Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

Advanced Materials, Год журнала: 2021, Номер 33(7)

Опубликована: Янв. 4, 2021

Chemodynamic therapy (CDT) is an emerging method that kills cancer cells by converting intracellular hydrogen peroxide (H2 O2 ) into highly toxic hydroxyl radicals (• OH). To overcome the current limitations of insufficient endogenous H2 and high concentration glutathione (GSH) in tumor cells, intelligent nanocatalytic theranostics (denoted as PGC-DOX) possesses both self-supply GSH-elimination properties for efficient presented. This nanoplatform constructed a facile one-step biomineralization using poly(ethylene glycol)-modified glucose oxidase (GOx) template to form biodegradable copper-doped calcium phosphate nanoparticles, followed loading doxorubicin (DOX). As enzyme catalyst, GOx can effectively catalyze generate , which not only starves but also supplies subsequent Fenton-like reaction. Meanwhile, redox reaction between released Cu2+ ions GSH will induce depletion reduce Fenton agent Cu+ ions, then trigger • OH -mediated reaction, resulting enhanced CDT efficacy. The integration GOx-mediated starvation therapy, CDT, DOX-induced chemotherapy, endow PGC-DOX with effective growth inhibition minimal side effects vivo.

Язык: Английский

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Biomedicine Meets Fenton Chemistry

Chemical Reviews, Год журнала: 2021, Номер 121(4), С. 1981 - 2019

Опубликована: Янв. 25, 2021

Since the first connection between Fenton chemistry and biomedicine, numerous studies have been presented in this field. Comprehensive presentation of guidance from a summary its representative applications cancer therapy would help us understand promote further development This comprehensive review supplies basic information regarding chemistry, including reactions Fenton-like reactions. Subsequently, current progress is discussed, with some corresponding examples presented. Furthermore, strategies for optimizing performance chemodynamic guided by are highlighted. Most importantly, future perspectives on combination biomedicine or wider range catalytic approaches We hope that will attract positive attention materials science, fields tighten their connections.

Язык: Английский

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Recent progress of chemodynamic therapy-induced combination cancer therapy

Nano Today, Год журнала: 2020, Номер 35, С. 100946 - 100946

Опубликована: Авг. 13, 2020

Язык: Английский

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Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Chemical Society Reviews, Год журнала: 2021, Номер 50(10), С. 6013 - 6041

Опубликована: Янв. 1, 2021

In this review, we systematically survey the most recent progress in engineering nanomedicine for intracellular glutathione consumption-augmented cancer therapy.

Язык: Английский

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Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics

Theranostics, Год журнала: 2020, Номер 10(10), С. 4557 - 4588

Опубликована: Янв. 1, 2020

In recent years, much progress has been motivated in stimuli-responsive nanocarriers, which could response to the intrinsic physicochemical and pathological factors diseased regions increase specificity of drug delivery. Currently, numerous nanocarriers have engineered with changes responding external stimuli, such as ultrasound, thermal, light magnetic field, well internal including pH, redox potential, hypoxia enzyme, etc. Nanocarriers respond stimuli tumor microenvironments or inside cancer cells for on-demanded delivery accumulation, controlled release, activation bioactive compounds, probes targeting ligands, size, charge conformation conversion, etc., leading sensing signaling, overcoming multidrug resistance, accurate diagnosis precision therapy. This review summarized general strategies developing advances, presented their applications delivery, imaging, therapy theranostics, illustrated clinical translation made prospects.

Язык: Английский

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Bioinspired Construction of a Nanozyme-Based H₂O₂ Homeostasis Disruptor for Intensive Chemodynamic Therapy

Journal of the American Chemical Society, Год журнала: 2020, Номер 142(11), С. 5177 - 5183

Опубликована: Фев. 26, 2020

The insufficient intracellular H2O2 level in tumor cells is closely associated with the limited efficacy of chemodynamic therapy (CDT). Despite tremendous efforts, engineering CDT agents a straightforward and secure supplying ability remains great challenge. Inspired by balance generation elimination cancer cells, herein, nanozyme-based homeostasis disruptor fabricated to elevate through facilitating production restraining for enhanced CDT. In formulation, superoxide dismutase-mimicking activity can convert O2•– H2O2, promoting H2O2. Simultaneously, suppression catalase depletion glutathione weaken transformation H2O. Thus, well-defined system could perturb give rise accumulation cells. raised would ultimately amplify Fenton-like reaction-based efficiency. Our work not only paves way engineer alternative intensive but also provides new insights into construction bioinspired materials.

Язык: Английский

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An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Апрель 8, 2020

Abstract The therapeutic effect of reactive oxygen species (ROS)-involved cancer therapies is significantly limited by shortage oxy-substrates, such as hypoxia in photodynamic therapy (PDT) and insufficient hydrogen peroxide (H 2 O ) chemodynamic (CDT). Here, we report a H /O self-supplying nanoagent, (MSNs@CaO -ICG)@LA, which consists manganese silicate (MSN)-supported calcium (CaO indocyanine green (ICG) with further surface modification phase-change material lauric acid (LA). Under laser irradiation, ICG simultaneously generates singlet emits heat to melt the LA. exposed CaO reacts water produce for hypoxia-relieved ICG-mediated PDT -supplying MSN-based CDT, acting an open source strategy ROS production. Additionally, MSNs-induced glutathione depletion protects from scavenging, termed reduce expenditure. This expenditure effective inhibiting tumor growth both vitro vivo, improves generation efficiency multi-level ROS-involved therapies.

Язык: Английский

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Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Small, Год журнала: 2021, Номер 18(6)

Опубликована: Ноя. 2, 2021

Abstract Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in tumor region, was first proposed by Bu, Shi, and co‐workers 2016. Recently, with rapid development of nanomaterials, CDT has attracted tremendous attention because its unique advantages: 1) It is tumor‐selective low side effects; 2) process does not depend on external field stimulation; 3) it can modulate hypoxic immunosuppressive microenvironment; 4) cost low. In addition Fe‐involved strategies, reaction‐mediated strategies have also been proposed, which are based many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, zinc. Moreover, combined therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, immunotherapy for achieving enhanced anticancer effects. Besides, there studies that extend application antibacterial field. This review introduces latest advancements nanomaterials‐involved from 2018 present proposes current limitations well future research directions related

Язык: Английский

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Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Advanced Materials, Год журнала: 2020, Номер 32(10)

Опубликована: Янв. 28, 2020

Abstract Despite the comprehensive applications in bioimaging, biosensing, drug/gene delivery, and tumor therapy of manganese oxide nanomaterials (MONs including MnO 2 , MnO, Mn O 3 4 x ) their derivatives, a review article focusing on MON‐based nanoplatforms has not been reported yet. Herein, representative progresses MONs synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, are mainly introduced. First, five kinds primary synthetic methods presented, thermal decomposition method, exfoliation strategy, permanganates reduction adsorption–oxidation hydro/solvothermal. Second, preparations hollow composite materials summarized specially. Then, chemical toxicity discussed. Next, diagnostic imaging sensing outlined. Finally, some rational designs photodynamic therapy, photothermal chemodynamic sonodynamic radiotherapy, magnetic hyperthermia, chemotherapy, gene starvation ferroptosis, immunotherapy, various combination highlighted.

Язык: Английский

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2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Апрель 13, 2021

Reactive oxygen species (ROS) are generated and consumed in living organism for normal metabolism. Paradoxically, the overproduction and/or mismanagement of ROS have been involved pathogenesis progression various human diseases. Here, we reported a two-dimensional (2D) vanadium carbide (V2C) MXene nanoenzyme (MXenzyme) that can mimic up to six naturally-occurring enzymes, including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione (GPx), thiol (TPx) haloperoxidase (HPO). Based on these enzyme-mimicking properties, constructed 2D V2C MXenzyme not only possesses high biocompatibility but also exhibits robust vitro cytoprotection against oxidative stress. Importantly, rebuilds redox homeostasis without perturbing endogenous antioxidant status relieves ROS-induced damage with benign vivo therapeutic effects, as demonstrated both inflammation neurodegeneration animal models. These findings open an avenue enable use remedial nanoplatform treat ROS-mediated inflammatory neurodegenerative

Язык: Английский

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