Intermolecular Assembly of Dual Hydrogen Bonding Regio‐Isomers Generates High‐Performance AIE Probes DOI Open Access
Ziwei Xu,

Bingling Zhang,

Shusen Chen

и другие.

Small, Год журнала: 2024, Номер 20(47)

Опубликована: Авг. 13, 2024

Abstract Regio‐isomers are utilized to design innovative AIE luminogens (AIEgens) by regulating molecular aggregation behavior. However, relevant examples limited, and the underlying mechanism is not fully understood. Herein, a regio‐isomer strategy used develop AIEgens precisely intermolecular interactions in solid state. Among regio‐isomers it investigated, ortho‐ isomer ( DCM‐O3‐O7 ) exhibits enhanced AIE‐activity than para ‐ DCM‐P6 ), size of ortho substituents crucial for performance. The revealed using DFT calculations single‐crystal analysis. Dual hydrogen bonds (C─H∙∙∙π C─H∙∙∙N) generated between molecules, which contributes form dimers, tetramers, 1D supramolecular structures crystal. By restricting intramolecular motion attenuating π – interactions, solid‐state fluorescence significantly enhanced. This strategy's effectiveness validated other donor–acceptor fluorophores, with DCM‐O6 its analogues serving as efficient probes bioimaging applications. Notably, DCM‐OM , bears morpholinyl instead piperidinyl group, displayed strong lysosome‐targeting ability photostability; DCM‐OP incorporated hydrophilic quaternary ammonium exhibited wash‐free imaging cell membrane‐targeting capabilities; nanoparticles enabled high‐fidelity vivo tumor imaging. Therefore, this affords general method designing bright AIEgens.

Язык: Английский

Lithiophilic Covalent Organic Framework as Anode Coating for High‐Performance Lithium Metal Batteries DOI
Xinyu Wu, Shuo‐Qing Zhang, Xiaoyi Xu

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(11)

Опубликована: Янв. 16, 2024

Abstract The growth of disorganized lithium dendrites and weak solid electrolyte interphase greatly impede the practical application metal batteries. Herein, we designed synthesized a new kind stable polyimide covalent organic frameworks (COFs), which have high density well‐aligned lithiophilic quinoxaline phthalimide units anchored within uniform one‐dimensional channels. COFs can serve as an artificial on anode, effectively guiding deposition ions inhibiting dendrites. unsymmetrical Li||COF−Cu battery exhibits Coulombic efficiency 99 % at current 0.5 mA cm −2 , be well retained up to 400 cycles. Meanwhile, Li‐COF||LFP full cell shows over charge 0.3 C. And its capacity maintained 91 even after 150 Therefore, significant electrochemical cycling stability illustrates feasibility employing in solving disordered

Язык: Английский

Процитировано

44
Anthraquinone centers modified covalent organic frameworks for boosted photocatalytic O2-to-H2O2 synthesis: Inhibiting the in-situ decomposition of H2O2 DOI
Yu Luo, Chenchen Liu, Jiahui Liu

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 481, С. 148494 - 148494

Опубликована: Янв. 4, 2024

Язык: Английский

Процитировано

36
Photocatalytic Carbon Dots‐Triggered Pyroptosis for Whole Cancer Cell Vaccines DOI Creative Commons
Quansheng Cheng, Tesen Zhang, Qingcheng Wang

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 12, 2024

Abstract Manufacturing whole cancer cell vaccines (WCCV) with both biosafety and efficacy is crucial for tumor immunotherapy. Pyroptotic cells, due to their highly immunogenic properties, present a promising avenue the development of WCCV. However, successful WCCV based on pyroptotic cells yet be accomplished. Here, facile strategy that utilized photocatalytic carbon dots (CDs) induce pyroptosis fabricating reported. Photocatalytic CDs are capable generating substantial amounts hydroxyl radicals can effectively decrease cytoplasmic pH values under white light irradiation. This process efficiently triggers through reactive oxygen species (ROS)‐mitochondria‐caspase 3‐gasdermin E pathway proton motive force‐driven mitochondrial ATP synthesis pathway. Moreover, in vitro, these CDs‐induced (PCIP) hyperactivate macrophage (M0–M1) upregulation major histocompatibility complex class II expression. In vivo, PCIP induced specific immune‐preventive effects melanoma breast mouse models anticancer immune memory, demonstrating effective work provides novel insights inducing bridges gap fabrication cells.

Язык: Английский

Процитировано

26
Advances in covalent organic frameworks for cancer phototherapy DOI
Nem Singh, Miae Won, Jusung An

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 506, С. 215720 - 215720

Опубликована: Фев. 16, 2024

Язык: Английский

Процитировано

20
Synthesis of single-crystalline sp2-carbon-linked covalent organic frameworks through imine-to-olefin transformation DOI
Shengxu Li, Shunqi Xu, En Lin

и другие.

Nature Chemistry, Год журнала: 2025, Номер 17(2), С. 226 - 232

Опубликована: Янв. 6, 2025

Язык: Английский

Процитировано

4
Trigger inducible tertiary lymphoid structure formation using covalent organic frameworks for cancer immunotherapy DOI Creative Commons
Liang Zhang, Boxin Zhang, Mengjie Zhang

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 2, 2025

The discovery of tertiary lymphoid structures (TLS) within tumor tissues provides a promising avenue to promote the efficacy cancer immunotherapy. Yet, lack effective strategies induce TLS formation poses substantial obstacle. Thus, exploration potential inducers for is great interest but remains challenging. Here, inspired by mechanism artificially cultivated pearls, covalent organic framework (COF) employed formation. Single-cell sequencing analysis reveals that this achieved promotion cytokine hypersecretion, which facilitates maturation, proliferation, and migration T B cells, critical triggering Furthermore, COF-mediated phototherapy in inducing validated both MC38 4MOSC1 female models. Notably, strong synergistic effect between αCTLA-4 observed, resulting eradication primary distant tumors, while also inhibiting recurrence. boosting immunotherapy, it challenging develop authors report able trigger

Язык: Английский

Процитировано

3
Biomaterials Elicit Pyroptosis Enhancing Cancer Immunotherapy DOI

Meng‐Jie Zhang,

Yuanyuan Wang,

Lin‐Lin Han

и другие.

Advanced Functional Materials, Год журнала: 2023, Номер 34(7)

Опубликована: Ноя. 5, 2023

Abstract Cancer immunotherapy has the potential to revolutionize treatment of malignant tumors, but its effectiveness is limited by low immune response rate and immune‐related adverse events. Pyroptosis, as an inflammatory programmed cell death type, triggers strong acute antitumor immunity, converting “cold” tumors “hot”. Particularly, biomaterials loading pyroptosis inducers targeting tumor microenvironment engineer pyroptosis, have achieved great progress in recent years. Herein, design strategy, mechanism pathway, role induce cancer are comprehensively reviewed. The present review focuses on application biomaterials‐induced immunotherapy, including nanogel, polymer prodrug, nanovesicle, mesoporous material. Additionally, synthesis a series stimuli‐responsive nanoplatforms, glutathione‐responsive, pH‐responsive, reactive oxygen species‐responsive, enzyme‐mimicking catalytic performance, described. Meanwhile, it augments multiple processes uptake, antigen presentation, T‐cell activation, expansion. Finally, perspectives pyroptosis‐mediated inflammation break through vascular basement membrane barrier achieving efficient volcanic penetration discussed. Artificial intelligence, multi‐omics analysis, anthropogenic animal models organoids presented, aiming provide guidance assistance for constructing effective controllable pyroptosis‐engineered improving immunotherapy.

Язык: Английский

Процитировано

26
Activated aggregation‐induced emission therapeutics agents for triggering regulated cell death DOI Creative Commons

Yu‐Qiang Zhao,

Le Yu,

Lanyun Zhang

и другие.

Aggregate, Год журнала: 2024, Номер 5(3)

Опубликована: Янв. 22, 2024

Abstract The induction of regulated cell death (RCD) through photo/ultrasound sensitization therapeutic agents has gained significant attention as a vital approach to combat drug resistance in tumors. Aggregation‐induced emission (AIE) generate reactive oxygen species activation, which can synergize with RCD inducers or directly induce RCD, ultimately resulting the tumor cells. presented comprehensive review delves into recent advancements AIE designed trigger inducers, encompassing apoptosis, necroptosis, pyroptosis, immunogenic death, autophagy, ferroptosis, and cuproptosis. Additionally, intricate regulatory mechanisms activatory‐AIE therapeutics influence distinct pathways are examined. A forward‐looking perspective on future developments pertinent challenges within this exciting realm is presented, anticipating continued evolution activatable transformative enhance therapy.

Язык: Английский

Процитировано

14
Polyphenols functionalized MOF encapsulated BPQDs for synergistic photothermal/photodynamic antibacterial properties and multifunctional food preservation DOI
Jiayi Wang,

Shufang Zhou,

Futai Lu

и другие.

Food Chemistry, Год журнала: 2024, Номер 451, С. 139451 - 139451

Опубликована: Апрель 24, 2024

Язык: Английский

Процитировано

11
Controlling the Degree of Interpenetration in Chiral Three-Dimensional Covalent Organic Frameworks via Steric Tuning DOI
Kaixuan Wang, Bang Hou, Jinqiao Dong

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(31), С. 21466 - 21475

Опубликована: Июль 24, 2024

Network interpenetration plays a crucial role in functionalizing porous framework materials. However, controlling the degree of covalent organic frameworks (COFs) to influence their pore sizes, shapes, and functionalities still remains significant challenge. Here, we demonstrate steric tuning strategy control COF modulate physicochemical properties. By imine condensations 1,1′-bi-2-naphthol-derived tetraaldehydes bearing different alkyl substituents with monomer tetra(p-aminophenyl)-methane, synthesized characterized family two-component three-component chiral COFs interpenetrated dia networks. The groups are periodically appended on walls, types/contents that can be synthetically tuned by minimizing repulsive interactions between groups. Specifically, –OH adopts an dia-c5 topology, those –OMe/–OEt take dia-c4 whereas bulky –OnPr/–OnBu exhibit noninterpenetrated dia-c1 topology. multivariate both –OnBu display either or depending proportion extent significantly affects porosity, thermal stability, chemical resulting varying selective performances adsorption separation dyes asymmetric catalysis. This work highlights potential using hindrance tune interpenetration, materials, broadening range applications.

Язык: Английский

Процитировано

11