Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(7), С. 7239 - 7257
Опубликована: Июль 8, 2024
Photodynamic
therapy
(PDT)
can
not
only
directly
eliminate
cancer
cells,
but
also
stimulate
antitumor
immune
responses.
It
affects
the
expression
of
checkpoints.
The
purpose
this
review
is
to
collect,
analyze,
and
summarize
recent
news
about
PDT
checkpoints,
along
with
their
inhibitors,
identify
future
research
directions
that
may
enhance
effectiveness
approach.
A
search
for
articles
published
between
January
2023
March
2024
was
conducted
in
PubMed/MEDLINE.
Eligibility
criteria
were
as
follows:
(1)
papers
describing
(2)
original
papers,
(3)
new
reports
field
(4)
both
vitro
vivo
papers.
Exclusion
included
written
a
language
other
than
Polish
or
English,
before
2023.
24
data
on
checkpoints
have
been
since
These
information
effects
attempts
associate
ICI
molecules
modulate
improve
immunosuppressive
environment
tumor,
resolve
PDT-related
problems.
They
focused
development
nanoparticles
delivery
photosensitizers
drugs
selectively
tumor.
effect
level
associated
activity
system
has
fully
elucidated
further,
area
are
divergent,
indicating
complexity
interaction
system.
PDT-based
strategies
shown
beneficial
utility
enhancing
induction
response
by
participating
triggering
immunogenic
cell
death,
exposure
tumor
antigens,
release
various
alarm
signals
together
promote
activation
dendritic
cells
components
demonstrated,
result
induced
therapy.
enables
multifaceted
regulation
tumor’s
environment,
which
potential
achieve
better
efficacy.
current
presented
evidence
PDT’s
ability
association
ICIs
inducing
an
effective
against
cells.
However,
these
studies
at
early
stage
many
more
observations
need
be
made
confirm
indicated
contribute
further
strategies.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Март 21, 2024
Abstract
Photodynamic
therapy
(PDT)
is
a
promising
cancer
treatment
but
has
limitations
due
to
its
dependence
on
oxygen
and
high-power-density
photoexcitation.
Here,
we
report
polymer-based
organic
photosensitizers
(PSs)
through
rational
PS
skeleton
design
precise
side-chain
engineering
generate
•O
2
−
•OH
under
oxygen-free
conditions
using
ultralow-power
808
nm
photoexcitation
for
tumor-specific
photodynamic
ablation.
The
designed
skeletons
can
electron-hole
pairs
sensitize
H
O
into
with
photoexcitation,
achieving
NIR-photoexcited
oxygen-independent
production.
Further,
compared
commonly
used
alkyl
side
chains,
glycol
oligomer
as
the
chain
mitigates
recombination
offers
more
molecules
around
generated
from
hydrophobic
skeletons,
which
yield
4-fold
stronger
production,
thus
allowing
an
high
PDT
effect.
Finally,
feasibility
of
developing
activatable
PSs
in
female
mice
further
demonstrated
irradiation
15
mW
cm
−2
.
study
not
only
provides
insights
mechanism
also
general
guideline
develop
NIR
PDT.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 868 - 868
Опубликована: Март 7, 2023
The
new
era
of
nanomedicine
offers
significant
opportunities
for
cancer
diagnostics
and
treatment.
Magnetic
nanoplatforms
could
be
highly
effective
tools
diagnosis
treatment
in
the
future.
Due
to
their
tunable
morphologies
superior
properties,
multifunctional
magnetic
nanomaterials
hybrid
nanostructures
can
designed
as
specific
carriers
drugs,
imaging
agents,
theranostics.
Multifunctional
are
promising
theranostic
agents
due
ability
diagnose
combine
therapies.
This
review
provides
a
comprehensive
overview
development
advanced
combining
optical
providing
photoresponsive
platforms
medical
applications.
Moreover,
this
discusses
various
innovative
developments
using
nanostructures,
including
drug
delivery,
treatment,
tumor-specific
ligands
that
deliver
chemotherapeutics
or
hormonal
resonance
imaging,
tissue
engineering.
Additionally,
artificial
intelligence
(AI)
used
optimize
material
properties
based
on
predicted
interactions
with
cell
membranes,
vasculature,
biological
fluid,
immune
system
enhance
effectiveness
therapeutic
agents.
Furthermore,
an
AI
approaches
assess
practical
utility
Finally,
presents
current
knowledge
perspectives
systems
models.
Heliyon,
Год журнала:
2024,
Номер
10(3), С. e25521 - e25521
Опубликована: Фев. 1, 2024
Nanomaterials
(NMs)
have
garnered
significant
attention
in
recent
decades
due
to
their
versatile
applications
a
wide
range
of
fields.
Thanks
tiny
size,
enhanced
surface
modifications,
impressive
volume-to-surface
area
ratio,
magnetic
properties,
and
customized
optical
dispersion.
NMs
experienced
an
incredible
upsurge
biomedical
including
diagnostics,
therapeutics,
drug
delivery.
This
minireview
will
focus
on
notable
examples
that
tackle
important
issues,
demonstrating
various
aspects
such
as
design,
synthesis,
morphology,
classification,
use
cutting-edge
applications.
Furthermore,
we
classified
outlined
the
distinctive
characteristics
advanced
nanoscale
particles
hybrid
NMs.
Meanwhile,
emphasize
potential
metal-organic
frameworks
(MOFs),
highly
group
These
MOFs
gained
recognition
promising
candidates
for
bio-applications,
bioimaging,
biosensing,
antiviral
therapy,
anticancer
nanomedicines,
theranostics,
immunotherapy,
photodynamic
photothermal
gene
Although
shown
great
field,
clinical
is
still
limited
by
issues
stability,
cytotoxicity,
biocompatibility,
health
concerns.
review
article
provides
thorough
analysis
offering
valuable
insights
researchers
investigating
explore
new
development,
expansion
opportunities.
Remarkably,
ponder
prospects
nanocomposites
conjunction
with
current
technology.
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
21(4), С. 1591 - 1608
Опубликована: Фев. 23, 2024
The
perpetuity
of
cancer
prevalence
at
a
global
level
calls
for
development
novel
therapeutic
approaches
with
improved
targetability
and
reduced
adverse
effects.
Conventional
treatments
have
multitude
limitations
such
as
nonselectivity,
invasive
nature,
severe
Chemotherapy
is
also
losing
its
efficacy
because
the
multidrug
resistance
in
majority
cancers.
To
address
these
issues,
selective
targeting-based
are
being
explored
an
effective
treatment.
Mitochondria,
moderator
crucial
cellular
pathways
like
metabolism,
apoptosis,
reactive
oxygen
species
(ROS)
homeostasis,
targeting
site.
Mitochondria-targeted
photodynamic
therapy
(PDT)
has
arisen
potential
approach
this
endeavor.
By
designing
photosensitizers
(PSs)
that
preferentially
accumulate
mitochondria,
PDT
offers
localized
technique
to
induce
cytotoxicity
cells.
In
review,
we
intend
explore
principles
challenges
associated
mitochondria-targeted
PDT,
including
variability
mitochondrial
function,
mitochondria-specific
PSs,
targeted
nanocarrier-based
monotherapy,
combination
therapies.
hurdles
faced
by
emerging
strategy
respect
safety,
optimization,
clinical
translation,
scalability
discussed.
Nonetheless,
exhibits
significant
capacity
treatment,
especially
other
modalities.
With
perpetual
research
technological
advancements,
treatment
great
addition
arsenal
options,
providing
better
tumor
while
reducing
damage
surrounding
healthy
tissues.
This
review
emphasizes
current
status
limitations,
future
prospects
pursuit
safe
efficacious
therapy.
ACS Applied Bio Materials,
Год журнала:
2023,
Номер
6(11), С. 4504 - 4517
Опубликована: Окт. 13, 2023
Cancer
phototherapy,
including
photodynamic
therapy
(PDT)
and
photothermal
(PTT),
has
been
extensively
studied
in
recent
years
because
of
its
noninvasive
properties,
high
efficiency,
improved
selectivity,
reduced
side
effects.
Gold
nanoclusters
(AuNCs)
have
the
advantages
biocompatibility,
biosafety,
excellent
photoresponse,
tumor
penetration
ability.
This
review
analyzes
use
AuNCs
phototherapy
from
three
aspects,
namely,
PDT,
PTT,
combination
therapy,
presents
potential
cancer
phototherapy.
aims
to
provide
readers
with
unique
advantages,
diversified
application
approaches,
bright
prospects
insights
into
strategies
for
applying
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(1)
Опубликована: Янв. 1, 2024
Abstract
Cancer
presents
a
formidable
challenge,
necessitating
innovative
therapies
that
maximize
effectiveness
while
minimizing
harm
to
healthy
tissues.
Nanotechnology
has
emerged
as
transformative
force
in
cancer
treatment,
particularly
through
nano‐enabled
photodynamic
therapy
(NE‐PDT),
which
leverages
precise
and
targeted
interventions.
NE‐PDT
capitalizes
on
photosensitizers
activated
by
light
generate
reactive
oxygen
species
(ROS)
initiate
apoptotic
pathways
cells.
Nanoparticle
enhancements
optimize
this
process,
improving
drug
delivery,
selectivity,
ROS
production
within
tumors.
This
review
dissects
NE‐PDT's
mechanistic
framework,
showcasing
its
potential
harness
apoptosis
potent
tool
therapy.
Furthermore,
the
explores
synergy
between
complementary
treatments
like
chemotherapy,
immunotherapy,
therapies,
highlighting
amplify
responses,
enhance
immune
recognition
of
cells,
inhibit
resistance
mechanisms.
Preclinical
clinical
advancements
demonstrate
efficacy
across
various
types.
Challenges
translating
into
practice
are
also
addressed,
emphasizing
need
for
optimizing
nanoparticle
design,
refining
dosimetry,
ensuring
long‐term
safety.
Ultimately,
represents
promising
approach
therapy,
utilizing
intricate
mechanisms
address
therapeutic
hurdles.
The
underscores
importance
understanding
interplay
nanoparticles,
generation,
pathways,
contributing
deeper
comprehension
biology
novel
strategies.
As
interdisciplinary
collaborations
continue
thrive,
offers
hope
effective
interventions,
where
manipulation
becomes
central
conquering
cancer.
article
is
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Nanomedicine
Oncologic
Disease
ACS Macro Letters,
Год журнала:
2024,
Номер
13(3), С. 288 - 295
Опубликована: Фев. 18, 2024
We
report
a
facile
stimuli-responsive
strategy
to
generate
reactive
oxygen
and
nitrogen
species
(ROS
RNS)
in
the
biological
milieu
from
photocleavable
water-soluble
block
copolymer
under
visible
light
irradiation
(427
nm,
2.25
mW/cm2).
An
anthraquinone-based
polymeric
nitric
oxide
(NO)
donor
(BCPx-NO)
is
synthesized,
which
exhibits
NO
release
range
of
40–65
μM
within
10
h
photoirradiation
with
half-life
30–103
min.
Additionally,
BCPx-NO
produces
peroxynitrite
(ONOO–)
singlet
(1O2)
photoirradiation.
To
understand
mechanism
photolysis
functional
group
blue
light,
we
prepared
small-molecule
N-nitrosamine
(NOD).
The
cellular
investigation
effect
spatiotemporally
controlled
ONOO–
1O2
generation
nanoparticles
triple
negative
breast
adenocarcinoma
(MDA-MB-231)
(white
5.83
mW/cm2;
total
dose
31.5
J/cm2)
showed
an
IC50
0.6
mg/mL.
using
photolabile
employed
ROS
RNS
setting
widens
horizon
for
their
potential
cancer
therapy.
ACS Nano,
Год журнала:
2023,
Номер
17(21), С. 20776 - 20803
Опубликована: Окт. 24, 2023
External
light
sources,
such
as
lasers,
emitting
diodes
(LEDs)
and
lamps,
are
widely
applied
in
photodynamic
therapy
(PDT);
however,
their
use
is
severely
limited
by
the
nature
of
shallow
tissue
penetration
depth.
The
recent
exploration
delivery
or
local
generation
on
tumor
sites
has
attracted
much
attention,
owing
to
fact
that
these
systems
significantly
endowed
with
high
penetration.
In
this
review,
we
briefly
introduced
principle
"on-spot
systems"
PDT.
These
divided
into
different
categories:
(1)
implantable
luminescence,
(2)
mechanoluminescence,
(3)
electrochemiluminescence,
(4)
Cerenkov
(5)
chemiluminescence,
(6)
bioluminescence.
Finally,
applications,
advantages,
disadvantages
PDT
will
be
appropriately
summarized
further
discussed
detail.
We
believe
review
provide
general
guidance
for
design
clinical
studies
PDT-mediated
cancer
treatments
unparalleled
merits.
