Confining metal nanoparticles and nanoclusters in covalent organic frameworks for biosensing and biomedicine DOI

Jianxin Ma,

Zhongjie Cai,

Faisal Ahmad

и другие.

Biosensors and Bioelectronics, Год журнала: 2025, Номер unknown, С. 117461 - 117461

Опубликована: Апрель 1, 2025

Язык: Английский

Two-Dimensional Covalent Organic Frameworks with Pentagonal Pores DOI
Fuxiang Wen, Kai Xu,

Yaoqian Feng

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(29), С. 19680 - 19685

Опубликована: Июль 9, 2024

The pore shapes of two-dimensional covalent organic frameworks (2D COFs) significantly limit their practical applications in separation and catalysis. Although various 2D COFs with polygonal pores have been well developed, constructing pentagonal remains an enormous challenge. In this work, we developed one kind the

Язык: Английский

Процитировано

20

Rapid and Highly Selective Dopamine Sensing with CuInSe2-Modified Nanocomposite DOI Open Access
Jing Li,

Guangzhong Xie,

Luwei Dai

и другие.

Journal of Composites Science, Год журнала: 2025, Номер 9(3), С. 123 - 123

Опубликована: Март 6, 2025

As an important neurotransmitter, the concentration of dopamine (DA) reflects certain physiological conditions and DA-related diseases. Rapid monitoring DA levels is great significance in regulating body health. However, regular electrochemical sensors suffer from poor sensitivity, low selectivity interference immunity, as well a complex preparation process. Herein, we developed accessible cost-effective sensor with copper indium selenide (CuInSe2 or CIS)-modified screen-printed carbon electrode for discrimination. This was using facile one-step hydrothermal method without high-temperature quenching. Benefitting inherent merits CIS conversion Cu2+ Cu+ during catalytic reaction, attained both excellent sensitivity (2.511 μA·µM−1·cm−1) among multiple substances interfering DA. work demonstrates potential to improve analytical performance traditional sensors.

Язык: Английский

Процитировано

11

In Vivo Electrochemical Biosensing Technologies for Neurochemicals: Recent Advances in Electrochemical Sensors and Devices DOI

Tuo Yang,

Tongjun Shen,

Bin Duan

и другие.

ACS Sensors, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

In vivo electrochemical sensing of neurotransmitters, neuromodulators, and metabolites plays a critical role in real-time monitoring various physiological or psychological processes the central nervous system. Currently, advanced biosensors technologies have been emerging as prominent ways to meet surging requirements neurotransmitters neuromodulators ranging from single cells brain slices, even entire brain. This review introduces fundamental working principles summarizes achievements biosensing including voltammetry, amperometry, potentiometry, field-effect transistor (FET), organic (OECT). According elaborate feature technology, versatile strategies devoted solve issues associated with neurochemicals under an intricate environment. Voltammetry is universal technique investigate complex matrices which could realize miniaturization electrodes, while amperometry serves well-suited approach offering high temporal resolution favorable for fast oxidation–reduction kinetics neurochemicals. Potentiometry realizes quantitative analysis by recording potential difference reduced invasiveness compatibility. FET OECT serve amplification higher sensitivity than traditional technologies. Furthermore, we point out current shortcomings address challenges perspectives

Язык: Английский

Процитировано

3

Highly catalytic Ce-based MOF for powering electrochemical aptasensing toward evaluating dissolution rate of microelement copper from tea-leaves DOI
Haili Chen, Jiaoling Wang, Wenwen Zhang

и другие.

Journal of Food Composition and Analysis, Год журнала: 2025, Номер 140, С. 107266 - 107266

Опубликована: Янв. 29, 2025

Язык: Английский

Процитировано

3

Electrochemical Sensing Mechanisms and Interfacial Design Strategies of Mesoporous Nanochannel Membranes in Biosensing Applications DOI
Hui Zeng, Kang Liang, Lei Jiang

и другие.

Accounts of Chemical Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

ConspectusPrecise and rapid detection of key biomolecules is crucial for early clinical diagnosis. These critical biomarkers are typically present at low concentrations within complex environments, presenting significant challenges their accurate reliable detection. Nowadays, electrochemical sensors based on nanochannel membranes have attracted attention due to high sensitivity, simplicity, response, label-free point-of-care capabilities. The confined arena provided by the nanochannels target recognition interactions facilitates signal amplification, leading enhanced performance. also can act as filters repel interferents enable in more environments. Thus, considered promising platforms biosensing applications. However, such uncontrollable structures unstable performance some materials limit applications theoretical advancements. To investigate relationship between architecture sensing achieve efficient performance, it essential construct with precise nanostructures possessing stable properties. With development nanomaterials technology, mesoporous robust, controllable, ordered mesostructures, along tunable surface properties tailored ion transport dynamics, emerged candidates achieving Additionally, investigating mechanisms influencing factors will provide valuable insights into optimizing sensor enhancing efficiency reliability technologies. In this Account, we highlight substantial advancements membranes, which mainly research work published our group. first section, explore underlying processes, including solid-liquid interfacial nanoconfinement effects (i.e., electrostatic interactions, hydrophilic/hydrophobic steric hindrance effects). We delve parameters geometry, materials, elements, external related impacts particular, point out that three-dimensional interconnected networks facilitate penetration lead an increased number binding sites, contributing sensitivity. composite or multilevel particularly when integrated stimuli pH, light, heat, introduce unexpected properties, understandings fundamental principles pertinent design intelligent, high-quality nanofluidic devices. Furthermore, conduct analysis integrating various strategies, offers opportunities biomedical monitoring, disease diagnosis, pharmaceutical industry. Finally, describe future directions potential commercial adoption. Nanochannel novel structures, functional porous may new trends applications, self-powered wearable monitoring. believe Account holds implications promoting interdisciplinary endeavors encompassing chemistry science nanotechnology well analysis, biosensing, science.

Язык: Английский

Процитировано

3

Electrochemical Biosensors for the Detection of Exosomal microRNA Biomarkers for Early Diagnosis of Neurodegenerative Diseases DOI Creative Commons

Jiacheng Yu,

Runzhi Zhou,

Shan Liu

и другие.

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 9, 2025

Early and precise diagnosis of neurodegenerative disorders like Alzheimer's (AD) Parkinson's (PD) is crucial for slowing their progression enhancing patient outcomes. Exosomal microRNAs (miRNAs) are emerging as promising biomarkers due to ability reflect the diseases' pathology, yet low abundance poses significant detection hurdles. This review article delves into burgeoning field electrochemical biosensors, designed exosomal miRNA biomarkers. Electrochemical biosensors offer a compelling solution, combining sensitivity required detect low-abundance with specificity needed discern profiles distinctive neural pathological states. We explore operational principles these including transduction mechanisms that facilitate detection. The also summarizes advancements in nanotechnology, signal enhancement, bioreceptor anchoring, microfluidic integration improve sensor accuracy. evidence use disease analyzed, focusing on clinical impact, diagnostic precision, obstacles faced practical applications. Their potential point-of-care testing regulatory considerations market entry discussed. Looking toward future, highlights forthcoming innovations might revolutionize early processes. impressive sensitivity, specificity, compatibility, track become instrumental diseases, possibly transforming care prognosis.

Язык: Английский

Процитировано

3

Topology Control of Covalent Organic Frameworks with Interlaced Unsaturated 2D and Saturated 3D Units for Boosting Electrocatalytic Hydrogen Peroxide Production DOI

Han Wu,

Lili Li,

Hongni Chen

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown

Опубликована: Авг. 13, 2024

Abstract Modulating the electronic state of multicomponent covalent organic framework (COF) electrocatalysts is crucial for enhancing catalytic activity. However, effect dimensionality on their physicochemical functionalities still lacking. Herein, we report an interlaced unsaturated 2D and saturated 3D strategy to develop multicomponent‐regulated COFs with tunable gradient high selectivity activity electrocatalysis. Compared two‐component model COFs, 2D/3D locally irregular dimensions structures are more practical in optimizing intrinsic electrode surface reaction mass transfer. Remarkably, 2D‐inserted TAE‐COF regulates adsorption mode OOH* species supply a favorable dynamic pathway H 2 O process, thereby achieving excellent production rate 8.50 mol g cat −1 h . Moreover, utilizing theoretical calculation situ ATR‐FTIR experiment, found that central carbon atom tetraphenyl‐based unit (site‐1 site‐6) potential active sites. This operating ability reactants dimensionality‐interconnected building blocks provides idea designing durable efficient electrocatalysts.

Язык: Английский

Процитировано

16

In situ monitoring of cytoplasmic dopamine levels by noble metals decorated carbon fiber tips DOI
Yihan Wang,

Tingya Wang,

Ke Huang

и другие.

Biosensors and Bioelectronics, Год журнала: 2024, Номер 250, С. 116087 - 116087

Опубликована: Янв. 29, 2024

Язык: Английский

Процитировано

10

Porous Materials for Early Diagnosis of Neurodegenerative Diseases DOI Creative Commons
Payam Arghavani, Hossein Daneshgar, Soheil Sojdeh

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Abstract Neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease, present formidable challenges in modern medicine due to their complex pathologies the absence of curative treatments. Despite advances symptomatic management, early diagnosis remains essential for mitigating progression improving patient outcomes. Traditional diagnostic methods, such as MRI, PET, cerebrospinal fluid biomarker analysis, are often inadequate detection these diseases. Emerging porous materials, including metal–organic frameworks (MOFs), covalent–organic (COFs), MXene, zeolites, silicon, offer promising new approaches neurodegenerative These characterized by highly tunable physicochemical properties, have potential capture concentrate disease‐specific biomarkers amyloid‐beta (Aβ), tau protein, alpha‐synuclein (α‐Syn). The integration materials into advanced biosensors real‐time holds promise revolutionizing neurodiagnostic, enabling non‐invasive, sensitive, specific platforms. Furthermore, incorporation artificial intelligence (AI) machine learning (ML) techniques analysis sensor data enhances accuracy allows more efficient interpretation profiles. AI ML can optimize feature selection, improve pattern recognition, facilitate prediction progression, making them indispensable tools personalized medicine. This review explores diagnostics, emphasizing design, functionality, synergistic role advancing clinical applications.

Язык: Английский

Процитировано

2

Trends in ready-to-use portable electrochemical sensing devices for healthcare diagnosis DOI

Anjana Sajeevan,

Reshmi A. Sukumaran,

Lakshmi R. Panicker

и другие.

Microchimica Acta, Год журнала: 2025, Номер 192(2)

Опубликована: Янв. 14, 2025

Язык: Английский

Процитировано

2