Advanced Drug Delivery Reviews, Год журнала: 2025, Номер 223, С. 115610 - 115610
Опубликована: Май 24, 2025
Язык: Английский
Green Chemistry, Год журнала: 2024, Номер 26(16), С. 9075 - 9103
Опубликована: Янв. 1, 2024
Towards the sustainable production of biomass-derived materials with smart functionality.
Язык: Английский
Процитировано
31
Journal of the American Chemical Society, Год журнала: 2024, Номер 146(19), С. 12941 - 12949
Опубликована: Апрель 30, 2024
Nucleic acids are mainly found in the mitochondria and nuclei of cells. Detecting nucleic mitochondrion nucleus cascade mode is crucial for understanding diverse biological processes. This study introduces a novel acid-based fluorescent styrene dye (SPP) that exhibits light-driven migration from to nucleus. By introducing N-arylpyridine on one side skeleton bis(2-ethylsulfanyl-ethy)-amino unit other side, we SPP excellent DNA specificity (16-fold, FDNA/Ffree) stronger binding force nuclear (−5.09 kcal/mol) than mitochondrial (−2.59 kcal/mol). initially accumulates then migrates within 10 s under light irradiation. tracking damage apoptotic cells, allows successful visualization differences between apoptosis ferroptosis. Finally, triphenylamine segment with photodynamic effects was incorporated into form photosensitizer (MTPA-SPP), which targets photosensitization irradiation enhanced cancer cell treatment. innovative molecule light-triggered mitochondrion-to-nucleus ability provides feasible approach situ identification acids, monitoring subcellular physiological events, efficient therapy.
Язык: Английский
Процитировано
16
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(36)
Опубликована: Июнь 14, 2024
Mitochondria, one of the most important organelles, represent a crucial subcellular target for fundamental research and biomedical applications. Despite significant advances in design DNA nanotechnologies variety bio-applications, dearth strategies that enable mitochondria targeting molecular imaging therapy remains an outstanding challenge this field. In Minireview, we summarize recent progresses on emerging application nanotechnology mitochondria-targeted tumor treatment. We first highlight engineering mitochondria-localized nanosensors situ detection diverse key molecules are essential to maintain mitochondrial functions, including microRNA, enzymes, small molecules, metal ions. Then, compile developments anti-tumor therapy, modularly designed nanodevices delivery therapeutic agents, programmed assembly interference. will place emphasis clarification chemical principles how nanobiotechnology can be various Finally, remaining challenges future directions field discussed, hoping inspire further development advanced toolkits both academic clinical regarding mitochondria.
Язык: Английский
Процитировано
12
Analytical Chemistry, Год журнала: 2024, Номер 96(14), С. 5560 - 5569
Опубликована: Март 26, 2024
Catalytic DNA circuits are desirable for sensitive bioimaging in living cells; yet, it remains a challenge to monitor these intricate signal communications because of the uncontrolled circuitry leakage and insufficient cell selectivity. Herein, simple yet powerful DNA-repairing enzyme (APE1) activation strategy is introduced achieve site-specific exposure catalytic circuit realizing selectively amplified imaging intracellular microRNA robust evaluation APE1-involved drug resistance. Specifically, reactants firmly blocked by recognition/cleavage site prevent undesirable off-site leakage. The caged has no target-sensing activity until its components activated via enzyme-mediated structural reconstitution finally transduces fluorescence within miRNA stimulation. designed demonstrates an enhanced signal-to-background ratio assay as compared with conventional enables cancer-cell-selective miRNA. In addition, shows sensing performance visualizing APE1-mediated chemoresistance cells, which anticipated in-depth clinical diagnosis chemotherapy research.
Язык: Английский
Процитировано
11
JACS Au, Год журнала: 2025, Номер 5(2), С. 550 - 570
Опубликована: Фев. 6, 2025
Cell surface engineering is a rapidly advancing field, pivotal for understanding cellular physiology and driving innovations in biomedical applications. In this regard, DNA nanotechnology offers unprecedented potential precisely manipulating functionalizing cell surfaces by virtue of its inherent programmability versatile functionalities. Herein, Perspective provides comprehensive overview emerging trends engineering, focusing on key nanostructure-based tools, their roles regulating physiological processes, We first discuss the strategies integrating molecules onto surfaces, including attachment oligonucleotides higher-order nanostructure. Second, we summarize impact DNA-based various such as membrane protein degradation, signaling transduction, intercellular communication, construction artificial components. Third, highlight applications DNA-engineered targeted therapies cancer inflammation, well capture/protection diagnostic detection. Finally, address challenges future directions nanotechnology-based engineering. This aims to provide valuable insights rational design contributing development precise personalized medicine.
Язык: Английский
Процитировано
2
Molecules, Год журнала: 2025, Номер 30(5), С. 1025 - 1025
Опубликована: Фев. 24, 2025
Mitochondria, as vital organelles, play a central role in subcellular research and biomedical innovation. Although functional nucleic acid (FNA) nanostructures have witnessed remarkable progress across numerous biological applications, strategies specifically tailored to target mitochondria for molecular imaging therapeutic interventions remain scarce. This review delves into the latest advancements leveraging FNA mitochondria-specific cancer therapy. Initially, we explore creation of FNA-based biosensors localized mitochondria, enabling real-time detection visualization critical molecules essential mitochondrial function. Subsequently, examine developments aimed at mitochondrial-targeted treatments, including modular nanodevices precise delivery agents programmable disrupting processes. Emphasis is placed on elucidating chemical principles underlying design mitochondrial-specific nanotechnology diverse uses. Lastly, address unresolved challenges outline prospective directions, with goal advancing field encouraging sophisticated tools both academic inquiry clinical applications centered mitochondria.
Язык: Английский
Процитировано
1
Nano Today, Год журнала: 2024, Номер 56, С. 102224 - 102224
Опубликована: Март 8, 2024
Язык: Английский
Процитировано
6
Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 212, С. 115387 - 115387
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
6
Accounts of Chemical Research, Год журнала: 2024, Номер unknown
Опубликована: Авг. 30, 2024
ConspectusIn recent years, the controlled assembly/disassembly of exogenous chemical components inside cells has become an emerging approach to regulating cell functions. However, construction dynamic material chemistry systems in living always remains highly challenging due complicated intracellular microenvironment. Nucleic acid is a category biological that can achieve efficient molecular assembly via specific base-pairing and perform functions Deoxyribonucleic (DNA) molecules exhibit superior performance assembly, including sequence programmability, molecule recognition ability, nanostructure predictability, as well unique traditional synthetic polymers do not carry, showing great superiority systems. Moreover, technologies DNA synthesis are relatively mature, conjugation with functional small be achieved through established methods, facilitating DNA-based materials more In addition, few have been proven show responsiveness toward different stimuli, functioning modules.In this Account, we summarize our work nanoassemblies from perspective stimulus types enzyme, H
Язык: Английский
Процитировано
5
Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155631 - 155631
Опубликована: Сен. 8, 2024
Язык: Английский
Процитировано
5