Multifunctional Hydrogels for the Healing of Diabetic Wounds

Advanced Healthcare Materials, Год журнала: 2023, Номер 13(1)

Опубликована: Сен. 13, 2023

Abstract The healing of diabetic wounds is hindered by various factors, including bacterial infection, macrophage dysfunction, excess proinflammatory cytokines, high levels reactive oxygen species, and sustained hypoxia. These factors collectively impede cellular behaviors the process. Consequently, this review presents intelligent hydrogels equipped with multifunctional capacities, which enable them to dynamically respond microenvironment accelerate wound in ways, stimuli ‐responsiveness, injectable self‐healing, shape ‐memory, conductive real‐time monitoring properties. relationship between multiple functions also discussed. Based on wounds, antibacterial, anti‐inflammatory, immunomodulatory, antioxidant, pro‐angiogenic strategies are combined hydrogels. application repair systematically discussed, aiming provide guidelines for fabricating exploring role therapeutic processes.

Язык: Английский

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Hyaluronic Acid‐Based Reactive Oxygen Species‐Responsive Multifunctional Injectable Hydrogel Platform Accelerating Diabetic Wound Healing

Advanced Healthcare Materials, Год журнала: 2023, Номер 13(4)

Опубликована: Ноя. 9, 2023

Diabetic wounds are more likely to develop into complex and severe chronic wounds. The objective of this study is assess a reactive oxygen species (ROS)-responsive multifunctional injectable hydrogel for the purpose diabetic wound healing. A (HA@Cur@Ag) successfully synthesized with dual antioxidant, antibacterial, anti-inflammatory properties by crosslinking thiol hyaluronic acid (SH-HA) disulfide-bonded hyperbranched polyethylene glycol (HB-PBHE) through Michael addition; while, incorporating curcumin liposomes silver nanoparticles (AgNPs). HA@Cur@Ag exhibits favorable biocompatibility, degradability, injectivity. outcomes in vitro vivo experiments demonstrate that can effectively be loaded release liposomes, as well ions, thereby facilitating healing multiple mechanisms, including ROS scavenging, bactericidal activity, effects, promotion angiogenesis. Transcriptome sequencing reveals suppresses activation tumour necrosis factor (TNF)/nuclear κB (NF-κB) pathway ameliorate oxidative stress inflammation These findings suggest ROS-responsive hydrogel, which possesses ability precisely coordinate integrate intricate biological molecular processes involved healing, notable potential expediting

Язык: Английский

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Herbal concoction Unveiled: A computational analysis of phytochemicals' pharmacokinetic and toxicological profiles using novel approach methodologies (NAMs)

Current Research in Toxicology, Год журнала: 2023, Номер 5, С. 100118 - 100118

Опубликована: Янв. 1, 2023

Herbal medications have an extensive history of use in treating various diseases, attributed to their perceived efficacy and safety. Traditional medicine practitioners contemporary healthcare providers shown particular interest herbal syrups, especially for respiratory illnesses associated with the SARS-CoV-2 virus. However, current understanding pharmacokinetic toxicological properties phytochemicals these mixtures is limited. This study presents a comprehensive computational analysis utilizing novel approach methodologies (NAMs) investigate profiles syrup, leveraging in-silico techniques prediction tools such as PubChem, SwissADME, Molsoft's database. Although molecular dynamics, docking, broader system-wide analyses were not considered, future studies hold potential further investigation areas. By combining drug-likeness simulation, researchers identify diverse suitable complex medication development examining pharmacokinetic-toxicological phytopharmaceutical syrup. The focuses on solutions infections, goal adding pool all-natural treatments ailments. research has revolutionize environmental alternative by models innovative analytical enhanced therapeutic benefits explore network-based systems biology approaches deeper interactions biological systems. Overall, our offers valuable insights into concoction. paves way advancements medicine. we acknowledge need address aforementioned topics that adequately covered this research.

Язык: Английский

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Advancing Predictive Risk Assessment of Chemicals via Integrating Machine Learning, Computational Modeling, and Chemical/Nano‐Quantitative Structure‐Activity Relationship Approaches

Advanced Intelligent Systems, Год журнала: 2024, Номер 6(4)

Опубликована: Фев. 14, 2024

The escalating use of novel chemicals and nanomaterials (NMs) across diverse sectors underscores the need for advanced risk assessment methods to safeguard human health environment. Traditional labor‐intensive approaches have given way computational methods. This review integrates recent developments in chemical nano‐quantitative structure‐activity relationship (QSAR) with machine learning modeling, offering a comprehensive predictive NMs chemicals. It explores nanodescriptors, their role predicting toxicity, amalgamation algorithms nano‐QSAR improved accuracy. article also investigates modeling techniques like molecular dynamics simulations, docking, mechanics/quantum mechanics physical properties. By consolidating these approaches, advocates more accurate efficient means assessing risks associated NMs/chemicals, promoting safe utilization minimizing adverse effects on A valuable resource researchers practitioners, informed decision‐making, advancing our understanding potential risks, is facilitated. Beyond studying systems at various scales, data from sources, enhancing accuracy fostering NMs/chemicals while impact

Язык: Английский

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Nanotechnology in healthcare, and its safety and environmental risks

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 15, 2024

Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract

Язык: Английский

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Harmonization Risks and Rewards: Nano-QSAR for Agricultural Nanomaterials

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(6), С. 2835 - 2852

Опубликована: Фев. 5, 2024

This comprehensive review explores the emerging landscape of Nano-QSAR (quantitative structure–activity relationship) for assessing risk and potency nanomaterials in agricultural settings. The paper begins with an introduction to Nano-QSAR, providing background rationale, explicitly states hypotheses guiding review. study navigates through various dimensions nanomaterial applications agriculture, encompassing their diverse properties, types, associated challenges. Delving into principles QSAR nanotoxicology, this article elucidates its application evaluating safety nanomaterials, while addressing unique limitations posed by these materials. narrative then transitions progression context exemplified insightful case studies that highlight both strengths inherent methodology. Emerging prospects hurdles tied agriculture are rigorously examined, casting light on important pathways forward, existing constraints, avenues research enhancement. Culminating a synthesis key insights, underscores significance shaping future nanoenabled agriculture. It provides strategic guidance steer forthcoming endeavors dynamic field.

Язык: Английский

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Navigating regulatory challenges in molecularly tailored nanomedicine

Опубликована: Апрель 25, 2024

Nanomedicine, a convergence of nanotechnology and medical sciences, has unleashed transformative potential in healthcare. However, harnessing the benefits nanomedicine requires thorough understanding its regulatory landscape. An in-depth discussion considerations, including molecular safety assessment, harmonization landscape, shaping future innovation, is presented this discourse. The assessment entails evaluating interactions between nanoparticles biomolecules, ensuring compatibility at level. Harmonization involves developing international standards guidelines for consistent approach, while innovations emphasizes integrating assessments into early stages development. Challenges encompass need standardized methods, balancing innovation with safety, addressing unique features novel designs. As landscape evolves, effective strategies must navigate intricate interplay molecules technologies, both patient access product safety.

Язык: Английский

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Leveraging Administrative Health Databases to Address Health Challenges in Farming Populations: Scoping Review and Bibliometric Analysis (1975-2024)

JMIR Public Health and Surveillance, Год журнала: 2025, Номер 11, С. e62939 - e62939

Опубликована: Янв. 9, 2025

Background Although agricultural health has gained importance, to date, much of the existing research relies on traditional epidemiological approaches that often face limitations related sample size, geographic scope, temporal coverage, and range events examined. To address these challenges, a complementary approach involves leveraging reusing data beyond its original purpose. Administrative databases (AHDs) are increasingly reused in population-based digital public health, especially for populations such as farmers, who distinct environmental risks. Objective We aimed explore reuse AHDs addressing issues within farming by summarizing current landscape AHD-based identifying key areas interest, gaps, unmet needs. Methods conducted scoping review bibliometric analysis using PubMed Web Science. Building upon previous reviews research, we comprehensive literature search 72 terms population AHDs. identify hot spots, directions, used keyword frequency, co-occurrence, thematic mapping. also explored profile exposome mapping co-occurrences between factors outcomes. Results Between 1975 April 2024, 296 publications across 118 journals, predominantly from high-income countries, were identified. Nearly one-third associated with well-established cohorts, Agriculture Cancer Agricultural Health Study. The most frequently included disease registers (158/296, 53.4%), electronic records (124/296, 41.9%), insurance claims (106/296, 35.8%), (95/296, 32.1%), hospital discharge (41/296, 13.9%). Fifty (16.9%) studies involved >1 million participants. broad exposure proxies used, (254/296, 85.8%) relied proxies, which failed capture specifics tasks. Research remains underexplored, predominant focus specific external exposome, particularly pesticide exposure. A limited have been examined, primarily cancer, mortality, injuries. Conclusions increasing use holds major potential advance populations. However, substantial gaps persist, low-income regions among underrepresented subgroups, women, children, contingent workers. Emerging issues, including per- polyfluoroalkyl substances, biological agents, microbiome, microplastics, climate change, warrant further research. Major persist understanding various conditions, cardiovascular, reproductive, ocular, sleep-related, age-related, autoimmune diseases. Addressing overlooked is essential comprehending risks faced communities guiding policies. Within this context, promoting conjunction other sources (eg, mobile social data, wearables) artificial intelligence approaches, represents promising avenue future exploration.

Язык: Английский

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Perspective on Quantitative Structure–Toxicity Relationship (QSTR) Models to Predict Hepatic Biotransformation of Xenobiotics

Livers, Год журнала: 2023, Номер 3(3), С. 448 - 462

Опубликована: Авг. 30, 2023

Biotransformation refers to the metabolic conversion of endogenous and xenobiotic chemicals into more hydrophilic substances. Xenobiotic biotransformation is accomplished by a restricted number enzymes with broad substrate specificities. The xenobiotics catalyzed various enzyme systems that can be divided four categories based on reaction they catalyze. primary concentration in cytochrome P450, while CYP responsible for are located within hepatic endoplasmic reticulum (microsomes). Cytochrome P450 (CYP450) also present extrahepatic tissues. Enzymes catalyzing reactions often determine intensity duration action drugs play key role chemical toxicity tumorigenesis. structure given biotransforming may differ among individuals, which cause differences rates biotransformation. study molecular mechanisms underlying liver injury fundamental preventing or devising new modalities treatment using chemicals. Active metabolites arise from parent drug compound one xenobiotic-processing generate different pharmacological toxicological properties. Understanding how exogenous (xenobiotics) metabolized, distributed, eliminated critical determining impact these compounds human health. Computational tools such as Biotransformer have been developed predict all possible enzymatic profiles linked production metabolites. construction metabolism maps capable binding DNA.

Язык: Английский

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Journey of micronanoplastics with blood components

RSC Advances, Год журнала: 2023, Номер 13(45), С. 31435 - 31459

Опубликована: Янв. 1, 2023

Micronanoplastics (MNPs) interact with blood components, resulting in anemia, cardiovascular diseases, etc. Research gaps include toxic impacts of real-world MNPs, monomers, co-pollutants complex, and so on, emphasizing the need for more research.

Язык: Английский

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