Tactics to Improve the Photodynamic Therapeutic Efficacy Based on Nanomaterials DOI
Yinghao Cao, Xiaoping Qian,

Mengqi Shi

et al.

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Comprehensive Summary The development of photodynamic therapy (PDT), from its initial discovery effects to current use in various medical conditions, is a testament therapeutic potential. Recent breakthroughs nanotechnology have significantly enhanced the effectiveness PDT. Typical nanomaterials (NMs), including metal‐organic frameworks (MOFs), covalent organic (COFs), and nanozymes been introduced enhance efficacy because they can delivery PSs, effectively overcome insufficient targeting specificity, limited tissue penetration depth, hypoxic microenvironments, thereby amplifying efficacy. However, clinical application these NMs PDT faces several challenges, concerns regarding biocompatibility, long‐term biosafety, economic feasibility. To further advance PDT, researchers should focus on designing improve outcomes, exploring combination therapies with conducting translational trials validate safety novel approaches. This review summarizes recent progress based NMs, especially MOFs, COFs their disease treatment. We aim provide guidance for future research practice advancing NMs‐enhanced paving way more effective strategies. Key Scientists

Language: Английский

Defect-enabling zirconium-based metal–organic frameworks for energy and environmental remediation applications DOI Creative Commons
Saba Daliran, Ali Reza Oveisi, Chung‐Wei Kung

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(12), P. 6244 - 6294

Published: Jan. 1, 2024

This review highlights the promising prospects of defective zirconium-based MOFs in addressing challenging energy- and environment-related problems, positioning them as versatile tools toward a cleaner more sustainable future.

Language: Английский

Citations

51
MOF magic: zirconium-based frameworks in theranostic and bio-imaging applications DOI
D. K. Gupta, Santosh Kumar, Mohmmad Younus Wani

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(11), P. 2691 - 2710

Published: Jan. 1, 2024

Over the past two decades, metal–organic frameworks (MOFs) have garnered substantial scientific interest across diverse fields, spanning gas storage, catalysis, biotechnology, and more.

Language: Английский

Citations

22
Guiding the rational design of biocompatible metal-organic frameworks for drug delivery DOI Creative Commons
Dhruv Menon, David Fairen‐Jimenez

Matter, Journal Year: 2025, Volume and Issue: 8(3), P. 101958 - 101958

Published: Jan. 29, 2025

Language: Английский

Citations

7
Phototherapy: progress, challenges, and opportunities DOI
Xi Yuan,

Junliang Zhou,

Lin Yuan

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Language: Английский

Citations

17
Nanocomposite hydrogel microneedles: a theranostic toolbox for personalized medicine DOI Creative Commons
Catarina Martins, Clara García‐Astrain, João Conde

et al.

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(8), P. 2262 - 2275

Published: Feb. 20, 2024

Abstract Due to the severity and high prevalence of cancer, as well its complex pathological condition, new strategies for cancer treatment diagnostics are required. As such, it is important design a toolbox that integrates multiple functions on single smart platform. Theranostic hydrogels offer an innovative personalized method tackle while also considering patient comfort, thereby facilitating future implementation translation clinic. In terms theranostic systems used in therapy, nanoparticles widely diagnostic therapeutic tools. Nanoparticles can achieve systemic circulation, evade host defenses, deliver drugs signaling agents at targeted site, diagnose treat disease cellular molecular level. this context, hydrogel microneedles have potential multifunctional operation medical devices, avoiding complications associated with delivery therapeutics. Compared oral administration subcutaneous injection, advantages such better compliance, faster onset action, improved permeability efficacy. addition, they comprise highly biocompatible polymers excellent degradability tunable properties. thus possibility expand through combined synergistic use their respective features. We review herein recent advances concerning processing methods material requirements within realm platforms, various approaches toward incorporation added functionality. Graphical

Language: Английский

Citations

14
An NIR Type I Photosensitizer Based on a Cyclometalated Ir(III)-Rhodamine Complex for a Photodynamic Antibacterial Effect toward Both Gram-Positive and Gram-Negative Bacteria DOI
Chuangjun Liu, Qihang Ding,

Y. B. Liu

et al.

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(28), P. 13059 - 13067

Published: June 28, 2024

Type I photosensitizers offer an advantage in photodynamic therapy (PDT) due to their diminished reliance on oxygen levels, thus circumventing the challenge of hypoxia commonly encountered PDT. In this study, we present synthesis and comprehensive characterization a novel type photosensitizer derived from cyclometalated Ir(III)-rhodamine complex. Remarkably, complex exhibits shift absorption fluorescence, transitioning "off" "on" states aprotic protic solvents, respectively, contrary initial expectations. Upon exposure light, demonstrates effective generation O2– ·OH radicals via mechanism. Additionally, it notable antibacterial activity against both Gram-positive Gram-negative bacteria, demonstrated through vitro vivo experiments. This research offers valuable insights for development photosensitizers.

Language: Английский

Citations

11
Degradable and Piezoelectric Hollow ZnO Heterostructures for Sonodynamic Therapy and Pro-Death Autophagy DOI
Lihan Cai, Tao Sun,

Fuping Han

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 24, 2024

Piezoelectric materials can generate charges and reactive oxygen species (ROS) under external force stimulation for ultrasound-induced sonodynamic therapy (SDT). However, their poor piezoelectricity, fast electron–hole pair recombination rate, biological toxicity of piezoelectric limit the therapeutic effects SDT. In this study, hollow ZnO (HZnO) nanospheres were synthesized by using a one-step method. The structure facilitated deformation HZnO ultrasound mechanical increased constant. Subsequently, black phosphorus quantum dots (BPQDs) arginine-glycine-aspartic acid peptide (RGD)-poly(ethylene glycol) (PEG) combined with to further enhance effect constructing heterojunctions enable tumor-targeting ability. During treatment, HZnO-BPQDs-PEG could degrade in an acidic tumor microenvironment release Zn2+ PO43– ions induce pro-death autophagy. ROS produced SDT also accelerated autophagy promoted ferroptosis cancer cells. This study demonstrates that has strong effectively cells, providing new idea design application therapy.

Language: Английский

Citations

10
Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy DOI Creative Commons
Francesca Melle, Dhruv Menon, João Conniot

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Abstract Despite improvements in cancer survival rates, metastatic and surgery‐resistant cancers, such as pancreatic cancer, remain challenging, with poor prognoses limited treatment options. Enhancing drug bioavailability tumors, while minimizing off‐target effects, is crucial. Metal–organic frameworks (MOFs) have emerged promising delivery vehicles owing to their high loading capacity, biocompatibility, functional tunability. However, the vast chemical diversity of MOFs complicates rational design biocompatible materials. This study employed machine learning molecular simulations identify suitable for encapsulating gemcitabine, paclitaxel, SN‐38, identified PCN‐222 an optimal candidate. Following loading, MOF formulations are improved colloidal stability biocompatibility. In vitro studies on cell lines shown cellular internalization, delayed release. Long‐term tests demonstrated a consistent performance over 12 months. vivo tumor‐bearing mice revealed that paclitaxel‐loaded PCN‐222, particularly hydrogel local administration, significantly reduced spread tumor growth compared free drug. These findings underscore potential effective system hard‐to‐treat cancers.

Language: Английский

Citations

2
Red/near-infrared light triggered photorelease via sensitized photolysis DOI
Donghao Lu,

Shu Yang,

Qiyu Yu

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216117 - 216117

Published: July 27, 2024

Language: Английский

Citations

9
Nanoscale Metal–Organic Frameworks and Nanoscale Coordination Polymers: From Synthesis to Cancer Therapy and Biomedical Imaging DOI
Xianghui Cao, Nana Feng, Qingqing Huang

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 21, 2024

Recently, there has been significant interest in nanoscale metal-organic frameworks (NMOFs) characterized by ordered crystal structures and coordination polymers (NCPs) featuring amorphous structures. These arise from the interactions between inorganic metal ions or clusters organic ligands. Their advantages, such as ability to tailor composition structure, efficiently encapsulate diverse therapeutic imaging agents within porous frameworks, inherent biodegradability, surface functionalization capability, position them promising carriers biomedical fields. This review provides an overview of synthesis modification strategies employed for NMOFs NCPs, along with their applications cancer treatment biological imaging. Finally, future directions challenges associated utilization NCPs diagnosis are also discussed.

Language: Английский

Citations

8