Two-Dimensional Covalent Organic Frameworks with Pentagonal Pores

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(29), P. 19680 - 19685

Published: July 9, 2024

The pore shapes of two-dimensional covalent organic frameworks (2D COFs) significantly limit their practical applications in separation and catalysis. Although various 2D COFs with polygonal pores have been well developed, constructing pentagonal remains an enormous challenge. In this work, we developed one kind the

Language: Английский

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Rapid and Highly Selective Dopamine Sensing with CuInSe2-Modified Nanocomposite

Journal of Composites Science, Journal Year: 2025, Volume and Issue: 9(3), P. 123 - 123

Published: March 6, 2025

As an important neurotransmitter, the concentration of dopamine (DA) reflects certain physiological conditions and DA-related diseases. Rapid monitoring DA levels is great significance in regulating body health. However, regular electrochemical sensors suffer from poor sensitivity, low selectivity interference immunity, as well a complex preparation process. Herein, we developed accessible cost-effective sensor with copper indium selenide (CuInSe2 or CIS)-modified screen-printed carbon electrode for discrimination. This was using facile one-step hydrothermal method without high-temperature quenching. Benefitting inherent merits CIS conversion Cu2+ Cu+ during catalytic reaction, attained both excellent sensitivity (2.511 μA·µM−1·cm−1) among multiple substances interfering DA. work demonstrates potential to improve analytical performance traditional sensors.

Language: Английский

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Highly catalytic Ce-based MOF for powering electrochemical aptasensing toward evaluating dissolution rate of microelement copper from tea-leaves

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: 140, P. 107266 - 107266

Published: Jan. 29, 2025

Language: Английский

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Electrochemical Biosensors for the Detection of Exosomal microRNA Biomarkers for Early Diagnosis of Neurodegenerative Diseases

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 9, 2025

Early and precise diagnosis of neurodegenerative disorders like Alzheimer's (AD) Parkinson's (PD) is crucial for slowing their progression enhancing patient outcomes. Exosomal microRNAs (miRNAs) are emerging as promising biomarkers due to ability reflect the diseases' pathology, yet low abundance poses significant detection hurdles. This review article delves into burgeoning field electrochemical biosensors, designed exosomal miRNA biomarkers. Electrochemical biosensors offer a compelling solution, combining sensitivity required detect low-abundance with specificity needed discern profiles distinctive neural pathological states. We explore operational principles these including transduction mechanisms that facilitate detection. The also summarizes advancements in nanotechnology, signal enhancement, bioreceptor anchoring, microfluidic integration improve sensor accuracy. evidence use disease analyzed, focusing on clinical impact, diagnostic precision, obstacles faced practical applications. Their potential point-of-care testing regulatory considerations market entry discussed. Looking toward future, highlights forthcoming innovations might revolutionize early processes. impressive sensitivity, specificity, compatibility, track become instrumental diseases, possibly transforming care prognosis.

Language: Английский

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Topology Control of Covalent Organic Frameworks with Interlaced Unsaturated 2D and Saturated 3D Units for Boosting Electrocatalytic Hydrogen Peroxide Production

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 13, 2024

Abstract Modulating the electronic state of multicomponent covalent organic framework (COF) electrocatalysts is crucial for enhancing catalytic activity. However, effect dimensionality on their physicochemical functionalities still lacking. Herein, we report an interlaced unsaturated 2D and saturated 3D strategy to develop multicomponent‐regulated COFs with tunable gradient high selectivity activity electrocatalysis. Compared two‐component model COFs, 2D/3D locally irregular dimensions structures are more practical in optimizing intrinsic electrode surface reaction mass transfer. Remarkably, 2D‐inserted TAE‐COF regulates adsorption mode OOH* species supply a favorable dynamic pathway H 2 O process, thereby achieving excellent production rate 8.50 mol g cat −1 h . Moreover, utilizing theoretical calculation situ ATR‐FTIR experiment, found that central carbon atom tetraphenyl‐based unit (site‐1 site‐6) potential active sites. This operating ability reactants dimensionality‐interconnected building blocks provides idea designing durable efficient electrocatalysts.

Language: Английский

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In situ monitoring of cytoplasmic dopamine levels by noble metals decorated carbon fiber tips

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 250, P. 116087 - 116087

Published: Jan. 29, 2024

Language: Английский

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In Vivo Electrochemical Biosensing Technologies for Neurochemicals: Recent Advances in Electrochemical Sensors and Devices

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

In vivo electrochemical sensing of neurotransmitters, neuromodulators, and metabolites plays a critical role in real-time monitoring various physiological or psychological processes the central nervous system. Currently, advanced biosensors technologies have been emerging as prominent ways to meet surging requirements neurotransmitters neuromodulators ranging from single cells brain slices, even entire brain. This review introduces fundamental working principles summarizes achievements biosensing including voltammetry, amperometry, potentiometry, field-effect transistor (FET), organic (OECT). According elaborate feature technology, versatile strategies devoted solve issues associated with neurochemicals under an intricate environment. Voltammetry is universal technique investigate complex matrices which could realize miniaturization electrodes, while amperometry serves well-suited approach offering high temporal resolution favorable for fast oxidation–reduction kinetics neurochemicals. Potentiometry realizes quantitative analysis by recording potential difference reduced invasiveness compatibility. FET OECT serve amplification higher sensitivity than traditional technologies. Furthermore, we point out current shortcomings address challenges perspectives

Language: Английский

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Porous Materials for Early Diagnosis of Neurodegenerative Diseases

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Abstract Neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease, present formidable challenges in modern medicine due to their complex pathologies the absence of curative treatments. Despite advances symptomatic management, early diagnosis remains essential for mitigating progression improving patient outcomes. Traditional diagnostic methods, such as MRI, PET, cerebrospinal fluid biomarker analysis, are often inadequate detection these diseases. Emerging porous materials, including metal–organic frameworks (MOFs), covalent–organic (COFs), MXene, zeolites, silicon, offer promising new approaches neurodegenerative These characterized by highly tunable physicochemical properties, have potential capture concentrate disease‐specific biomarkers amyloid‐beta (Aβ), tau protein, alpha‐synuclein (α‐Syn). The integration materials into advanced biosensors real‐time holds promise revolutionizing neurodiagnostic, enabling non‐invasive, sensitive, specific platforms. Furthermore, incorporation artificial intelligence (AI) machine learning (ML) techniques analysis sensor data enhances accuracy allows more efficient interpretation profiles. AI ML can optimize feature selection, improve pattern recognition, facilitate prediction progression, making them indispensable tools personalized medicine. This review explores diagnostics, emphasizing design, functionality, synergistic role advancing clinical applications.

Language: Английский

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Trends in ready-to-use portable electrochemical sensing devices for healthcare diagnosis

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(2)

Published: Jan. 14, 2025

Language: Английский

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Hydrogen‐Bonded Organic Framework Films Integrated with Wavy Structured Design for Wearable Bioelectronics

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Abstract The integration of hydrogen‐bonded organic frameworks (HOFs) with flexible electronic technologies offers a promising strategy for monitoring detailed health information, owing to their inherent porosity, excellent biocompatibility, and tunable catalytic capabilities. However, application in wearable real‐time remains largely unexplored, primarily due the mechanical mismatch between traditionally fragile HOFs particles softness human skin. Herein, this study demonstrates an epidermal biosensor that maintains reliable sensing capability even under extreme deformation complex environmental conditions by integrating films wavy bioelectrodes. This ultrasensitive detection capabilities, limit 49.64 nM, accurately measures nutritional content sweat while conforming curved skin surfaces. sensor's performance is comparable those obtained using high‐performance liquid chromatography (HPLC). More strikingly, scratched can be regenerated through simple solvent rinsing process, enabling reuse fabrication new biosensors offering significant advantage over conventional materials. work has potential inspire development more devices, leveraging structural adaptability diversity personalized healthcare applications monitoring.

Language: Английский

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