerabilities, may open up avenues treatment clinical context.

Язык: Английский

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Programmable NIR‐II Photothermal‐Enhanced Starvation‐Primed Chemodynamic Therapy using Glucose Oxidase‐Functionalized Ancient Pigment Nanosheets

Small, Год журнала: 2020, Номер 16(25)

Опубликована: Май 28, 2020

Chemodynamic therapy (CDT) has attracted considerable attention recently, but the poor reaction kinetics restrict its practical utility in clinic. Herein, glucose oxidase (GOx) functionalized ancient pigment nanosheets (SrCuSi4 O10 , SC) for programmable near-infrared II (NIR-II) photothermal-enhanced starvation primed CDT is developed. The SC (SC NSs) are readily exfoliated from bulk suspension water and subsequently with GOx to form nanocatalyst (denoted as SC@G NSs). Upon laser irradiation, photothermal effect of NSs can enhance catalytic activity NIR-II therapy, which effectively eliminates intratumoral produces abundant hydrogen peroxide (H2 O2 ). Importantly, high photothermal-conversion efficiency (46.3%) second biological window permits deep-seated tumors under guidance photoacoustic imaging. Moreover, acidity amplification due gluconic acid generation will turn accelerate degradation NSs, facilitating release strontium (Sr) copper (Cu) ions. Both elevated H2 released ions prime Cu2+ /Sr2+ -H2 enhanced CDT. Thus, a established combat cancer minimal side effects.

Язык: Английский

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Manganese‐Based Tumor Immunotherapy

Advanced Materials, Год журнала: 2022, Номер 35(19)

Опубликована: Сен. 19, 2022

Abstract As an essential micronutrient, manganese (Mn) participates in various physiological processes and plays important roles host immune system, hematopoiesis, endocrine function, oxidative stress regulation. Mn‐based nanoparticles are considered to be biocompatible show versatile applications nanomedicine, particular utilized tumor immunotherapy the following ways: 1) acting as a nanocarrier deliver immunotherapeutic agents for immunotherapy; 2) serving adjuvant regulate microenvironment enhance 3) activating host's system through cGAS‐STING pathway trigger 4) real‐time monitoring effect by magnetic resonance imaging (MRI) since Mn 2+ ions ideal MRI contrast agent which can significantly T 1 ‐weighted signal after binding proteins. This comprehensive review focuses on most recent progress of nanoplatforms immunotherapy. The characteristics first discussed guide design multifunctional nanoplatforms. Then biomedical nanoplatforms, including alone, immunotherapy‐involved multimodal synergistic therapy, imaging‐guided detail. Finally, challenges future developments highlighted.

Язык: Английский

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An Acidity‐Unlocked Magnetic Nanoplatform Enables Self‐Boosting ROS Generation through Upregulation of Lactate for Imaging‐Guided Highly Specific Chemodynamic Therapy

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(17), С. 9562 - 9572

Опубликована: Фев. 16, 2021

Chemodynamic therapy is an emerging tumor therapeutic strategy. However, the anticancer effects are greatly limited by strong acidity requirements for effective Fenton-like reaction, and inevitably "off-target" toxicity. Herein, we develop acidity-unlocked nanoplatform (FePt@FeOx@TAM-PEG) that can accurately perform high-efficient tumor-specific catalysis treatment, through dual pathway of cyclic amplification Notably, pH-responsive peculiarity tamoxifen (TAM) drug allows catalytic activity FePt@FeOx to be "turn-on" in acidic microenvironments, while keeping silence neutral condition. Importantly, released TAM within cancer cells able inhibit mitochondrial complex I, leading upregulated lactate content thereby accumulated intracellular H+, which overcome intrinsically insufficient tumor. Through positive feedback loop, large amount active nanocatalyzers access endogenous H2O2, exerting improved reaction more Finally, such smart enables self-boosting generation reactive oxygen species (ROS) induces oxidative stress, substantial outcomes vivo, may provide a new insight cascade reducing toxicity surrounding normal tissues.

Язык: Английский

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Nanoplatform-based cascade engineering for cancer therapy

Chemical Society Reviews, Год журнала: 2020, Номер 49(24), С. 9057 - 9094

Опубликована: Янв. 1, 2020

This review provides a comprehensive overview of the recent advances in nanoplatform-based cascade engineering for cancer therapy, by concentrating on design smart nanoplatforms and implementation specific processes.

Язык: Английский

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pH-Sensitive nanoscale materials as robust drug delivery systems for cancer therapy

Chinese Chemical Letters, Год журнала: 2020, Номер 31(6), С. 1345 - 1356

Опубликована: Март 2, 2020

Язык: Английский

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Immunogenic Cell Death Augmented by Manganese Zinc Sulfide Nanoparticles for Metastatic Melanoma Immunotherapy

ACS Nano, Год журнала: 2022, Номер 16(9), С. 15471 - 15483

Опубликована: Авг. 18, 2022

Both T-cell deprivation and insufficient tumor immunogenicity seriously hinder the efficacy of immune-mediated destruction in melanoma. In this work, an amphiphilic polyethylene glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane) copolymer with a thermally sensitive flowable core (mPEG-b-PHEP) was chosen to incorporate IR780 dye manganese zinc sulfide nanoparticles (ZMS) form polymer micelles (denoted PPIR780-ZMS), which precisely controlled release ZMS after being triggered by near-infrared light (NIR). Mn2+-mediated chemodynamic therapy (CDT) photothermal trigger boosted generation reactive oxygen species (ROS), making PPIR780-ZMS smart bomblets vivo. It demonstrated that could maximize immunogenic cell death (ICD) cancer, is characterized abundant damage-associated molecular pattern (DAMP) exposure. As result, cytotoxic T cells (CD8+) helper (CD4+) expanded infiltrated neoplastic foci, further reprogrammed suppressive microenvironment (TME) against primary pulmonary metastases safe systemic cytokine expression. addition, cGAS-STING signaling pathway activation enhanced antitumor immunity nanocomposite, providing practical strategy for expanding use Mn-based nanostructures.

Язык: Английский

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A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO₃ for Synergistic Tumor Therapy

Angewandte Chemie International Edition, Год журнала: 2020, Номер 59(41), С. 18042 - 18047

Опубликована: Июнь 27, 2020

Abstract Ca 2+ , a ubiquitous but nuanced modulator of cellular physiology, is meticulously controlled intracellularly. However, intracellular regulation, such as mitochondrial buffering capacity, can be disrupted by 1 O 2 . Thus, the overload, which recognized one important cell pro‐death factors, logically achieved synergism with exogenous delivery. Reported herein nanoscale covalent organic framework (NCOF)‐based nanoagent, namely CaCO 3 @COF‐BODIPY‐2I@GAG ( 4 ), embedded nanoparticle (NP) and surface‐decorated BODIPY‐2I photosensitizer (PS) glycosaminoglycan (GAG) targeting agent for CD44 receptors on digestive tract tumor cells. Under illumination, light‐triggered not only kills cells directly, also leads to their dysfunction overload. An enhanced antitumor efficiency via photodynamic therapy (PDT) overload synergistic therapy.

Язык: Английский

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