Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Год журнала: 2024, Номер 124(9), С. 5505 - 5616

Опубликована: Апрель 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Язык: Английский

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Bulk Depolymerization of Methacrylate Polymers via Pendent Group Activation

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(9), С. 6217 - 6224

Опубликована: Фев. 21, 2024

In this study, we present an efficient approach for the depolymerization of poly(methyl methacrylate) (PMMA) copolymers synthesized via conventional radical polymerization. By incorporating low mol % phthalimide ester-containing monomers during polymerization process, colorless and transparent polymers closely resembling unfunctionalized PMMA are obtained, which can achieve >95% reversion to methyl methacrylate (MMA). Notably, our catalyst-free bulk method exhibits exceptional efficiency, even high-molecular-weight polymers, including ultrahigh-molecular-weight (10

Язык: Английский

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Recyclable surgical, consumer, and industrial adhesives of poly(α-lipoic acid)

Science, Год журнала: 2024, Номер 385(6711), С. 877 - 883

Опубликована: Авг. 22, 2024

Polymer adhesives play an important role in many medical, consumer, and industrial products. Polymers of α-lipoic acid (αLA) have the potential to fulfill need for versatile environmentally friendly adhesives, but their performance is plagued by spontaneous depolymerization. We report a family stabilized αLA polymer that can be tailored variety medical or nonmedical uses sustainably sourced recycled closed-loop manner. Minor changes monomer composition afforded pressure-sensitive adhesive functions well dry wet conditions, as structural with strength equivalent conventional epoxies. surgical superglue successfully sealed murine amniotic sac ruptures, increasing fetal survival from 0 100%.

Язык: Английский

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Design of depolymerizable polymers toward a circular economy

Green Chemistry, Год журнала: 2024, Номер 26(5), С. 2384 - 2420

Опубликована: Янв. 1, 2024

While our society is facing the challenge of accumulating plastic waste, this review discusses recent advances towards polymer circularity with an emphasis on manipulations monomer–polymer equilibrium to create chemically recyclable polymers.

Язык: Английский

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Defining Reactivity–Deconstructability Relationships for Copolymerizations Involving Cleavable Comonomer Additives

ACS Macro Letters, Год журнала: 2024, Номер 13(5), С. 521 - 527

Опубликована: Апрель 16, 2024

The incorporation of cleavable comonomers as additives into polymers can imbue traditional with controlled deconstructability and expanded end-of-life options. efficiency which comonomer (CCAs) enable deconstruction is sensitive to their local distribution within a copolymer backbone, dictated by copolymerization behavior. While qualitative heuristics exist that describe deconstructability, comprehensive quantitative connections between CCA loadings, reactivity ratios, polymerization mechanisms, reactions on the copolymers containing CCAs have not been established. Here, we broadly define these relationships using stochastic simulations characterizing various mechanisms (e.g., coltrolled/living, free-radical, reversible ring-opening polymerizations), ratio pairs (spanning 2 orders magnitude 0.01 100), loadings (2.5% 20%), sequence-dependent behavior). We show general agreement simulated experimentally observed fragment sizes from literature, demonstrating predictive power methods used herein. These results will guide development more efficient inform formulation deconstructable materials.

Язык: Английский

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Quantitative, Regiospecific, and Stereoselective Radical Ring-Opening Polymerization of Monosaccharide Cyclic Ketene Acetals

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(8), С. 5056 - 5062

Опубликована: Фев. 12, 2024

Cyclic ketene acetals (CKAs) are among the most well-studied monomers for radical ring-opening polymerization (rROP). However, ring-retaining side reactions and low reactivities in homopolymerization copolymerization remain significant challenges existing CKAs. Here, we report that a class of monosaccharide CKAs can be facilely prepared from short scalable synthetic route undergo quantitative, regiospecific, stereoselective rROP. NMR analyses degradation experiments revealed reaction mechanism involving propagating at C2 position pyranose with different monosaccharides exhibiting distinct stereoselectivity addition monomer. Furthermore, maleimide was found to improve incorporation efficiency CKA vinyl produced unique degradable terpolymers carbohydrate motifs polymer backbone.

Язык: Английский

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From health supplement to versatile monomer: Radical ring-opening polymerization and depolymerization of α-lipoic acid

Polymer, Год журнала: 2024, Номер 304, С. 127167 - 127167

Опубликована: Май 11, 2024

Язык: Английский

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Biomass-derived closed-loop recyclable chemically crosslinked polymer composites for green soft electronics

Chemical Engineering Journal, Год журнала: 2024, Номер 488, С. 150818 - 150818

Опубликована: Март 29, 2024

Язык: Английский

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Biological applications of lipoic acid-based polymers: an old material with new promise

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(19), С. 4574 - 4583

Опубликована: Янв. 1, 2024

Lipoic acid (LA) is a versatile antioxidant that has been used in the treatment of various oxidation-reduction diseases over past 70 years. Owing to its large five-membered ring tension, dynamic disulfide bond LA highly active, enabling formation poly(lipoic acid) (PLA) via ring-opening polymerization (ROP). Herein, we first summarize disulfide-mediated ROP strategies, providing basic routes for designing and preparing PLA-based materials. PLA, as biologically derived, low toxic, easily modified material, possesses bonds universal non-covalent carboxyl groups. We also shed light on biomedical applications materials based their biological structural features further divide recent works into six categories: antibacterial, anti-inflammation, anticancer, adhesive, flexible electronics, 3D-printed tissue scaffolds. Finally, challenges future prospects associated with PLA are discussed.

Язык: Английский

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Photoiniferter Polymerization: Illuminating the History, Ascendency, and Renaissance

Progress in Polymer Science, Год журнала: 2024, Номер 156, С. 101871 - 101871

Опубликована: Авг. 22, 2024

Язык: Английский

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