Materials,
Год журнала:
2023,
Номер
16(18), С. 6143 - 6143
Опубликована: Сен. 9, 2023
This
review
article
explores
the
multiple
applications
and
potential
of
metal-organic
frameworks
(MOFs)
in
biomedical
field.
With
their
highly
versatile
tunable
properties,
MOFs
present
many
possibilities,
including
drug
delivery,
biomolecule
recognition,
biosensors,
immunotherapy.
Their
crystal
structure
allows
precise
tuning,
with
ligand
typology
metal
geometry
playing
critical
roles.
MOFs’
ability
to
encapsulate
drugs
exhibit
pH-triggered
release
makes
them
ideal
candidates
for
precision
medicine,
cancer
treatment.
They
are
also
gene
carriers
genetic
disorders
have
been
used
biosensors
as
contrast
agents
magnetic
resonance
imaging.
Despite
complexities
encountered
modulating
properties
interactions
biological
systems,
further
research
on
is
imperative.
The
primary
focus
this
provide
a
comprehensive
examination
these
applications,
highlighting
current
achievements
encountered.
Such
efforts
will
uncover
untapped
creating
innovative
tools
emphasizing
need
invest
continued
exploration
promising
Bioengineering & Translational Medicine,
Год журнала:
2023,
Номер
8(3)
Опубликована: Фев. 10, 2023
Abstract
Radiosensitizers
are
compounds
or
nanostructures,
which
can
improve
the
efficiency
of
ionizing
radiation
to
kill
cells.
Radiosensitization
increases
susceptibility
cancer
cells
radiation‐induced
killing,
while
simultaneously
reducing
potentially
damaging
effect
on
cellular
structure
and
function
surrounding
healthy
tissues.
Therefore,
radiosensitizers
therapeutic
agents
used
boost
effectiveness
treatment.
The
complexity
heterogeneity
cancer,
multifactorial
nature
its
pathophysiology
has
led
many
approaches
each
approach
been
proven
some
extent,
but
no
definitive
treatment
eradicate
discovered.
current
review
discusses
a
broad
range
nano‐radiosensitizers,
summarizing
possible
combinations
radiosensitizing
NPs
with
several
other
types
therapy
options,
focusing
benefits
drawbacks,
challenges,
future
prospects.
Advanced Materials,
Год журнала:
2024,
Номер
36(23)
Опубликована: Фев. 23, 2024
Clinical
treatment
of
cancer
commonly
incorporates
X-ray
radiation
therapy
(XRT),
and
developing
spatially
precise
radiation-activatable
drug
delivery
strategies
may
improve
XRT
efficacy
while
limiting
off-target
toxicities
associated
with
systemically
administered
drugs.
Nevertheless,
achieving
this
has
been
challenging
thus
far
because
typically
rely
on
radical
species
short
lifespans,
the
inherent
nature
hypoxic
acidic
tumor
microenvironments
encourage
heterogeneous
effects.
It
is
hypothesized
that
challenge
could
be
bypassed
by
using
scintillating
nanoparticles
emit
light
upon
absorption,
locally
forming
therapeutic
depots
in
tissues.
Thus
a
nanoparticle
platform
(Scintillating
Drug
Depot;
SciDD)
enables
local
release
cytotoxic
payloads
only
after
activation
developed,
thereby
toxicity.
As
proof-of-principle,
SciDD
used
to
deliver
microtubule-destabilizing
payload
MMAE
(monomethyl
auristatin
E).
With
as
little
2
Gy
irradiation
tumors,
are
released
effectively
kill
cells.
XRT-mediated
demonstrated
multiple
mouse
models
showed
over
alone
(p
<
0.0001).
This
work
shows
can
act
depot
spatiotemporally
controlled
therapeutics.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
19(2), С. 100903 - 100903
Опубликована: Март 11, 2024
Radiotherapy
is
a
well-established
cytotoxic
therapy
for
local
solid
cancers,
utilizing
high-energy
ionizing
radiation
to
destroy
cancer
cells.
However,
this
method
has
several
limitations,
including
low
energy
deposition,
severe
damage
surrounding
normal
cells,
and
high
tumor
resistance
radiation.
Among
various
radiotherapy
methods,
boron
neutron
capture
(BNCT)
emerged
as
principal
approach
improve
the
therapeutic
ratio
of
malignancies
reduce
lethality
tissue,
but
it
remains
deficient
in
terms
insufficient
accumulation
well
short
retention
time,
which
limits
curative
effect.
Recently,
series
radiosensitizers
that
can
selectively
accumulate
specific
organelles
cells
have
been
developed
precisely
target
radiotherapy,
thereby
reducing
side
effects
tissue
damage,
overcoming
radioresistance,
improving
radiosensitivity.
In
review,
we
mainly
focus
on
field
nanomedicine-based
discuss
organelle-targeted
radiosensitizers,
specifically
nucleus,
mitochondria,
endoplasmic
reticulum
lysosomes.
Furthermore,
carriers
used
BNCT
are
particularly
presented.
Through
demonstrating
recent
developments
radiosensitization,
hope
provide
insight
into
design
clinical
treatment.
Chemical Science,
Год журнала:
2023,
Номер
14(13), С. 3642 - 3651
Опубликована: Янв. 1, 2023
An
iodide-containing
cationic
covalent
organic
framework
as
a
nonmetallic
radiosensitizer
increases
X-ray
deposition
and
enhances
radiotherapy
of
colon
cancer
in
vitro
vivo
by
inducing
ferroptosis.
Lung
cancer
remains
a
formidable
global
health
challenge
that
necessitates
inventive
strategies
to
improve
therapeutic
outcomes.
Conventional
treatments,
including
surgery,
chemotherapy,
and
radiation,
have
demonstrated
limitations
in
achieving
sustained
responses.
Therefore,
the
explora-tion
of
novel
approaches
encompasses
range
interventions
show
promise
enhancing
outcomes
for
patients
with
lung
cancer,
particularly
those
facing
advanced
or
refractory
cases.
These
groundbreaking
hold
potential
overcome
resistance
offer
personalized
solutions.
Despite
rapid
evolution
emerging
therapies,
persistent
challenges
such
as
resistance,
toxicity,
patient
selection
underscore
need
continued
development.
Consequently,
landscape
therapy
is
transforming
in-troduction
precision
medicine,
immunotherapy,
innovative
modalities.
Addi-tionally,
multifaceted
approach
involving
combination
therapies
through
integration
tar-geted
agents,
immunotherapies,
traditional
cytotoxic
treatments
addresses
heterogeneity
while
minimizing
adverse
effects.
This
review
provides
brief
overview
latest
are
reshaping
treatment.
As
these
progress
clinical
trials
integrate
into
standard
care,
more
effective,
targeted,
comes
focus,
instilling
renewed
hope
challenging
diagnoses.
Frontiers in Chemistry,
Год журнала:
2023,
Номер
11
Опубликована: Ноя. 24, 2023
Hafnium-based
nanomaterials
(Hf-NMs)
have
attracted
the
interest
of
numerous
biomedical
researchers
by
their
unique
properties.
Recent
years
witnessed
significant
advancements
in
field
nanomaterials,
particularly
context
cancer
diagnosis
and
treatment.
However,
research
this
area,
especially
concerning
clinical
application
has
not
been
thoroughly
reviewed.
This
review
will
cover:
1)
Classification
synthesis
including
Hafnium
oxide
Metal-Organic
Frameworks/nanoscale
coordination
polymers
(MOFs/NCPs);
2)
act
as
contrast
enhancement
agent
for
imaging,
hafnium-based
used
liquid
biopsy;
3)
therapy,
radiotherapy,
photodynamic
various
combined
therapy;
4)
Translation,
toxicity,
safety
Hf-NMs
human
preclinical
animal
models.
More
attention
be
given
to
translation
cancer.
Despite
the
growing
body
of
research
on
nanotechnology
for
esophageal
cancer
(EC),
a
comprehensive
bibliometric
analysis
in
this
field
has
yet
to
be
conducted.
This
study
aims
fill
gap
by
analyzing
global
trends,
key
contributors,
and
emerging
themes
EC.
A
was
performed
publications
from
1980
2024,
using
data
Web
Science
Core
Collection.
The
conducted
VOSviewer,
CiteSpace,
R
package
'bibliometrix'
visualize
collaboration
networks,
thematic
areas.
included
419
documents
authored
2952
researchers
44
countries.
significant
increase
observed,
particularly
after
2011,
with
China,
United
States,
Japan
leading
contributions.
Prominent
institutions,
including
Zhengzhou
University
Chinese
Academy
Sciences,
were
identified
as
players.
predominantly
focused
drug
delivery
systems,
nanomedicine,
treatment
mechanisms,
trends
development
advanced
nanomaterials
personalized
therapies.
applications
EC
highlights
findings
underscore
crucial
role
advancing
strategies
identify
areas
future
interdisciplinary
collaboration.
