Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 20, 2025
Afterglow
occurring
after
light
excitation
ceases
offers
a
safer
source
to
the
laser-activated
verteporfin
therapy
approved
by
FDA
for
choroidal
neovascularization
(CNV).
However,
conventional
afterglow
molecules,
especially
adamantane-dioxetanes
with
high
steric
hindrance,
exhibit
limited
chemiexcitation,
restricting
electron
transfer
and
diminishing
therapeutic
effects.
Here,
we
constructed
ultrabright
nanosystems
integrating
low-hindrance
cyclobutane
moieties
into
dioxetane
framework.
Among
these
substituents,
benzyl
oxocyclobutane-dioxetane
is
brightest
molecule
due
its
lowest
showing
35.7
times
faster
relative
chemiexcitation
rate
59
higher
intensity
than
adamantane-dioxetane,
alongside
three-order-of-magnitude
increase
in
total
emission.
Consequently,
at
equivalent
concentration,
oxocyclobutane-dioxetane-based
nanosystem
produces
nearly
five
more
singlet
oxygen
free
verteporfin.
In
CNV
mouse
model,
cyclic
treatment
our
reduced
lesion
areas
64.9%,
outperforming
39.3%
reduction
achieved
counterpart.
By
eliminating
need
laser
activation,
this
strategy
minimizes
ocular
damage,
providing
safe
effective
other
retinal
disorders.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Afterglow
luminescence
provides
ultrasensitive
optical
detection
by
minimizing
tissue
autofluorescence
and
increasing
the
signal-to-noise
ratio.
However,
due
to
lack
of
suitable
unimolecular
afterglow
scaffolds,
current
agents
are
nanocomposites
containing
multiple
components
with
limited
performance
have
rarely
been
applied
for
cancer
theranostics.
Herein,
we
report
synthesis
a
series
oxathiine-containing
donor-acceptor
block
semiconducting
polymers
(PDCDs)
observation
their
high
photoreactivity
strong
near-infrared
(NIR)
luminescence.
We
reveal
that
PDCDs
absorb
NIR
light
undergo
photodynamic
process
generate
singlet
oxygen
(1O2),
which
intramolecularly
transfers
efficiently
reacts
oxathiine
form
intermediates
low
Gibbs
free
energy
changes
required
this
photoreaction.
Following
intramolecular
transfer
from
donor
acceptor
block,
emission
is
produced
PDCDs.
Owing
efficient
cascade
photochemical
process,
PDCD-based
nanoparticles
achieve
higher
brightness
longer
compared
most
reported
agents,
even
after
ultrashort
photoirradiation
only
3
s.
Furthermore,
within
PDCD
can
be
inhibited
bioconjugation
quencher-linked
peptide.
This
allows
construction
cancer-activatable
theranostic
probe
(CATP)
switches
on
signal
function
in
presence
cancer-overexpressed
enzyme.
Thereby,
CATP
represents
first
phototheranostic
permits
cancer-specific
therapy
under
preclinical
settings.
In
summary,
study
molecular
guideline
develop
probes
photoreactive
polymers.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 11, 2025
The
application
of
photodynamic
therapy
(PDT)
is
limited
by
unsatisfactory
therapeutic
efficacy
and
dose-dependent
phototoxicity
in
clinical
settings.
Intravenous
nano-drug
delivery
systems
(NDDSs)
hold
promise
for
enhancing
the
efficiency
photosensitive
drugs,
but
often
result
aggregation-caused
quenching
(ACQ)
effects,
preventing
site-specific
activation.
We
exploited
manganese
(Mn2+)-pyrochloric
acid
(PPa)
nanocomplexes
coordinated
using
photosensitizer
PPa
metal
Mn
ion
treatment
osteosarcoma.
were
precisely
co-assembled
water
to
stably
co-deliver
Mn2+
PPa,
enabling
tumor-specific
release
fluorescence
recovery.
Following
laser
irradiation,
activated
significantly
enhanced
killing
effects
on
primary
cancer
cells.
Additionally,
ions
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
interferon
genes
(STING)
pathway,
promoting
maturation
dendritic
cells
(DCs)
augmenting
CD8+-mediated
antitumor
immune
responses.
This
study
advances
on-demand
activation
drugs
immunotherapy
toward
applicability
exploiting
Mn2+-PPa
with
high
activatability
effectiveness
targeted
PDT
immunotherapy.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
Due
to
O2
dependence,
hypoxia-induced
apoptosis
resistance,
and
immunosuppressive
microenvironment,
the
effect
of
traditional
photodynamic
therapy
toward
hypoxic
solid
tumors
is
severely
limited.
Herein,
we
report
an
O2-independent
photocatalyst
(EBSe)
for
tumor
immunotherapy
potentiation
via
synergism
near-infrared
(NIR)
light-induced
ferroptosis/pyroptosis/oncosis.
Simple
Se
ethyl
modifications
on
methylene
blue
(MB)
endow
EBSe
with
a
remarkable
phototoxicity
enhancement
(>2500
folds)
excellent
index
(PI
>
32,000)
4T1
cells
under
hypoxia.
exhibits
self-adaptive
processes
that
generate
enhanced
type
I/II
ROS
normoxia
elevate
carbon
radical
production
Interestingly,
shows
much
higher
cell
uptake
undergoes
photoinduced
lysosomal-to-nucleus
translocation,
which
activates
ferroptosis,
pyroptosis,
oncosis.
The
three
nonapoptotic
pathways
potentiates
antitumor
immune
responses
in
tumor-bearing
mice.
This
work
offers
reliable
strategy
developing
powerful
PSs
overcome
resistance
microenvironment
tumors.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(21), С. 5157 - 5161
Опубликована: Янв. 1, 2024
The
ability
to
detect
and
visualize
cellular
events
associated
biological
analytes
is
essential
for
the
understanding
of
their
physiological
pathological
functions.
Chemical Society Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
An
overview
of
the
recent
advances
in
reactive
oxygen
species-mediated
organic
long-persistent
luminophores,
including
their
history,
working
mechanisms,
design
strategies,
and
biomedical
applications.
