Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(27), P. 13050 - 13060
Published: Jan. 1, 2024
Supramolecular
hydrogels
serve
as
an
excellent
platform
to
enable
in
situ
reactive
oxygen
species
(ROS)
generation
while
maintaining
controlled
localized
conditions,
thereby
mitigating
cytotoxicity.
Herein,
we
demonstrate
hydrogel
formation
using
guanosine-5'-monophosphate
(GMP)
with
tetra(4-carboxylphenyl)
ethylene
(1)
exhibit
aggregation-induced
emission
(AIE)
and
tunable
mechanical
strength
the
presence
of
divalent
metal
ions
such
Ca2+,
Mg2+,
Fe2+.
The
addition
leads
structural
transformation
metallogels
(M-1GMP).
Furthermore,
incorporation
Fe2+
into
(Fe-1GMP)
promotes
Fenton
reaction
that
could
be
upregulated
upon
adding
ascorbic
acid
(AA),
demonstrating
antibacterial
efficacy
via
ROS
generation.
In
vitro
studies
on
AA-loaded
Fe-1GMP
bacterial
killing
against
E.
coli,
S.
aureus
vancomycin-resistant
enterococci
(VRE)
strains.
Finally,
vivo
involving
topical
administration
Balb/c
mice
skin
infections
further
suggest
potential
hydrogel.
Taken
together,
its
unique
combination
tunability,
capability
can
used
for
biomedical
applications,
particularly
wound
healing
infection
control.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: March 21, 2024
Abstract
Photodynamic
therapy
(PDT)
is
a
promising
cancer
treatment
but
has
limitations
due
to
its
dependence
on
oxygen
and
high-power-density
photoexcitation.
Here,
we
report
polymer-based
organic
photosensitizers
(PSs)
through
rational
PS
skeleton
design
precise
side-chain
engineering
generate
•O
2
−
•OH
under
oxygen-free
conditions
using
ultralow-power
808
nm
photoexcitation
for
tumor-specific
photodynamic
ablation.
The
designed
skeletons
can
electron-hole
pairs
sensitize
H
O
into
with
photoexcitation,
achieving
NIR-photoexcited
oxygen-independent
production.
Further,
compared
commonly
used
alkyl
side
chains,
glycol
oligomer
as
the
chain
mitigates
recombination
offers
more
molecules
around
generated
from
hydrophobic
skeletons,
which
yield
4-fold
stronger
production,
thus
allowing
an
high
PDT
effect.
Finally,
feasibility
of
developing
activatable
PSs
in
female
mice
further
demonstrated
irradiation
15
mW
cm
−2
.
study
not
only
provides
insights
mechanism
also
general
guideline
develop
NIR
PDT.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 868 - 868
Published: March 7, 2023
The
new
era
of
nanomedicine
offers
significant
opportunities
for
cancer
diagnostics
and
treatment.
Magnetic
nanoplatforms
could
be
highly
effective
tools
diagnosis
treatment
in
the
future.
Due
to
their
tunable
morphologies
superior
properties,
multifunctional
magnetic
nanomaterials
hybrid
nanostructures
can
designed
as
specific
carriers
drugs,
imaging
agents,
theranostics.
Multifunctional
are
promising
theranostic
agents
due
ability
diagnose
combine
therapies.
This
review
provides
a
comprehensive
overview
development
advanced
combining
optical
providing
photoresponsive
platforms
medical
applications.
Moreover,
this
discusses
various
innovative
developments
using
nanostructures,
including
drug
delivery,
treatment,
tumor-specific
ligands
that
deliver
chemotherapeutics
or
hormonal
resonance
imaging,
tissue
engineering.
Additionally,
artificial
intelligence
(AI)
used
optimize
material
properties
based
on
predicted
interactions
with
cell
membranes,
vasculature,
biological
fluid,
immune
system
enhance
effectiveness
therapeutic
agents.
Furthermore,
an
AI
approaches
assess
practical
utility
Finally,
presents
current
knowledge
perspectives
systems
models.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(3), P. e25521 - e25521
Published: Feb. 1, 2024
Nanomaterials
(NMs)
have
garnered
significant
attention
in
recent
decades
due
to
their
versatile
applications
a
wide
range
of
fields.
Thanks
tiny
size,
enhanced
surface
modifications,
impressive
volume-to-surface
area
ratio,
magnetic
properties,
and
customized
optical
dispersion.
NMs
experienced
an
incredible
upsurge
biomedical
including
diagnostics,
therapeutics,
drug
delivery.
This
minireview
will
focus
on
notable
examples
that
tackle
important
issues,
demonstrating
various
aspects
such
as
design,
synthesis,
morphology,
classification,
use
cutting-edge
applications.
Furthermore,
we
classified
outlined
the
distinctive
characteristics
advanced
nanoscale
particles
hybrid
NMs.
Meanwhile,
emphasize
potential
metal-organic
frameworks
(MOFs),
highly
group
These
MOFs
gained
recognition
promising
candidates
for
bio-applications,
bioimaging,
biosensing,
antiviral
therapy,
anticancer
nanomedicines,
theranostics,
immunotherapy,
photodynamic
photothermal
gene
Although
shown
great
field,
clinical
is
still
limited
by
issues
stability,
cytotoxicity,
biocompatibility,
health
concerns.
review
article
provides
thorough
analysis
offering
valuable
insights
researchers
investigating
explore
new
development,
expansion
opportunities.
Remarkably,
ponder
prospects
nanocomposites
conjunction
with
current
technology.
Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(4), P. 1591 - 1608
Published: Feb. 23, 2024
The
perpetuity
of
cancer
prevalence
at
a
global
level
calls
for
development
novel
therapeutic
approaches
with
improved
targetability
and
reduced
adverse
effects.
Conventional
treatments
have
multitude
limitations
such
as
nonselectivity,
invasive
nature,
severe
Chemotherapy
is
also
losing
its
efficacy
because
the
multidrug
resistance
in
majority
cancers.
To
address
these
issues,
selective
targeting-based
are
being
explored
an
effective
treatment.
Mitochondria,
moderator
crucial
cellular
pathways
like
metabolism,
apoptosis,
reactive
oxygen
species
(ROS)
homeostasis,
targeting
site.
Mitochondria-targeted
photodynamic
therapy
(PDT)
has
arisen
potential
approach
this
endeavor.
By
designing
photosensitizers
(PSs)
that
preferentially
accumulate
mitochondria,
PDT
offers
localized
technique
to
induce
cytotoxicity
cells.
In
review,
we
intend
explore
principles
challenges
associated
mitochondria-targeted
PDT,
including
variability
mitochondrial
function,
mitochondria-specific
PSs,
targeted
nanocarrier-based
monotherapy,
combination
therapies.
hurdles
faced
by
emerging
strategy
respect
safety,
optimization,
clinical
translation,
scalability
discussed.
Nonetheless,
exhibits
significant
capacity
treatment,
especially
other
modalities.
With
perpetual
research
technological
advancements,
treatment
great
addition
arsenal
options,
providing
better
tumor
while
reducing
damage
surrounding
healthy
tissues.
This
review
emphasizes
current
status
limitations,
future
prospects
pursuit
safe
efficacious
therapy.
ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(11), P. 4504 - 4517
Published: Oct. 13, 2023
Cancer
phototherapy,
including
photodynamic
therapy
(PDT)
and
photothermal
(PTT),
has
been
extensively
studied
in
recent
years
because
of
its
noninvasive
properties,
high
efficiency,
improved
selectivity,
reduced
side
effects.
Gold
nanoclusters
(AuNCs)
have
the
advantages
biocompatibility,
biosafety,
excellent
photoresponse,
tumor
penetration
ability.
This
review
analyzes
use
AuNCs
phototherapy
from
three
aspects,
namely,
PDT,
PTT,
combination
therapy,
presents
potential
cancer
phototherapy.
aims
to
provide
readers
with
unique
advantages,
diversified
application
approaches,
bright
prospects
insights
into
strategies
for
applying
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Jan. 1, 2024
Abstract
Cancer
presents
a
formidable
challenge,
necessitating
innovative
therapies
that
maximize
effectiveness
while
minimizing
harm
to
healthy
tissues.
Nanotechnology
has
emerged
as
transformative
force
in
cancer
treatment,
particularly
through
nano‐enabled
photodynamic
therapy
(NE‐PDT),
which
leverages
precise
and
targeted
interventions.
NE‐PDT
capitalizes
on
photosensitizers
activated
by
light
generate
reactive
oxygen
species
(ROS)
initiate
apoptotic
pathways
cells.
Nanoparticle
enhancements
optimize
this
process,
improving
drug
delivery,
selectivity,
ROS
production
within
tumors.
This
review
dissects
NE‐PDT's
mechanistic
framework,
showcasing
its
potential
harness
apoptosis
potent
tool
therapy.
Furthermore,
the
explores
synergy
between
complementary
treatments
like
chemotherapy,
immunotherapy,
therapies,
highlighting
amplify
responses,
enhance
immune
recognition
of
cells,
inhibit
resistance
mechanisms.
Preclinical
clinical
advancements
demonstrate
efficacy
across
various
types.
Challenges
translating
into
practice
are
also
addressed,
emphasizing
need
for
optimizing
nanoparticle
design,
refining
dosimetry,
ensuring
long‐term
safety.
Ultimately,
represents
promising
approach
therapy,
utilizing
intricate
mechanisms
address
therapeutic
hurdles.
The
underscores
importance
understanding
interplay
nanoparticles,
generation,
pathways,
contributing
deeper
comprehension
biology
novel
strategies.
As
interdisciplinary
collaborations
continue
thrive,
offers
hope
effective
interventions,
where
manipulation
becomes
central
conquering
cancer.
article
is
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Nanomedicine
Oncologic
Disease
ACS Macro Letters,
Journal Year:
2024,
Volume and Issue:
13(3), P. 288 - 295
Published: Feb. 18, 2024
We
report
a
facile
stimuli-responsive
strategy
to
generate
reactive
oxygen
and
nitrogen
species
(ROS
RNS)
in
the
biological
milieu
from
photocleavable
water-soluble
block
copolymer
under
visible
light
irradiation
(427
nm,
2.25
mW/cm2).
An
anthraquinone-based
polymeric
nitric
oxide
(NO)
donor
(BCPx-NO)
is
synthesized,
which
exhibits
NO
release
range
of
40–65
μM
within
10
h
photoirradiation
with
half-life
30–103
min.
Additionally,
BCPx-NO
produces
peroxynitrite
(ONOO–)
singlet
(1O2)
photoirradiation.
To
understand
mechanism
photolysis
functional
group
blue
light,
we
prepared
small-molecule
N-nitrosamine
(NOD).
The
cellular
investigation
effect
spatiotemporally
controlled
ONOO–
1O2
generation
nanoparticles
triple
negative
breast
adenocarcinoma
(MDA-MB-231)
(white
5.83
mW/cm2;
total
dose
31.5
J/cm2)
showed
an
IC50
0.6
mg/mL.
using
photolabile
employed
ROS
RNS
setting
widens
horizon
for
their
potential
cancer
therapy.
