Phototherapy: progress, challenges, and opportunities

Science China Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

Язык: Английский

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Porphyrin-graphdiyne analogue modified MXene nanosheets for highly efficient, stable and long-term antibacterials

Next Materials, Год журнала: 2025, Номер 6, С. 100485 - 100485

Опубликована: Янв. 1, 2025

Язык: Английский

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Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 12

Опубликована: Фев. 11, 2025

The application of photodynamic therapy (PDT) is limited by unsatisfactory therapeutic efficacy and dose-dependent phototoxicity in clinical settings. Intravenous nano-drug delivery systems (NDDSs) hold promise for enhancing the efficiency photosensitive drugs, but often result aggregation-caused quenching (ACQ) effects, preventing site-specific activation. We exploited manganese (Mn2+)-pyrochloric acid (PPa) nanocomplexes coordinated using photosensitizer PPa metal Mn ion treatment osteosarcoma. were precisely co-assembled water to stably co-deliver Mn2+ PPa, enabling tumor-specific release fluorescence recovery. Following laser irradiation, activated significantly enhanced killing effects on primary cancer cells. Additionally, ions cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) pathway, promoting maturation dendritic cells (DCs) augmenting CD8+-mediated antitumor immune responses. This study advances on-demand activation drugs immunotherapy toward applicability exploiting Mn2+-PPa with high activatability effectiveness targeted PDT immunotherapy.

Язык: Английский

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Reactive oxygen species-mediated organic long-persistent luminophores light up biomedicine: from two-component separated nano-systems to integrated uni-luminophores

Chemical Society Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

An overview of the recent advances in reactive oxygen species-mediated organic long-persistent luminophores, including their history, working mechanisms, design strategies, and biomedical applications.

Язык: Английский

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Lysosomal-targeted fluorescent probe based pH regulating reactivity for tracking cysteine dynamics under oxidative stress

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(21), С. 5157 - 5161

Опубликована: Янв. 1, 2024

The ability to detect and visualize cellular events associated biological analytes is essential for the understanding of their physiological pathological functions.

Язык: Английский

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Tumor microenvironment ameliorative and adaptive nanoparticles with photothermal-to-photodynamic switch for cancer phototherapy

Biomaterials, Год журнала: 2024, Номер 313, С. 122771 - 122771

Опубликована: Авг. 25, 2024

Язык: Английский

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Highly Photoreactive Semiconducting Polymers with Cascade Intramolecular Singlet Oxygen and Energy Transfer for Cancer-Specific Afterglow Theranostics

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Afterglow luminescence provides ultrasensitive optical detection by minimizing tissue autofluorescence and increasing the signal-to-noise ratio. However, due to lack of suitable unimolecular afterglow scaffolds, current agents are nanocomposites containing multiple components with limited performance have rarely been applied for cancer theranostics. Herein, we report synthesis a series oxathiine-containing donor-acceptor block semiconducting polymers (PDCDs) observation their high photoreactivity strong near-infrared (NIR) luminescence. We reveal that PDCDs absorb NIR light undergo photodynamic process generate singlet oxygen (1O2), which intramolecularly transfers efficiently reacts oxathiine form intermediates low Gibbs free energy changes required this photoreaction. Following intramolecular transfer from donor acceptor block, emission is produced PDCDs. Owing efficient cascade photochemical process, PDCD-based nanoparticles achieve higher brightness longer compared most reported agents, even after ultrashort photoirradiation only 3 s. Furthermore, within PDCD can be inhibited bioconjugation quencher-linked peptide. This allows construction cancer-activatable theranostic probe (CATP) switches on signal function in presence cancer-overexpressed enzyme. Thereby, CATP represents first phototheranostic permits cancer-specific therapy under preclinical settings. In summary, study molecular guideline develop probes photoreactive polymers.

Язык: Английский

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Development of Nanostructured Lipid Carriers Loaded with Purpurin-18 N propargylimide methyl ester to Improve Photodynamic Therapy

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106767 - 106767

Опубликована: Март 1, 2025

Язык: Английский

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X-ray Induced Persistent Type I Photodynamic Therapy with Enhanced Hypoxia Tolerance and Chemoradiotherapy

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

The hypoxic tumor microenvironment (TME), inadequate penetration depth of Vis/NIR light, and lack sustaining reactive oxygen species (ROS) production capability photosensitizers pose significant obstacles to the widespread clinic applications photodynamic therapy (PDT). Herein, we developed a "persistent type I X-PDT" platform simultaneously overcome these three limitations. Such nanoplatform could generate efficient ROS (•OH O2•–) under X-ray irradiation in both normoxic environments. persists cells for more than 4 h, even after source is removed. Notably, persistent X-PDT does not increase levels hypoxia-inducible factor-1 alpha (HIF-1α) vascular endothelial growth factor (VEGF) vitro vivo. Moreover, further enhance radiotherapy efficacy conditions, Pt (IV) prodrug was also introduced, which can be reduced cisplatin selectively cells, functioning only as chemodrug but radiosensitizer.

Язык: Английский

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Albumin Modulated Homodimer as an Efficient Photosensitizer for Long‐Term Imaging‐Guided Tumor Therapy Directed with Sunlight Irradiation

Small, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Abstract The reactive oxygen species (ROS) amplification caused by inevitable plasma albumin encapsulation is still a challenge to circumvent the systemic adverse effects in photodynamic therapy (PDT) process. Herein, disulfide bond linked homodimer, Cy1280, which modulated accurately balance fluorescence and ROS generation exhibit weak sealed PDT effect during blood circulation, exploited. Cy1280 can be specifically internalized dispersed at tumor site via Organic Anion Transporter Proteins (OATPs) thiol‐disulfide exchange mediated synergistic uptake activated after mild sunlight irradiation (100 ± 5 Klx) sensitize neighboring cellular mitochondria execute direct protein dysfunction effect. dynamic covalent chemistry (DCC) facilitates prolonged sustained retention tumors (>336 h) demonstrates efficacy of imaging‐guided solid‐tumor tumor‐bearing BALB/C mice. This study resolves stubborn impotent penetration bulky‐sized nanoparticles high interstitial pressure with manner, long‐term circulation manipulated also improve whole body phototoxic symptom. advantageous feature provides promising candidate for overcoming off‐target phototoxicity inadequate accumulation challenges clinical translation photosensitizers (PSs).

Язык: Английский

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