Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
α-Lipoic
acid
(αLA)
is
an
attractive
building
block
for
medical
adhesives.
However,
due
to
poor
water
solubility
of
αLA
and
high
hydrophobicity
poly(αLA),
elevated
temperatures,
organic
solvents,
or
complex
preparations
are
typically
required
obtain
deliver
αLA-based
adhesives
biological
tissue.
Here,
we
report
powder
low-viscosity
liquid
superglues
that
polymerize
bond
rapidly
upon
contact
with
wet
A
monomeric
mixture
αLA,
sodium
lipoate,
activated
ester
lipoic
was
used
formulate
the
versatile
Stress-strain
measurements
confirmed
flexibility
adhesive.
Moreover,
a
small
molecule
regenerative
drug
successfully
incorporated
into
released
from
adhesive
without
altering
physical
properties.
In
vitro
in
vivo
studies
developed
their
cell
tissue
compatibility,
biodegradability,
potential
sustained
delivery.
inherent
ionic
nature
adhesives,
they
demonstrated
electric
conductivity
sensitivity
deformation,
allowing
development
tissue-adherent
strain
sensor.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(9), P. 5505 - 5616
Published: April 16, 2024
The
recent
emergence
of
nanomedicine
has
revolutionized
the
therapeutic
landscape
and
necessitated
creation
more
sophisticated
drug
delivery
systems.
Polymeric
nanoparticles
sit
at
forefront
numerous
promising
designs,
due
to
their
unmatched
control
over
physiochemical
properties
such
as
size,
shape,
architecture,
charge,
surface
functionality.
Furthermore,
polymeric
have
ability
navigate
various
biological
barriers
precisely
target
specific
sites
within
body,
encapsulate
a
diverse
range
cargo
efficiently
release
this
in
response
internal
external
stimuli.
However,
despite
these
remarkable
advantages,
presence
wider
clinical
application
is
minimal.
This
review
will
provide
comprehensive
understanding
vehicles.
affecting
be
outlined
first,
followed
by
description
nanoparticle
designs
preparation
methods,
beginning
with
polymers
on
which
they
are
based.
meticulously
explore
current
performance
against
myriad
diseases
including
cancer,
viral
bacterial
infections,
before
finally
evaluating
advantages
crucial
challenges
that
determine
potential
decades
come.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(9), P. 6217 - 6224
Published: Feb. 21, 2024
In
this
study,
we
present
an
efficient
approach
for
the
depolymerization
of
poly(methyl
methacrylate)
(PMMA)
copolymers
synthesized
via
conventional
radical
polymerization.
By
incorporating
low
mol
%
phthalimide
ester-containing
monomers
during
polymerization
process,
colorless
and
transparent
polymers
closely
resembling
unfunctionalized
PMMA
are
obtained,
which
can
achieve
>95%
reversion
to
methyl
methacrylate
(MMA).
Notably,
our
catalyst-free
bulk
method
exhibits
exceptional
efficiency,
even
high-molecular-weight
polymers,
including
ultrahigh-molecular-weight
(10
Science,
Journal Year:
2024,
Volume and Issue:
385(6711), P. 877 - 883
Published: Aug. 22, 2024
Polymer
adhesives
play
an
important
role
in
many
medical,
consumer,
and
industrial
products.
Polymers
of
α-lipoic
acid
(αLA)
have
the
potential
to
fulfill
need
for
versatile
environmentally
friendly
adhesives,
but
their
performance
is
plagued
by
spontaneous
depolymerization.
We
report
a
family
stabilized
αLA
polymer
that
can
be
tailored
variety
medical
or
nonmedical
uses
sustainably
sourced
recycled
closed-loop
manner.
Minor
changes
monomer
composition
afforded
pressure-sensitive
adhesive
functions
well
dry
wet
conditions,
as
structural
with
strength
equivalent
conventional
epoxies.
surgical
superglue
successfully
sealed
murine
amniotic
sac
ruptures,
increasing
fetal
survival
from
0
100%.
ACS Macro Letters,
Journal Year:
2024,
Volume and Issue:
13(5), P. 521 - 527
Published: April 16, 2024
The
incorporation
of
cleavable
comonomers
as
additives
into
polymers
can
imbue
traditional
with
controlled
deconstructability
and
expanded
end-of-life
options.
efficiency
which
comonomer
(CCAs)
enable
deconstruction
is
sensitive
to
their
local
distribution
within
a
copolymer
backbone,
dictated
by
copolymerization
behavior.
While
qualitative
heuristics
exist
that
describe
deconstructability,
comprehensive
quantitative
connections
between
CCA
loadings,
reactivity
ratios,
polymerization
mechanisms,
reactions
on
the
copolymers
containing
CCAs
have
not
been
established.
Here,
we
broadly
define
these
relationships
using
stochastic
simulations
characterizing
various
mechanisms
(e.g.,
coltrolled/living,
free-radical,
reversible
ring-opening
polymerizations),
ratio
pairs
(spanning
2
orders
magnitude
0.01
100),
loadings
(2.5%
20%),
sequence-dependent
behavior).
We
show
general
agreement
simulated
experimentally
observed
fragment
sizes
from
literature,
demonstrating
predictive
power
methods
used
herein.
These
results
will
guide
development
more
efficient
inform
formulation
deconstructable
materials.
ACS Macro Letters,
Journal Year:
2025,
Volume and Issue:
unknown, P. 207 - 213
Published: Feb. 3, 2025
Bottlebrush
(BB)
polymers,
with
their
densely
grafted
side
chains
and
unique
architecture,
are
highly
advantageous
for
drug
delivery
due
to
high
functional
group
density
conjugation,
unimolecular
nature,
enhanced
biodistribution
properties.
These
attributes
enable
extended
blood
circulation
half-life,
improved
tumor
tissue
penetration,
tumoral
accumulation.
However,
the
typically
nondegradable,
all-carbon
backbones
of
most
BB
polymers
limit
suitability
applications
requiring
controlled
clearance
biodegradability.
To
address
this,
we
developed
degradable
poly(disulfide)
synthesized
via
reversible
addition–fragmentation
chain
transfer
(RAFT)
copolymerization
α-lipoic
acid
(LA),
a
renewable
readily
available
compound,
acrylate-based
inimers.
copolymers
feature
initiating
sites
subsequent
synthesis.
Using
an
atom
radical
polymerization
(ATRP)
grafting-from
methodology,
relatively
low
dispersities
(Đ
=
1.30–1.53),
backbone
degrees
(DPbb),
molar
masses
(Mn,MALS
650–2700
kg/mol).
The
easily
cleavable
disulfide
bonds
enabled
degradation
under
mild
reducing
conditions.
Beyond
hydrophilic
tri(ethylene
glycol)
methyl
ether
acrylate
(TEGA)
chains,
cationic,
anionic,
zwitterionic
demonstrating
broad
monomer
compatibility.
This
scalable
approach
produces
water-soluble,
tunable
architectures
predictable
molecular
weights.
By
addressing
need
degradability
in
this
work
advances
potential
delivery,
offering
functionality,
biocompatibility,
sustainability.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(5), P. 2384 - 2420
Published: Jan. 1, 2024
While
our
society
is
facing
the
challenge
of
accumulating
plastic
waste,
this
review
discusses
recent
advances
towards
polymer
circularity
with
an
emphasis
on
manipulations
monomer–polymer
equilibrium
to
create
chemically
recyclable
polymers.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(8), P. 5056 - 5062
Published: Feb. 12, 2024
Cyclic
ketene
acetals
(CKAs)
are
among
the
most
well-studied
monomers
for
radical
ring-opening
polymerization
(rROP).
However,
ring-retaining
side
reactions
and
low
reactivities
in
homopolymerization
copolymerization
remain
significant
challenges
existing
CKAs.
Here,
we
report
that
a
class
of
monosaccharide
CKAs
can
be
facilely
prepared
from
short
scalable
synthetic
route
undergo
quantitative,
regiospecific,
stereoselective
rROP.
NMR
analyses
degradation
experiments
revealed
reaction
mechanism
involving
propagating
at
C2
position
pyranose
with
different
monosaccharides
exhibiting
distinct
stereoselectivity
addition
monomer.
Furthermore,
maleimide
was
found
to
improve
incorporation
efficiency
CKA
vinyl
produced
unique
degradable
terpolymers
carbohydrate
motifs
polymer
backbone.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(19), P. 4574 - 4583
Published: Jan. 1, 2024
Lipoic
acid
(LA)
is
a
versatile
antioxidant
that
has
been
used
in
the
treatment
of
various
oxidation-reduction
diseases
over
past
70
years.
Owing
to
its
large
five-membered
ring
tension,
dynamic
disulfide
bond
LA
highly
active,
enabling
formation
poly(lipoic
acid)
(PLA)
via
ring-opening
polymerization
(ROP).
Herein,
we
first
summarize
disulfide-mediated
ROP
strategies,
providing
basic
routes
for
designing
and
preparing
PLA-based
materials.
PLA,
as
biologically
derived,
low
toxic,
easily
modified
material,
possesses
bonds
universal
non-covalent
carboxyl
groups.
We
also
shed
light
on
biomedical
applications
materials
based
their
biological
structural
features
further
divide
recent
works
into
six
categories:
antibacterial,
anti-inflammation,
anticancer,
adhesive,
flexible
electronics,
3D-printed
tissue
scaffolds.
Finally,
challenges
future
prospects
associated
with
PLA
are
discussed.
