Proceedings of the National Academy of Sciences,
Год журнала:
2025,
Номер
122(16)
Опубликована: Апрель 16, 2025
Most
bioorthogonal
photouncaging
reactions
preferentially
occur
in
polar
environments
to
accommodate
biological
applications
the
aqueous
cellular
milieu.
However,
they
are
not
precisely
designed
chemically
adapt
diverse
microenvironments
of
cell.
Herein,
we
report
a
hydrophobic
reaction
with
tailored
photolytic
kinetics
toward
solvent
polarity.
Structural
modulations
aminobenzoquinone-based
photocage
reveal
impact
cyclic
ring
size,
steric
substituent,
and
electronic
substituent
on
individual
uncaging
(
k
H2O
dioxane
)
polarity
preference
/
).
Rational
incorporation
optimized
moieties
leads
up
20.2-fold
nonpolar
kinetic
selectivity
Further
photochemical
spectroscopic
characterizations
theoretical
calculations
together
uncover
mechanism
underlying
polarity-dependent
kinetics.
The
uncaged
ortho-quinone
methide
product
bears
covalent
reactivity
nucleophiles
protein
revealed
by
tandem
mass
spectrometry.
Finally,
demonstrate
application
such
lipophilic
chemistry
selective
labeling
profiling
proteins
proximity
lipid
droplets
inside
human
fatty
liver
tissues.
Together,
this
work
studies
effects
adapts
it
suborganelle-targeted
profiling.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(8), С. 3976 - 4019
Опубликована: Янв. 1, 2024
This
review
focuses
on
the
design
strategy,
spectroscopic
characteristics,
and
functionalization
of
mitochondrion-targeted
BODIPY
dyes,
providing
an
overview
these
dyes
for
bioimaging
photodynamic
therapy.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(32)
Опубликована: Апрель 3, 2024
Abstract
Thin‐film
fluorescent
sensors
play
critical
roles
in
the
gas
sensing
field.
However,
materials
for
practical
applications
are
limited,
because
of
aggregation‐caused
quenching
(ACQ)
effect
and
photobleaching.
This
study
investigates
a
host–guest
thin‐film
fluorescence
sensor
by
incorporating
probe
into
metal–organic
framework
(MOF).
The
molecule
Me
4
BOPHY‐1
acts
as
recognition
neurotoxin
analog
diethylchlorophosphite
(DCP).
MOF
(ZIF‐8)
provides
nanocavities
confinement
guest
molecules,
which
reduces
self‐aggregation
molecules
pre‐enriches
target
gas.
By
applying
ZIF‐8
to
disperse
ACQ
can
be
effectively
overcome.
quantum
efficiency
is
increased
from
0.76%
19.72%,
enables
its
ability
with
fast
response
time
3
s
detection
limit
low
1.13
ppb.
Besides,
facilitates
selectivity
enhancement
through
effect,
weakening
interference
HCl.
Moreover,
also
ensures
high
photo‐stability
well
thermal
stability.
It
maintain
intensity
under
4800
s’
laser
irradiation.
Thus,
design
strategy
offers
3S
(sensitivity,
selectivity,
stability)
toward
analytes.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(15), С. 10993 - 11001
Опубликована: Апрель 5, 2024
Photoreactions
of
(coumarin-4-yl)methyl
derivatives
have
been
extensively
studied
in
many
fields
chemistry,
including
organic
synthesis
and
photoinduced
drug
delivery
systems.
The
identification
the
reaction
intermediates
involved
photoreactions
is
crucial
not
only
for
elucidating
mechanism
but
also
application
photoreactions.
In
this
study,
7-diethylamino(coumarin-4-yl)methyl
thioester
1a
[−SC(O)CH3],
thionoester
1b
[−OC(S)CH3],
ester
1c
[−OC(O)CH3]
were
investigated
to
clarify
intermediary
species
their
chemical
behavior.
While
a
radical
pair
[i.e.,
CH3C(O)S•]
plays
an
important
role
1b,
ion
cation,
CH3CO2–]
was
key
photoreaction
1c.
18O-isotope-labeling
revealed
negligible
recombination
process
within
pair.
unprecedented
observation
rationalized
by
open-shell
character
whose
formation
confirmed
through
product
analysis
transient
absorption
spectroscopy.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(12), С. 8417 - 8424
Опубликована: Март 18, 2024
Photocages
enable
scientists
to
take
full
control
over
the
activity
of
molecules
using
light
as
a
biocompatible
stimulus.
Their
emerging
applications
in
photoactivated
therapies
call
for
efficient
uncaging
near-infrared
(NIR)
window,
which
represents
fundamental
challenge.
Here,
we
report
synthetically
accessible
cyanine
photocages
that
liberate
alcohol,
phenol,
amine,
and
thiol
payloads
upon
irradiation
with
NIR
up
820
nm
aqueous
media.
The
display
unique
chameleon-like
behavior
operate
via
two
distinct
mechanisms:
photooxidation
heterolytic
bond
cleavage.
latter
process
constitutes
first
example
direct
scission
by
single
photon
ever
observed
dyes
or
at
wavelengths
exceeding
800
nm.
Modulation
beating
rates
human
cardiomyocytes
achieved
light-actuated
release
adrenergic
agonist
etilefrine
submicromolar
concentrations
low
doses
(∼12
J
cm
Chemical Communications,
Год журнала:
2024,
Номер
60(45), С. 5770 - 5789
Опубликована: Янв. 1, 2024
This
highlight
reviews
various
strategies
for
constructing
BODIPY-based
photocages,
their
photodecaging
mechanisms,
and
applications
in
the
biomedical
field.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(19)
Опубликована: Апрель 13, 2024
The
emerging
field
of
photopharmacology
is
a
promising
chemobiological
methodology
for
optical
control
drug
activities
that
could
ultimately
solve
the
off-target
toxicity
outside
disease
location
many
drugs
treatment
given
pathology.
use
photolytic
reactions
looks
very
attractive
light-activated
release
but
requires
to
develop
sensitive
red
or
near-infrared
light
excitation
better
tissue
penetration.
This
review
will
present
concepts
triplet-triplet
annihilation
upconversion-based
photolysis
and
their
recent
in
vivo
applications
light-induced
delivery
using
photoactivatable
nanoparticles.
