Nanotechnology in healthcare, and its safety and environmental risks

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 15, 2024

Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract

Язык: Английский

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Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts

Cancer Nanotechnology, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 17, 2025

Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.

Язык: Английский

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Exploring NP-GLIDE coatings: A leap forward in the innovation of omniphobic surfaces

Reactive and Functional Polymers, Год журнала: 2024, Номер 205, С. 106050 - 106050

Опубликована: Сен. 11, 2024

Язык: Английский

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AI and ML-based risk assessment of chemicals: predicting carcinogenic risk from chemical-induced genomic instability

Frontiers in Toxicology, Год журнала: 2024, Номер 6

Опубликована: Ноя. 26, 2024

Chemical risk assessment plays a pivotal role in safeguarding public health and environmental safety by evaluating the potential hazards risks associated with chemical exposures. In recent years, convergence of artificial intelligence (AI), machine learning (ML), omics technologies has revolutionized field assessment, offering new insights into toxicity mechanisms, predictive modeling, management strategies. This perspective review explores synergistic AI/ML deciphering clastogen-induced genomic instability for carcinogenic prediction. We provide an overview key findings, challenges, opportunities integrating highlighting successful applications case studies across diverse sectors. From predicting genotoxicity mutagenicity to elucidating molecular pathways underlying carcinogenesis, integrative approaches offer comprehensive framework understanding exposures mitigating risks. Future perspectives advancing cancer prevention through data integration, advanced techniques, translational research, policy implementation are discussed. By implementing capabilities technologies, researchers policymakers can enhance protection, inform regulatory decisions, promote sustainable development healthier future.

Язык: Английский

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Integrated approaches for immunotoxicity risk assessment: challenges and future directions

Deleted Journal, Год журнала: 2024, Номер 1(1)

Опубликована: Окт. 29, 2024

The integration of immunotoxicity data into chemical risk assessment paradigms is essential for comprehensively evaluating the potential health hazards posed by exposures. This review provides a comprehensive overview methodologies, challenges, and future directions integrating frameworks. It discusses fundamental principles immunotoxicology its relevance to assessment, highlighting critical roles immune system in defense against harmful agents. Next, we explore traditional frameworks, including exposure hazard identification, dose–response characterization, need incorporating endpoints enhance characterization estimation. Subsequently, delve modelling immunotoxicity, elucidating principles, methods, case studies illustrating relationships extrapolation from animal humans. Furthermore, discuss focusing on identification immunotoxic hazards, evaluation endpoints, utilization immunological biomarkers assessment. We then examine cumulative strategies, presenting conceptual framework assessing risks multiple exposures methods different chemicals. Lastly, emerging trends high-throughput screening assays, omics technologies, computational modelling, alternative testing along with regulatory implications research needs. valuable insights researchers, regulators, stakeholders involved public protection, facilitating development evidence-based strategies safeguarding human associated

Язык: Английский

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Macro/Microgel‐Encapsulated, Biofilm‐Armored Living Probiotic Platform for Regenerating Bacteria‐Infected Diabetic Wounds

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Abstract Infectious diabetic wounds pose an arduous threat to contemporary healthcare. The combination of refractory biofilms, persistent inflammation, and retarded angiogenesis can procure non‐unions life‐threatening complications, calling for advanced therapeutics potent orchestrate anti‐infective effectiveness, benign biocompatibility, pro‐reparative immunomodulation, angiogenic regeneration. Herein, embracing the emergent “living bacterial therapy” paradigm, a designer probiotic‐in‐hydrogel wound dressing platform is demonstrated. constructed employing “macrogel/microgel/biofilm” hierarchical encapsulation strategy, with Lactobacillus casei as model probiotic. Alginate gels, in both macro micro forms, along self‐produced probiotic served encapsulating agents. Specifically, live probiotics are enclosed within alginate microspheres, embedded into bulk matrix, cultivated facilitate biofilm self‐encasing. This multiscale confinement protected averted their inadvertent escape, while enabling sustained secretion, proper reservation, localized delivery therapeutically active metabolites, such lactic acid. resulting biosystem, validated vitro/ovo/vivo, elicited well‐balanced antibacterial activities biological compatibility, alongside prominent pro‐healing, vasculogenic anti‐inflammatory potencies, thus accelerating regeneration infected full‐thickness excisional mice. Such multiple encapsulation‐engineered “all‐in‐one” tactic may shed new light on safe efficient adoption bacteria treating chronic infectious diseases.

Язык: Английский

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Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Abstract Unexpected toxicity has become a significant obstacle to drug candidate development, accounting for 30% of discovery failures. Traditional assessment through animal testing is costly and time‐consuming. Big data artificial intelligence (AI), especially machine learning (ML), are robustly contributing innovation progress in toxicology research. However, the optimal AI model different types usually varies, making it essential conduct comparative analyses methods across domains. The diverse sources also pose challenges researchers focusing on specific studies. In this review, 10 categories drug‐induced examined, summarizing characteristics applicable ML models, including both predictive interpretable algorithms, striking balance between breadth depth. Key databases tools used prediction highlighted, toxicology, chemical, multi‐omics, benchmark databases, organized by their focus function clarify roles prediction. Finally, strategies turn into opportunities analyzed discussed. This review may provide with valuable reference understanding utilizing available resources bridge mechanistic insights, further advance application drugs‐induced

Язык: Английский

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Innovations in Functional Materials and Advanced Imaging Techniques for Targeting Extramural Venous Invasion (EMVI) in Colorectal Cancer: A Comprehensive Review

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Язык: Английский

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The Dawn of a New Pharmaceutical Epoch: Can AI and Robotics Reshape Drug Formulation?

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(29)

Опубликована: Авг. 18, 2024

Abstract Over the last four decades, pharmaceutical companies’ expenditures on research and development have increased 51‐fold. During this same time, clinical success rates for new drugs remained unchanged at about 10 percent, predominantly due to lack of efficacy and/or safety concerns. This persistent problem underscores need innovate across entire drug process, particularly in formulation, which is often deprioritized under‐resourced.

Язык: Английский

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Imiquimod-Loaded Nanosystem for Treatment Human Papillomavirus-Induced Lesions

Pharmaceutics, Год журнала: 2024, Номер 16(7), С. 864 - 864

Опубликована: Июнь 27, 2024

Human papillomavirus (HPV)-associated cervical cancer is the most common among women worldwide. The treatment options are strongly related to increased infertility in women. Imiquimod (IQ) an imidazoquinoline, which has proven antiviral effects against persistent HPV infection by activating immune cells via Toll-like receptors 7/8 when formulated carriers, like nanogels, for topical use. An effective alternative conventional therapies nanoparticle drug delivery system. We studied lipidic nanoparticles with IQ (Lipo IQ) and functionalized them a DNA aptamer, AT11 AT11), improve selectivity combined efficacy of essential oils. formulations showed that physicochemical properties adequate vaginal have antimicrobial activity at higher concentrations (with MIC50 starting from 0.625%). final exhibited cytotoxicity cells, enhanced oils without affecting healthy resulting less than 10% cell viability HeLa over 60% NHDF cells. Essential potentiate Lipo IQ’s effectiveness, while increases As suggested results permeation assay, were internalized Overall, obtained synergistic effect nanosystem cytotoxic promotes towards

Язык: Английский

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